US2005118292A1PendingUtilityA1
Dioscorea extracts
Priority: Dec 1, 2003Filed: Dec 1, 2003Published: Jun 2, 2005
Est. expiryDec 1, 2023(expired)· nominal 20-yr term from priority
A61K 38/20A61K 36/8945
47
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Claims
Abstract
An extract from a tuber of a Dioscorea plant. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant and a cytokine, as well as methods of enhancing proliferation of bone marrow or spleen cells and stimulating regeneration of a specific lineage of hematopoietic cells.
Claims
exact text as granted — not AI-modified1 . An extract from a tuber of a Dioscorea plant, wherein the extract is soluble in water and insoluble in an aqueous solution containing 65-90% ethanol between 0° C. and 25° C.
2 . The extract of claim 1 , wherein the Dioscorea plant is D. batatas Decne, D. alata L., D. pseudojaponica , or D. alata L. var. purpurea (Roxb.) M. Pouch.
3 . The extract of claim 1 , wherein the aqueous solution contains 70-80% ethanol.
4 . The extract of claim 3 , wherein the Dioscorea plant is D. batatas Decne, D. alata L., D. pseudojaponica , or D. alata L. var. purpurea (Roxb.) M. Pouch.
5 . The extract of claim 3 , wherein the aqueous solution contains 75% ethanol.
6 . The extract of claim 5 , wherein the Dioscorea plant is D. batatas Decne, D. alata L., D. pseudojaponica , or D. alata L. var. purpurea (Roxb.) M. Pouch.
7 . The extract of claim 6 , wherein the Dioscorea plant is D. batatas Decne.
8 . A composition comprising an extract from a tuber of a Dioscorea plant and a cytokine.
9 . The composition of claim 8 , wherein the cytokine is interleukin-2.
10 . The composition of claim 9 , wherein the Dioscorea plant is D. batatas.
11 . The composition of claim 8 , wherein the extract is soluble in water and insoluble in an aqueous solution containing 65-90% ethanol between 0° C. and 25° C.
12 . The composition of claim 11 , wherein the cytokine is interleukin-2.
13 . The composition of claim 12 , wherein the Dioscorea plant is D. batatas.
14 . The composition of claim 11 , wherein the aqueous solution contains 70-80% ethanol.
15 . The composition of claim 14 , wherein the cytokine is interleukin-2.
16 . The composition of claim 15 , wherein the Dioscorea plant is D. batatas.
17 . The composition of claim 14 , wherein the aqueous solution contains 75% ethanol.
18 . The composition of claim 17 , wherein the cytokine is interleukin-2.
19 . The composition of claim 18 , wherein the Dioscorea plant is D. batatas.
20 . A method of enhancing proliferation of bone marrow or spleen cells, the method comprising administering to a subject in need thereof an effective amount of an extract from a tuber of a Dioscorea plant.
21 . The method of claim 20 , wherein the extract is soluble in water and insoluble in an aqueous solution containing 65-90% ethanol between 0° C. and 25° C.
22 . The method of claim 21 , wherein the Dioscorea plant is D. batatas Decne, D. alata L., D. pseudojaponica , or D. alata L. var. purpurea (Roxb.) M. Pouch.
23 . The method of claim 21 , wherein the aqueous solution contains 70-80% ethanol.
24 . The method of claim 23 , wherein the Dioscorea plant is D. batatas Decne, D. alata L., D. pseudojaponica , or D. alata L. var. purpurea (Roxb.) M. Pouch.
25 . The method of claim 23 , wherein the aqueous solution contains 75% ethanol.
26 . The method of claim 25 , wherein the Dioscorea plant is D. batatas Decne, D. alata L., D. pseudojaponica , or D. alata L. var. purpurea (Roxb.) M. Pouch.
27 . The method of claim 20 , wherein the bone marrow cells are CFU-GM, CFU-GEMM, or CFU-BFU-E cells.
28 . The method of claim 27 , wherein the Dioscorea plant is D. batatas Decne, D. alata L., D. pseudojaponica , or D. alata L. var. purpurea (Roxb.) M. Pouch.
29 . A method of enhancing proliferation of bone marrow or spleen cells, the method comprising administering to a subject in need thereof an effective amount of an extract from a tuber of a Dioscorea plant and an effective amount of a cytokine.
30 . The method of claim 29 , wherein the cytokine is interleukin-2.
31 . The method of claim 30 , wherein the Dioscorea plant is D. batatas.
32 . The method of claim 31 , wherein the extract is soluble in water and insoluble in an aqueous solution containing 65-90% ethanol between 0° C. and 25° C.
33 . The method of claim 32 , wherein the cytokine is interleukin-2.
34 . The method of claim 33 , wherein the Dioscorea plant is D. batatas.
35 . The method of claim 32 , wherein the aqueous solution contains 70-80% ethanol.
36 . The method of claim 35 , wherein the cytokine is interleukin-2.
37 . The method of claim 36 , wherein the Dioscorea plant is D. batatas.
38 . The method of claim 35 , wherein the aqueous solution contains 75% ethanol.
39 . The method of claim 38 , wherein the cytokine is interleukin-2.
40 . The method of claim 39 , wherein the Dioscorea plant is D. batatas.
41 . The method of claim 28 , wherein the bone marrow cells are CFU-GM, CFU-GEMM, or CFU-BFU-E cells.
42 . The method of claim 41 , wherein the cytokine is interleukin-2.
43 . The method of claim 42 , wherein the Dioscorea plant is D. batatas.Join the waitlist — get patent alerts
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