Atopic dermatitis treatment method

Abstract

Compositions are provided for treating atopic dermatitis, other atopic diseases and other inflammatory or allergic skin disorders. The compositions include proteins from Molluscum Contagiosum Virus (MCV), or fragments, variants, analogs, and derivatives thereof which exhibit AD inhibiting activity. Examples of MCV proteins which exhibit AD inhibiting activity include MC148P1, MC148P2, MC148P3, other MC148P type proteins, and fragments, variants, analogs, and derivatives of MC148P1, MC148P2, MC148P3, and other MC148P type proteins which possess AD inhibiting activity. The fragments, variants, analogs and derivatives may be less than 100% homologous to MCV proteins so long as they are sufficiently homologous such that AD inhibiting activity is preserved.

1 . A method, comprising: 
 administering to a patient having atopic dermatitis a composition comprising a MC148P protein which possesses atopic dermatitis inhibiting activity.    
     
     
         2 . The method according to  claim 1 , wherein the MC148P protein is selected from the group consisting of MC148P1, MC148P2, MC148P3 and fragments, variants, analogs, and derivatives of MC148P1, MC148P2, and MC148P3 which possess atopic dermatitis inhibiting activity.  
     
     
         3 . The method according to  claim 1 , wherein administering the composition includes topically applying the composition.  
     
     
         4 . The method according to  claim 1 , wherein administering the composition includes injecting the composition.  
     
     
         5 . The method according to  claim 1 , wherein administering the composition includes iontophoresis.  
     
     
         6 . The method according to  claim 1 , wherein administering the composition includes electroporation.  
     
     
         7 . The method according to  claim 1 , wherein the composition includes a dimethyl sulfoxide carrier.  
     
     
         8 . The method according to  claim 1 , wherein the composition includes an azone carrier.  
     
     
         9 . The method according to  claim 1 , wherein the composition includes a liposomal carrier.  
     
     
         10 . The method according to  claim 1 , wherein the composition is delivered locally to an area where atopic dermatitis is believed to be present.  
     
     
         11 . The method according to  claim 1  the composition is delivered to a patient with an atonic disease or allergic skin disorder  
     
     
         12 . A kit, comprising: 
 multiple separately packaged portions of a composition adapted for treating atopic dermatitis comprising a MC148P protein which possesses atopic dermatitis inhibiting activity.    
     
     
         13 . The kit according to  claim 12 , wherein the MC148P protein is selected from the group consisting of MC148P1, MC148P2, MC148P3 and fragments, variants, analogs, and derivatives of MC148P1, MC148P2, and MC148P3 which possess atopic dermatitis inhibiting activity.  
     
     
         14 . The kit according to  claim 12 , wherein the kit further includes 
 instructions teaching administration of the composition to a patient having atopic dermatitis.    
     
     
         15 . The kit according to  claim 14 , wherein the instructions teach locally delivering the composition to an area adjacent where atopic dermatitis is believed to be present.  
     
     
         16 . The kit according to  claim 14 , wherein the instructions teach topically applying the composition.  
     
     
         17 . The kit according to  claim 14 , wherein the instructions teach injecting the composition.  
     
     
         18 . The kit according to  claim 14 , wherein the instructions teach administering the composition through iontophoresis and/or electroporation.  
     
     
         19 . The kit according to  claim 12 , wherein the composition includes a dimethyl sulfoxide carrier.  
     
     
         20 . The kit according to  claim 12 , wherein the composition includes an azone carrier.  
     
     
         21 . The kit according to  claim 12 , wherein the kit is also used for the treatment of other atopic diseases and other inflammatory and or allergic skin disorders.