Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade

Abstract

The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

1 . A compound having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;  
 B is selected from the group consisting of: 
 (i) phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 32 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 36 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 32 , is optionally substituted by R 33 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 36 , is optionally substituted by R 35 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 33  and R 35 , respectively, is optionally substituted by R 34 ;  
 (ii) hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ; and  
 (iii) C3-C12 cycloalkyl or a C4-C9 saturated heterocyclyl, wherein (a) each ring carbon may be optionally substituted with R 33 , (b) a ring carbon, other than the ring carbon at the point of attachment of B to A, may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, (c) a ring carbon or nitrogen in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (d) a ring carbon or nitrogen in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 3 , (e) a ring carbon or nitrogen atom, if present, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (f) a ring carbon or nitrogen, if present, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , (g) a ring carbon or nitrogen, if present, in a first gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 10 , is optionally substituted by R 11 , (h) a ring carbon or nitrogen, if present, in a second gamma position relative to the carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 12 , is optionally substituted by R 33 , and (i) a ring carbon or nitrogen, if present, in a delta position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 11  and R 33 , respectively, is optionally substituted by R 34 ;  
 
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, alkoxyamino, alkanoyl, haloalkanoyl, amidino, guanidino, alkylenedioxy, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfamido, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, amidosulfonyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, and cyano;  
 A is bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is selected from the group consisting of O, S, C(O), (R 1 )NC(O), (R 7 )NC(S), and N(R 7 ), with the proviso that W 7  is bonded to the N(H) on the pyridine ring;  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 Ja is N or C—X 0 ;  
 Jb is N or C—R 1 ;  
 X 0  is independently selected from the group consisting of hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 1  is selected from the group consisting of: 
 (i) hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 (ii) taken with X 1  or R 2  to form —W═X—Y=Z-; wherein —W═X—Y=Z- forms an aryl or heteroaryl of 5 or 6 ring-members; and  
 (iii) taken with X 1  or R 2  bonded together to form C5-C8 cycloalkenyl ring or a partially saturated C5-C8 heterocyclyl ring, wherein said cycloalkenyl ring or heterocyclyl ring is optionally substituted with one or more of the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ;  
 
 W, X, Y, and Z are independently selected from the group consisting of C(R 9 ), C(R 10 ), C(R 11 ), C(R 12 ), N, N(R 10 ), O, S and a bond with the proviso that one of W, X, Y, and Z is independently selected to be a bond when one of W, X, Y, and Z is O or S, with the further proviso that no more than one of W, X, Y, and Z is optionally selected from the group consisting of O and S, and with the additional proviso that no more than three of W, X, Y, and Z are optionally N or N(R 10 );  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of: 
 (i) a bond, (CR 41 R 42 ) q  wherein q is 1 or 2, and (CH(R 41 )) g —W 0 —(CH(R 42 )) p  wherein g and p are integers independently selected from 0 through 3 and W 0  is selected from the group consisting of O, S, C(O), S(O), N(R 41 ), and ON(R 41 ); and  
 (ii) (CH(R 41 )) e —W 22 —(CH(R 42 )) h  wherein e and h are independently 0 or 1 and W 22  is selected from the group consisting of CR 41 ═CR 42 , 1,2-cyclopropyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 2,3-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, and 3,4-tetrahydrofuranyl, wherein Z 0  is directly bonded to the pyridine ring and W 22  is optionally substituted with one or more substituents selected from the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ;  
 
 R 41  and R 42  are independently selected from the group consisting of hydrido, hydroxy, alkyl, and amino;  
 Q is selected from the group consisting of: 
 (i) phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ; and  
 (ii) hydrido with the proviso that Z 0  is other than a bond;  
 
 K is selected form the group consisting of: 
 (i) CR 4a R 4b ; and  
 (ii) (CH(R 14 )) j -T wherein j is 0 or 1 and T is a bond or N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 
 R 4a  and R 4b  are independently selected from the group consisting of hydrido, hydroxyalkyl, alkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;  
 R 14  is hydrido or halo;  
 E 0  is selected from the group consisting of: 
 (i) E 1 , with the proviso that K is CR 4a R 4b , is E 1  wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), S(O) 2 N(H), and N(H)S(O) 2 ; and  
 (ii) E 2 , with the proviso that K is (CH(R 14 )) j -T, is E 2  wherein E 2  is selected from the group consisting of C(O)N(H), (H)NC(O), C(S)N(H), (H)NC(S), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 
 Y 0  is selected from the group consisting of: 
 (i) the formula  
                     
