Hypoglycemic agent

Abstract

A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.

1 - 19 . (canceled).  
     
     
         20 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (2):  
       
         
           
           
               
               
           
         
       
       (wherein X 1  and X 2  each independently represents an alkoxy group, an amino group, a mono-lower alkylamino group, a di-lower alkylamino group, or a hydroxyl group; R and R′ each independently represents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group; R 3  and R 4  each independently represents an alkyl group, a substituted alkyl group, or a heterocyclic group; R and R 3 , and/or R1 and R 4  may be taken together to form an alkylene group; C* represents an asymmetric carbon (either (R)-form or (S)-form); and X represents an alkylene group).  
     
     
         21 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (3):  
       
         
           
           
               
               
           
         
       
       (wherein X 1  and X 2  each independently represents an alkoxy group, an amino group, a mono-lower alkylamino group, a di-lower alkylamino group, or a hydroxyl group; R and R′ each independently represents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group; X represents an alkylene group; n indicates an integer of from 1 to 3).  
     
     
         22 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (4) (when it is an optically-active compound, it contains both (R)-form and (S)-form thereof):  
       
         
           
           
               
               
           
         
       
       (wherein X 1  represents an alkoxy group, an amino group, a mono-lower alkylamino group, a di-lower alkylamino group, or a hydroxyl group; R, R′ and R″ each independently represents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group; R 3′  and Ro 3   each independently represents a hydrogen atom, an alkyl group, a substituted alkyl group, or a heterocyclic group; R and R 3′ , and/or R″ and R o   3  may be taken together to form an alkylene group; n indicates an integer of from 1 to 3).  
     
     
         23 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (5) (when it is an optically-active compound, it contains both (R)-form and (S)-form thereof):  
       
         
           
           
               
               
           
         
       
       (wherein X 1  represents an alkoxy group, an amino group, a mono-lower alkylamino group, a di-lower alkylamino group, or a hydroxyl group; R and R′ each independently represents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group; R 3 ′, R 4 ″ and R 5  each independently represents a hydrogen atom, an alkyl group, a substituted alkyl group, or a heterocyclic group; R and R 3′  may be taken together to form an alkylene group; n indicates an integer of from 1 to 3).  
     
     
         24 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (6) (when it is an optically-active compound, it contains both (R)-form and (S)-form thereof):  
       
         
           
           
               
               
           
         
       
       [wherein X 1  represents an alkoxy group, an amino group, a mono-lower alkylamino group, a di-lower alkylamino group, or a hydroxyl group; R represents a hydrogen atom, an alkyl group, a substituted alkyl group, or a heterocyclic group; R 6  and R 7  each independently represents an alkyl group, an aralkyl group, or a group of the following formula (6′):  
       
         
           
           
               
               
           
         
       
       (wherein R 8  and R 9  each independently represents a hydrogen atom, an alkyl group, a nitro group, or a halogen atom); R 6  and R 3  may be taken together to form an alkylene group] 
     
     
         25 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (9):  
       
         
           
           
               
               
           
         
       
       [wherein R 10  and R 11  each independently represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, (CH 2 ) m NRR′, (CH2) m N + RR′R″, —(CH2) m SR, —(CH 2 ) m S + RR′, —(CH 2 ) n COOR or —(CH 2 ) n CONRR′ (where m indicates an integer of from 0 to 4; and R, R′ and R″ each independently represents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group)].  
     
     
         26 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (10):  
       
         
           
           
               
               
           
         
       
     
     
         27 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (11):  
       
         
           
           
               
               
           
         
       
       (wherein X 0   − ; represents Cl − , Br −  or I − ).  
     
     
         28 . Zinc(II) organic complexes having, as a ligand, a compound of a general formula (12):  
       
         
           
           
               
               
           
         
       
       (wherein R −12  and R 13  each independently represents an alkyl group, an aryl group, or an aralkyl group).  
     
     
         29 . A food that contains a zinc(II) organic complex having, as a ligand, any of L-lactic acid, quinic acid, L-carnitine (vitamin B T ), vitamin C, vitamin U or L-theanine.  
     
     
         30 . The food according to  claim 29  wherein said food is a health food or a supplementary health food.