Inosine compounds and their use for treating or preventing an inflammation or reperfusion disease

Abstract

Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.

1 - 9 . (canceled)  
     
     
         10 . A method for treating a reperfusion disease, comprising administering to a patient in need thereof an effective amount of a compound of formula I:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 1  is C 2 -C 6  acyl, SO 3 H, P 2 O 6 H 3  or P 3 O 9 H 4 ; and  
 R 2 , R 3  and R 4  are independently H, C 2 -C 6  acyl, SO 3 H, PO 3 H 2 , P 2 O 6 H 3  or P 3 O 9 H 4 .  
 
     
     
         11 . The method of  claim 10 , wherein 
 R 1  is C 2 -C 6  acyl, SO 3 H, P 2 O 6 H 3 , P 3 O 9 H 4  or a pharmaceutically acceptable salt thereof; and    R 2 , R 3  and R 4  are H.    
     
     
         12 . The method of  claim 10 , wherein R 1  is —SO 3 H, or a pharmaceutically acceptable salt thereof.  
     
     
         13 . The method of  claim 10 , wherein R 1  is P 2 O 6 H 3 , or a pharmaceutically acceptable salt thereof.  
     
     
         14 . The method of  claim 10 , wherein R 1  is P 3 O 9 H 4 , or a pharmaceutically acceptable salt thereof.  
     
     
         15 . The method of  claim 10 , wherein R 1  is C 2 -C 6  acyl.  
     
     
         16 . The method of  claim 15 , wherein the C 2 -C 6  acyl is acetyl.  
     
     
         17 . The method of  claim 10 , wherein the reperfusion disease is hemorrhagic shock, septic shock, sepsis, a disease caused by solid organ transplantation, cadiopulmonary bypass surgery, compartment syndrome, crush injury, splanchnic ischemia-reperfusion, myocardial infarction and stroke.  
     
     
         18 - 75 . (canceled)  
     
     
         76 . The method of  claim 10 , wherein R 2 , R 3 , and R 4  are each hydrogen, and R 1  is —SO 3   − Na + .