  wherein J 5 , J 6 , D 5 , D 6  and the ring carbon atoms to which they are attached define a phenyl or 5- or 6-membered heteroaryl ring, T, wherein one of J 5  and J 6  is absent when T is a 5-membered heteroaryl ring, J 5  is optionally substituted by R 17  when J 5  is a carbon atom, J 6  is optionally substituted by R 18  when J 6  is a carbon atom, D 5  is optionally substituted by R 16  when D 5  is a carbon atom and D 5  is optionally substituted by R 19  when D 6  is a carbon atom;  
 (ii) Y AT  wherein Y AT  is Q b -Q s ; and  
 (iii) Q b -Q ss  wherein Q s  is (CH(R 14 )) e —W 2 —(CH(R 15 )) h , wherein e and h are independently 1 or 2 and W 2  is CR 4a ═CR 4b  with the proviso that (CH(R 14 )) e  is bonded to E 0 ;  
 
 R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time, with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 2  are independently selected from the group consisting of hydrido, alkyl, hydroxy, amino, alkylamino and dialkylamino;  
 Q s  is selected from the group consisting of a bond, (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 4, and (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 3 and W 1  is selected from the group consisting of C(O)N(R 14 ), (R 14 )NC(O), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , and N(R 14 ), with the proviso that R 14  is selected from other than halo when directly bonded to N, and with the additional proviso that (CR 37 R 38 ) b  and (CR 37 R 38 ) b , and (CH(R 14 )) c  are bonded to E 0 ;  
 R 37  is independently selected from the group consisting of hydrido, alkyl, and haloalkyl; and  
 R 38  is selected from the group conisting of hydrido, alkyl, haloalkyl, aroyl or heteroaroyl, wherein R 38  is optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19 .  
 
     
     
         2 . The compound of  claim 1  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;  
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 32 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 36 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 32 , is optionally substituted by R 33 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 36 , is optionally substituted by R 35 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 33  and R 35 , respectively, is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 Ja is N or C—X 0 ;  
 Jb is N or C—R 1 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 11 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 Y 0  is the formula  
                     
 wherein J 1 , J 6 , D 5 , D 6  and the ring carbon atoms to which they are attached define a phenyl or 5- or 6-membered heteroaryl ring, T, wherein one of J 5  and J 6  is absent when T is a 5-membered heteroaryl ring, J 5  is optionally substituted by R 17  when J 5  is a carbon atom, J 6  is optionally substituted by R 18  when J 6  is a carbon atom, D 5  is optionally substituted by R 16  when D 5  is a carbon atom and D 6  is optionally substituted by R 19  when D 6  is a carbon atom;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, alkyl, and hydroxy; and  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         3 . The compound of  claim 2  or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;    B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 32 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 36 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 32 , is optionally substituted by R 33 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 36 , is optionally substituted by R 35 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 33  and R 35 , respectively, is optionally substituted by R 34 ;    R 32 , R 33 , R 34 , R 35 , and R 35  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;    A is selected from the group consisting of a bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;    Ja is N or C—X o ;    Jb is N or C—R 1 ;    R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;    R 2  is Z 0 -Q;    Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;    Q is selected from the group consisting of phenyl and 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;    R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;    R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;    Y 0  is selected from the group consisting of:                                            R 17  and R 18  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;    R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano; and  
 (ii) C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
   Q b  is C(NR 25 )NR 23 R 24  or hydrido, with the proviso that no more than one of R 23  and R 24  is hydroxy at the same time;    R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, ethyl, and hydroxy; and    Q s  is selected from the group consisting of a bond, CH 2  and CH 2 CH 2 .    
     
     
         4 . The compound of  claim 3  or a pharmaceutically acceptable salt thereof, wherein; 
 M is N→O;    B is selected from the group consisting of 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;    A is selected from the group consisting of CH 2 , CH 3 CH, CF 3 CH, NHC(O), CH 2 CH 2 , and CH 2 CH 2 CH 2 ;    Ja is N or C—X 0 ;    Jb is N or C—R 1 ;    R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;    R 2  is Z 0 -Q;    Z 0  is selected from the group consisting of a bond, CH 2 , O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;    Q is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl, 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl, 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl, 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;    Y 0  is selected from the group consisting of:                          R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano; and  
 (ii) C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
   R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;    Q b  is C(NR 25 )NR 23 R 24  or hydrido;    R 23 , R 24 , and R 25  are independently hydrido or methyl; and    Q s  is CH 2 .    
     
