N-acyl-phosphatidyl-ethanolamines and/or mixtures of n-acyl-ethanolamines with phosphatidic acids or lysophosphatidic acids

Abstract

Pharmaceutical, cosmetic and dietetic compositions and functional foods, constituted by: A) phospholipid mixtures containing N-acyl-phosphatidyl-ethanolamines (NAPEs) and/or B) phospholipid mixtures containing N-acyl-ethanol amines (NAEs) together with phosphatidic acids (PAs) and/or lysophosphatidic acids (LPAs) with the proviso that said N-acyl-phosphatidyl-ethanolamines (NAPEs) do not include N-oleoyl-phosphatidyl-ethanolamine. as well as new phosphobioflavonic complexes of NAPE or NAE with one or more bioflavonoids, are disclosed.

1 . Pharmaceutical, cosmetic and dietetic compositions and functional foods, constituted by: 
 A) phospholipid mixtures containing N-acyl-phosphatidyl-ethanolamines (NAPEs);    and/or    B) phospholipids mixtures containing N-acyl-ethanolamines (NAEs) together with phosphatidic acids (PAs) and/or lysophosphatidic acids (LPAs),    with the proviso that said N-acyl-phosphatidyl-ethanolamines (NAPEs) do not include N-oleoyl-phosphatidyl-ethanolamine.    
     
     
         2 . Compositions as claimed in  claim 1  wherein the phospholipid mixtures are constituted by complexes of one or more bioflavones with NAPE or NAE plus PA and/or LPA.  
     
     
         3 . Compositions as claimed in  claim 1 , also containing amphiphilic surfactants.  
     
     
         4 . Functional foodstuffs containing the compositions claimed in  claim 1 .  
     
     
         5 . The use of phospholipid mixtures containing 
 A) N-acyl-phosphatidyl-ethanolamines (NAPEs);    and/or    B) phospholipid mixtures containing N-acyl-ethanolamines (NAEs) together with phosphatidic acids (PAs) and/or lysophosphatidic acids (LPAs).    for the preparation of medicaments having anorexic activity or of medicaments or foodstuffs for the treatment of aging, obesity and excess weight; diabetes; cerebro-degenerative disorders such as Alzheimer's disease, Parkinson's disease and senile dementia; stress, depression; tumours; menopaulsal syndromes; osteoporosis; prostate hypertrophy; skin aging; panniculopathy (cellulitis) and alopecia.    
     
     
         6 . Phosphobioflavonic complexes of bioflavonoids with phospholipids active components selected from N-acyl-phosphatidyl-ethanolamines (NAPE) and/or N-acyl-ethanolamines (NAE) plus Phosphatidic Acid (PA) and/or N-acyl-ethanolamines plus Lysophosphatidic acid (LPA).