Orally administrable composition for the photoprotection of the skin

Abstract

An orally administrable composition for the photoprotection of the skin which comprises the combination of i) at least one probiotic lactic acid bacterium or a culture supernatant thereof, and ii) at least one carotenoid or derivative, included into an orally acceptable carrier.

1 . An orally administrable composition for the photoprotection of the skin comprising a photoprotecting effective amount of at least one probiotic lactic acid bacterium or a culture supernatant thereof, and at least one carotenoid or derivative, included in an orally acceptable carrier.  
     
     
         2 . A composition according to  claim 1 , wherein the lactic acid bacterium is selected from the group consisting of Lactobacilli and Bifidobacteria.  
     
     
         3 . A composition according to  claim 1 , wherein the lactic acid bacterium is selected from the group consisting of  Lactobacillus johnsonii, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei  or  Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium animalis, Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum , and mixtures thereof.  
     
     
         4 . A composition according to  claim 1 , wherein the lactic acid bacterium is selected from the group consisting of CNCM I-1225, CNCM I-2116, CNCM I-2168 and CNCM I-2170.  
     
     
         5 . A composition according to  claim 1 , wherein the probiotic lactic acid bacterium is included in the carrier in a form selected from the group consisting of live form, semi-active and deactivated form.  
     
     
         6 . A composition according to  claim 1 , wherein the carotenoid is selected from the group consisting of a cartenoid with and without provitamin A activity.  
     
     
         7 . A composition according to  claim 1 , wherein the carrier is a food.  
     
     
         8 . A composition according to  claim 7 , wherein the food is selected from the group consisting of milk, yoghurt, curd, cheese, fermented milks, milk based fermented products, ice-creams, fermented cereal based products, milk based powders, and infant formula.  
     
     
         9 . A composition according to  claim 8 , wherein the food may be in a drinkable solution.  
     
     
         10 . A composition according to  claim 1 , which further comprises a component selected from the group consisting of a yeast extract and a bioactive molecule.  
     
     
         11 . A method for producing an orally administrable composition for the protection of the skin comprising the steps of using a photoprotecting effective amount of at least one probiotic lactic acid bacterium or a culture supernatant thereof and at least one carotenoid, included in an orally acceptable carrier, for preparing the composition.  
     
     
         12 . The method according to  claim 11 , wherein the lactic acid bacterium is selected from the group consisting of  Lactobacillus johnsonii, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei  or  Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium animalis, Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum , and mixtures thereof.  
     
     
         13 . The method according to  claim 11 , wherein the lactic acid bacterium is selected from the group consisting of CNCM I-1225, CNCM I-2116, CNCM I-2168, CNCM I-2170 and ATCC 27536.  
     
     
         14 . The method according to  claim 11 , wherein the probiotic lactic acid bacterium is present in the carrier in an amount of from about 10 5  to 10 12  cfu/g of the carrier.  
     
     
         15 . The method according to  claim 11 , wherein the carotenoid is present in the carrier in an amount of from 10% to 20% by weight.  
     
     
         16 . A method for improving the photoprotective function of the skin, which comprises the step of orally administering to an individual a therapeutically-effective amount of a composition comprising the combination of at least one probiotic lactic acid bacteria or a culture supernatant thereof, and at least one carotenoid or derivative, in an orally acceptable carrier.  
     
     
         17 . A method according to  claim 16 , wherein the composition is selected from the group consisting of Lactobacilli and Bifidobacteria.  
     
     
         18 . A method according to  claim 16 , wherein the lactic acid bacterium is selected from the group consisting of  Lactobacillus johnsonii, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei  or  Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium animalis, Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum , and mixtures thereof.  
     
     
         19 . A method according to  claim 16 , wherein the lactic acid bacterium is selected from the group consisting of CNCM I-1225, CNCM I-2116, CNCM I-2168 and CNCM I-2170.  
     
     
         20 . A method according to  claim 16 , wherein the probiotic lactic acid bacterium is included into the carrier in a form selected from the group consisting of live form, semi-active and deactivated form.  
     
     
         21 . A method according to  claim 16 , wherein the carotenoid is selected from the group consisting of a cartenoid with and without provitamin A activity.  
     
     
         22 . A method according to  claim 16 , wherein the carrier is a food.  
     
     
         23 . A method according to  claim 16 , wherein the food is selected from the group consisting of milk, yoghurt, curd, cheese, fermented milks, milk based fermented products, ice-creams, fermented cereal based products, milk based powders, and infant formula.  
     
     
         24 . A method according to  claim 16 , wherein the food may be in a drinkable solution.  
     
     
         25 . A composition according to  claim 1 , wherein the probiotic lactic acid bacterium is included into the carrier in a lyophilized powder attention.  
     
     
         26 . A composition according to  claim 1 , wherein the carotenoid is selected from the group consisting of β-carotene, γ-carotene, α-carotene, lycopene, zeaxanthine and luteine, or mixtures thereof.  
     
     
         27 . A composition according to  claim 1 , wherein the carrier is a pharmaceutical product.  
     
     
         28 . A composition according to  claim 7 , wherein the pharmaceuticals carrier is selected from the group consisting of tablets, liquid suspensions, dried oral supplement, wet oral supplement, and dry-tube-feeding.  
     
     
         29 . A composition according to  claim 1 , wherein the carrier is a nutritional supplement for oral administration.  
     
     
         30 . A composition according to  claim 29 , wherein the nutritional supplement for oral administration is in a form selected from the group consisting of capsules, soft capsules, tablets, pastes or pastilles, gums, drinkable solutions, and emulsions.