US2005059625A1PendingUtilityA1

Immunostimulatory nucleic acid molecules

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Assignee: UNIV IOWA RES FOUNDPriority: Jul 15, 1994Filed: Jul 2, 2004Published: Mar 17, 2005
Est. expiryJul 15, 2014(expired)· nominal 20-yr term from priority
Inventors:Arthur M. KriegJoel KlineDennis KlinmanAlfred Steinberg
A61P 37/02A61P 31/04A61P 37/06A61P 37/04A61P 35/00A61P 43/00A61P 31/12A61P 33/00A61P 31/10A61P 31/00A61P 7/00A61P 37/08A61P 19/02A61P 17/00A61P 1/16A61P 1/04A61P 1/00A61P 17/06A61P 1/02A61P 11/06C12N 2310/315C12N 15/117A61K 31/7125A61K 2039/55561A61K 31/7048A61K 39/39C07H 21/00C12Q 1/68C12N 2310/17A61K 31/00A61K 31/4706A61K 31/711A61K 39/00Y02A50/30
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Claims

Abstract

Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

Claims

exact text as granted — not AI-modified
1 - 18 . (Cancelled)  
     
     
         19 . A method for blocking apoptosis in a murine or human cell comprising contacting the murine or human cell with an immunostimulatory oligonucleotide.  
     
     
         20 . The method of  claim 19 , wherein the immunostimulatory oligonucleotide is a CpG oligonucleotide.

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