Use of a compound inactivating the kinase a protein in a composition containg a cosmetically acceptable medium in order to lighten the skin

Abstract

A method of using a compound to lighten the skin by inactivating protein kinase A. The compound may be in a composition with either a pharmacologically or cosmetically acceptable medium. Depending upon the medium and concentration of the compound, the composition may be used either therapeutically or non-therapeutically.

1 - 26 . (canceled)  
     
     
         27 . A method of lightening skin comprising inactivating the protein kinase A with a composition comprising: 
 a) a cosmetically acceptable medium; and    b) a compound.    
     
     
         28 . A method of lightening skin comprising inactivating the protein kinase A with a composition comprising: 
 a) a cosmetically acceptable medium; and    b) a compound of general formula (I):                          or salts thereof, wherein: 
 1) R 1  represents the characterizing chain of a fatty acid comprising: 
 i) about 3 to about 30 carbon atoms; and  
 ii) a characteristic comprising at least one member selected from the group consisting of: 
 aa) saturated;  
 bb) unsaturated;  
 cc) linear; and  
 dd) branched;  
 
 
 2) R 2  represents the characterizing chain of an amino acid; and  
 3) m is between about 1 and about 50.  
   
     
     
         29 . The method of  claim 28 , wherein said compound comprises a radical of general formula (II):  
         R 1 —C(═O)—  (II)  
       wherein said radical comprises about 7 to about 22 carbon atoms.  
     
     
         30 . The method of  claim 29 , wherein said radical comprises at least one member selected from the group consisting of: 
 a) octanoyl;    b) decanoyl;    c) undecylenoyl;    d) dodecanoyl;    e) tetradecanoyl;    f) hexadecanoyl;    g) octadecanoyl;    h) eicosanoyl;    i) docosanoyl;    j) 8-octadecenoyl;    k) eicosenoyl;    l) 13-docosenoyl;    m) 9,12-octadecadienoyl; and    n) 9,12,15-octadecatrienoyl radical.    
     
     
         31 . The method of  claim 30 , wherein said radical comprises at least one member selected from the group consisting of: 
 a) octanoyl;    b) ω-undecylenoyl;    c) dodecanoyl;    d) hexadecanoyl;    e) 8-octadecenoyl;    f) 13-docosenoyl;    g) 9,12-octadecadienoyl; and    h) 9,12,15-octadecatrienoyl.    
     
     
         32 . The method of  claim 31 , wherein said R 2  further comprises at least one member selected from the group consisting of: 
 a) glycine;    b) alanine;    c) serine;    d) aspartic acid;    e) glutamic acid;    f) valine;    g) threonine;    h) arginine;    i) lysine;    j) proline leucine;    k) phenylalanine;    l) isoleucine;    m) histidine;    n) tyrosine;    o) tryptophan;    p) asparagine;    q) glutamine;    r) cysteine;    s) cystine;    t) methionine;    u) hydroxyproline;    v) hydroxylysine;    w) sarcosine; and    x) ornithine.    
     
     
         33 . The method of  claim 32 , further comprising a residue, said residue comprising at least one member selected from the group consisting of: 
 a) a residue of general formula (IIIa)      —HN—CH(R 2 )—C(═O)—  (IIIa),    and    b) a residue of general formula (IIIb)                          
     
     
         34 . The method of  claim 33 , wherein said R 2  comprises at least one member selected from the group consisting of: 
 a) phenylalanine;    b) tyrosine;    c) histidine;    d) methionine;    e) cysteine; and    f) tryptophan.    
     
     
         35 . The method of  claim 34 , wherein said m is less than about 5.  
     
     
         36 . The method of  claim 35 , wherein said m is less than or equal to about 2.  
     
     
         37 . The method of  claim 36 , wherein said m is less than or equal to about 1.4.  
     
     
         38 . The method of  claim 37 , wherein said m is equal to about 1.  
     
     
         39 . A method which may be used for treating skin comprising lightening said skin non-therapeutically with a composition, wherein said composition comprises: 
 a) a cosmetically acceptable medium; and    b) an effective amount of at least one compound that inactivates protein kinase A.    
     
     
         40 . The method of  claim 39 , wherein said composition comprises between about 0.01 % and about 10% of its total weight of said compound.  
     
     
         41 . The method of  claim 40 , wherein said composition comprises between about 0.1% and about 5% of its total weight of said compound.  
     
     
         42 . The method of  claim 41 , wherein said composition comprises between about 1% and about 5% of its total weight of said compound.  
     
     
         43 . A composition which may be used for lightening the skin comprising: 
 a) a pharmaceutically acceptable medium; and    b) an effective amount of at least one compound that inactivates protein kinase A.    
     
     
         44 . The composition of  claim 43 , wherein: 
 a) said composition is pharmaceutical; and    b) said composition is suitable for therapeutic use.    
     
     
         45 . The method of  claim 44 , wherein said composition comprises between about 0.01 % and about 10% of its total weight of said compound.  
     
     
         46 . The method of  claim 45 , wherein said composition comprises between about 0.1% and about 5% of its total weight of said compound.  
     
     
         47 . The method of  claim 46 , wherein said composition comprises between about 1% and about 5% of its total weight of said compound.  
     
     
         48 . The method of  claim 27 , wherein said compound also inactivates adenylate cyclase.  
     
     
         49 . The method of  claim 33 , wherein: 
 a) said radical comprises at least one member selected from the group consisting of: 
 1) octanoyl radicals; and  
 2) ω-undecylenoyl radicals; and  
   b) said residue comprises at least one member selected from the group consisting of:                          wherein said R 2  represents the characterizing chain of phenylalanine.    
     
     
         50 . The method of  claim 48 , wherein: 
 a) said radical comprises at least one member selected from the group consisting of: 
 1) octanoyl radicals; and  
 2) ω-undecylenoyl radicals; and  
   b) said residue comprises at least one member selected from the group consisting of:                          wherein said R 2  represents the characterizing chain of phenylalanine.    
     
     
         51 . The method of  claim 42 , wherein said compound also inactivates adenylate cyclase.  
     
     
         52 . The composition of  claim 47 , wherein said compound also inactivates adenylate cyclase.  
     
     
         53 . The method of  claim 38 , wherein said compound further comprises an affinity for the melanocyte specific hormone (α-MSH) receptor.  
     
     
         54 . The method of  claim 51 , wherein said compound further comprises an affinity for the melanocyte specific hormone (α-MSH) receptor.  
     
     
         55 . The composition of  claim 52 , wherein said compound further comprises an affinity for the melanocyte specific hormone (α-MSH) receptor.  
     
     
         56 . A composition comprising N-(ω-undecylenoyl)phenylalanine of formula (Ia):  
       
         
           
           
               
               
           
         
       
     
     
         57 . The composition of  claim 56 , wherein said composition is used cosmetics.  
     
     
         58 . A pharmaceutical composition comprising: 
 a) a pharmaceutically acceptable medium; and    b) an effective amount of the compound N-(ω-undecylenoyl)phenylalanine of formula (Ia):                          
     
     
         59 . A composition comprising an emulsion, wherein said emulsion comprises between about 0.01% and about 10% of its total weight, the compound N-(ω-undecylenoyl)phenylalanine of formula (Ia):  
       
         
           
           
               
               
           
         
       
     
     
         60 . The composition of  claim 59 , wherein said emulsion comprises between about 0.1% and about 5% of its total weight of said compound.  
     
     
         61 . The composition of  claim 60 , wherein said emulsion further comprises between about 1% and about 5% of its total weight of said compound.