Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same

Abstract

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.

1 - 19 . (canceled)  
     
     
         20 . A method for suppressing Mixed Lymphocyte Reaction by using a compound of the formula:  
       
         
           
           
               
               
           
         
       
       wherein 
 R 1  is hydroxy or pharmaceutically acceptable protected hydroxy selected from the group consisting of 1-(lower alkylthio)(lower)alkyloxy, tri(lower)alkylsilyloxy, lower alkyl-diphenyl-siloxy, pharmaceutically acceptable organic carboxylic acyloxy, pharmaceutically acceptable organic sulfonic acyloxy, and pharmaceutically acceptable organic carbamic acyloxy,  
 R 2  is hydrogen or the same meanings as R 1 ,  
 R 3  is methyl, ethyl, propyl or allyl, n is an integer of 1 or 2, and  
 the symbol of a line and dotted line is a single bond or a double bond, or pharmaceutically acceptable basic salt thereof.  
 
     
     
         21 . The method of  claim 20 , wherein the compound is  
       
         
           
           
               
               
           
         
       
     
     
         22 . The method of  claim 20 , wherein the compound is  
       
         
           
           
               
               
           
         
       
     
     
         23 . The method of  claim 20 , wherein the compound is