     
         5 . The compound of  claim 2  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 32 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 36 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 32 , is optionally substituted by R 33 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 36 , is optionally substituted by R 35 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 33  and R 35 , respectively, is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12  respectively, is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 Y 0  is the formula  
                     
 wherein J 5 , J 6 , D 5 , D 6  and the ring carbon atoms to which they are attached define a phenyl or 5- or 6-membered heteroaryl ring, T, wherein one of J 5  and J 6  is absent when T is a 5-membered heteroaryl ring, J 5  is optionally substituted by R 17  when J 5  is a carbon atom, J 6  is optionally substituted by R 18  when J 6  is a carbon atom, D 5  is optionally substituted by R 16  when D 5  is a carbon atom and D 6  is optionally substituted by R 19  when D 6  is a carbon atom;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently hydrido or alkyl; and  
 Q s  is CH 2 .  
 
     
     
         6 . The compound of  claim 5  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, and 5-isoxazolyl, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 32 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 36 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 32 , is optionally substituted by R 33 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 36 , is optionally substituted by R 35 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 33  and R 35  respectively, is optionally substituted by R 34 ;    R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;    A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, and CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, chloro, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;    R 2  is selected from the group consisting of phenyl and 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;    R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;    R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;    Y 0  is selected from the group consisting of:                          R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;    Q b  is NR 20 R 21  or C(NR 25 )NR 23 R 24 ;    R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, and ethyl; and    Q s  is CH 2 .    
     
     
         7 . The compound of  claim 6  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;    A is CH 2  or CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl, 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl, 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;    Y 0  is selected from the group consisting of:                          R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;    R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;    Q b  is C(NR 25 )NR 23 R 24 ;    R 23 , R 24 , and R 25  are independently hydrido or methyl; and    Q s  is CH 2 .    
     
     
         8 . The compound of  claim 7  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 4-methylphenyl, phenyl, 2-imidazoyl, 3-pyridyl, 4-pyridyl, and 3-trifluoromethyl-2-pyridyl;    A is CH 2  or CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl, 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl; and    Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amdinobenzyl.    
     
     
         9 . The compound of  claim 2  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is 2-imidazoyl, A is CH 2 CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido; or  
 R 2  is 3-amino-5-carboxyphenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido.  
 
     
     
         10 . The compound of  claim 1  having the structure:  
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein;  
         M is N or N→O;  
         B is selected from the group consisting of hydrido, C2-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
         R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
         A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
         R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
         R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
         Ja is N or C—X 0 ;  
         Jb is N or C—R 1 ;  
         R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
         R 2  is Z 0 -Q;  
         Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
         R 41  and R 42  are independently hydrido or alkyl;  
         Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;  
         R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
         R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
         Y 0  is the formula  
         
           
             
             
                 
                 
             
           
         
         wherein J 5 , J 6 , D 5 , D 6  and the ring carbon atoms to which they are attached define a phenyl or 5- or 6-membered heteroaryl ring, T, wherein one of J 5  and J 6  is absent when T is a 5-membered heteroaryl ring, J 5  is optionally substituted by R 17  when J 5  is a carbon atom, J 6  is optionally substituted by R 18  when J 6  is a carbon atom, D 5  is optionally substituted by R 16  when D 5  is a carbon atom and D 6  is optionally substituted by R 19  when D 6  is a carbon atom;  
         R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
         R 16  or R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
         Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
         R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, and hydroxy; and  
         Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
       
     
     
         11 . The compound of  claim 10  or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;    B is selected from the group consisting of hydrido, ethyl, 2-propynyl,    2-propenyl, propyl, isopropyl, butyl, 2-butenyl, 3-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 1-methyl-2-butynyl, 3-pentyl, 1-ethyl-2-propenyl, 2-methylbutyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 2-methyl-3-butynyl, 3-methylbutyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-propyl-2-propenyl, 1-ethyl-2-butynyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 6-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-5-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methyl-4-hexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-4-pentenyl, 1-butyl-2-propenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;    R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;    A is selected from the group consisting of bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;    Ja is N or C—X 0 ;    Jb is N or C—R 1 ;    R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;    R 2  is Z 0 -Q;    Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;    Q is selected from the group consisting of phenyl and 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 1 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;    R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;    R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;    Y 0  is selected from the group consisting of:                                            R 17  and R 18  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;    R 16  or R 19  are selected from the group consisting of: 
 (i) hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano; and  
 (ii) NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
   Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ) with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;    R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, propyl, butyl, isopropyl, and hydroxy; and    Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .    
     
     
         12 . The compound of  claim 11  or a pharmaceutically acceptable salt thereof, wherein; 
 M is N→O;    B is selected from the group consisting of hydrido, ethyl, 2-propenyl,    2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;    A is selected from the group consisting of a bond, CH 2 , NHC(O), CH 2 CH 2 , CH 2 CH 2 CH 2 , and CH 3 CHCH 2 ;    Ja is N or C—X 0 ;    Jb is N or C—R 1 ;    R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;    R 2  is Z 0 -Q;    Z 0  is selected from the group consisting of a bond, CH 2 , O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;    Q is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl, 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl, 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl, 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;    Y 0  is selected from the group consisting of:                          R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano; and  
 (ii) C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido and not more than one of R 16  may (C(NR 25 )NR 23 R 24  at the same time;  
   R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;    Q b  is C(NR 25 )NR 23 R 24  or hydrido;    R 23 , R 24 , and R 25  are independently hydrido or methyl; and    Q s  is CH 2 .    
     
