Composition for treatment of infections of humans and animals

Abstract

This disclosure provides pharmaceutical compositions which include oil extract from plants from the Labiatae family. In particular, the compositions can be formulated by combining extracts of essential oils from plants of the Labiatae family with an organic acid or a Group I salt. It is believed that the antimicrobial activity of the pharmaceutical composition is due to the presence of organic phenols, such as isopropyl-o-cresol, in the oil extract from the plants.

We claim:  
     
         1 . A pharmaecutical composition for treating a microbial infection in an animal, said composition comprising: 
 (a) antimicrobial compound, wherein said antimicrobial compound comprises an organic phenolic compound chemically reacted with a Group I salt; and    (b) a pharmaceutically acceptable carrier.    
     
     
         2 . The pharmaceutical composition of  claim 1  wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.  
     
     
         3 . The pharmaceutical composition of  claim 1  wherein the Group I salt is a Group I chloride salt.  
     
     
         4 . The pharmaceutical composition of  claim 3  wherein the Group I salt is selected from the group consisting of sodium chloride, potassium chloride and combinations thereof.  
     
     
         5 . The pharmaceutical composition of  claim 1  wherein the antimicrobial compound comprises isopropyl-o-cresol and isopropyl-cresol chemically reacted with sodium chloride and potassium chloride.  
     
     
         6 . The pharmaceutical composition of  claim 1  comprising 10% antimicrobial compound.  
     
     
         7 . The pharmaceutical composition of  claim 1  wherein the antimicrobial compound comprises sodium-para-cresol, potassium-para-cresol, sodium-M-cresol and potassium-M-cresol.  
     
     
         8 . The pharmaceutical composition of  claim 1  wherein the antimicrobial compound comprises 97 wt % sodium-para-cresol and potassium-para-cresol and 3 wt % sodium-M-cresol and potassium-M-cresol.  
     
     
         9 . The pharmaceutical composition of  claim 1  wherein the microbial infection is selected from the group consisting of a bacterial infection, fungal infection, protozoan infection and yeast infection.  
     
     
         10 . The pharmaceutical composition of  claim 1  wherein the animal is selected from the group consisting of humans, horses, cows, pigs, sheep, goats, rabbits, dogs, cats, chickens, turkeys, ducks and birds.  
     
     
         11 . A method for treating a microbial infection in an animal, said method comprising: 
 (a) administering to the animal an antimicrobial compound, wherein said antimicrobial compound comprises an organic phenolic compound chemically reacted with a Group I salt.    
     
     
         12 . The method of  claim 1  wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.  
     
     
         13 . The method of  claim 11  wherein the Group I salt is a Group I chloride salt.  
     
     
         14 . The method of  claim 13  wherein the Group I salt is selected from the group consisting of sodium chloride, potassium chloride and combinations thereof.  
     
     
         15 . The method of  claim 11  wherein the antimicrobial compound comprises isopropyl-o-cresol and isopropyl-cresol chemically reacted with sodium chloride and potassium chloride.  
     
     
         16 . The method of  claim 11  wherein the antimicrobial compound comprises sodium-para-cresol, potassium-para-cresol, sodium-M-cresol and potassium-M-cresol.  
     
     
         17 . The method of  claim 11  wherein the antimicrobial compound comprises 97 wt % sodium-para-cresol and potassium-para-cresol and 3 wt % sodium-M-cresol and potassium-M-cresol.  
     
     
         18 . The method of  claim 11  wherein the microbial infection is selected from the group consisting of a bacterial infection, fungal infection, protozoan infection and yeast infection.  
     
     
         19 . The method of  claim 11  wherein the animal is selected from the group consisting of humans, horses, cows, pigs, sheep, goats, rabbits, dogs, cats, chickens, turkeys, ducks and birds.  
     
     
         20 . A method of preparing an antimicrobial compound, comprising: 
 (a) mixing an organic phenolic compound and a Group I salt in a mixer at a speed of about 200 RPM to about 2000 RPM.    
     
     
         21 . The method of  claim 20  wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.  
     
     
         22 . The method of  claim 20  wherein the Group I salt is a Group I chloride salt.  
     
     
         23 . The method of  claim 22  wherein the Group I salt is selected from the group consisting of sodium chloride, potassium chloride and combinations thereof.  
     
     
         24 . The method of  claim 20  further comprising mixing at a temperature between about 60° C. and about 100° C.  
     
     
         25 . The method of  claim 20  further comprising mixing for about 1 to about 20 minutes.  
     
     
         26 . The method of  claim 20  further comprising mixing for about 5 to about 15 minutes.  
     
     
         27 . A method of preparing an antimicrobial compound comprising: 
 (a) mixing an organic phenolic compound and an organic acid in a mixer at a speed of about 200 RPM to about 2000 RPM.    
     
     
         28 . The method of  claim 27  wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.  
     
     
         29 . The method of  claim 27  wherein the organic acid is selected from the group consisting of propionic acid, fumaric acid, citric acid, folic acid and combinations thereof.  
     
     
         30 . The method of  claim 27  further comprising mixing at a temperature between about 60° C. and about 100° C.  
     
     
         31 . The method of  claim 27  further comprising mixing for about 1 to about 20 minutes.  
     
     
         32 . The method of  claim 27  further comprising mixing for about 5 to about 15 minutes.  
     
     
         33 . An apparatus for high speed mixing, comprising: 
 (a) a receptacle, said receptacle comprising an inner wall, an outer wall and a base which define a cavity;    (b) a rotor which comprises a drive shaft and at least one blade;    (c) a heating element; and    (d) a motor.    
     
     
         34 . The apparatus of  claim 33  wherein the inner and outer walls of the receptacle are formed from a thermally conductive material selected from the group consisting of ceramic, metal, plastic and glass.  
     
     
         35 . The apparatus of  claim 33  wherein the inner and outer walls of the receptacle are formed from a metal.  
     
     
         36 . The apparatus of  claim 35  wherein the metal comprises stainless steel.  
     
     
         37 . The apparatus of  claim 33  wherein the inner and outer walls are spaced apart to define a gap.  
     
     
         38 . The apparatus of  claim 37  wherein the gap is configured to receive a heating element.  
     
     
         39 . The apparatus of  claim 37  wherein the gap is configured to receive a liquid.  
     
     
         40 . The apparatus of  claim 33  further comprising an input conduit and an output conduit.  
     
     
         41 . The apparatus of  claim 40  further comprising valves having open and closed positions configured and arranged to allow reactants to be fed into the cavity and product to be removed from the cavity when in an open position and obstruct passage of reactants or products when in a closed position.  
     
     
         42 . The apparatus of  claim 40  wherein the rotor comprises a plurality of blades configured as at least one propeller.  
     
     
         43 . The apparatus of  claim 42  wherein the rotor comprises a plurality of coaxial propellers.