Polynucleotide and polypeptide sequences of canine cathepsin S

Abstract

DNAs encoding canine Cathepsin S have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

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         7 . A mono-specific antibody specifically immunologically reactive with canine cathepsin S protein.  
     
     
         8 . The antibody of  claim 7 , wherein the antibody blocks protease activity of the canine Cathepsin S protein.  
     
     
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