     
         13 . The compound of  claim 10  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, C2-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 Y 0  is the formula  
                     
 wherein J 5 , J 6 , D 5 , D 6  and the ring carbon atoms to which they are attached define a phenyl or 5- or 6-membered heteroaryl ring, T, wherein one of J 5  and J 6  is absent when T is a 5-membered heteroaryl ring, J 5  is optionally substituted by R 17  when J 5  is a carbon atom, J 6  is optionally substituted by R 18  when J 6  is a carbon atom, D 5  is optionally substituted by R 16  when D 5  is a carbon atom and D 6  is optionally substituted by R 19  when D 6  is a carbon atom;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ) and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 21 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently hydrido or alkyl; and  
 Q s  is CH 2 .  
 
     
     
         14 . The compound of  claim 13  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 3-pentyl, 2-methylbutyl, 2-methyl-2-butenyl, 3-methylbutyl, 3-methyl-2-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methyl-4-hexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;    R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;    A is selected from the group consisting of: 
 (i) a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, and CH 2 CH 2 ; and  
 (ii) CH 2 N(CH 3 ), CH 2 N(CH 2 CH 3 ), CH 2 CH 2 N(CH 3 ), and CH 2 CH 2 N(CH 2 CH 3 ) with the proviso that B is hydrido;  
   X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, chloro, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;    R 2  is selected from the group consisting of phenyl and 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 3 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;    R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;    R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;    Y 0  is selected from the group consisting of:                          R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;    Q b  is selected from the group consisting of NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 );    R 20 , R 21 R 23 , R 24 , R 25 , and R 25  are independently selected from the group consisting of hydrido, methyl, and ethyl; and    Q s  is CH 2 .    
     
     
         15 . The compound of  claim 14  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;    A is selected from the group consisting of a bond, CH 2 , CH 3 CH, and CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl, 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl, 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;    Y 0  is selected from the group consisting of:                          R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;    R 17  and R 19  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;    Q b  is C(NR 25 )NR 23 R 24 ;    R 23 , R 24 , and R 25  are independently hydrido or methyl; and    Q s  is CH 2 .    
     
     
         16 . The compound of  claim 15  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;    A is selected from the group consisting of a bond, CH 2 , CH 3 CH, and CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl, 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl; and    Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amidinobenzyl.    
     
     
         17 . The compound of  claim 10  wherein the compound is selected from the group consisting of:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 R 2  is 3-aminophenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 5-amino-2-fluorophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 2-methyl-3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propenyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is (R)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propynyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-pentyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methypropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is propyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 6-amidocarbonylhexyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-hydroxypropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methylpropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-methoxy-2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methoxyethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 5-amidino-2-thienylmethyl, and R 1  is chloro;  
 R 2  is 5-amino-2-methylthiophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is bromo;  
 R 2  is 3-amino-5-carboxamidophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzyl-N-methylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-phenyl-2-propyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2,4-dichlorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(4-bromobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-isobutylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cycloheptylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-pyridylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-pyridylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-(4-methoxyphenyl)ethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-phenylpropyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2,2-diphenylethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-naphthylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(1,2,3,4-tetrahydronaphth-2-ylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is hydrido;  
 R 2  is 3-carboxyphenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro; or  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzylbenzyl, and R 1  is hydrido.  
 
     
     
         18 . The compound of  claim 1  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;  
 B is a C3-C7 cycloalkyl or a C4-C6 saturated heterocyclyl, wherein (a) each ring carbon is optionally substituted with R 33 , (b) a ring carbon, other than the ring carbon at the point of attachment, is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, (c) a ring carbon or nitrogen in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (d) a ring carbon or nitrogen in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (e) a ring carbon or nitrogen, if present, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (f) a ring carbon or nitrogen, if present, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , (g) a ring carbon or nitrogen, if present, in a first gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 10 , is optionally substituted by R 11 , and (h) a ring carbon or nitrogen, if present, in a second gamma position relative to the carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 12 , is optionally substituted by R 33 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 R 34  is selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, and cyano;  
 R 33  is selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 Ja is N or C—X 0 ;  
 Jb is N or C—R 1 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;  
 Y 0  is the formula  
                     
