US2005085547A1PendingUtilityA1
Molecules for inducing differentiation of dendritic cells

Assignee: COUNCIL SCIENT IND RESPriority: Oct 20, 2003Filed: Dec 31, 2003Published: Apr 21, 2005
Est. expiryOct 20, 2023(expired)· nominal 20-yr term from priority
Inventors:Anil Chatterji Krishnamurthy Natarajan Venkatasamy Manivel Kanury Subba Rao Parameswaran Subrayan Vinod Singh Ramasamy Anand Ehrlich Desa
A61P 43/00A61P 37/02A61P 35/04A61K 31/185C07C 305/06A61K 31/194A61K 31/16A61K 31/19C07C 309/17C07C 309/18A61K 31/195A61P 19/08A61P 19/02A61P 19/10C07C 307/02A61K 31/255
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References
Claims
Abstract

The present invention is related to compounds having general formula Z-OC(CR n1 R n2 )—CO-Z wherein Z=OH or NH 2 and n1=n2=1 to 8, for modulation of immune response by differentiation dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR 3 R 4 —CR 2 (NHR 1 )—COOH, ZOC—CR 5 R 6 —CR 3 R 4 —C(NHR 2 )—COOH, ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 (NHR 2 )—COOH wherein Z=OH or NH 2 ; R 1 to R 8 denotes H, SO 3 H, or OSO 3 H. In addition, the dicarboxylic acids and their amides ZOC—(CH 2 ) n —CR 1 R 2 —COOH, where Z=OH or NH 2 ; and n=1, 2, 3. The groups R 1 /R 2 =H/SO 3 H or OSO 3 H or CH 2 —SO 3 H or CH 2 —OSO 3 H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn. The composition consists of varying amounts of the above amino acid/dicarboxylic acid derivatives or their pharmaceutically acceptable alkali/alkaline earth metal salts or their salts, the processes for the preparation of the aforesaid compounds useful for the differentiation and maturation of dendritic cells.
Claims

exact text as granted — not AI-modified
1 . A compound of general formula Z-OC(C R n1 R n2 )—CO-Z wherein Z=OH or NH 2  and n1=n2=1 to 8.  
     
     
         2 . A compound as claimed in  claim 1  having a structure as shown below and bearing general formula ZOC—CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         3 . A compound as claimed in  claim 1  having a structure as shown below and bearing general formula ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         4 . A compound as claimed in  claim 1  having a structure as shown below and bearing general formula ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         5 . A Compound as claimed in  claim 2 , wherein the compound is selected from the group consisting of: 
 I [L-Aspartic acid, N-Sulfonic acid],    II [2α,3-dicarboxy, propane-1-sulfonic acid],    III [2α,3-dicarboxy, propane-1-sulfate],    IV [1α,2-carboxy ethane sulfonic acid],    V [1α,2-carboxy ethane sulfate],    VI [D-aspartic acid, N-sulfonic acid],    VII [2β,3-carboxy, propane-1-sulfonic acid],    VIII [2β,3-carboxy, propane-1-sulfate],    IX [1β,2-carboxy ethane-1-sulfonic acid],    X [1β,2-carboxy ethane-1-sulfate],    XI [D-aspartic acid, 3α-sulfonic acid],    XII [D-aspartic acid, 3α-sulfate],    XIII [D-aspartic acid, 3β-sulfonic acid],    XIV [D-aspartic acid, 3β-sulfate],    XV [L-asparagine, N-sulfonic acid],    XVI [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX [1α-carboxy, 2-carboxamido, ethane sulfate],    XX [L-asparagine, 3α-sulfonic acid],    XXI [L-asparagine, 3α-sulfate],    XXII [L-asparagine, 3β-sulfonic acid],    XXIII [L-asparagine, 3β-sulfate,    XXIV [D-asparagine, N-sulfonic acid],    XXV [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX [D-asparagine, 3α-sulfonic acid],    XXX [D-asparagine, 3α-sulfate],    XXXI [D-asparagine, 3β-sulfonic acid],    XXXII [D-asparagine, 3β-sulfate],    XXXIII [L-glutamic acid, N-sulfonic acid],    XXXIV [2α,4-dicarboxy, butane-1-sulfonic acid],    XXXV [2α,4-dicarboxy, butane-1-sulfate],    XXXVI [1α,3-dicarboxy, propane sulfonic acid],    XXXVII [1α,3-dicarboxy, propane sulfate],    XXXVIII [1β,3-dicarboxy, propane sulfate],    XXXIX [1β,3-dicarboxy, propane sulfonic acid],    
     
