Method of inducing differentiation of dendritic cells

Abstract

The present invention is related to compounds having general formula Z-OC (CR n1 R n2 )—CO-Z wherein Z=OH or NH 2 and n1=n2=1 to 8, useful for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR 3 R 4 —CR 2 (NHR 1 )—COOH, ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 (NHR 2 )—COOH, ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 N 2 )—COOH wherein Z=OH or NH 2 ; R 1 to R 8 denotes H, SO 3 H, or OSO 3 H. In addition, the dicarboxylic acids and their amides ZOC—(CH 2 ) n —CR 1 R 2 —COOH, where Z=OH or NH 2 ; and n=1, 2, 3. The groups R 1 /R 2 =H/SO 3 H or OSO 3 H or CH 2 —SO 3 H or CH 2 —OSO 3 H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn. The composition consists of varying amounts of the above amino acid/dicarboxylic acid derivatives or their pharmaceutically acceptable alkali/alkaline earth metal salts or their salts, the processes for the preparation of the aforesaid compounds useful for the differentiation and maturation of dendritic cells.

1 . A method for modulation of immune response by differentiation of dendritic cells, said method comprising the step of administration a pharmaceutical acceptable amount of a compound having general formula Z-OC (C R n1 R n2 )—CO-Z wherein Z=OH or NH 2  and n1=n2=1 to 8 and subject to need thereof optionally with an additive, excipient , diluents or carrier.  
     
     
         2 . A method as claimed in  claim 1 , wherein said compound useful in vaccine formulation to prevent more efficient and faster presentation of antigens to T-cells thereby initiate primary protective Th1 immune response and help in the clearance of the pathogen.  
     
     
         3 . A method as claimed in  claim 1 , wherein said compound having a structure as herein and bearing general formula ZOC—CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         4 . A method as claimed in  claim 1 , wherein said compound having a structure as herein and bearing general formula ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         5 . A method as claimed in  claim 1 , wherein said compound having structure as herein and bearing general formula ZOC—CR 7 R 8 —CR 5 R—CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         6 . A method as claimed in  claim 1 , wherein said compound in non-toxic to monocytes.  
     
     
         7 . A method as claimed in  claim 1 , wherein said compound in non-toxic to macrophages.  
     
     
         8 . A method as claimed in  claim 1 , wherein additives are different divalent metal cations such as Mg, Ca and Zn.  
     
     
         9 . A method as claimed in  claim 1 , wherein additives are amino acid/dicarboxylic acid derivatives and their pharmaceutically acceptable selected alkali/alkaline earth metal salts.  
     
     
         10 . A method as claimed in  claim 3 , wherein the compound is selected from the group consisting of: 
 I. [L-Aspartic acid, N-Sulfonic acid],    II. [2α,3-dicarboxy, propane-1-sulfonic acid],    III. [2α,3-dicarboxy, propane-1-sulfate],    IV. [1α,2-carboxy ethane sulfonic acid],    V. [1α,2-carboxy ethane sulfate],    VI. [D-aspartic acid, N-sulfonic acid],    VII. [2β,3-carboxy,propane-1-sulfonic acid],    VIII. [2β,3-carboxy,propane-1-sulfate],    IX. [1β,2-carboxy ethane-1-sulfonic acid],    X. [1β,2-carboxy ethane-1-sulfate],    XI. [D-aspartic acid, 3α-sulfonic acid],    XII. [D-aspartic acid, 3α-sulfate],    XIII. [D-aspartic acid, 30-sulfonic acid],    XIV. [D-aspartic acid, 3β-sulfate],    XV. [L-asparagine,N-sulfonic acid],    XVI. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX. [1α-carboxy, 2-carboxamido, ethane sulfate],    XX. [L-asparagine, 3α-sulfonic acid],    XXI. [L-asparagine, 3α-sulfate],    XXII. [L-asparagine, 3β-sulfonic acid],    XXIII. [L-asparagine, 30-sulfate,    XXIV. [D-asparagine, N-sulfonic acid],    XXV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII. [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XVIII. [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX. [D-asparagine, 3α-sulfonic acid],    XXX. [D-asparagine, 3α-sulfate],    XXXI. [D-asparagine, 30-sulfonic acid],    XXXII. [D-asparagine, 3β-sulfate],    XXIII. [L-glutamic acid, N-sulfonic acid],    XXIV. [2α,4-dicarboxy, butane-1-sulfonic acid],    XXXV. [2α,4-dicarboxy, butane-1-sulfate],    XXVI. [1α,3-dicarboxy, propane sulfonic acid],    XXVII. [1α,3-dicarboxy, propane sulfate],    XVIII. [1β,3-dicarboxy, propane sulfate],    XXIX. [1β,3-dicarboxy, propane sulfonic acid],    
     
