Effects of sporoderm-broken germination activated ganoderma spores on promotion of proliferation and/or differentiation of neural stem cells in injured spinal cord

Abstract

The present invention provides a method for promoting proliferation and/or differentiation of neural stem cells in a mammal, which comprises orally administering sporoderm-broken germination activated Ganoderma lucidum spores (GASP) to the mammal. The effects of GASP on proliferation and/or differentiation of neural stem cells are particularly prominent in mammals after a spinal cord injury.

1 . A method for promoting proliferation of neural stem cells in a mammal comprising: 
 administering an effective amount of sporoderm-broken germination activated  Ganoderma  spores (GASP) to a mammal.    
     
     
         2 . The method according to  claim 1 , wherein said promotion of proliferation of neural stem cells occur after a spinal cord injury.  
     
     
         3 . The method according to  claim 1 , wherein said GASP are orally administered to said mammal.  
     
     
         4 . The method according to  claim 1 , wherein said mammal is human.  
     
     
         5 . The method according to  claim 1 , wherein said spinal cord injury is caused by compression or severance of the spinal cord.  
     
     
         6 . The method according to  claim 1 , wherein said spinal cord injury is caused by a trauma.  
     
     
         7 . The method according to  claim 1 , wherein said spinal cord injury is caused by a disease.  
     
     
         8 . A method for promoting differentiation of neural stem cells in a mammal comprising: 
 administering an effective amount of sporoderm-broken germination activated  Ganoderma  spores (GASP) to a mammal.    
     
     
         9 . The method according to  claim 8 , wherein said neural stem cells having spinal cord injury.  
     
     
         10 . The method according to  claim 8 , wherein said promotion of differentiation of said neural stem cells occur after a spinal cord injury.  
     
     
         11 . The method according to  claim 8 , wherein said neural stem cells are differentiated into neurons.  
     
     
         12 . The method according to  claim 8 , wherein said neural stem cells are differentiated into astrocytes.  
     
     
         13 . The method according to  claim 8 , wherein said neural stem cells are differentiated into oligodendrocytes.  
     
     
         14 . The method according to  claim 8 , wherein said GASP are orally administered to said mammal.  
     
     
         15 . The method according to  claim 8 , wherein said mammal is human.  
     
     
         16 . The method according to  claim 8 , wherein said spinal cord injury is caused by compression or severance of the spinal cord.  
     
     
         17 . The method according to  claim 8 , wherein said spinal cord injury is caused by a trauma.  
     
     
         18 . The method according to  claim 8 , wherein said spinal cord injury is caused by a disease.  
     
     
         19 . A method for promoting proliferating and differentiating neural stem cells in a mammal comprising: 
 administering an effective amount of sporoderm-broken germination activated  Ganoderma  spores (GASP) to a mammal.    
     
     
         20 . The method according to  claim 19 , wherein said proliferating and differentiating of said neural stem cells occur after a spinal cord injury.