Method for administering glp-1 molecules

Abstract

The invention encompasses formulations that demonstrate the feasibility of oral absorption comprising GLP-1 compounds and specified delivery agents.

1 . A formulation comprising a GLP-1 compound and a delivery agent selected from the group consisting of Delivery agent 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, and 56.  
     
     
         2 . The formulation of  claim 1 , wherein the GLP-1 compound is selected from the group consisting of GLP-1 compounds of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, and SEQ ID NO:14.  
     
     
         3 . The formulation of  claim 1 , wherein the GLP-1 compound is selected from the group consisting of GLP-1 compounds of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:12, SEQ ID NO:13, and SEQ ID NO:14.  
     
     
         4 . The formulation of  claim 1 , wherein the GLP-1 compound is selected from the group consisting of GLP-1 compounds of SEQ ID NO:2, SEQ ID NO:12, SEQ ID NO:13, and SEQ ID NO:14.  
     
     
         5 . The formulation of  claim 1 , wherein the GLP-1 compound is of SEQ ID NO:13 or SEQ ID NO:14.