     
         11 . A method as claimed in  claim 4 , wherein the compound is selected from the group consisting of: 
 I. [D-glutamic acid, N-sulfonic acid],    II. 2β,4-dicarboxy, butane-1-sulfonic acid],    III. [2β,4-dicarboxy, butane-1-sulfate],    IV. [D-glutamic acid, 3α-sulfonic acid],    V. [D-glutamic acid, 3α-sulfate],    VI. [D-glutamic acid, 3β-sulfonic acid],    VII. [D-glutamic acid, 3β-sulfate],    VIII. [D-glutamic acid, 4α-sulfonic acid],    IX. [D-glutamic acid, 4α-sulfate],    X. [D-glutamic acid, 4β-sulfonic acid],    XI. [D-glutamic acid, 3β-sulfate],    XII. [L-glutamine, N-sulfonic acid],    XIII. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX. [D-glutamine, N-sulfonic acid],    XX. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [D-glutamine, 3α-sulfonic acid],    XXIII. [D-glutamine, 3α-sulfate],    XXIV. [D-glutamine, 3β-sulfonic acid],    XXV. [D-glutamine, 3β-sulfate],    XXVI. [D-glutamine, 4α-sulfonic acid],    XXVII. [D-glutamine, 4α-sulfate],    XXVIII. [D-glutamine, 4β-sulfonic acid],    XXIX. [D-glutamine, 4β-sulfate],    XXX. [L-homoglutamic acid, N-sulfonic acid],    XXXI. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII. [Pentane-2α,5-dicarboxy-1-sulfate],    XXXIII. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XXXIV. [Butane-1α,4-dicarboxy-1-sulfate],    XXXV. [D-homoglutamic acid, N-sulfonic acid],    XXXVI. [Pentane-213, 5-dicarboxy-1-sulfonic acid],    XXXVII. [Pentane-2β,5-dicarboxy-1-sulfate],    XXXVIII. [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXXIX. [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         12 . A method as claimed in  claim 5 , wherein the compound is selected from the group consisting of 
 I. [D-homoglutamic acid, 3α-sulfonic acid],    II. [D-homoglutamic acid, 3α-sulfate],    III. [D-homoglutamic acid, 30-sulfonic acid],    IV. [D-homoglutamic acid, 3β-sulfate],    V. [D-homoglutamic acid, 4α-sulfonic acid],    VI. [D-homoglutamic acid, 4α-sulfate],    VII. [D-homoglutamic acid, 4β-sulfonic acid],    VIII. [D-homoglutamic acid, 413-sulfate],    IX. [D-homoglutamic acid, 5α-sulfate],    X. [D-homoglutamic acid, 5α-sulfate],    XI. [D-homoglutamic acid, 51-sulfonic acid],    XII. [D-homoglutamic acid, 5β-sulfate],    XIII. [L-homoglutamine, N-sulfonic acid],    XIV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XVI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XVII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XVIII. [D-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXII. [D-homoglutamine, 3α-sulfonic acid],    XXIII. [D-homoglutamine, 3α-sulfate],    XXIV. [D-homoglutamine, 3β-sulfonic acid],    XXV. [D-homoglutamine, 3β-sulfate],    XXVI. [D-homoglutamine, 4α-sulfonic acid],    XXVII. [D-homoglutamine, 4α-sulfate],    XVIII. [D-homoglutamine, 413-sulfonic acid],    XXIX. [D-homoglutamine, 4β-sulfate],    XXX. [D-homoglutamine, 5α-sulfonic acid],    XXXI. [D-homoglutamine, 5α-sulfate],    XXXII. [D-homoglutamine, 50-sulfonic acid] and    XXIII. [D-homoglutamine, 5β-sulfate].    
     
     
         13 . A method as claimed in  claim 3 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 3 R 4 —CR 1 R 2 -COOH wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 SO   3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 SO   3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R=R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    XXVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined.    
     
     
         14 . A method as claimed in  claim 4 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH, wherein: Z=OH or NH 2 , R 1 , to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =&=H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =&=H, R 1 =NHSO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO   3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =F4=R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R=R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XXXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XXXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XXXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined.    
     
     
         15 . A method as claimed in  claim 5 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH, wherein: Z=OH or NH 2 , R 1 , to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 I. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    II. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =—CH 2 SO   3 H is the same meaning as is before defined;    III. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    IV. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    V. A compound as claimed in  claim 1 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    VI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    VII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    VIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    IX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    X. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 5 =R(=R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XIV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XV. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XVI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XIX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    XX. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    XXI. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    XXII. A compound as claimed in  claim 1 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R=R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 SO   3 H is the same meaning as is before defined;    XXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    XXVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R=R 4 R 5 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XXX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    XXXI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XXXII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R=R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XXIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R=R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XXIV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XXXV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R=R 8 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    XL. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    XLI. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    XLII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    XLIII. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    
     
     
         16 . A method as claimed in  claim 10 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [L-Aspartic acid, N-Sulfonic acid],    II. [2α,3-dicarboxy, propane-1-sulfonic acid],    III. [2α,3-dicarboxy, propane-1-sulfate],    IV. [1α,2-carboxy ethane sulfonic acid],    V. [1α,2-carboxy ethane sulfate],    VI. [D-aspartic acid, N-sulfonic acid],    VII. [2β,3-carboxy,propane-1-sulfonic acid],    VIII. [2β,3-carboxy,apropane-1-sulfate],    IX. [1β,2-carboxy ethane-1-sulfonic acid],    X. [1β,2-carboxy ethane-1-sulfate],    XI. [D-aspartic acid, 3α-sulfonic acid],    XII. [D-aspartic acid, 3α-sulfate],    XIII. [D-aspartic acid, 3β-sulfonic acid],    XIV. [D-aspartic acid, 3β-sulfate],    XV. [L-asparagine,N-sulfonic acid],    XVI. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX. [1α-carboxy, 2-carboxamido, ethane sulfate],    XX. [L-asparagine, 3α-sulfonic acid],    XXI. [L-asparagine, 3α-sulfate],    XXII. [L-asparagine, 3β-sulfonic acid],    XXIII. [L-asparagine, 3β-sulfate,    XXIV. [D-asparagine, N-sulfonic acid],    XXV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII. [lP-carboxy, 2-carboxamido, ethane sulfonic acid],    XVIII. [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX. [D-asparagine, 3α-sulfonic acid],    XXX. [D-asparagine, 3α-sulfate],    XXXI. [D-asparagine, 3β-sulfonic acid],    XXXII. [D-asparagine, 3β-sulfate],    XXIII. [L-glutamic acid, N-sulfonic acid],    XXIV. [2α,4-dicarboxy, butane-1-sulfonic acid],    XXV. [2α,4-dicarboxy, butane-1-sulfate],    XXVI. [1α,3-dicarboxy, propane sulfonic acid],    XVII. [1α,3-dicarboxy, propane sulfate],    VIII. [1β,3-dicarboxy, propane sulfate],    XXIX. [1 β,3-dicarboxy, propane sulfonic acid],    
     