     
         6 . A Compound as claimed in  claim 3 , wherein the compound is selected from the group consisting of: 
 I. [D-glutamic acid, N-sulfonic acid],    II. 2β,4-dicarboxy, butane-1-sulfonic acid],    III. [2β,4-dicarboxy, butane-1-sulfate],    IV. [D-glutamic acid, 3α-sulfonic acid],    V. [D-glutamic acid, 3α-sulfate],    VI. [D-glutamic acid, 3β-sulfonic acid],    VII. [D-glutamic acid, 3β-sulfate],    VIII. [D-glutamic acid, 4α-sulfonic acid],    IX. [D-glutamic acid, 4α-sulfate],    X. [D-glutamic acid, 4β-sulfonic acid],    XI. [D-glutamic acid, 3β-sulfate],    XII. [L-glutamine, N-sulfonic acid],    XIII. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX. [D-glutamine, N-sulfonic acid],    XX. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [D-glutamine, 3α-sulfonic acid],    XXIII. [D-glutamine, 3α-sulfate],    XXIV. [D-glutamine, 3β-sulfonic acid],    XXV. [D-glutamine, 3β-sulfate],    XXVI. [D-glutamine, 4α-sulfonic acid],    XXVII. [D-glutamine, 4α-sulfate],    XVIII. [D-glutamine, 4β-sulfonic acid],    XXIX. [D-glutamine, 4β-sulfate],    XXX. [L-homoglutamic acid, N-sulfonic acid],    XXXI. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII. [Pentane-2α,5-dicarboxy-1-sulfate],    XXIII. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XXIV. [Butane-1α,4-dicarboxy-1-sulfate],    XXXV. [D-homoglutamic acid, N-sulfonic acid],    XXVI. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    XXVII. [Pentane-2β,5-dicarboxy-1-sulfate],    XVIII. [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXIX. [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         7 . A Compound as claimed in  claim 4 , wherein the compound is selected from the group consisting of 
 I. [D-homoglutamic acid, 3α-sulfonic acid],    II. [D-homoglutamic acid, 3α-sulfate],    III. [D-homoglutamic acid, 3β-sulfonic acid],    IV. [D-homoglutamic acid, 3β-sulfate],    V. [D-homoglutamic acid, 4α-sulfonic acid],    VI. [D-homoglutamic acid, 4α-sulfate],    VII. [D-homoglutamic acid, 4β-sulfonic acid],    VIII. [D-homoglutamic acid, 4β-sulfate],    IX. [D-homoglutamic acid, 5α-sulfate],    X. [D-homoglutamic acid, 5α-sulfate],    XI. [D-homoglutamic acid, 5β-sulfonic acid],    XII. [D-homoglutamic acid, 5β-sulfate],    XIII. [L-homoglutamine, N-sulfonic acid],    XIV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XVI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XVII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XVIII. [D-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXII. [D-homoglutamine, 3α-sulfonic acid],    XXIII. [D-homoglutamine, 3α-sulfate],    XXIV. [D-homoglutamine, 3β-sulfonic acid],    XXV. [D-homoglutamine, 3β-sulfate],    XXVI. [D-homoglutamine, 4α-sulfonic acid],    XXVII. [D-homoglutamine, 4α-sulfate],    XVIII. [D-homoglutamine, 4β-sulfonic acid],    XXIX. [D-homoglutamine, 4β-sulfate],    XXX. [D-homoglutamine, 5α-sulfonic acid],    XXXI. [D-homoglutamine, 5α-sulfate],    XXXII. [D-homoglutamine, 5β-sulfonic acid] and    XXIII. [D-homoglutamine, 5β-sulfate].    
     
     
         8 . Novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 3 R 4 —CR 1 R 2 —COOH as claimed in  claim 2 , wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined.    
     
     
         9 . Novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH as claimed in  claim 3 , wherein: Z=OH or NH 2 , R 1 , to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XXVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XXXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XXXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XXXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined.    
     
     
         10 . Novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH as claimed in  claim 4 , wherein: Z=OH or NH 2 , R 1 , to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =P4=R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =—CH 2 SO 3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =&amp;=H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XXVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XXXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XXXVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XXXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XL. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    XLI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    XLII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    XLIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    
     
     
         11 . A Compound as claimed in  claim 5 , wherein said compound is non-toxic salts selected from the group consisting of: 
 XL. [L-Aspartic acid, N-Sulfonic acid],    XLI. [2α,3-dicarboxy, propane-1-sulfonic acid],    XLII. [2α,3-dicarboxy, propane-1-sulfate],    XLIII. [1α,2-carboxy ethane sulfonic acid],    XLIV. [1α,2-carboxy ethane sulfate],    XLV. [D-aspartic acid, N-sulfonic acid],    XLVI. [2β,3-carboxy, propane-1-sulfonic acid],    XLVII. [2β,3-carboxy, propane-1-sulfate],    XLVIII. [1β,2-carboxy ethane-1-sulfonic acid],    XLIX. [1β,2-carboxy ethane-1-sulfate],    L. [D-aspartic acid, 3α-sulfonic acid],    LI. [D-aspartic acid, 3α-sulfate],    LII. [D-aspartic acid, 3β-sulfonic acid],    LIII. [D-aspartic acid, 3β-sulfate],    LIV. [L-asparagine, N-sulfonic acid],    LV. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    LVI. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    LVII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    LVIII. [1α-carboxy, 2-carboxamido, ethane sulfate],    LIX. [L-asparagine, 3α-sulfonic acid],    LX. [L-asparagine, 3α-sulfate],    LXI. [L-asparagine, 3β-sulfonic acid],    LXII. [L-asparagine, 3β-sulfate,    LXIII. [D-asparagine, N-sulfonic acid],    LXIV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    LXV. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    LXVI. [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    LXVII. [1β-carboxy, 2-carboxamido, ethane sulfate],    LXVIII. [D-asparagine, 3α-sulfonic acid],    LXLX. [D-asparagine, 3α-sulfate],    LXX. [D-asparagine, 3β-sulfonic acid],    LXXI. [D-asparagine, 3β-sulfate],    LXXII. [L-glutamic acid, N-sulfonic acid],    LXXIII. [2α,4-dicarboxy, butane-1-sulfonic acid],    LXXIV. [2α,4-dicarboxy, butane-1-sulfate],    LXXV. [1α,3-dicarboxy, propane sulfonic acid],    LXXVI. [1α,3-dicarboxy, propane sulfate],    LXXVII. [1β,3-dicarboxy, propane sulfate],    LXXVIII. [1β,3-dicarboxy, propane sulfonic acid],    
     
