Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation

Abstract

The present invention provides novel diagnostic compositions comprising a radiolabeled LTB4 binding agent and a radiolabeled perfusion imaging agent, diagnostic kits comprising such compositions, and methods of concurrent imaging in a mammal comprising administering a radiolabeled LTB4 binding agent and a radiolabeled perfusion imaging agent, and concurrently detecting the radiolabeled LTB4 binding agent bound at the LTB4 receptor and the radiolabeled perfusion imaging agent.

We claim:  
     
         1 . A method of diagnosing and localizing sites of inflammation and perfusion abnormalities in a single dual isotope imaging procedure.  
     
     
         2 . A method of diagnostic imaging comprising the concurrent detection and localization of sites of ischemic tissue injury and perfusion abnormalities in a single imaging procedure.  
     
     
         3 . A method according to  claim 2 , wherein the imaging procedure is one or more procedure selected from the group, CT imaging, ultrasound, and scintigraphy.  
     
     
         4 . A method of diagnosing and localizing sites of inflammation and perfusion abnormalities in a single dual imaging procedure.  
     
     
         5 . A method according to  claim 4 , wherein the imaging procedure is one or more procedure selected from the group, CT imaging, ultrasound, and scintigraphy.  
     
     
         6 . A method of diagnostic imaging comprising the concurrent detection and localization of sites of of ischemic tissue injury (e.g. reperfusion injury), vulnerable plaque, bacterial endocarditis or cardiac transplant rejection in a single dual imaging procedure.  
     
     
         7 . A method according to  claim 6 , wherein the imaging procedure is one or more procedure selected from the group, CT imaging, ultrasound, and scintigraphy.  
     
     
         8 . A method of diagnostic imaging comprising the concurrent detection and localization of sites of vulnerable plaque and perfusion abnormalities in a single imaging procedure.  
     
     
         9 . A method according to  claim 8 , wherein the imaging procedure is one or more procedure selected from the group, CT imaging, ultrasound, and scintigraphy.  
     
     
         10 . A method of diagnostic imaging comprising the concurrent detection and localization of sites of cardiac infection and perfusion abnormalities in a single imaging procedure.  
     
     
         11 . A method according to  claim 10 , wherein the imaging procedure is one or more procedure selected from the group, CT imaging, ultrasound, and scintigraphy.  
     
     
         12 . A method of diagnostic imaging comprising the concurrent detection and localization of sites of cardiac transplant rejection and perfusion abnormalities in a single imaging procedure.  
     
     
         13 . A method according to  claim 12 , wherein the imaging procedure is one or more procedure selected from the group, CT imaging, ultrasound, and scintigraphy.