     
         17 . A method as claimed in  claim 11 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [D-glutamic acid, N-sulfonic acid],    II. [2β,4-dicarboxy, butane-1-sulfonic acid],    III. [2β,4-dicarboxy, butane-1-sulfate],    IV. [D-glutamic acid, 3α-sulfonic acid],    V. [D-glutamic acid, 3α-sulfate],    VI. [D-glutamic acid, 3β-sulfonic acid],    VII. [D-glutamic acid, 3β-sulfate],    VIII. [D-glutamic acid, 4α-sulfonic acid],    IX. [D-glutamic acid, 4α-sulfate],    X. [D-glutamic acid, 4β-sulfonic acid],    XI. [D-glutamic acid, 3β-sulfate],    XII. [L-glutamine, N-sulfonic acid],    XIII. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII. [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX. [D-glutamine, N-sulfonic acid],    XX. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [D-glutamine, 3α-sulfonic acid],    XXIII. [D-glutamine, 3α-sulfate],    XXIV. [D-glutamine, 3β-sulfonic acid],    XXV. [D-glutamine, 3β-sulfate],    XXVI. [D-glutamine, 4α-sulfonic acid],    XXVII. [D-glutamine, 4α-sulfate],    XXVIII. [D-glutamine, 4β-sulfonic acid],    XXIX. [D-glutamine, 413-sulfate],    XXX. [L-homoglutamic acid, N-sulfonic acid],    XXXI. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII. [Pentane-2α,5-dicarboxy-1-sulfate],    XXXIII. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XXXIV. [Butane-1α,4-dicarboxy-1-sulfate],    XXXV. [D-homoglutamic acid, N-sulfonic acid],    XXXVI. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    XXXVII. [Pentane-2β,5-dicarboxy-1-sulfate],    XXXVIII. [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXXIX. [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         18 . A method as claimed in  claim 12 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I. [D-homoglutamic acid, 3α-sulfonic acid],    II. [D-homoglutamic acid, 3α-sulfate],    III. [D-homoglutamic acid, 3β-sulfonic acid],    IV. [D-homoglutamic acid, 3β-sulfate],    V. [D-homoglutamic acid, 4α-sulfonic acid],    VI. [D-homoglutamic acid, 4α-sulfate],    VII. [D-homoglutamic acid, 40-sulfonic acid],    VIII. [D-homoglutamic acid, 4β-sulfate],    IX. [D-homoglutamic acid, 5α-sulfate],    X. [D-homoglutamic acid, 5α-sulfate],    XI. [D-homoglutamic acid, 5β-sulfonic acid],    XII. [D-homoglutamic acid, 50-sulfate],    XIII. [L-homoglutamine, N-sulfonic acid],    XIV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XV. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XVI. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XVII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XVIII. [D-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Butane-I p -carboxy, 4-carboxamido-1-sulfonic acid],    XXI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXII. [D-homoglutamine, 3α-sulfonic acid],    XXIII. [D-homoglutamine, 3α-sulfate],    XXIV. [D-homoglutamine, 3β-sulfonic acid],    XXV. [D-homoglutamine, 31-sulfate],    XXVI. [D-homoglutamine, 4α-sulfonic acid],    XXVII. [D-homoglutamine, 4α-sulfate],    XVIII. [D-homoglutamine, 4β-sulfonic acid],    XXIX. [D-homoglutamine, 413-sulfate],    XXX. [D-homoglutamine, 5α-sulfonic acid],    XXXI. [D-homoglutamine, 5α-sulfate],    XXXII. [D-homoglutamine, 51-sulfonic acid] and    XXIII. [D-homoglutamine, 5β-sulfate].    
     
     
         19 . A method as claimed in  claim 16 , wherein said compound is selected from the group consisting of aspartic acid, asparagine and corresponding de-amino analogs: 
 I. [L-Aspartic acid, N-Sulfonic acid],    II. [2α,3-dicarboxy, propane-1-sulfonic acid],    III. [2α,3-dicarboxy, propane-1-sulfate],    IV. [1α,2-carboxy ethane sulfonic acid],    V. [1α,2-carboxy ethane sulfate],    VI. [D-aspartic acid, N-sulfonic acid],    VII. [2β,3-carboxy,propane-1-sulfonic acid],    VIII. [2β,3-carboxy,propane-1-sulfate],    LX. [1β,2-carboxy ethane-1-sulfonic acid],    X. [1β,2-carboxy ethane-1-sulfate],    XI. [D-aspartic acid, 3α-sulfonic acid],    XII. [D-aspartic acid, 3α-sulfate],    XIII. [D-aspartic acid, 3β-sulfonic acid],    XIV. [D-aspartic acid, 3β-sulfate],    XV. [L-asparagine,N-sulfonic acid],    XVI. [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII. [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII. [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX. [1α-carboxy, 2-carboxamido, ethane sulfate],    XX. [L-asparagine, 3α-sulfonic acid],    XXI. [L-asparagine, 3α-sulfate],    XXII. [L-asparagine, 3β-sulfonic acid],    XXIII. [L-asparagine, 3β-sulfate,    XXIV. [D-asparagine, N-sulfonic acid],    XXV. [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII. [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XVIII. [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX. [D-asparagine, 3α-sulfonic acid],    XXX. [D-asparagine, 3α-sulfate],    XXXI. [D-asparagine, 3β-sulfonic acid],    XXXII. [D-asparagine, 3β-sulfate],    
     