 wherein J 5 , J 6 , D 5 , D 6  and the ring carbon atoms to which they are attached define a phenyl or 5- or 6-membered heteroaryl ring, T, wherein one of J 5  and J 6  is absent when T is a 5-membered heteroaryl ring, J 5  is optionally substituted by R 17  when J 5  is a carbon atom, J 6  is optionally substituted by R 18  when J 6  is a carbon atom, D 5  is optionally substituted by R 16  when D 5  is a carbon atom and D 6  is optionally substituted by R 19  when D 6  is a carbon atom;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21  or and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , and R 21  are independently selected from the group consisting of hydrido, alkyl, and hydroxy; and  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         19 . The compound of  claim 18  or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;    B is selected from the group consisting of cyclopropyl, cyclobutyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, thiaetan-3-yl, cyclopentyl, cyclohexyl, norbornyl, 7-oxabicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexan-6-yl, cycloheptyl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 4H-2-pyranyl, 4H-3-pyranyl, 4H-4-pyranyl, 4H-pyran-4-one-2-yl, 4H-pyran-4-one-3-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein (a) each ring carbon is optionally substituted with R 33 , (b) a ring carbon or nitrogen in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (c) a ring carbon or nitrogen in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (d) a ring carbon or nitrogen, if present, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , and (e) a ring carbon or nitrogen, if present, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 ;    R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;    R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;    R 33  is selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;    A is selected from the group consisting of a bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;    Ja is N or C—X 0 ;    Jb is N or C—R 1 ;    R 1  and X 0  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;    R 2  is Z 0 -Q;    Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;    Q is selected from the group consisting of phenyl and 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;    Y 0  is selected from the group consisting of:                                            R 17  and R 18  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;    R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano; and  
 (ii) C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
   Q b  is C(NR 25 )NR 23 R 24  or hydrido, with the proviso that no more than one of R 23  and R 24  is hydroxy at the same time;    R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, ethyl, and hydroxy; and    Q s  is selected from the group consisting of a bond, CH 2  and CH 2 CH 2 .    
     
     
         20 . The compound of  claim 19  or a pharmaceutically acceptable salt thereof, wherein; 
 M is NO;    B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, 1-pyrrolidinyl, 1-piperidinyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 7-oxabicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexan-6-yl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 4H-2-pyranyl, 4H-3-pyranyl, 4H-4-pyranyl, 4H-pyran-4-one-2-yl, 4H-pyran-4-one-3-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl;    A is selected from the group consisting of a bond, CH 2 , NHC(O), CH 2 CH 2 , and CH 2 CH 2 CH 2 ;    Ja is N or C—X 0 ;    Jb is N or C—R 1 ;    R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;    R 2  is Z 0 -Q;    Z 0  is selected from the group consisting of a bond, CH 2 , O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;    Q is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl, 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl, 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl, 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;    Y 0  is selected from the group consisting of:                          R 15  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 (ii) C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
   R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;    Q b  is C(NR 25 )NR 23 R 24  or hydrido;    R 23 , R 24 , and R 25  are independently hydrido or methyl; and    Q s  is CH 2 .    
     
     
         21 . The compound of  claim 18  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is a C3-C7 cycloalkyl or a C4-C6 saturated heterocyclyl, wherein (a) each ring carbon is optionally substituted with R 33 , (b) a ring carbon, other than the ring carbon at the point of attachment, is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, (c) a ring carbon or nitrogen in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (d) a ring carbon or nitrogen in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (e) a ring carbon or nitrogen, if present, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 1 , is optionally substituted by R 10 , (f) a ring carbon or nitrogen, if present, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , (g) a ring carbon or nitrogen, if present, in a first gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 10 , is optionally substituted by R 11 , and (h) a ring carbon or nitrogen, if present, in a second gamma position relative to the carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 12 , is optionally substituted by R 33 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 R 34  is independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, and cyano;  
 R 33  is selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, cyano and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;  
 Y 0  is the formula  
                     
 wherein J 5 , J 6 , D 1 , D 6  and the ring carbon atoms to which they are attached define a phenyl or 5- or 6-membered heteroaryl ring, T, wherein one of J 5  and J 6  is absent when T is a 5-membered heteroaryl ring, J 5  is optionally substituted by R 17  when J 5  is a carbon atom, J 6  is optionally substituted by R 18  when J 6  is a carbon atom, D 5  is optionally substituted by R 16  when D 5  is a carbon atom and D 6  is optionally substituted by R 19  when D 6  is a carbon atom;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  and R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently hydrido or alkyl; and  
 Q s  is CH 2 .  
 
