Product and method for obtaining specific immunisation with one or more antigens

Abstract

The invention provides means and methods for vaccinating an animal or a human to obtain therein an immune response against at least one antigen, comprising different vaccine compositions for sequential administration to said animal or said human, each containing at least said antigen or a precursor thereof, wherein said vaccine compositions differ from each other by the presence therein of a different vector.

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         18 . A kit that induces or stimulates an immune response in an animal or human against at least one antigen, wherein the antigen is of a virus causing temporary, or long lasting immune impairment, wherein the kit comprises at least three different immunogenic compositions, wherein each of the immunogenic compositions comprises a vector encoding the antigen; and wherein the vectors are not the same.  
     
     
         19 . A kit according to  claim 18 , wherein the antigen is a lentivirus.  
     
     
         20 . A kit according to  claim 18 , wherein at least part of the vectors function as an adjuvant.  
     
     
         21 . A kit according to  claim 20 , wherein the adjuvant function directs the immune response toward a more T helper 1 type or T helper 2 type of response, or both.  
     
     
         22 . A kit according to  claim 18 , wherein the antigen comprises at least an immunogenic part, derivative and/or analogue of a lentivirus gag, pol, rev, tat, nef, or env protein or a combination thereof.  
     
     
         23 . A kit according to  claim 18 , wherein at least one of the immunogenic compositions comprises a nucleic acid encoding at least one proteinaceous molecule for inducing and/or boosting an immune response against the antigen.  
     
     
         24 . A kit according to claims  18 , wherein one of the vectors comprises a nucleic acid which encodes at least one proteinaceous molecule capable of modulating an immune response.  
     
     
         25 . A kit according to  claim 18 , wherein one of the vectors is a nucleic acid delivery vehicle comprising said nucleic acid.  
     
     
         26 . A kit according to  claim 25 , wherein said nucleic acid delivery vehicle is selected from the group consisting of a Semliki Forest Virus particle, a poxvirus particle, a herpes virus particle and an adenovirus particle.