Neuroprotective composition and uses thereof

Abstract

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

1 - 19 . (canceled)  
     
     
         20 . A method for preparing a neuroprotective composition, characterized in that it comprises the steps of: 
 a) providing a therapeutically effective amount of: i) pyruvate, ii) at least one antioxidant; and iii) at least one lipid; and    b) mixing together the components i), ii) an iii) of step a) in a physiological buffered saline solution to obtain a pharmaceutically acceptable homologous suspension.    
     
     
         21 . The method of  claim 20 , further comprising centrifuging the homologous suspension.  
     
     
         22 . The method of  claim 20 , further comprising filtering the homologous suspension.  
     
     
         23 . A neuroprotective composition comprising a therapeutically effective amount of pyruvate at least one antioxidant and at least one lipid in a physiological buffered saline solution.