US2005090489A1PendingUtilityA1

Use of a substance which binds to the peripheral benzodiazepine receptor in the treatment of cutaneous stress

42
Priority: Nov 17, 1998Filed: Jul 26, 2004Published: Apr 28, 2005
Est. expiryNov 17, 2018(expired)· nominal 20-yr term from priority
Inventors:Pierre CasellasJean-Marie Deroco
A61P 37/00A61P 39/06A61P 31/22A61P 17/06A61P 17/04A61P 17/00A61P 17/16A61Q 17/04A61K 31/19A61Q 19/08A61K 2800/70A61K 31/203A61K 8/494A61K 31/74A61Q 19/00Y10S435/803Y10S435/886A61K 31/5513A61K 8/49
42
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Claims

Abstract

A composition containing a peripheral benzodiazepine receptor ligand for topical use in the treatment of cutaneous stress.

Claims

exact text as granted — not AI-modified
1 - 15 . (canceled)  
     
     
         16 . A topical composition for treating cutaneous stress containing as active principle a substance that binds to the peripheral benzodiazepine receptors:  
     
     
         17 . A composition according to  claim 16  wherein the substance that binds to the peripheral benzodiazepine receptor is a peripheral benzodiazepine receptor agonist chosen from synthetic molecules, natural extraction substances and substances obtained by fermentation.  
     
     
         18 . A composition according to  claim 17  wherein the substance that binds to the peripheral benzodiazepine receptor is RO 5-4864.  
     
     
         19 . A composition according to  claim 17  wherein the substance that binds to the peripheral benzodiazepine receptor is obtained by fermentation.  
     
     
         20 . A composition according to  claim 19  wherein the substance that binds to the peripheral benzodiazepine receptor is a fermentation product of  Nocardia SRL  4988,  Streptomyces SRL  5186 or  Actinosinnema SRL  5189.  
     
     
         21 . A composition according to  claim 17  wherein the substance that binds to the peripheral benzodiazepine receptor is present in an amount of from 0.00001% to 20% by weight relative to the total weight of the composition.  
     
     
         22 . A composition according to  claim 21  wherein the substance that binds to the peripheral benzodiazepine receptor is present in an amount of from 0.001% to 10% by weight relative to the total weight of the composition.  
     
     
         23 . A composition according to  claim 17  additionally containing a hydroxy acid or a retinoid.  
     
     
         24 . A composition according to  claim 23  wherein the hydroxy acid is chosen from α-hydroxy acids an  
     
     
         25 . A composition according to  claim 23  wherein the retinoid is chosen from retinoic acid and derivatives thereof, and retinol and esters thereof.  
     
     
         26 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a substance that binds to the peripheral benzodiazepine receptor.  
     
     
         27 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 17 .  
     
     
         28 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 18 .  
     
     
         29 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 19 .  
     
     
         30 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 20 .  
     
     
         31 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 21 .  
     
     
         32 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 22 .  
     
     
         33 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 23 .  
     
     
         34 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 24 .  
     
     
         35 . A method for the treatment of cutaneous stress which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 25 .  
     
     
         36 . A method for reducing wrinkles, reducing solar erythema or protecting against free radicals which comprises topically administering to a subject in need of such treatment an effective amount of a composition according to  claim 17 .  
     
     
         37 . A method for reducing wrinkles, reducing solar erythema or protecting against free radicals which comprises topically administering an effective amount of a composition according to  claim 18 .  
     
     
         38 . A method for reducing wrinkles, reducing solar erythema or protecting against free radicals which comprises topically administering an effective amount of a composition according to  claim 20 .  
     
     
         39 . Strain  Nocardia  species SRL 4988 filed at the C.N.C.M. of the Institut Pasteur under No. 1-2305 and its productive mutants.  
     
     
         40 . Strain  Streptomyces  species SRL 5186 filed at the C.N.C.M. of the Institut Pasteur under No. 1-2306 and its productive mutants.  
     
     
         41 . Strain  Actinosinnema  species SRL 5189 filed at the C.N.C.M. of the Institut Pasteur under No. 1-2307 and its productive mutants.

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