Device based on nitinol with a polyphosphazene coating

Abstract

The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.

1 . A device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering based on at least one polymer having the following general formula (I),  
       
         
           
           
               
               
           
         
         in which n is 2 to ∞, the radicals R 1  to R 6  are identical or different and are an alkoxy, alkyl sulfonyl, dialkylamino or aryloxy radical or a heterocycloalkyl or heteroaryl radical having nitrogen as a heteroatom.  
       
     
     
         2 . The device as claimed in  claim 1 , where an ultra-thin TiO 2  layer is arranged on the surface of the substrate based on nitinol.  
     
     
         3 . The device as claimed in  claim 1 , where at least one of the radicals R 1  to R 6  is an alkoxy radical which is substituted by at least one fluorine atom.  
     
     
         4 . The device as claimed in  claim 1 , where the polymer is poly[bis(trifluoroethoxy)-phosphazene].  
     
     
         5 . The device as claimed in  claim 1 , where between the surface of the substrate based on nitinol and the covering is arranged a layer which contains an adhesion promoter.  
     
     
         6 . The device as claimed in  claim 5 , where the adhesion promoter is a compound containing a polar end group, in particular an organosilicon compound.  
     
     
         7 . The device as claimed in  claim 6 , the organosilicon compound being aminopropyl-trimethoxysilane.  
     
     
         8 . The device as claimed in  claim 1 , the substrate based on nitinol being coated completely with a covering based on at least one polymer having the general formula (I).  
     
     
         9 . The device as claimed in  claim 1 , the substrate based on nitinol being present in the form of an at least partially perforated tube.  
     
     
         10 . The device as claimed in  claim 1 , the covering based on at least one polymer having the general formula (I) being micro-structured.  
     
     
         11 . A process for the production of a device as claimed in  claim 1 , comprising the steps: 
 (a) making available of a substrate based on nitinol,    (b) exposure of the substrate based on nitinol to a plasma treatment,    (c) optionally hydroxylation of the surface treated in step (b) and application of an adhesion promoter and    (d) coating of the substrate with at least one polymer according to formula (I), as defined in one of the preceding claims.    
     
     
         12 . The process as claimed in  claim 11 , the plasma in step (b) being an air or oxygen plasma.  
     
     
         13 . The process as claimed in  claim 11 , where after step (d) the polymer coating is micro-structured by means of laser beams, electron beams or X-rays or a hot wire.  
     
     
         14 . The use of the device as claimed in  claim 1  as an artificial implant, vascular or non-vascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.  
     
     
         15 . The device as claimed in  claim 2 , 
 where at least one of the radicals R 1  to R 6  is an alkoxy radical which is substituted by at least one fluorine atom;    where the polymer is poly[bis(trifluoroethoxy)-phosphazene];    where between the surface of the substrate based on nitinol and the covering is arranged a layer which contains an adhesion promoter;    where the adhesion promoter is a compound containing a polar end group, in particular an organosilicon compound;    the organosilicon compound being aminopropyl-trimethoxysilane;    the substrate based on nitinol being coated completely with a covering based on at least one polymer having the general formula (I);    the substrate based on nitinol being present in the form of an at least partially perforated tube;    the covering based on at least one polymer having the general formula (I) being micro-structured;    
     
     
         16 . A process for the production of a device as claimed in  claim 15 , comprising the steps: 
 (a) making available of a substrate based on nitinol,    (b) exposure of the substrate based on nitinol to a plasma treatment,    (c) optionally hydroxylation of the surface treated in step (b) and application of an adhesion promoter and    (d) coating of the substrate with at least one polymer according to formula (I), as defined in one of the preceding claims.    
     
     
         17 . The process as claimed in  claim 16 , the plasma in step (b) being an air or oxygen plasma; 
 where after step (d) the polymer coating is micro-structured by means of laser beams, electron beams or X-rays or a hot wire.    
     
     
         18 . The use of the device as claimed in  claim 15  as an artificial implant, vascular or non-vascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.  
     
     
         19 . The use of the device as claimed in  claim 16  as an artificial implant, vascular or non-vascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.  
     
     
         20 . The use of the device as claimed in  claim 17  as an artificial implant, vascular or non-vascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.