US2005118571A1PendingUtilityA1
Production of replicative hepatitis C virus
Est. expiryJun 20, 2020(expired)· nominal 20-yr term from priority
C12N 2770/24222C12N 7/00C12N 15/1131C12N 2770/24221C12N 2310/127C12N 2310/123C07K 14/005
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Claims
Abstract
A nucleic acid having a first nucleotide sequence encoding an infectious hepatitis C virus, a second nucleotide sequence encoding a ribozyme, and an inducible promoter operably linked to the first and second nucleotide sequences, the ribozyme being configured to remove a 3′ sequence unnecessary for replication of the infectious hepatitis C virus from a transcript initiated by the inducible, is described. A cell containing the nucleic acid and methods of using the cell are also described.
Claims
exact text as granted — not AI-modified1 - 16 . (canceled)
17 . A nucleic acid comprising a first nucleotide sequence encoding an infectious hepatitis C virus, a second nucleotide sequence encoding a ribozyme and, an inducible promoter operably linked to the first and second nucleotide sequences, the ribozyme being configured to remove a 3′ sequence unnecessary for replication of the infectious hepatitis C virus from a transcript initiated by the inducible promoter.
18 . The nucleic acid of claim 17 , wherein the inducible promoter is a T7 promoter.
19 . The nucleic acid of claim 17 , wherein the ribozyme is a hepatitis D virus ribozyme.
20 . (canceled)
21 . A cell comprising the nucleic acid of claim 17 .
22 . The nucleic acid of claim 17 , wherein the nucleic acid is a vector.
23 . The nucleic acid of claim 22 , wherein the vector is a plasmid.
24 . The nucleic acid of claim 17 , wherein the nucleic acid is an integration cassette.
25 . A cell comprising the nucleic acid of claim 22 .
26 . A cell comprising the nucleic acid of claim 24.Join the waitlist — get patent alerts
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