Modifications of the trometamol salt of R-thioctic acid as well as a process for their production

Abstract

The invention relates to new modifications of the trometamol salt of R-thioctic acid of the formula I, processes for their production, pharmaceutical preparations containing these modifications, and their medical application.

1 . Modification A of the compound I  
       
         
           
           
               
               
           
         
       
       characterized by the X-ray diffraction pattern in which reflections not coinciding with the reflections of the other modifications are observed inter alia at 14.8°2θ(5.96 Å), 19.99°2θ(4.44 Å), 20.88°2θ(4.25 Å), 22.78°2θ(3.90 Å), 24.53°2θ(3.63 Å), 25.66°2θ(3.47 Å), 30.05°2θ(2.97 Å) and at 37.29°2θ(2.41 Å).  
     
     
         2 . Modification B of the compound I characterized by the X-ray diffraction pattern in which reflections not coinciding with the reflections of the other modification are observed inter alia at 13.80°2θ(6.41 Å), 15.22°2θ(5.82 Å), 17.50°2θ(5.06 Å) and at 23.48°2θ(3.79 Å).  
     
     
         3 . Mixtures of arbitrary composition of the modifications A and B of compound I.