     
         12 . A Compound as claimed in  claim 6 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [D-glutamic acid, N-sulfonic acid],    II. [2β,4-dicarboxy, butane-1-sulfonic acid],    III. [2β,4-dicarboxy, butane-1-sulfate],    IV. [D-glutamic acid, 3α-sulfonic acid],    V. [D-glutamic acid, 3α-sulfate],    VI. [D-glutamic acid, 3β-sulfonic acid],    VII. [D-glutamic acid, 3β-sulfate],    VIII. [D-glutamic acid, 4α-sulfonic acid],    IX. [D-glutamic acid, 4α-sulfate],    X. [D-glutamic acid, 4β-sulfonic acid],    XI. [D-glutamic acid, 3β-sulfate],    XII. [L-glutamine, N-sulfonic acid],    XIII. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX. [D-glutamine, N-sulfonic acid],    XX. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [D-glutamine, 3α-sulfonic acid],    XXIII. [D-glutamine, 3α-sulfate],    XXIV. [D-glutamine, 3β-sulfonic acid],    XXV. [D-glutamine, 3β-sulfate],    XXVI. [D-glutamine, 4α-sulfonic acid],    XXVII. [D-glutamine, 4α-sulfate],    XXVIII. [D-glutamine, 4β-sulfonic acid],    XXIX. [D-glutamine, 4β-sulfate],    XXX. [L-homoglutamic acid, N-sulfonic acid],    XXXI. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII. [Pentane-2α,5-dicarboxy-1-sulfate],    XXXIII. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XXXIV. [Butane-1α,4-dicarboxy-1-sulfate],    XXXV. [D-homoglutamic acid, N-sulfonic acid],    XXXVI. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    XXXVII. [Pentane-2β,5-dicarboxy-1-sulfate],    XXXVIII. [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXIX. [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         13 . A Compound as claimed in  claim 7 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [D-homoglutamic acid, 3α-sulfonic acid],    II. [D-homoglutamic acid, 3α-sulfate],    III. [D-homoglutamic acid, 3β-sulfonic acid],    IV. [D-homoglutamic acid, 3β-sulfate],    V. [D-homoglutamic acid, 4α-sulfonic acid],    VI. [D-homoglutamic acid, 4α-sulfate],    VII. [D-homoglutamic acid, 4β-sulfonic acid],    VIII. [D-homoglutamic acid, 4β-sulfate],    IX. [D-homoglutamic acid, 5α-sulfate],    X. [D-homoglutamic acid, 5α-sulfate],    XI. [D-homoglutamic acid, 5β-sulfonic acid],    XII. [D-homoglutamic acid, 5β-sulfate],    XIII. [L-homoglutamine, N-sulfonic acid],    XIV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XVI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XVII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XVIII. [D-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXII. [D-homoglutamine, 3α-sulfonic acid],    XXIII. [D-homoglutamine, 3α-sulfate],    XXIV. [D-homoglutamine, 3β-sulfonic acid],    XXV. [D-homoglutamine, 3β-sulfate],    XXVI. [D-homoglutamine, 4α-sulfonic acid],    XXVII. [D-homoglutamine, 4α-sulfate],    XVIII. [D-homoglutamine, 4β-sulfonic acid],    XXIX. [D-homoglutamine, 4β-sulfate],    XXX. [D-homoglutamine, 5α-sulfonic acid],    XXXI. [D-homoglutamine, 5α-sulfate],    XXXII. [D-homoglutamine, 5β-sulfonic acid] and    XXIII. [D-homoglutamine, 5β-sulfate].    
     
     
         14 . A compound as claimed in  claim 11 , wherein said compound is selected from the group consisting of aspartic acid, asparagine and corresponding de-amino analogs: 
 I. [L-Aspartic acid, N-Sulfonic acid],    II. [2α,3-dicarboxy, propane-1-sulfonic acid],    III. [2α,3-dicarboxy, propane-1-sulfate],    IV. [1α,2-carboxy ethane sulfonic acid],    V. [1α,2-carboxy ethane sulfate],    VI. [D-aspartic acid, N-sulfonic acid],    VII. [2β,3-carboxy, propane-1-sulfonic acid],    VIII. [2β,3-carboxy, propane-1-sulfate],    IX. [1β,2-carboxy ethane-1-sulfonic acid],    X. [1β,2-carboxy ethane-1-sulfate],    XI. [D-aspartic acid, 3α-sulfonic acid],    XII. [D-aspartic acid, 3α-sulfate],    XIII. [D-aspartic acid, 3β-sulfonic acid],    XIV. [D-aspartic acid, 3β-sulfate],    XV. [L-asparagine, N-sulfonic acid],    XVI. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX. [1α-carboxy, 2-carboxamido, ethane sulfate],    XX. [L-asparagine, 3α-sulfonic acid],    XXI. [L-asparagine, 3α-sulfate],    XXII. [L-asparagine, 3β-sulfonic acid],    XXIII. [L-asparagine, 3β-sulfate,    XXIV. [D-asparagine, N-sulfonic acid],    XXV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII. [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII. [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX. [D-asparagine, 3α-sulfonic acid],    XXX. [D-asparagine, 3α-sulfate],    XXXI. [D-asparagine, 3β-sulfonic acid],    XXXII. [D-asparagine, 3β-sulfate],    
     