     
         20 . A method as claimed in  claim 17 , wherein said compound is selected from the group consisting of glutamic acid, glutamine and corresponding de-amino analogs: 
 I. [L-glutamic acid, N-sulfonic acid],    II. [2α,4-dicarboxy, butane-1-sulfonic acid],    III. [2α,4-dicarboxy, butane-1-sulfate],    IV. [1α,3-dicarboxy, propane sulfonic acid],    V. [1α,3-dicarboxy, propane sulfate],    VI. [1β,3-dicarboxy, propane sulfate],    VII. [1β,3-dicarboxy, propane sulfonic acid],    VIII. [D-glutamic acid, N-sulfonic acid],    IX. [2β,4-dicarboxy, butane-1-sulfonic acid],    X. [2β,4-dicarboxy, butane-1-sulfate],    XI. [D-glutamic acid, 3α-sulfonic acid],    XII. [D-glutamic acid, 3α-sulfate],    XIII. [D-glutamic acid, 3β-sulfonic acid],    XIV. [D-glutamic acid, 3β-sulfate],    XV. [D-glutamic acid, 4α-sulfonic acid],    XVI. [D-glutamic acid, 4α-sulfate],    XVII. [D-glutamic acid, 41-sulfonic acid],    XVIII. [D-glutamic acid, 3β-sulfate],    XIX. [L-glutamine, N-sulfonic acid],    XX. [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI. [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XXII. [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXIII. [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XXIV. [1βP-carboxy, 3-carboxamido, propane-1-sulfate],    XXV. [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI. [D-glutamine, N-sulfonic acid],    XXVII. [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XVIII. [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXIX. [D-glutamine, 3α-sulfonic acid],    XXX. [D-glutamine, 3α-sulfate],    XXXI. [D-glutamine, 31-sulfonic acid],    XXXII. [D-glutamine, 3β-sulfate],    XXXIII. [D-glutamine, 4α-sulfonic acid],    XXXIV. [D-glutamine, 4α-sulfate],    XXXV. [D-glutamine, 4β-sulfonic acid],    XXXVI. [D-glutamine, 4β-sulfate],    XXXVII. [L-homoglutamic acid, N-sulfonic acid],    XXXVIII. [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXIX. [Pentane-2α,5-dicarboxy-1-sulfate],    XL. [Butane-1α,4-dicarboxy-1-sulfonic acid],    XLI. [Butane-1α,4-dicarboxy-1-sulfate],    
     
     
         21 . A method as claimed in  claim 18 , wherein said compound is selected from the group consisting of homoglutamic acid, homoglutamine and corresponding de-amino analogs: 
 I. [D-homoglutamic acid, N-sulfonic acid],    II. [Pentane-2β,5-dicarboxy-1-sulfonic acid],    III. [Pentane-2β,5-dicarboxy-1-sulfate],    IV. [Butane-1β,4-dicarboxy-1-sulfonic acid],    V. [Butane-1β,4-dicarboxy-1-sulfate],    VI. [D-homoglutamic acid, 3α-sulfonic acid],    VII. [D-homoglutamic acid, 3α-sulfate],    VIII. [D-homoglutamic acid, 3β-sulfonic acid],    IX. [D-homoglutamic acid, 3β-sulfate],    X. [D-homoglutamic acid, 4α-sulfonic acid],    XI. [D-homoglutamic acid, 4α-sulfate],    XII. [D-homoglutamic acid, 4β-sulfonic acid],    XIII. [D-homoglutamic acid, 4β-sulfate],    XIV. [D-homoglutamic acid, 5α-sulfate],    XV. [D-homoglutamic acid, 5α-sulfate],    XVI. [D-homoglutamic acid, 513-sulfonic acid],    XVII. [D-homoglutamic acid, 5β-sulfate],    XVIII. [L-homoglutamine, N-sulfonic acid],    XIX. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XX. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XXI. [Butane-i 1α-carboxy, 4-carboxamido-1-sulfonic acid],    XXII. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XXIII. [D-homoglutamine, N-sulfonic acid],    XXIV. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XXV. [Butane-i p -carboxy, 4-carboxamido-1-sulfonic acid],    XXVI. [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXVII. [D-homoglutamine, 3α-sulfonic acid],    XVIII. [D-homoglutamine, 3α-sulfate],    XXIX. [D-homoglutamine, 3β-sulfonic acid],    XXX. [D-homoglutamine, 3β-sulfate],    XXXI. [D-homoglutamine, 4α-sulfonic acid],    XXXII. [D-homoglutamine, 4α-sulfate],    XXIII. [D-homoglutamine, 4β-sulfonic acid],    XXIV. [D-homoglutamine, 4β-sulfate],    XXXV. [D-homoglutamine, 5α-sulfonic acid],    XXVI. [D-homoglutamine, 5α-sulfate],    XXVII. [D-homoglutamine, 513-sulfonic acid] and    XVIII. [D-homoglutamine, 5β-sulfate].    
     
     
         22 . Use of a composition comprising general formula Z-OC (C R n1 R n2 )—CO-Z wherein Z=OH or NH 2  and n1=n2=1 to 8 together with an additive, excipient, diluents or carrier for modulation of immune response by differentiation of dendritic cells, by administration a pharmaceutical acceptable amount to a subject need thereof.  
     
     
         23 . Use of the composition as claimed in  claim 22 , wherein said compound useful in vaccine formulation to prevent more efficient and faster presentation of antigens to T-cells thereby initiate primary protective Th1 immune response and help in the clearance of the pathogen.  
     
     
         24 . Use of the composition as claimed in  claim 22 , wherein said compound having a structure as herein and bearing general formula ZOC—CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         25 . Use of the composition as claimed in  claim 22 , wherein said compound having a structure as herein and bearing general formula ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         26 . Use of the composition as claimed in  claim 22 , wherein said compound having structure as herein and bearing general formula ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1  to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H  
       
         
           
           
               
               
           
         
       
     
     
         27 . Use of the composition as claimed in  claim 22 , wherein said compound in non-toxic to monocytes.  
     
     
         28 . Use of the composition as claimed in  claim 22 , wherein said compound in non-toxic to macrophages.  
     
     
         29 . Use of the composition as claimed in  claim 22 , wherein additives are different divalent metal cations such as Mg, Ca and Zn.  
     
     
         30 . Use of the composition as claimed in  claim 22 , wherein additives are amino acid/dicarboxylic acid derivatives and their pharmaceutically acceptable selected alkali/alkaline earth metal salts.  
     
