Closure device and methods for making and using them

Abstract

A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

1 . A tissue engaging device, comprising: 
 a plurality of curved elements defining a first curved region and a second curved region, said curved elements connected to one another thereby defining an offset pattern; and    at least one tine extending from one of the curved elements defining the first curved region.    
   
   
       2 . The device of  claim 1 , further comprising a second tine, wherein said second tine has a length greater than said first tine.  
   
   
       3 . The device of  claim 1 , wherein said plurality of curved elements are formed as a unitary member from a single sheet of material.  
   
   
       4 . The device of  claim 3 , wherein said closure device is made by chemical etching said material.  
   
   
       5 . The device of  claim 3 , wherein said closure device is made by stamping said material.  
   
   
       6 . The device of  claim 1 , wherein at least one tine has a first thickness, a second thickness, wherein a transition section defines the two thicknesses.  
   
   
       7 . The device of  claim 1 , further comprising a plurality of tines, said tines extending from said first curved region.  
   
   
       8 . The device of  claim 7 , wherein said plurality of tines extend from said first curved region in an alternating pattern.  
   
   
       9 . The device of  claim 8 , wherein at least two tines have a length greater than the others.  
   
   
       10 . The device of  claim 1 , further comprises a radiopaque coating disposed on at least one side of the plurality of curved elements.  
   
   
       11 . The device of  claim 1 , further comprising at least one radiopaque marker associated with at least one of the curved elements.  
   
   
       12 . The device of  claim 1 , wherein the plurality of curved elements define a generally planar surface, wherein said generally planer surface is movable towards a transverse configuration extending out of the plane.  
   
   
       13 . The device of  claim 12 , wherein the plurality of curved elements are biased towards the planar configuration.  
   
   
       14 . The device of  claim 8 , wherein adjacent tines have at least one first curved region disposed between them.  
   
   
       15 . The device of  claim 10 , wherein the radiopaque coating is chosen from the group consisting of gold, tantalum, platinum, platinum/iridium.  
   
   
       16 . A tissue engaging device, the tissue engaging device comprising: 
 a plurality of curved elements having a first surface and a second surface defining a plane, wherein the plurality of curved elements define a first curved region and a second curved region, said curved elements coupled to one another and defining an offset pattern; and    at least one tine extending from one of curved elements defining the first curved region.    
   
   
       17 . The device of  claim 16 , further comprising a beneficial agent disposed upon at least one surface.  
   
   
       18 . The device of  claim 17 , wherein the beneficial agent enhances hemostasis.  
   
   
       19 . The device of  claim 17 , wherein the beneficial agent is a synthetic peptide.  
   
   
       20 . The device of  claim 16 , wherein a second beneficial agent is disposed upon said second surface.  
   
   
       21 . The device of  claim 20 , wherein said first and second beneficial agents are similar.  
   
   
       22 . The device of  claim 20 , wherein said first and second beneficial agents are dissimilar.  
   
   
       23 . The device of  claim 16 , wherein said plurality of curved elements are biased towards said planar configuration.  
   
   
       24 . The device of  claim 23 , wherein said plurality of curved elements is movable between said generally planar configuration and a generally cylindrical configuration.