     
     
         22 . The compound of  claim 21  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, bicyclo[3.1.0]hexan-6-yl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein (a) each ring carbon is optionally substituted with R 33 , (b) a ring carbon or nitrogen in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (c) a ring carbon or nitrogen in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (d) a ring carbon or nitrogen, if present, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , and (e) a ring carbon or nitrogen, if present, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 ;    R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;    R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;    R 33  is selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, carboxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, cyano, and Q b ;    A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, CH 2 CH 2 , and CH 2 CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, chloro, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;    R 2  is selected from the group consisting of phenyl and 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 3 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 3 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;    Y 0  is selected from the group consisting of:                          R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;    Q b  is NR 20 R 21  or C(NR 25 )NR 23 R 24 ;    R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, and ethyl; and    Q b  is CH 2 .    
     
     
         23 . The compound of  claim 22  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 1-pyrrolidinyl and 1-piperidinyl;    A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl, 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl, 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;    Y 0  is selected from the group consisting of:                          R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;    R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;    Q b  is C(NR 25 )NR 23 R 24 ;    R 23 , R 24 , and R 25  are independently hydrido or methyl; and    Q s  is CH 2 .    
     
     
         24 . The compound of  claim 23  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, and 1-piperidinyl;    A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;    X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl, 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl; and    Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amdinobenzyl.    
     
     
         25 . The compound of  claim 18  wherein the compound is selected from the group consisting of:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 R 2  is 3-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 5-amino-2-thienyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is oxalan-2-yl, A is CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-piperidinyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-pyrrolidinyl, A is CH 2 CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 2-amino-6-carboxy-4-pyridyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, and R 1  is chloro; or  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, and R 1  is chloro.  
 
     
     
         26 . The compound of  claim 1  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;  
 B is selected from the group consisting of: 
 (i) phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 32 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 36 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 32 , is optionally substituted by R 33 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 36 , is optionally substituted by R 35 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 33  and R 35  respectively, is optionally substituted by R 31 ;  
 (ii) hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ; and  
 (iii) C3-C12 cycloalkyl or a C4-C9 saturated heterocyclyl, wherein (a) each ring carbon may be optionally substituted with R 331  (b) a ring carbon, other than the ring carbon at the point of attachment of B to A, may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, (c) a ring carbon or nitrogen in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (d) a ring carbon or nitrogen in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 3 , (e) a ring carbon or nitrogen atom, if present, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (f) a ring carbon or nitrogen, if present, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , (g) a ring carbon or nitrogen, if present, in a first gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 10 , is optionally substituted by R 11 , (h) a ring carbon or nitrogen, if present, in a second gamma position relative to the carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 12 , is optionally substituted by R 33 , and (i) a ring carbon or nitrogen, if present, in a delta position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 11  and R 33 , respectively, is optionally substituted by R 34 ;  
 
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkylenedioxy, haloalkylthio, alkanoyloxy, alkoxy, hydroxy, amino, alkoxyamino, haloalkanoyl, nitro, alkylamino, alkylthio, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkylsulfonamido, amidosulfonyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyalkyl, alkylamino, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, alkoxyamino, alkanoyl, haloalkanoyl, amidino, guanidino, alkylenedioxy, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfamido, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, amidosulfonyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, and cyano;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is selected from the group consisting of O, S, C(O), (R 7 )NC(O), (R 7 )NC(S), and N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 Ja is N or C—X 0 ;  
 Jb is N or C—R 1 ;  
 R 1  and X 0  are independently selected from the group consisting of hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of: 
 (i) a bond, (CR 41 R 42 ) q  wherein q is 1 or 2, and (CH(R 41 )) g —W 0 —(CH(R 42 )) p  wherein g and p are integers independently selected from 0 through 3 and W 0  is selected from the group consisting of O, S, C(O), S(O), N(R 41 ), and ON(R 41 ); and  
 (ii) (CH(R 41 )) e —W 22 —(CH(R 42 )) h  wherein e and h are independently 0 or 1 and W 22  is selected from the group consisting of CR 41 ═CR 42 , 1,2-cyclopropyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 2,3-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, and 3,4-tetrahydrofuranyl, wherein Z 0  is directly bonded to the pyridine ring and W 22  is optionally substituted with one or more substituents selected from the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ; R 41  and R 42  are independently selected from the group consisting of hydrido, hydroxy, alkyl, and amino;  
 
 Q is selected from the group consisting of: 
 (i) phenyl or a heteroaryl of 5 or 6 ring members, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ; and  
 (ii) hydrido with the proviso that Z 0  is selected from other than a bond;  
 
