Container for linezolid intravenous solution

Abstract

The present invention is a container for an IV aqueous solution of a Gram-positive oxazolidinone agent, such as linezolid a the compound of formula: which comprises having the container-solution contact surface material be a polyolefin.

1 . A container for an IV aqueous solution of a Gram-positive oxazolidinone agent which comprises having the container-solution contact surface material is made of at least 50% polyolefin.  
   
   
       2 . A container for an IV aqueous solution according to  claim 1  where the container is selected from the group consisting of a bag, a bottle, a vial, a large volume parenteral, a small volume parenteral, a prefilled syringe and a cassette.  
   
   
       3 . A container for an IV aqueous solution according to  claim 2  where the container is a bag, a bottle, a vial and a prefilled syringe.  
   
   
       4 . A container for an IV aqueous solution according to  claim 2  where the container is a bag.  
   
   
       5 . A container for an IV aqueous solution according to  claim 2  where the container is a bottle.  
   
   
       6 . A container for an IV aqueous solution according to  claim 2  where the container is a vial.  
   
   
       7 . A container for an IV aqueous solution according to  claim 2  where the container is a prefilled syringe.  
   
   
       8 . A container for an IV aqueous solution according to  claim 1  where the container-solution contact surface is made of polyolefin or made primarily of polyolefin.  
   
   
       9 . A container for an IV aqueous solution according to  claim 8  where the container-solution contact surface is made of from about 50 to about 100% polyolefin.  
   
   
       10 . A container for an IV aqueous solution according to  claim 9  where the container-solution contact surface is made of from about 70 to about 90% polyolefin.  
   
   
       11 . A container for an IV aqueous solution according to  claim 10  where the container-solution contact surface is made of from about 80% polyolefin.  
   
   
       12 . A container for an IV aqueous solution according to  claim 1  where the container-solution contact surface is made of polyolefin.  
   
   
       13 . A container for an IV aqueous solution according to  claim 1  where the polyolefin is selected from the group consisting of polyethylene, polypropylene, polybutenes, polyisoprenes and polypentenes and copolymers and mixtures thereof.  
   
   
       14 . A container for an IV aqueous solution according to  claim 13  where the polyolefin is selected from the group consisting of polyethylene and polypropylene.  
   
   
       15 . A container for an IV aqueous solution according to  claim 14  where the polyolefin is polypropylene.  
   
   
       16 . A container for an IV aqueous solution according to  claim 1  where the a Gram-positive oxazolidinone agent is selected from the group consisting of linezolid and eperezolid.  
   
   
       17 . A container for an IV aqueous solution according to  claim 16  where the Gram-positive oxazolidinone agent is linezolid.  
   
   
       18 . A method of preventing loss of a Gram-positive oxazolidinone agent during and following terminal sterilization with moist heat in an IV aqueous solution to be terminal sterilized with moist heat which comprises: 
 (1) placing the IV aqueous solution in a container to be sterilized where the container-solution contact surface material is made of at least 50% polyolefin and    (2) moist heat sterilizing the container-solution.    
   
   
       19 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 18  where the container is selected from the group consisting of a bag, a bottle, a vial, a large volume parenteral, a small volume parenteral, a prefilled syringe and a cassette.  
   
   
       20 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 19  where the container is a bag, a bottle, a vial and a prefilled syringe.  
   
   
       21 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 20  where the container is a bag.  
   
   
       22 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 18  where the container-solution contact surface is made of polyolefin or made primarily of polyolefin.  
   
   
       23 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 22  where the container-solution contact surface is made of from about 50 to about 100% polyolefin.  
   
   
       24 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 23  where the container-solution contact surface is made of from about 70 to about 90% polyolefin.  
   
   
       25 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 24  where the container-solution contact surface is made of from about 80% polyolefin.  
   
   
       26 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 18  where the container-solution contact surface is made of polyolefin.  
   
   
       27 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 18  where the polyolefin is selected from the group consisting of polyethylene, polypropylene, polybutenes, polyisoprenes and polypentenes and copolymers and mixtures thereof.  
   
   
       28 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 27  where the polyolefin is selected from the group consisting of polyethylene and polypropylene.  
   
   
       29 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 28  where the polyolefin is polypropylene.  
   
   
       30 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 18  where the Gram-positive oxazolidinone agent is selected from the group consisting of linezolid and eperezolid.  
   
   
       31 . A method of preventing loss of a Gram-positive oxazolidinone agent according to  claim 30  where the Gram-positive oxazolidinone agent is linezolid.