Combined agents for treatment of glaucoma

Abstract

A pharmaceutical composition for the prophylaxis or treatment of glaucoma which comprises an angiotensin II antagonist and timolol maleate and a method for the prophylaxis or treatment of glaucoma by administering the composition to a patient. The angiotensin II antagonist is of the following formula (I):

1 . A pharmaceutical composition for the prophylaxis or treatment of glaucoma comprising a pharmaceutically effective amount of (i) an angiotensin II antagonist of the following formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof:  
       
         
           
           
               
               
           
         
       
       wherein R 1  represents a group having the following formula (Ia):  
       
         
           
           
               
               
           
         
       
       and (ii) timolol maleate, either alone or in combination with a pharmacologically acceptable carrier.  
     
     
         2 . The pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 1 , wherein a ratio of the angiotensin II antagonist (i) to the timolol maleate (ii) is 10:1 to 100:1.  
     
     
         3 . The pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 1 , which is in a form suitable for topical administration to the eyes.  
     
     
         4 . A method for preventing or treating glaucoma comprising administering to a warm blooded animal in need thereof the pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 1 .  
     
     
         5 . A method for preventing glaucoma comprising administering to a human in need thereof the pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 1 .  
     
     
         6 . A method for preventing glaucoma comprising administering to a human in need thereof the pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 2 .  
     
     
         7 . A method for preventing glaucoma comprising administering to a human in need thereof the pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 3 .  
     
     
         8 . A method for treating glaucoma comprising administering to a human in need thereof the pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 1 .  
     
     
         9 . A method for treating glaucoma comprising administering to a human in need thereof the pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 2 .  
     
     
         10 . A method for treating glaucoma comprising administering to a human in need thereof the pharmaceutical composition for the prophylaxis or treatment of glaucoma according to  claim 3 .  
     
     
         11 . A method for preventing or treating glaucoma comprising administering to a warm blooded animal a pharmaceutically effective amount of active ingredients, the active ingredients comprising (i) an angiotensin II antagonist of the following formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof:  
       
         
           
           
               
               
           
         
       
       wherein R 1  represents a group having the following formula (Ia)  
       
         
           
           
               
               
           
         
       
       and (ii) timolol maleate, the active ingredients (i) and (ii) being administered simultaneously, separately or successively.  
     
     
         12 . The method according to  claim 11 , wherein the warm blooded animal is human.  
     
     
         13 . The method according to  claim 12 , wherein the method is for treating glaucoma.  
     
     
         14 . The method according to  claim 12 , wherein the method is for preventing glaucoma.