     
         31 . Use of the composition as claimed in  claim 22 , wherein the compound is selected from the group consisting of: 
 I [L-Aspartic acid, N-Sulfonic acid],    II [2α,3-dicarboxy, propane-1-sulfonic acid],    III [2α,3-dicarboxy, propane-1-sulfate],    IV [1α,2-carboxy ethane sulfonic acid],    V [1α,2-carboxy ethane sulfate],    VI [D-aspartic acid, N-sulfonic acid],    VII [2β,3-carboxy,propane-1-sulfonic acid],    VIII [2β,3-carboxy,propane-1-sulfate],    IX [1β,2-carboxy ethane-1-sulfonic acid],    X [1β,2-carboxy ethane-1-sulfate],    XI [D-aspartic acid, 3α-sulfonic acid],    XII [D-aspartic acid, 3α-sulfate],    XIII [D-aspartic acid, 3β-sulfonic acid],    XIV [D-aspartic acid, 3β-sulfate],    XV [L-asparagine,N-sulfonic acid],    XVI [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX [1α-carboxy, 2-carboxamido, ethane sulfate],    XX [L-asparagine, 3α-sulfonic acid],    XXI [L-asparagine, 3α-sulfate],    XXII [L-asparagine, 3β-sulfonic acid],    XXIII [L-asparagine, 3β-sulfate,    XXIV [D-asparagine, N-sulfonic acid],    XXV [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX [D-asparagine, 3α-sulfonic acid],    XXX [D-asparagine, 3α-sulfate],    XXXI [D-asparagine, 3β-sulfonic acid],    XXXII [D-asparagine, 3β-sulfate],    XXXIII [L-glutamic acid, N-sulfonic acid],    XXXIV [2α,4-dicarboxy, butane-1-sulfonic acid],    XXXV [2α,4-dicarboxy, butane-1-sulfate],    XXXVI [1α,3-dicarboxy, propane sulfonic acid],    XXXVII [1α,3-dicarboxy, propane sulfate],    XXXVIII [1β,3-dicarboxy, propane sulfate],    XXXIX [1β,3-dicarboxy, propane sulfonic acid],    
     
     
         32 . Use of the composition as claimed in  claim 22 , wherein the compound is selected from the group consisting of: 
 I [D-glutamic acid, N-sulfonic acid],    II 213, 4-dicarboxy, butane-1-sulfonic acid],    III [2β,4-dicarboxy, butane-1-sulfate],    IV [D-glutamic acid, 3α-sulfonic acid],    V [D-glutamic acid, 3α-sulfate],    VI [D-glutamic acid, 3β-sulfonic acid],    VII [D-glutamic acid, 3β-sulfate],    VIII [D-glutamic acid, 4α-sulfonic acid],    IX [D-glutamic acid, 4α-sulfate],    X [D-glutamic acid, 4β-sulfonic acid],    XI [D-glutamic acid, 3β-sulfate],    XII [L-glutamine, N-sulfonic acid],    XIII [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX [D-glutamine, N-sulfonic acid],    XX [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII [D-glutamine, 3α-sulfonic acid],    XXIII [D-glutamine, 3α-sulfate],    XXIV [D-glutamine, 30-sulfonic acid],    XXV [D-glutamine, 30-sulfate],    XXVI [D-glutamine, 4α-sulfonic acid],    XXVII [D-glutamine, 4α-sulfate],    XXVIII [D-glutamine, 40-sulfonic acid],    XXIX [D-glutamine, 4β-sulfate],    XXX [L-homoglutamic acid, N-sulfonic acid],    XXXI [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII [Pentane-2α,5-dicarboxy-1-sulfate],    XXXIII [Butane-1α,4-dicarboxy-1-sulfonic acid],    XXXIV [Butane-1α,4-dicarboxy-1-sulfate],    XXXV [D-homoglutamic acid, N-sulfonic acid],    XXXVI [Pentane-2β,5-dicarboxy-1-sulfonic acid],    XXXVII [Pentane-2β,5-dicarboxy-1-sulfate], 3(WXVIII [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXIX [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         33 . Use of the composition as claimed in  claim 22 , wherein the compound is selected from the group consisting of XXIV. [D-homoglutamic acid, 3α-sulfonic acid], 
 XXXV. [D-homoglutamic acid, 3α-sulfate],    XXVI. [D-homoglutamic acid, 30-sulfonic acid],    XVII. [D-homoglutamic acid, 3β-sulfate],    XVIII. [D-homoglutamic acid, 4α-sulfonic acid],    XXIX. [D-homoglutamic acid, 4α-sulfate],    XL. [D-homoglutamic acid, 40-sulfonic acid],    XLI. [D-homoglutamic acid, 4β-sulfate],    XLII. [D-homoglutamic acid, 5α-sulfate],    XLIII. [D-homoglutamic acid, 5α-sulfate],    XLIV. [D-homoglutamic acid, 5β-sulfonic acid],    XLV. [D-homoglutamic acid, 50-sulfate],    XLVI. [L-homoglutamine, N-sulfonic acid],    XLVII. [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XLVIII. [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XLIX. [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    L. [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    LI. [D-homoglutamine, N-sulfonic acid],    LII. [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    LIII. [Butane-i , -carboxy, 4-carboxamido-1-sulfonic acid],    LIV. [Butane-i 1-carboxy, 4-carboxamido-1-sulfate],    LV. [D-homoglutamine, 3α-sulfonic acid],    LVI. [D-homoglutamine, 3α-sulfate],    LVII. [D-homoglutamine, 3β-sulfonic acid],    LVIII. [D-homoglutamine, 3β-sulfate],    LIX. [D-homoglutamine, 4α-sulfonic acid],    LX. [D-homoglutamine, 4α-sulfate],    LXI. [D-homoglutamine, 4β-sulfonic acid],    LXII. [D-homoglutamine, 4β-sulfate],    LXIII. [D-homoglutamine, 5α-sulfonic acid],    LXIV. [D-homoglutamine, 5α-sulfate],    LXV. [D-homoglutamine, 5β-sulfonic acid] and    LXVI. [D-homoglutamine, 5-sulfate].    
     
     
         34 . Use of the composition as claimed in  claim 22 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 3 R 4 —CR 1 R 2 —COOH wherein: Z=OH or NH 2 , R 1 , to R 4  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H XXIII. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined; 
 XXIV. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 SO   3 H is the same meaning as is before defined;    XXXV. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XXVI. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    XVII. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XVIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XL. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XLI. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    XLII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    XLIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XLIV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    XLV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    XLVI. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    XLVII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    LVIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 SO   3 H is the same meaning as is before defined;    XLIX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    L. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =SO 3 H is the same meaning as is before defined;    LI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =H, R 1 =OSO 3 H is the same meaning as is before defined;    LII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    LIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    LIV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    LV. A compound as claimed in  claim 1 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    LVI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    LVII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    LVIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    LIX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =SO 3 H is the same meaning as is before defined;    LX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =H, R 2 =OSO 3 H is the same meaning as is before defined;    LXI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    LXII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    LXIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    LXIV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined.    
     