 K is CHR 4a  wherein R 4a  is selected from the group consisting of hydrido, hydroxyalkyl, alkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;  
 E 0  is selected from the group consisting of a bond, C(O)N(H), (H)NC(O), (R 7 )NS(O) 2 , and S(O) 2 N(R 7 );  
 Y AT  is Q b -Q s ;  
 Q s  is (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 4, R 37  is selected from the group consisting of hydrido, alkyl, and haloalkyl, and R 38  is selected from the group consisting of hydrido, alkyl, haloalkyl, aroyl, and heteroaroyl with the proviso that there is at least one aroyl or heteroaroyl substituent, with the further proviso that no more than one aroyl or heteroaroyl is bonded to (CR 37 R 38 ) b  at the same time, with the still further proviso that said aroyl and said heteroaroyl are optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 11 , with another further proviso that said aroyl and said heteroaroyl are bonded to the CR 37 R 38  that is directly bonded to E 0 , with still another further proviso that no more than one alkyl or one haloalkyl is bonded to a CR 37 R 38  at the same time, and with the additional proviso that said alkyl and haloalkyl are bonded to a carbon other than the one bonding said aroyl or said heteroaroyl;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  are selected from the group consisting of: 
 (i) hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano; and  
 (ii) NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 2 ) and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time and with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time; and  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, amino, alkylamino and dialkylamino.  
 
     
     
         27 . The compound of  claim 26  having the structure:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 M is N or N→O;  
 B is selected from the group consisting of: 
 (i) phenyl and 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, and 5-isoxazolyl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 32 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 36 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 32 , is optionally substituted by R 33 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 36 , is optionally substituted by R 35 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 33  and R 35 , respectively, is optionally substituted by R 34 ;  
 (ii) hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 3-pentyl, 2-methylbutyl, 2-methyl-2-butenyl, 3-methylbutyl, 3-methyl-2-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methyl-4-hexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ; and  
 (iii) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, bicyclo[3.1.0]hexan-6-yl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein (a) each ring carbon is optionally substituted with R 33 , (b) a ring carbon or nitrogen in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (c) a ring carbon or nitrogen in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (d) a ring carbon or nitrogen, if present, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , and (e) a ring carbon or nitrogen, if present, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 11 , is optionally substituted by R 12 ;  
 
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 Ja is N or C—X 0 ;  
 Jb is N or C—R 1 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is selected from the group consisting of phenyl and 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl heteroaryl rings, wherein (a) a ring carbon in a first alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 9 , (b) a ring carbon in a second alpha position relative to the ring carbon at the point of attachment is optionally substituted by R 13 , (c) a ring carbon, in a first beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 9 , is optionally substituted by R 10 , (d) a ring carbon, in a second beta position relative to the ring carbon at the point of attachment and in an alpha position relative to the ring atom optionally substituted by R 13 , is optionally substituted by R 12 , and (e) a ring carbon, if present, in the gamma position relative to the ring carbon at the point of attachment and in an alpha position relative to each of the ring atoms optionally substituted by R 10  and R 12 , respectively, is optionally substituted by R 11 ;  
 Y AT  is Q b -Q s ;  
 Q s  is selected from the group consisting of: C[R 37 (benzoyl)(CR 37 R 38 ) b ], C[R 37 (2-pyridylcarbonyl)(CR 37 R 38 ) b ], C[R 37 (3-pyridylcarbonyl)(CR 37 R 38 ) b ], C[R 37 (4-pyridylcarbonyl)(CR 37 R 38 ) b ], C[R 37 (2-thienylcarbonyl)(CR 37 R 38 ) b ], C[R 37 (3-thienylcarbonyl)(CR 37 R 38 ) b ], C[R 37 (2-thiazolylcarbonyl)(CR 37 R 38 ) b ], C[R 37 (4-thiazolylcarbonyl)(CR 37 R 38 ) b ], and C[R 37 (5-thiazolylcarbonyl)((CR 37 R 38 ) b ], wherein b is an integer selected from 1 through 3, R 37  and R 38  are independently selected from the group consisting of hydrido, alkyl, and haloalkyl, with the proviso that said benzoyl and the heteroaroyls are optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19  with the proviso that R 17  and R 18  are optionally substituted at a carbon selected from other than the meta and para carbons relative to the carbonyl of the benzoyl or heteroaroyl, with the further proviso that said benzoyl or said heteroaroyl are bonded to the carbon directly bonded to amide nitrogen of the 1-(amidocarbonymethylene) group, and with the still further proviso that is no more than one alkyl or one haloalkyl is bonded to a CR 37 R 38  at the same time;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24  or N(R 26 )C(NR 25 )N(R 23 )(R 24 ) and R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, and ethyl.  
 
