Growth hormone secretagogues

Abstract

What is disclosed are growth hormone secretagogues, and their uses, of formula (I) wherein R1 is C 6 H 5 CH 2 OCH 2 —, C 6 H 5 (CH 2 ) 3 — or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C 1 -C 6 alkylpiperidin-1-yl or NR2R2; R2 are each independently a C 1 to C 6 alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF 3 , C 1 -C 6 alkoxy or phenyl; and R4 is H or CH 3 , or a pharmaceutically acceptable salt or solvate thereof.

1 - 6 . (canceled)  
     
     
         7 . A pharmaceutical formulation according to which comprises 
 (a) a first active ingredient selected from the group consisting of the following structurally depicted compounds:                          or a pharmaceutically acceptable salt or solvate thereof;    (b) a second active ingredient which is a bone-antiresorptive agent selected from the group consisting of selective estrogen receptor modulators, bisphosphonates, calcitonin, and PTH; and    (c) one or more pharmaceutically acceptable carriers, diluents, or excipients.    
     
     
         8 . (canceled)  
     
     
         9 . A pharmaceutical formulation according to  claim 7  wherein said bone-antiresorptive agent is a bisphosphonate.  
     
     
         10 . A pharmaceutical formulation according to  claim 7  wherein said bone-antiresorptive agent is a selective estrogen receptor modulator.  
     
     
         11 . A pharmaceutical formulation according to  claim 7  wherein said bone-antiresorptive agent is calcitonin.  
     
     
         12 . A pharmaceutical formulation according to  claim 7  wherein said bone-antiresorptive agent is PTH.  
     
     
         13 . A pharmaceutical formulation according to  claim 7  wherein the first active ingredient is a compound of the formula  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof.  
     
     
         14 . A pharmaceutical formulation according to  claim 7  wherein the first active ingredient is a compound of the formula  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof.  
     
     
         15 . A pharmaceutical formulation according to  claim 7  wherein the first active ingredient is a compound of the formula  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof.  
     
     
         16 . A pharmaceutical formulation according to  claim 9  wherein the first active ingredient is a compound of the formula  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof.  
     
     
         17 . A pharmaceutical formulation according to  claim 10  wherein the first active ingredient is a compound of the formula  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof.  
     
     
         18 . A pharmaceutical formulation according to  claim 11  wherein the first active ingredient is a compound of the formula  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof.  
     
     
         19 . A pharmaceutical formulation according to  claim 12  wherein the first active ingredient is a compound of the formula  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof.  
     
     
         20 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment an effective amount of the pharmaceutical formulation according to  claim 7 .  
     
     
         21 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment an effective amount of the pharmaceutical formulation according to  claim 9 .  
     
     
         22 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 10 .  
     
     
         23 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 11 .  
     
     
         24 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 12 .  
     
     
         25 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 13 .  
     
     
         26 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 14 .  
     
     
         27 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 15 .  
     
     
         28 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 16 .  
     
     
         29 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 17 .  
     
     
         30 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 18 .  
     
     
         31 . A method of treating or preventing osteoporosis comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 19 .  
     
     
         32 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 7 .  
     
     
         33 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment an effective amount of the pharmaceutical formulation according to  claim 9 .  
     
     
         34 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 10 .  
     
     
         35 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 11 .  
     
     
         36 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 12 .  
     
     
         37 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 13 .  
     
     
         38 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 14 .  
     
     
         39 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 15 .  
     
     
         40 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 16 .  
     
     
         41 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 17 .  
     
     
         42 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 18 .  
     
     
         43 . A method of treating or preventing loss of muscle strength comprising administering to a patient in need of treatment and effective amount of the pharmaceutical formulation according to  claim 19.