     
         15 . A compound as claimed in  claim 12 , wherein said compound is selected from the group consisting of glutamic acid, glutamine and corresponding de-amino analogs: 
 I. [L-glutamic acid, N-sulfonic acid],    II. [2α,4-dicarboxy, butane-1-sulfonic acid],    III. [2α,4-dicarboxy, butane-1-sulfate],    IV. [1α,3-dicarboxy, propane sulfonic acid],    V. [1α,3-dicarboxy, propane sulfate],    VI. [1β,3-dicarboxy, propane sulfate],    VII. [1β,3-dicarboxy, propane sulfonic acid],    VIII. [D-glutamic acid, N-sulfonic acid],    IX. [2β,4-dicarboxy, butane-1-sulfonic acid],    X. [2β,4-dicarboxy, butane-1-sulfate],    XI. [D-glutamic acid, 3α-sulfonic acid],    XII. [D-glutamic acid, 3α-sulfate],    XIII. [D-glutamic acid, 3β-sulfonic acid],    XIV. [D-glutamic acid, 3β-sulfate],    XV. [D-glutamic acid, 4α-sulfonic acid],    XVI. [D-glutamic acid, 4α-sulfate],    XVII. [D-glutamic acid, 4β-sulfonic acid],    XVIII. [D-glutamic acid, 3β-sulfate],    XIX. [L-glutamine, N-sulfonic acid],    XX. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXIII. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XXIV. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XXV. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [D-glutamine, N-sulfonic acid],    XXVII. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXVIII. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXIX. [D-glutamine, 3α-sulfonic acid],    XXX. [D-glutamine, 3α-sulfate],    XXXI. [D-glutamine, 3β-sulfonic acid],    XXXII. [D-glutamine, 3β-sulfate],    XXXIII. [D-glutamine, 4α-sulfonic acid],    XXXIV. [D-glutamine, 4α-sulfate],    XXXV. [D-glutamine, 4β-sulfonic acid],    XXXVI. [D-glutamine, 4β-sulfate],    XXXVII. [L-homoglutamic acid, N-sulfonic acid],    XXVIII. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXIX. [Pentane-2α,5-dicarboxy-1-sulfate],    XL. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XLI. [Butane-1α,4-dicarboxy-1-sulfate],    
     
     
         16 . A compound as claimed in  claim 13 , wherein said compound is selected from the group consisting of homoglutamic acid, homoglutamine and corresponding de-amino analogs: 
 I. [D-homoglutamic acid, N-sulfonic acid],    II. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    III. [Pentane-2β,5-dicarboxy-1-sulfate],    IV. [Butane-1β,4-dicarboxy-1-sulfonic acid],    V. [Butane-1β,4-dicarboxy-1-sulfate],    VI. [D-homoglutamic acid, 3α-sulfonic acid],    VII. [D-homoglutamic acid, 3α-sulfate],    VIII. [D-homoglutamic acid, 3β-sulfonic acid],    IX. [D-homoglutamic acid, 3β-sulfate],    X. [D-homoglutamic acid, 4α-sulfonic acid],    XI. [D-homoglutamic acid, 4α-sulfate],    XII. [D-homoglutamic acid, 4β-sulfonic acid],    XIII. [D-homoglutamic acid, 4β-sulfate],    XIV. [D-homoglutamic acid, 5α-sulfate],    XV. [D-homoglutamic acid, 5α-sulfate],    XVI. [D-homoglutamic acid, 5β-sulfonic acid],    XVII. [D-homoglutamic acid, 5β-sulfate],    XVIII. [L-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XXI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XXII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XXIII. [D-homoglutamine, N-sulfonic acid],    XXIV. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XXV. [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXVI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXVII. [D-homoglutamine, 3α-sulfonic acid],    XXVIII. [D-homoglutamine, 3α-sulfate],    XXIX. [D-homoglutamine, 3β-sulfonic acid],    XXX. [D-homoglutamine, 3β-sulfate],    XXXI. [D-homoglutamine, 4α-sulfonic acid],    XXXII. [D-homoglutamine, 4α-sulfate],    XXXIII. [D-homoglutamine, 4β-sulfonic acid],    XXXIV. [D-homoglutamine, 4β-sulfate],    XXXV. [D-homoglutamine, 5α-sulfonic acid],    XXVI. [D-homoglutamine, 5α-sulfate],    XVII. [D-homoglutamine, 5β-sulfonic acid] and    XVIII. [D-homoglutamine, 5β-sulfate].    
     
     
         17 . A compound as claimed in  claim 1 , wherein incubation of BM leukocyte precursors with different concentrations of the synthetic compound increases the cell surface densities of CD11c, CD80, CD54 and CD11c to various levels with maximum up regulation at 200 mM.  
     
     
         18 . A compound as claimed in  claim 1 , wherein it gives the fold increase in the levels of molecules of cells stimulated with either 15 ng/ml of GM-CSF or 200 mM of the synthetic compound at 48 h of incubation.  
     
     
         19 . A compound as claimed in  claim 1 , wherein the viability of the cultures is more than 99% at the end of the incubation period at this concentration of the synthetic compound.  
     