     
         35 . Use of the composition as claimed in  claim 22 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH, wherein: Z=OH or NH 2 , R 1 , to R 6  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H XVII. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =NHSO 3 H is the same meaning as is before defined; 
 XVIII. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    XXIX. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XL. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    XLI. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XLII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the sane meaning as is before defined;    XLIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    XLIV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    XLV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    XLVI. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    XLVII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    LVIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    XLIX. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    L. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    LI. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    LII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    LIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    LIV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    LV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    LVI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 SO   3 H is the same meaning as is before defined;    LVII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    LVIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =SO 3 H is the same meaning as is before defined;    LIX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =H, R 1 =OSO 3 H is the same meaning as is before defined;    LX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =OSO 3 H is the same meaning as is before defined;    LXI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =SO 3 H is the same meaning as is before defined;    LXII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    LXIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    LXIV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    LXV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    LXVI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R=R 4 =R 5 =R 6 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    LXVII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    LXVIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    LXIX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    LXX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R=R 4 =R 3 =&=H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    LXXI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    LXXII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined.    
     
     
         36 . Use of the composition as claimed in  claim 22 , wherein novel sulfonic acid/sulfate derivatives of the formulae ZOC—CR 7 R 8 —CR 5 R 6 —CR 3 R 4 —CR 1 R 2 —COOH, wherein: Z=OH or NH 2 , R 1 , to R 8  denotes H, NH 2 , SO 3 H, or OSO 3 H, CH 2 —SO 3 H, CH 2 —OSO 3 H, NHSO 3 H 
 XLIV. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    XLV. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =—CH 2 SO   3 H is the same meaning as is before defined;    XLVI. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    XLVII. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    LVIII. A compound as claimed in  claim 22 , wherein Z=OH, R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    XLIX. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    L. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    LI. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 OSO 3 H is the same meaning as is before defined;    LII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    LIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    LIV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 5 =Z6=R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    LV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    LVI. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    LVII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    LVIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    LIX. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    LX. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    LXI. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    LXII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    LXIII. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    LXIV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    LXV. A compound as claimed in  claim 22 , wherein Z=OH, R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    LXVI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =NHSO 3 H is the same meaning as is before defined;    LXVII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 SO 3 H is the same meaning as is before defined;    LXVIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =CH 2 OSO 3 H is the same meaning as is before defined;    LXIX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =SO 3 H is the same meaning as is before defined;    LXX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 2 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 1 =OSO 3 H is the same meaning as is before defined;    LXXI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NHSO 3 H is the same meaning as is before defined;    LXXII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =CH 2 SO 3 H is the same meaning as is before defined;    LXXIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =SO 3 H is the same meaning as is before defined;    LXXIV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =OSO 3 H is the same meaning as is before defined;    LXXV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =SO 3 H is the same meaning as is before defined;    LXXVI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 5 =F 6 =R 7 =R 8 =H, R 2 =NH 2 , R 3 =OSO 3 H is the same meaning as is before defined;    LXXVII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =SO 3 H is the same meaning as is before defined;    LXXVIII. A compound as claimed in  claim 22 , wherein Z—NH 2 , R 1 =R 3 =R 5 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 4 =OSO 3 H is the same meaning as is before defined;    LXXIX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =SO 3 H is the same meaning as is before defined;    LXXX. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 7 =R 8 =H, R 2 =NH 2 , R 5 =OSO 3 H is the same meaning as is before defined;    LXXXI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =SO 3 H is the same meaning as is before defined;    IOLXXXII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 8 =H, R 2 =NH 2 , R 6 =OSO 3 H is the same meaning as is before defined;    LXXXIII. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R=H, R 2 =NH 2 , R 7 =SO 3 H is the same meaning as is before defined;    I LXXXIV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 4 =R 3 =R 6 =R 5 =R 8 =H, R 2 =NH 2 , R 7 =OSO 3 H is the same meaning as is before defined;    LXXXV. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =SO 3 H is the same meaning as is before defined;    LXXXVI. A compound as claimed in  claim 22 , wherein Z=NH 2 , R 1 =R 3 =R 5 =R 4 =R 7 =R 6 =H, R 2 =NH 2 , R 8 =OSO 3 H is the same meaning as is before defined;    
     
     
         37 . Use of the composition as claimed in  claim 22 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I [L-Aspartic acid, N-Sulfonic acid],    II [2α,3-dicarboxy, propane-1-sulfonic acid],    III [2α,3-dicarboxy, propane-1-sulfate],    IV [1α,2-carboxy ethane sulfonic acid],    V [1α,2-carboxy ethane sulfate],    VI [D-aspartic acid, N-sulfonic acid],    VII [2β,3-carboxy,propane-1-sulfonic acid],    VIII [2β,3-carboxy,propane-1-sulfate],    IX [1β,2-carboxy ethane-1-sulfonic acid],    X [1β,2-carboxy ethane-1-sulfate],    XI [D-aspartic acid, 3α-sulfonic acid],    XII [D-aspartic acid, 3α-sulfate],    XIII [D-aspartic acid, 3β-sulfonic acid],    XIV [D-aspartic acid, 3β-sulfate],    XV [L-asparagine, N-sulfonic acid],    XVI [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX [1α-carboxy, 2-carboxamido, ethane sulfate],    XX [L-asparagine, 3α-sulfonic acid],    XXI [L-asparagine, 3α-sulfate],    XXII [L-asparagine, 3β-sulfonic acid],    XXIII [L-asparagine, 3β-sulfate,    XXIV [D-asparagine, N-sulfonic acid],    XXV [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII [1β-carboxy, 2-carboxamido, ethane sulfate],    XXIX [D-asparagine, 3α-sulfonic acid],    XXX [D-asparagine, 3α-sulfate],    XXXI [D-asparagine, 3β-sulfonic acid],    XXXII [D-asparagine, 30-sulfate],    XXXIII [L-glutamic acid, N-sulfonic acid],    XXXIV [2α,4-dicarboxy, butane-1-sulfonic acid],    XXXV [2α,4-dicarboxy, butane-1-sulfate],    XXXVI [1α,3-dicarboxy, propane sulfonic acid],    XXVII [1α,3-dicarboxy, propane sulfate],    XVIII [1β,3-dicarboxy, propane sulfate],    XXXIX [1β,3-dicarboxy, propane sulfonic acid],    
     
