Devices and methods for percutaneously treating aortic valve stenosis

Abstract

Devices and methods for their use in percutaneously increasing the aortic valve flow of a stenotic aortic valve are provided. The subject devices include an aortic valve isolation element, a shunt element and an aortic valve flushing element. Also provided are systems and kits that include the subject devices and can be employed in practicing the subject methods. The subject devices, methods, systems and kits find use in treating conditions associated with the presence of stenotic aortic valves.

1 . A device comprising: 
 (a) a valve isolation element that includes: 
 (i) a ventricular side aortic valve occlusion element; and  
 (ii) an ascending aorta occlusion element; and  
   (b) an aortic valve flushing element.    
     
     
         2 . The device according to  claim 1 , wherein said flushing element includes: 
 (a) a fluid introducing element; and    (b) a fluid aspiration element.    
     
     
         3 . The device according to  claim 2 , wherein said fluid introducing element is in fluid communication with a source of stenotic dissolution fluid.  
     
     
         4 . The device according to  claim 4 , wherein said stenotic dissolution fluid is an acidic dissolution fluid.  
     
     
         5 . The device according to  claim 1 , wherein said ventricular side aortic valve occlusion element is a balloon.  
     
     
         6 . The device according to  claim 1 , wherein said ventricular side aortic valve occlusion element is a funnel.  
     
     
         7 . The device according to  claim 1 , wherein said device further includes shunt element that provides for blood flow through an aortic valve isolated with said valve isolation element.  
     
     
         8 . The device according to  claim 7 , wherein said shunt element further includes a valve element.  
     
     
         9 . The device according to  claim 8 , wherein said valve is positioned distal from said isolation element.  
     
     
         10 . The device according to  claim 8 , wherein said valve is positioned proximal to said isolation element.  
     
     
         11 . The device according to  claim 1 , wherein said device further includes a fluid flow diverter element.  
     
     
         12 . The device according to  claim 1 , wherein said device is configured for percutaneous delivery to a target site.  
     
     
         13 . The device according to  claim 13 , wherein said device further comprises an integrated introducer.  
     
     
         14 . The device according to  claim 1 , wherein said an ascending aorta occlusion element has an isolation bell configuration.  
     
     
         15 . A method of increasing the aortic valve area of a stenotic aortic valve, said method comprising: 
 (a) isolating said stenotic aortic valve with a valve isolation element that includes: 
 (i) a ventricular side aortic valve occlusion element; and  
 (ii) an ascending aorta occlusion element; and  
   (b) flushing said isolated stenotic aortic valve with a stenosis dissolution fluid for a period of time sufficient to increase said stenotic aortic valve's aortic valve area.    
     
     
         16 . The method according to  claim 15 , wherein said flushing comprises contacting said isolated stenotic aortic valve with said stenosis dissolution fluid and removing fluid from said isolated stenotic aortic valve.  
     
     
         17 . The method according to  claim 16 , wherein said dissolution fluid is an acidic dissolution fluid.  
     
     
         18 . The method according to  claim 15 , wherein said method further comprises contacting said isolated stenotic aortic valve with a dissolution fluid attenuating fluid.  
     
     
         19 . The method according to  claim 18 , wherein said dissolution fluid is an acidic dissolution fluid and said dissolution fluid attenuating fluid is a pH elevating fluid.  
     
     
         20 . The method according to  claim 19 , wherein said pH elevating fluid is a buffer.  
     
     
         21 - 31 . (canceled)