Novel agents for ameliorating motor disorder

Abstract

A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.

1 . A medicament for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P.  
     
     
         2 . The medicament for ameliorating dyskinesia according to  claim 1  wherein said peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P is a peptide or a series of peptides with a cytotoxicity-inhibitory activity having the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.  
     
     
         3 . The medicament for ameliorating dyskinesia according to  claim 1  or  2  wherein said peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P is a peptide or a series of peptides having the amino acid sequences of the formula (I): 
 Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Xaa Cys Cys His Cys Arg His Leu (SEQ ID NO: 1) and/or the formula (II):    Thr Gly Ser Ala Ile Thr Xaa Gln Cys Lys Glu Asn Leu Pro Ser Leu Cys Ser Xaa Gln Gly Leu Arg Ala Glu Glu Asn Ile (SEQ ID NO: 2). wherein Xaa represents selenocysteine, or said amino acid sequences with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.    
     
     
         4 . The medicament for ameliorating dyskinesia according to  claim 1  wherein said dyskinesia is one associated with neurodegenerative diseases.  
     
     
         5 . The medicament for ameliorating dyskinesia according to  claim 1  wherein said dyskinesia is one associated with aging, traumatic neuropathy, cerebrovascular disorders or immunopathy.  
     
     
         6 . A medicament for treating neurodegenerative diseases, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P.  
     
     
         7 . The medicament for treating neurodegenerative diseases according to  claim 6  wherein said neurodegenerative diseases are selected from ataxia, epilepsy, motor neuron disorder, aging, traumatic neuropathy, cerebrovascular disorders or immunopathy.