     
         20 . A compound as claimed in  claim 1 , useful to induce differentiation of dendritic cells and modulation of immune response controlled by dendritic cell.  
     
     
         21 . A compound as claimed in  claim 1 , useful in vaccine formulation to prevent more efficient and faster presentation of antigens to T-cells thereby initiate primary protective Th1 immune response and help in the clearance of the pathogen.  
     
     
         22 . A process for preparing the compounds having general formula Z-OC(CR n1 R n2 )—CO-Z wherein Z=OH or NH 2  and n1=n2=1 to 8 said process comprising the steps of: 
 a) reacting tertiary butyl ester of di carboxylic acid and its derivatives having carbon 1 to 10 with thionyl chloride and triethyl amine in presence of low boiling halogenated solvent at a temperature in the range of 10 to 35° C.    b) stirring the solution of step (a) unless thin layer chromatography (TLC) shows complete consumption of starting material.    c) evaporating the solvent and obtaining crude product.    d) drying the crude and adding water to the same to obtain a slurry.    e) stirring the slurry for a time period in the range of 0.5 to 3 hr,    f) adding CH 2 Cl 2  and TFA to the solution and stirring the solution for about 24 hrs    g) evaporating the solvent and drying in vacuum to obtain the desired product.    
     
     
         24 . A process as claimed in  claim 22 , wherein tertiary butyl ether is either mono butyl ether or di-butyl ether.  
     
     
         25 . A process as claimed in  claim 22 , wherein low boiling halogenated solvent used is dichlormethane  
     
     
         26 . A process as claimed in  claim 22  wherein in step (a), dichloromethane used is free from water.  
     
     
         27 . A process as claimed in  claim 22  wherein in step (b), stirring is carried out for a period in the range of 5 to 10 hours.  
     
     
         28 . A process as claimed in  claim 22  wherein in step (d), dimethylchloride is used in the range of 3 to 10 equivalent.  
     
     
         29 . A Pharmaceutical composition comprising the effective amount of a compound selected from the general formula Z-OC(CR n1 R n2 )—CO-Z wherein Z=OH or NH 2  and n1=n2=1 to 8 along with an additive, excipient, diluents or carrier.  
     
     
         30 . A composition as claimed in  claim 29 , wherein said compound useful in vaccine formulation to prevent more efficient and faster presentation of antigens to T-cells thereby initiate primary protective Th1 immune response and help in the clearance of the pathogen.  
     
     
         31 . A composition as claimed in  claim 29 , wherein said compound having a structure as herein and bearing general formula ZOC—CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         32 . A composition as claimed in  claim 29 , wherein said compound having a structure as herein and bearing general formula ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         33 . A composition as claimed in  claim 29 , wherein said compound having structure as herein and bearing general formula ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         34 . A composition as claimed in  claim 29 , wherein said compound in non-toxic to monocytes.  
     
     
         35 . A composition as claimed in  claim 29 , wherein said compound in non-toxic to macrophages.  
     
     
         36 . A composition as claimed in  claim 29 , wherein additives are different divalent metal cations such as Mg, Ca and Zn.  
     
     
         37 . A composition as claimed in  claim 29 , wherein additives are amino acid/dicarboxylic acid derivatives and their pharmaceutically acceptable selected alkali/alkaline earth metal salts.  
     
     
         38 . A composition as claimed in  claim 29 , wherein the compound is selected from the group consisting of: 
 I. [L-Aspartic acid, N-Sulfonic acid],    II. [2α,3-dicarboxy, propane-1-sulfonic acid],    III. [2α,3-dicarboxy, propane-1-sulfate],    IV. [1α,2-carboxy ethane sulfonic acid],    V. [1α,2-carboxy ethane sulfate],    VI. [D-aspartic acid, N-sulfonic acid],    VII. [2β,3-carboxy, propane-1-sulfonic acid];    VIII. [2β,3-carboxy, propane-1-sulfate],    IX. [1β,2-carboxy ethane-1-sulfonic acid],    X. [1β,2-carboxy ethane-1-sulfate],    XI. [D-aspartic acid, 3α-sulfonic acid],    XII. [D-aspartic acid, 3α-sulfate],    XIII. [D-aspartic acid, 3β-sulfonic acid],    XIV. [D-aspartic acid, 3β-sulfate],    XV. [L-asparagine, N-sulfonic acid],    XVI. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX. [1α-carboxy, 2-carboxamido, ethane sulfate],    XX. [L-asparagine, 3α-sulfonic acid],    XXI. [L-asparagine, 3α-sulfate],    XXII. [L-asparagine, 3β-sulfonic acid],    XXIII. [L-asparagine, 3β-sulfate,    XXIV. [D-asparagine, N-sulfonic acid],    XXV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII. [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII. [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX. [D-asparagine, 3α-sulfonic acid],    XXX. [D-asparagine, 3α-sulfate],    XXXI. [D-asparagine, 3β-sulfonic acid],    XXXII. [D-asparagine, 3β-sulfate],    XXXIII. [L-glutamic acid, N-sulfonic acid],    XXXIV. [2α,4-dicarboxy, butane-1-sulfonic acid],    XXXV. [2α,4-dicarboxy, butane-1-sulfate],    XXXVI. [1α,3-dicarboxy, propane sulfonic acid],    XXXVII. [1α,3-dicarboxy, propane sulfate],    XXXVIII. [1β,3-dicarboxy, propane sulfate],    XXXIX. [1β,3-dicarboxy, propane sulfonic acid],    
     