     
     
         28 . The compound of  claim 27  or a pharmaceutically acceptable salt thereof, wherein; 
 M is N→O;    B is selected from the group consisting of: 
 (i) 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;  
 (ii) hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl; and  
 (iii) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 1-pyrrolidinyl and 1-piperidinyl;  
   A is selected from the group consisting of a bond, CH 2 , CH 3 CH, CH 2 CH 2 , and CH 2 CH 2 CH 2 ;    Ja is N or C—X 0 ;    Jb is N or C—R 1 ;    R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, fluoro, and chloro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl, 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl, 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;    Y AT  is Q b -Q s ;    Q s  is selected from the group consisting of:    [CH(benzoyl)](CH 2 ) b , [CH(2-pyridylcarbonyl)](CH 2 ) b , [CH(3-pyridylcarbonyl)](CH 2 ) b , [CH(4-pyridylcarbonyl)](CH 2 ) b , [CH(2-thienylcarbonyl)](CH 2 ) b , [CH(3-thienylcarbonyl)](CH 2 ) b , [CH(2-thiazolylcarbonyl)](CH 2 ) b , [CH(4-thiazolylcarbonyl)](CH 2 ) b , and [CH(5-thiazolylcarbonyl)](CH 2 ) b , wherein b is an integer selected from 1 through 3, with the proviso that said benzoyl and said heteroaroyls are optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19  with the proviso that R 17  and R 18  are optionally substituted at a carbon selected from other than the meta and para carbons relative to the carbonyl of the benzoyl or the heteroaroyl, and that said benzoyl or said heteroaroyl are bonded to the carbon directly bonded to amide nitrogen of the 1-(amidocarbonymethylene) group;    R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;    R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;    Q b  is N(R 26 )C(NR 25 )N(R 23 )(R 24 ); and    R 23 , R 24 , R 25 , and R 26  are independently hydrido or methyl.    
     
     
         29 . The compound of  claim 28  or a pharmaceutically acceptable salt thereof, wherein; 
 M is N→O;    B is selected from the group consisting of: 
 (i) 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 4-methylphenyl, phenyl, 2-imidazoyl, 3-pyridyl, 4-pyridyl, and 3-trifluoromethyl-2-pyridyl;  
 (ii) hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl; and  
 (iii) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, and 1-piperidinyl;  
   A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;    Ja is C—X 0 ;    Jb is C—R 1 ;    X o  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;    R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl, 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl; and    Y AT  is selected from the group consisting of 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, 5-guanidino-1-oxo-1-(4-thiazolyl)-2-pentyl, 5-guanidino-1-oxo-1-(5-thiazolyl)-2-pentyl, 5-guanidino-1-oxo-1-(4-amino-2-thiazolyl)-2-pentyl, and 5-guanidino-1-oxo-1-phenyl-2-pentyl.    
     
     
         30 . The compound of  claim 26  wherein the compound is selected from the group consisting of:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3,5-diaminophenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is aminomethyl, and X o  is chloro;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3-carboxy-5-aminophenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3-carboxy-5-aminophenyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido; or  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, R 1  is chloro, and X o  is hydrido.  
 
     
     
         31 . A composition for inhibiting thrombotic conditions in blood comprising a compound of  claim 1  and a pharmaceutically acceptable carrier.  
     
     
         32 . A method for inhibiting thrombotic conditions in blood comprising adding to blood a therapeutically effective amount of the composition of  claim 31 .  
     
     
         33 . A method for inhibiting formation of blood platelet aggregates in blood comprising adding to blood a therapeutically effective amount of the composition of  claim 31 .  
     
     
         34 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of the composition of  claim 31 .  
     
     
         35 . A method for treating or preventing venuous thromboembolism and pulmonary embolism in a mammal comprising administering to the mammal a therapeutically effective amount of the composition of  claim 31 .  
     
     
         36 . A method for treating or preventing deep vein thrombosis in a mammal comprising administering to the mammal a therapeutically effective amount of the composition of  claim 31 .  
     
     
         37 . A method for treating or preventing cardiogenic thromboembolism in a mammal comprising administering to the mammal a therapeutically effective amount of the composition of  claim 31 .  
     
     
         38 . A method for treating or preventing thromboembolic stroke in humans and other mammals comprising administering to the mammal a therapeutically effective amount of the composition of  claim 31 .  
     
     
         39 . A method for treating or preventing thrombosis associated with cancer and cancer chemotherapy in humans and other mammals comprising administering to the mammal a therapeutically effective amount of the composition of  claim 31 .  
     
     
         40 . A method for treating or preventing unstable angina in humans and other mammals comprising administering to the mammal a therapeutically effective amount of the composition of  claim 31 .  
     
     
         41 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of a compound of  claim 1  with a therapeutically effective amount of fibrinogen receptor antagonist.