Composition comprising paroxetine and a pharmaceutically acceptable glycyrrhizinate salt

Abstract

A taste-masked formulation of paroxetine comprises a dry blend of paroxetine and a glycyrrhyzinate, especially paroxetine hydrochloride and ammonium glycyrrhyzinate, as a dispersible powder or moulded into a dispersible or chewable tablet.

What is claimed is:  
     
         1 . A composition which is a dry blend of: 
 paroxetine free base, or a pharmaceutically acceptable salt or solvate of paroxetine, and a pharmaceutically acceptable glycyrrhyzinate salt.    
     
     
         2 . A pharmaceutical composition which is a dry blend of: 
 paroxetine free base, or a pharmaceutically acceptable salt or solvate of paroxetine, a pharmaceutically acceptable glycyrrhyzinate salt, and one or more pharmaceutically acceptable excipients.    
     
     
         3 . A composition according to  claim 2  which is in powder form.  
     
     
         4 . A composition according to  claim 2  which is a shaped composition.  
     
     
         5 . A composition according to  claim 2 , including one or more dispersing agents.  
     
     
         6 . A composition according to  claim 5  in which the dispersing agent is selected from polyvinyl pyrrolidone, calcium carbonate and sodium starch glycolate.  
     
     
         7 . A composition according to  claim 2  including one or more taste masking agents, sweeteners or flavourings.  
     
     
         8 . A composition according to  claim 1  in which the paroxetine salt is paroxetine hydrochloride.  
     
     
         9 . A composition according to  claim 1  in which the glycyrrhyzinate salt is ammonium glycyrrhyzinate.  
     
     
         10 . (Cancelled)  
     
     
         11 . Method of treating one or more of the Disorders which comprises administering a composition according to  claim 1  to a person suffering from one or more of the Disorders.