47153, a human glycosyltransferase family member and uses therefor

Abstract

The invention provides isolated nucleic acids molecules, designated 47153 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47153 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47153 gene has been introduced or disrupted. The invention still further provides isolated 47153 proteins, fusion proteins, antigenic peptides and anti-47153 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

1 - 22 . (canceled)  
     
     
         23 . An isolated polypeptide selected from the group consisting of: 
 a) an isolated polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence of SEQ ID NO:2; and    b) an isolated polypeptide encoded by a nucleic acid molecule which is at least 95% identical to the nucleic acid sequence of SEQ ID NO:1 or SEQ ID NO:3;    wherein the polypeptide has glycosyltransferase activity.    
     
     
         24 . An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2.  
     
     
         25 . An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:2.  
     
     
         26 . An isolated polypeptide which is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3.  
     
     
         27 . The polypeptide of  claim 23 , further comprising heterologous amino acid sequences.  
     
     
         28 . The polypeptide of claims  24 , further comprising heterologous amino acid sequences.  
     
     
         29 . The polypeptide of claims  26 , further comprising heterologous amino acid sequences.