Novel human endothelin converting enzyme-like proteins and polynucleotides encoding the same

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

1 - 6 . (canceled)  
     
     
         7 . An isolated nucleic acid molecule that encodes the amino acid sequence shown in SEQ ID NO:4.  
     
     
         8 . The isolated nucleic acid molecule of  claim 7  wherein said nucleic acid molecule comprises the polynucleotide sequence described in SEQ ID NO: 3.  
     
     
         9 . A recombinant expression vector comprising the nucleic acid molecule of  claim 7 .  
     
     
         10 . The recombinant expression vector of  claim 9  wherein said nucleic acid molecule comprises the polynucleotide sequence described in SEQ ID NO: 3.  
     
     
         11 . A host cell comprising the recombinant expression vector of  claim 9 .  
     
     
         12 . A gene delivery system comprising: 
 (a) the nucleic acid molecule described in SEQ ID NO:1; or    (b) the nucleic acid molecule comprising the nucleic acid sequence of SEQ ID NO:3.    
     
     
         13 . The gene delivery system of  claim 12 , wherein said isolated nucleic acid molecule is present in a cationic lipid complex.  
     
     
         14 . The gene delivery system of  claim 12 , wherein said isolated nucleic acid molecule is present in a viral vector.  
     
     
         15 . An antibody having immunospecificity for the polypeptide sequence of SEQ ID NO:2.