Method for treating autoimmune diseases and screening method for preventive or therapeutic agent for the same

Abstract

The present invention is directed to a method for treating autoimmune diseases comprising administering RBAp48 production suppressor or inhibitor; a screening method for a preventive or therapeutic agent for autoimmune diseases comprising determining RBAp48 production suppressing effect or inhibitory effect of a sample; a diagnosis agent or a diagnosing kit for autoimmune diseases containing a reagent for measuring RBAp48 level in gland tissue; and a diagnosis method for autoimmune diseases comprising measuring RBAp48 level in gland tissue.

1 . A method for treating an autoimmune disease, comprising administering an RBAp48 production suppressor or an RBAp48 production inhibitor.  
     
     
         2 . The method according to  claim 1 , wherein the autoimmune disease is Sjögren's syndrome.  
     
     
         3 . A screening method for a preventive or therapeutic agent for an autoimmune disease, comprising determining RBAp48 production suppressing effect or RBAp48 production inhibitory effect of a sample.  
     
     
         4 . The method according to  claim 3 , wherein the autoimmune disease is Sjögren's syndrome.  
     
     
         5 . A diagnosis agent or a diagnosing kit for an autoimmune disease, containing a reagent for measuring RBAp48 level in gland tissues.  
     
     
         6 . The diagnosis agent or the diagnosing kit according to  claim 5 , wherein the autoimmune disease is Sjögren's syndrome.  
     
     
         7 . A diagnosis method for an autoimmune disease, comprising determining RBAp48 level in gland tissues.  
     
     
         8 . The method according to  claim 7 , wherein the autoimmune disease is Sjögren's syndrome.  
     
     
         9 . A screening method for an apoptosis inhibitor, comprising determining RBAp48 production suppressing effect or RBAp48 production inhibitory effect of a sample.