     
         38 . Use of the composition as claimed in  claim 22 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I [D-glutamic acid, N-sulfonic acid],    II [2β,4-dicarboxy, butane-1-sulfonic acid],    III [2β,4-dicarboxy, butane-1-sulfate],    IV [D-glutamic acid, 3α-sulfonic acid],    V [D-glutamic acid, 3α-sulfate],    VI [D-glutamic acid, 3β-sulfonic acid],    VII [D-glutamic acid, 3β-sulfate],    VIII [D-glutamic acid, 4α-sulfonic acid],    IX [D-glutamic acid, 4α-sulfate],    X [D-glutamic acid, 4β-sulfonic acid],    XI [D-glutamic acid, 3β-sulfate],    XII [L-glutamine, N-sulfonic acid],    XIII [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XIV [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XV [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVI [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XVII [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XIX [D-glutamine, N-sulfonic acid],    XX [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXII [D-glutamine, 3α-sulfonic acid],    XXIII [D-glutamine, 3α-sulfate],    XXIV [D-glutamine, 3β-sulfonic acid],    XXV [D-glutamine, 3β-sulfate],    XXVI [D-glutamine, 4α-sulfonic acid],    XXVII [D-glutamine, 4α-sulfate],    XXVIII [D-glutamine, 4β-sulfonic acid],    XXIX [D-glutamine, 413-sulfate],    XXX [L-homoglutamic acid, N-sulfonic acid],    XXXI [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXII [Pentane-2α,5-dicarboxy-1-sulfate],    XXXIII [Butane-1α,4-dicarboxy-1-sulfonic acid],    XXXIV [Butane-1α,4-dicarboxy-1-sulfate],    XXXV [D-homoglutamic acid, N-sulfonic acid],    XXXVI [Pentane-2β,5-dicarboxy-1-sulfonic acid],    XXXVII [Pentane-2β,5-dicarboxy-1-sulfate],    XXXVIII [Butane-1β,4-dicarboxy-1-sulfonic acid],    XXXIX [Butane-1β,4-dicarboxy-1-sulfate],    
     
     
         39 . Use of the composition as claimed in  claim 22 , wherein said compound is non-toxic salts selected from the group consisting of: 
 I [D-homoglutamic acid, 3α-sulfonic acid],    II [D-homoglutamic acid, 3α-sulfate],    III [D-homoglutamic acid, 3β-sulfonic acid],    IV [D-homoglutamic acid, 3β-sulfate],    V [D-homoglutamic acid, 4α-sulfonic acid],    VI [D-homoglutamic acid, 4α-sulfate],    VII [D-homoglutamic acid, 4β-sulfonic acid],    VIII [D-homoglutamic acid, 4β-sulfate],    IX [D-homoglutamic acid, 5α-sulfate],    X [D-homoglutamic acid, 5α-sulfate],    XI [D-homoglutamic acid, 5β-sulfonic acid],    XII [D-homoglutamic acid, 5β-sulfate],    XIII [L-homoglutamine, N-sulfonic acid],    XIV [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XV [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XVI [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XVII [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XVIII [D-homoglutamine, N-sulfonic acid],    XIX [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XX [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXI [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXII [D-homoglutamine, 3α-sulfonic acid],    XXIII [D-homoglutamine, 3α-sulfate],    XXIV [D-homoglutamine, 3β-sulfonic acid],    XXV [D-homoglutamine, 3β-sulfate],    XXVI [D-homoglutamine, 4α-sulfonic acid],    XXVII [D-homoglutamine, 4α-sulfate],    XXVIII [D-homoglutamine, 413-sulfonic acid],    XXIX [D-homoglutamine, 4β-sulfate],    XXX [D-homoglutamine, 5α-sulfonic acid],    XXXI [D-homoglutamine, 5α-sulfate],    XXXII [D-homoglutamine, 50-sulfonic acid] and    XXXIII [D-homoglutamine, 5β-sulfate].    
     