     
         39 . A composition as claimed in  claim 29 , wherein the compound is selected from the group consisting of: 
 I. [D-glutamic acid, N-sulfonic acid],    II. 2β,4-dicarboxy, butane-1-sulfonic acid],    III. [2β,4-dicarboxy, butane-1-sulfate],    IV. [D-glutamic acid, 3α-sulfonic acid],    V. [D-glutamic acid, 3α-sulfate],    VI. [D-glutamic acid, 3β-sulfonic acid],    VII. [D-glutamic acid, 3β-sulfate],    VIII. [D-glutamic acid, 4α-sulfonic acid],    IX. [D-glutamic acid, 4α-sulfate],    X. [D-glutamic acid, 4β-sulfonic acid],    XI. [D-glutamic acid, 3β-sulfate],    XII. [L-glutamine, N-sulfonic acid],    XIII. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX. [D-glutamine, N-sulfonic acid],    XX. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [D-glutamine, 3α-sulfonic acid],    XXIII. [D-glutamine, 3α-sulfate],    XXIV. [D-glutamine, 3β-sulfonic acid],    XXV. [D-glutamine, 3β-sulfate],    XXVI. [D-glutamine, 4α-sulfonic acid],    XXVII. [D-glutamine, 4α-sulfate],    XXVIII. [D-glutamine, 4β-sulfonic acid],    XXIX. [D-glutamine, 4β-sulfate],    XXX. [L-homoglutamic acid, N-sulfonic acid],    XXXI. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII. [Pentane-2α,5-dicarboxy-1-sulfate],    XXXIII. [Butane-1 α,4-dicarboxy-1-sulfonic acid],    XXXIV. [Butane-1α,4-dicarboxy-1-sulfate],    XXXV. [D-homoglutamic acid, N-sulfonic acid],    XXXVI. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    XXXVII. [Pentane-2β,5-dicarboxy-1-sulfate],    XXXVIII. [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXXIX. [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         40 . A composition as claimed in  claim 29 , wherein the compound is selected from the group consisting of 
 I. [D-homoglutamic acid, 3α-sulfonic acid],    II. [D-homoglutamic acid, 3α-sulfate],    III. [D-homoglutamic acid, 3β-sulfonic acid],    IV. [D-homoglutamic acid, 3β-sulfate],    V. [D-homoglutamic acid, 4α-sulfonic acid],    VI. [D-homoglutamic acid, 4α-sulfate],    VII. [D-homoglutamic acid, 4β-sulfonic acid],    VIII. [D-homoglutamic acid, 4β-sulfate],    IX. [D-homoglutamic acid, 5α-sulfate],    X. [D-homoglutamic acid, 5α-sulfate],    XI. [D-homoglutamic acid, 5β-sulfonic acid],    XII. [D-homoglutamic acid, 5β-sulfate],    XIII. [L-homoglutamine, N-sulfonic acid],    XIV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XVI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XVII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XVIII. [D-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXII. [D-homoglutamine, 3α-sulfonic acid],    XXIII. [D-homoglutamine, 3α-sulfate],    XXIV. [D-homoglutamine, 3β-sulfonic acid],    XXV. [D-homoglutamine, 3β-sulfate],    XXVI. [D-homoglutamine, 4α-sulfonic acid],    XXVII. [D-homoglutamine, 4α-sulfate],    XVIII. [D-homoglutamine, 4β-sulfonic acid],    XXIX. [D-homoglutamine, 4β-sulfate],    XXX. [D-homoglutamine, 5α-sulfonic acid],    XXXI. [D-homoglutamine, 5α-sulfate],    XXXII. [D-homoglutamine, 5β-sulfonic acid] and    XXIII. [D-homoglutamine, 5β-sulfate].    
     
     
         41 . A composition as claimed in  claim 29 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined.    
     
     
         42 . A composition as claimed in  claim 29 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH, wherein: Z=OH or NH 2 , R 1 , to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =&amp;=H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XXXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XXXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XXXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined.    
     
     
         43 . A composition as claimed in  claim 29 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH, wherein: Z=OH or NH 2 , R 1 , to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =—CH 2 SO 3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =&amp;=R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =&amp;=R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XXXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XXXVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 3 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XXXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 1 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XL. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    XLI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    XLII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    XLIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    
     
     
         44 . A composition as claimed in  claim 29 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [L-Aspartic acid, N-Sulfonic acid],    II. [2α,3-dicarboxy, propane-1-sulfonic acid],    III. [2α,3-dicarboxy, propane-1-sulfate],    IV. [1α,2-carboxy ethane sulfonic acid],    V. [1α,2-carboxy ethane sulfate],    VI. [D-aspartic acid, N-sulfonic acid],    VII. [2β,3-carboxy, propane-1-sulfonic acid],    VIII. [2β,3-carboxy, propane-1-sulfate],    IX. [1β,2-carboxy ethane-1-sulfonic acid],    X. [1β,2-carboxy ethane-1-sulfate],    XI. [D-aspartic acid, 3α-sulfonic acid],    XII. [D-aspartic acid, 3α-sulfate],    XIII. [D-aspartic acid, 3β-sulfonic acid],    XIV. [D-aspartic acid, 3β-sulfate],    XV. [L-asparagine, N-sulfonic acid],    XVI. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX. [1α-carboxy, 2-carboxamido, ethane sulfate],    XX. [L-asparagine, 3α-sulfonic acid],    XXI. [L-asparagine, 3α-sulfate],    XXII. [L-asparagine, 3β-sulfonic acid],    XXIII. [L-asparagine, 3β-sulfate,    XXIV. [D-asparagine, N-sulfonic acid],    XXV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII. [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII. [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX. [D-asparagine, 3α-sulfonic acid],    XXX. [D-asparagine, 3α-sulfate],    XXXI. [D-asparagine, 3β-sulfonic acid],    XXXII. [D-asparagine, 3β-sulfate],    XXXIII. [L-glutamic acid, N-sulfonic acid],    XXXIV. [2α,4-dicarboxy, butane-1-sulfonic acid],    XXXV. [2α,4-dicarboxy, butane-1-sulfate],    XXXVI. [1α,3-dicarboxy, propane sulfonic acid],    XXXVII. [1α,3-dicarboxy, propane sulfate],    XXVIII. [1β,3-dicarboxy, propane sulfate],    XXXIX. [1β,3-dicarboxy, propane sulfonic acid],    
     
