US2005036983A1PendingUtilityA1

In vivo use of water absorbent polymers

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Priority: Nov 20, 2000Filed: Sep 24, 2004Published: Feb 17, 2005
Est. expiryNov 20, 2020(expired)· nominal 20-yr term from priority
Inventors:Jaime SimonAlan D. Strickland
A61P 9/10A61P 7/10A61P 7/00A61P 39/02A61P 9/04A61P 3/00A61K 31/78A61K 47/32A61K 31/74A61P 13/12A61P 1/00A61K 31/716A61K 9/5073A61K 31/715A61K 9/1635
54
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Claims

Abstract

The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.

Claims

exact text as granted — not AI-modified
1 . A composition for removing fluid from the intestinal tract of a host comprising an enterically coated, non-systemic, non-toxic, water-absorbing polymer as the active ingredient, wherein the water-absorbing polymer absorbs at least 20 times its weight in physiological saline.  
     
     
         2 . The composition of  claim 1  wherein the polymer is capable of absorbing at least 30 times its weight in physiological saline  
     
     
         3 . The composition of  claim 2  wherein the polymer is capable of absorbing at least 40 times its weight in physiological saline.  
     
     
         4 . The composition of  claim 1  wherein the polymer is formed by polymerizing acrylate containing monomers.  
     
     
         5 . The composition of  claim 1  wherein the polymer is formed by polymerizing monomer comprising acrylic acid or salts thereof.  
     
     
         6 . The composition of  claim 1  wherein the polymer is a polysaccharide.  
     
     
         7 . The composition of  claim 1  wherein the polymer is a crosslinked polyally amine.  
     
     
         8 . The composition of  claim 1  wherein the polymer is provided in bead form.  
     
     
         9 . A method for removing fluid and waste products from the intestinal tract of a host by directly delivering multiple polymers to the intestinal tract.  
     
     
         10 . The method according to  claim 9  wherein the multiple polymers comprise at least one water absorbent polymer capable of absorbing at least 20 times its weight in physiological saline.  
     
     
         11 . The composition of  claim 10  wherein the polymer absorbs at least 30 times its weight in physiological saline.  
     
     
         12 . The composition of  claim 11  wherein the polymer absorbs at least 40 times its weight in physiological saline.  
     
     
         13 . The composition of  claim 10  wherein the water absorbent polymer is formed by polymerizing acrylate containing monomers.  
     
     
         14 . The composition of  claim 10  wherein the water absorbent polymer is formed by polymerizing monomer comprising acrylic acid or salts thereof.  
     
     
         15 . The composition of  claim 10  wherein the water absorbent polymer is a polysaccharide.  
     
     
         16 . The composition of  claim 10  wherein the water absorbent polymer is a crosslinked polyallylamine.  
     
     
         17 . The composition of  claim 10  wherein the polymer is provided in bead form.  
     
     
         18 . A method for removing fluid from the intestinal tract of a host by directly delivering a water absorbent polymer to the intestinal tract through intestinal tubes, wherein the water absorbent polymer absorbs at least 20 times its weight in physiological saline.  
     
     
         19 . The composition of  claim 18  wherein the polymer absorbs at least 30 times its weight in physiological saline.  
     
     
         20 . The composition of  claim 19  wherein the polymer absorbs at least 40 times its weight in physiological saline.  
     
     
         21 . The composition of  claim 18  wherein the polymer is formed by polymerizing acrylate containing monomers.  
     
     
         22 . The composition of  claim 18  wherein the polymer is formed by polymerizing monomer comprising acrylic acid or salts thereof.  
     
     
         23 . The composition of  claim 18  wherein the polymer is a polysaccharide.  
     
     
         24 . The composition of  claim 18  wherein the polymer is a crosslinked polyallylamine.  
     
     
         25 . The composition of  claim 18  wherein the polymer is provided in bead form.

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