     
         40 . Use of the composition as claimed in  claim 22 , wherein said compound is selected from the group consisting of aspartic acid, asparagine and corresponding de-amino analogs: 
 I [L-Aspartic acid, N-Sulfonic acid],    II [2α,3-dicarboxy, propane-1-sulfonic acid],    III [2α,3-dicarboxy, propane-1-sulfate],    IV [1α,2-carboxy ethane sulfonic acid],    V [1α,2-carboxy ethane sulfate],    VI [D-aspartic acid, N-sulfonic acid],    VII [2β,3-carboxy,propane-1-sulfonic acid],    VIII [2β,3-carboxy,propane-1-sulfate],    IX [1β,2-carboxy ethane-1-sulfonic acid],    X [1β,2-carboxy ethane-1-sulfate],    XI [D-aspartic acid, 3α-sulfonic acid],    XII [D-aspartic acid, 3α-sulfate],    XIII [D-aspartic acid, 3β-sulfonic acid],    XIV [D-aspartic acid, 30-sulfate],    XV [L-asparagine,N-sulfonic acid],    XVI [2α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XVII [2α-carboxy, 3-carboxamido, propane-1-sulfate],    XVIII [1α-carboxy, 2-carboxamido, ethane sulfonic acid],    XIX [1α-carboxy, 2-carboxamido, ethane sulfate],    XX [L-asparagine, 3α-sulfonic acid],    XXI [L-asparagine, 3α-sulfate],    XXII [L-asparagine, 3β-sulfonic acid],    XXIII [L-asparagine, 30-sulfate,    XXIV [D-asparagine, N-sulfonic acid],    XXV [2β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI [2β-carboxy, 3-carboxamido, propane-1-sulfate],    XXVII [1β-carboxy, 2-carboxamido, ethane sulfonic acid],    XXVIII [1-carboxy, 2-carboxamido, ethane sulfate],    XXLX [D-asparagine, 3α-sulfonic acid],    XXX [D-asparagine, 3α-sulfate],    XXXI [D-asparagine, 30-sulfonic acid],    XXXII [D-asparagine, 3β-sulfate], 41. Use of the composition as claimed in  claim 22 , wherein said compound is selected from the group consisting of glutamic acid, glutamine and corresponding de-amino analogs:    I [L-glutamic acid, N-sulfonic acid],    II [2α,4-dicarboxy, butane-1-sulfonic acid],    III [2α,4-dicarboxy, butane-1-sulfate],    IV [1α,3-dicarboxy, propane sulfonic acid],    V [1α,3-dicarboxy, propane sulfate],    VI [1β,3-dicarboxy, propane sulfate],    VII [1β,3-dicarboxy, propane sulfonic acid],    VIII [D-glutamic acid, N-sulfonic acid],    IX [2β,4-dicarboxy, butane-1-sulfonic acid],    X [2β,4-dicarboxy, butane-1-sulfate],    XI [D-glutamic acid, 3α-sulfonic acid],    XII [D-glutamic acid, 3α-sulfate],    XIII [D-glutamic acid, 3β-sulfonic acid],    XIV [D-glutamic acid, 313-sulfate],    XV [D-glutamic acid, 4α-sulfonic acid],    XVI [D-glutamic acid, 4α-sulfate],    XVII [D-glutamic acid, 4β-sulfonic acid],    XVIII [D-glutamic acid, 3β-sulfate],    XIX [L-glutamine, N-sulfonic acid],    XX [2α-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXI [2α-carboxy, 4-carboxamido, butane-1-sulfate],    XXII [1α-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXIII [1α-carboxy, 3-carboxamido, propane-1-sulfate],    XXIV [1β-carboxy, 3-carboxamido, propane-1-sulfate],    XXV [1β-carboxy, 3-carboxamido, propane-1-sulfonic acid],    XXVI [D-glutamine, N-sulfonic acid],    XXVII [2β-carboxy, 4-carboxamido, butane-1-sulfonic acid],    XXVIII [2β-carboxy, 4-carboxamido, butane-1-sulfate],    XXIX [D-glutamine, 3α-sulfonic acid],    XXX [D-glutamine, 3α-sulfate],    XXXI [D-glutamine, 3β-sulfonic acid],    XXXII [D-glutamine, 3β-sulfate],    XXXIII [D-glutamine, 4α-sulfonic acid],    XXXIV [D-glutamine, 4α-sulfate],    XXXV [D-glutamine, 4β-sulfonic acid],    XXXVI [D-glutamine, 4β-sulfate],    XXXVII [L-homoglutamic acid, N-sulfonic acid],    XXXVIII [Pentane-2α,5-dicarboxy-1-sulfonic acid],    XXXIX [Pentane-2α,5-dicarboxy-1-sulfate],    XL [Butane-1α,4-dicarboxy-1-sulfonic acid],    XLI [Butane-1α,4-dicarboxy-1-sulfate], 42. Use of the composition as claimed in  claim 22 , wherein said compound is selected from the group consisting of homoglutamic acid, homoglutamine and corresponding de-amino analogs:    I [D-homoglutamic acid, N-sulfonic acid],    II [Pentane-2β,5-dicarboxy-1-sulfonic acid],    III [Pentane-2β,5-dicarboxy-1-sulfate],    IV [Butane-1β,4-dicarboxy-1-sulfonic acid],    V [Butane-1β,4-dicarboxy-1-sulfate],    VI [D-homoglutamic acid, 3α-sulfonic acid],    VII [D-homoglutamic acid, 3α-sulfate],    VIII [D-homoglutamic acid, 3β-sulfonic acid],    IX [D-homoglutamic acid, 313-sulfate],    X [D-homoglutamic acid, 4α-sulfonic acid],    XI [D-homoglutamic acid, 4α-sulfate],    XII [D-homoglutamic acid, 413-sulfonic acid],    XIII [D-homoglutamic acid, 4β-sulfate],    XIV [D-homoglutamic acid, 5α-sulfate],    XV [D-homoglutamic acid, 5α-sulfate],    XVI [D-homoglutamic acid, 5β-sulfonic acid],    XVII [D-homoglutamic acid, 5β-sulfate],    XVIII [L-homoglutamine, N-sulfonic acid],    XIX [Pentane-2α-carboxy, 5-carboxamido-1-sulfonic acid],    XX [Pentane-2α-carboxy, 5-carboxamido-1-sulfate],    XXI [Butane-1α-carboxy, 4-carboxamido-1-sulfonic acid],    XXII [Butane-1α-carboxy, 4-carboxamido-1-sulfate],    XXIII [D-homoglutamine, N-sulfonic acid],    XXIV [Pentane-2β-carboxy, 5-carboxamido-1-sulfonic acid],    XXV [Butane-1β-carboxy, 4-carboxamido-1-sulfonic acid],    XXVI [Butane-1β-carboxy, 4-carboxamido-1-sulfate],    XXVII [D-homoglutamine, 3α-sulfonic acid],    XXVIII [D-homoglutamine, 3α-sulfate],    XXIX [D-homoglutamine, 3β-sulfonic acid],    XXX [D-homoglutamine, 30-sulfate],    XXXI [D-homoglutamine, 4α-sulfonic acid],    XXXII [D-homoglutamine, 4α-sulfate],    XXXIII [D-homoglutamine, 4β-sulfonic acid],    XXXIV [D-homoglutamine, 4β-sulfate],    XXXV [D-homoglutamine, 5α-sulfonic acid],    XXXVI [D-homoglutamine, 5α-sulfate],    XXVII [D-homoglutamine, 50-sulfonic acid] and    XXVIII [D-homoglutamine, 5β-sulfate].