     
         45 . A composition as claimed in  claim 29 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [D-glutamic acid, N-sulfonic acid],    II. [2β,4-dicarboxy, butane-1-sulfonic acid],    III. [2β,4-dicarboxy, butane-1-sulfate],    IV. [D-glutamic acid, 3α-sulfonic acid],    V. [D-glutamic acid, 3α-sulfate],    VI. [D-glutamic acid, 3β-sulfonic acid],    VII. [D-glutamic acid, 3β-sulfate],    VIII. [D-glutamic acid, 4α-sulfonic acid],    IX. [D-glutamic acid, 4α-sulfate],    X. [D-glutamic acid, 4β-sulfonic acid],    XI. [D-glutamic acid, 3β-sulfate],    XII. [L-glutamine, N-sulfonic acid],    XIII. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX. [D-glutamine, N-sulfonic acid],    XX. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [D-glutamine, 3α-sulfonic acid],    XXIII. [D-glutamine, 3α-sulfate],    XXIV. [D-glutamine, 3β-sulfonic acid],    XXV. [D-glutamine, 3β-sulfate],    XXVI. [D-glutamine, 4α-sulfonic acid],    XXVII. [D-glutamine, 4α-sulfate],    XVIII. [D-glutamine, 4β-sulfonic acid],    XXIX. [D-glutamine, 4β-sulfate],    XXX. [L-homoglutamic acid, N-sulfonic acid],    XXXI. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII. [Pentane-2α,5-dicarboxy-1-sulfate],    XXIII. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XXIV. [Butane-1α,4-dicarboxy-1-sulfate],    XXXV. [D-homoglutamic acid, N-sulfonic acid],    XXVI. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    XXVII. [Pentane-2β,5-dicarboxy-1-sulfate],    XVIII. [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXIX. [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         45 . A composition as claimed in  claim 29 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [D-homoglutamic acid, 3α-sulfonic acid],    II. [D-homoglutamic acid, 3α-sulfate],    III. [D-homoglutamic acid, 3β-sulfonic acid],    IV. [D-homoglutamic acid, 3β-sulfate],    V. [D-homoglutamic acid, 4α-sulfonic acid],    VI. [D-homoglutamic acid, 4α-sulfate],    VII. [D-homoglutamic acid, 4β-sulfonic acid],    VIII. [D-homoglutamic acid, 4β-sulfate],    IX. [D-homoglutamic acid, 5α-sulfate],    X. [D-homoglutamic acid, 5α-sulfate],    XI. [D-homoglutamic acid, 5β-sulfonic acid],    XII. [D-homoglutamic acid, 5β-sulfate],    XIII. [L-homoglutamine, N-sulfonic acid],    XIV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XVI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XVII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XVIII. [D-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXII. [D-homoglutamine, 3α-sulfonic acid],    XXIII. [D-homoglutamine, 3α-sulfate],    XXIV. [D-homoglutamine, 3β-sulfonic acid],    XXV. [D-homoglutamine, 3β-sulfate],    XXVI. [D-homoglutamine, 4α-sulfonic acid],    XXVII. [D-homoglutamine, 4α-sulfate],    XVIII. [D-homoglutamine, 4β-sulfonic acid],    XXIX. [D-homoglutamine, 4β-sulfate],    XXX. [D-homoglutamine, 5α-sulfonic acid],    XXXI. [D-homoglutamine, 5α-sulfate],    XXXII. [D-homoglutamine, 5β-sulfonic acid] and    XXIII. [D-homoglutamine, 5β-sulfate].    
     
     
         46 . A composition as claimed in  claim 29 , wherein said compound is selected from the group consisting of aspartic acid, asparagine and corresponding de-amino analogs: 
 I. [L-Aspartic acid, N-Sulfonic acid],    II. [2α,3-dicarboxy, propane-1-sulfonic acid],    III. [2α,3-dicarboxy, propane-1-sulfate],    IV. [1α,2-carboxy ethane sulfonic acid],    V. [1 α,2-carboxy ethane sulfate],    VI. [D-aspartic acid, N-sulfonic acid],    VII. [2β,3-carboxy, propane-1-sulfonic acid],    VIII. [2β,3-carboxy, propane-1-sulfate],    IX. [1β,2-carboxy ethane-1-sulfonic acid],    X. [1β,2-carboxy ethane-1-sulfate],    XI. [D-aspartic acid, 3α-sulfonic acid],    XII. [D-aspartic acid, 3α-sulfate],    XIII. [D-aspartic acid, 3β-sulfonic acid],    XIV. [D-aspartic acid, 3β-sulfate],    XV. [L-asparagine, N-sulfonic acid],    XVI. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX. [1α-carboxy, 2-carboxamido, ethane sulfate],    XX. [L-asparagine, 3α-sulfonic acid],    XXI. [L-asparagine, 3α-sulfate],    XXII. [L-asparagine, 3β-sulfonic acid],    XXIII. [L-asparagine, 3β-sulfate,    XXIV. [D-asparagine, N-sulfonic acid],    XXV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII. [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII. [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX. [D-asparagine, 3α-sulfonic acid],    XXX. [D-asparagine, 3α-sulfate],    XXXI. [D-asparagine, 3β-sulfonic acid],    XXXII. [D-asparagine, 3β-sulfate],    
     
     
         47 . A composition as claimed in  claim 29 , wherein said compound is selected from the group consisting of glutamic acid, glutamine and corresponding de-amino analogs: 
 I. [L-glutamic acid, N-sulfonic acid],    II. [2α,4-dicarboxy, butane-1-sulfonic acid],    III. [2α,4-dicarboxy, butane-1-sulfate],    IV. [1α,3-dicarboxy, propane sulfonic acid],    V. [1α,3-dicarboxy, propane sulfate],    VI. [1β,3-dicarboxy, propane sulfate],    VII. [1β,3-dicarboxy, propane sulfonic acid],    VIII. [D-glutamic acid, N-sulfonic acid],    IX. [2β,4-dicarboxy, butane-1-sulfonic acid],    X. [2β,4-dicarboxy, butane-1-sulfate],    XI. [D-glutamic acid, 3α-sulfonic acid],    XII. [D-glutamic acid, 3α-sulfate],    XIII. [D-glutamic acid, 3β-sulfonic acid],    XIV. [D-glutamic acid, 3β-sulfate],    XV. [D-glutamic acid, 4α-sulfonic acid],    XVI. [D-glutamic acid, 4α-sulfate],    XVII. [D-glutamic acid, 4β-sulfonic acid],    XVIII. [D-glutamic acid, 3β-sulfate],    XIX. [L-glutamine, N-sulfonic acid],    XX. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXIII. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XXIV. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XXV. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [D-glutamine, N-sulfonic acid],    XXVII. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XVIII. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXIX. [D-glutamine, 3α-sulfonic acid],    XXX. [D-glutamine, 3α-sulfate],    XXXI. [D-glutamine, 3β-sulfonic acid],    XXXII. [D-glutamine, 3β-sulfate],    XXIII. [D-glutamine, 4α-sulfonic acid],    XXIV. [D-glutamine, 4α-sulfate],    XXXV. [D-glutamine, 4β-sulfonic acid],    XXVI. [D-glutamine, 4β-sulfate],    XXVII. [L-homoglutamic acid, N-sulfonic acid],    XVIII. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXIX. [Pentane-2α,5-dicarboxy-1-sulfate],    XL. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XLI. [Butane-1α,4-dicarboxy-1-sulfate],    
     
     
         48 . A composition as claimed in  claim 29 , wherein said compound is selected from the group consisting of homoglutamic acid, homoglutamine and corresponding de-amino analogs: 
 I. [D-homoglutamic acid, N-sulfonic acid],    II. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    III. [Pentane-2β,5-dicarboxy-1-sulfate],    IV. [Butane-1β,4-dicarboxy-1-sulfonic acid],    V. [Butane-1β,4-dicarboxy-1-sulfate],    VI. [D-homoglutamic acid, 3α-sulfonic acid],    VII. [D-homoglutamic acid, 3α-sulfate],    VIII. [D-homoglutamic acid, 3β-sulfonic acid],    IX. [D-homoglutamic acid, 3β-sulfate],    X. [D-homoglutamic acid, 4α-sulfonic acid],    XI. [D-homoglutamic acid, 4α-sulfate],    XII. [D-homoglutamic acid, 4β-sulfonic acid],    XIII. [D-homoglutamic acid, 4β-sulfate],    XIV. [D-homoglutamic acid, 5α-sulfate],    XV. [D-homoglutamic acid, 5α-sulfate],    XVI. [D-homoglutamic acid, 5β-sulfonic acid],    XVII. [D-homoglutamic acid, 5β-sulfate],    XVIII. [L-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XXI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XXII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XXIII. [D-homoglutamine, N-sulfonic acid],    XXIV. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XXV. [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXVI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXVII. [D-homoglutamine, 3α-sulfonic acid],    XXVIII. [D-homoglutamine, 3α-sulfate],    XXIX. [D-homoglutamine, 3β-sulfonic acid],    XXX. [D-homoglutamine, 3β-sulfate],    XXXI. [D-homoglutamine, 4α-sulfonic acid],    XXXII. [D-homoglutamine, 4α-sulfate],    XXXIII. [D-homoglutamine, 4β-sulfonic acid],    XXXIV. [D-homoglutamine, 4β-sulfate],    XXXV. [D-homoglutamine, 5α-sulfonic acid],    XXXVI. [D-homoglutamine, 5α-sulfate],    XXXVII. [D-homoglutamine, 5β-sulfonic acid] and    XXXVIII. [D-homoglutamine, 5β-sulfate].
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