Purine derivatives having, in particular, anti-proliferative properties and their biological uses

Abstract

This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.

1 . A compound of formula I:  
       
         
           
           
               
               
           
         
         wherein:  
         R 2  is R—NH, wherein R is saturated or unsaturated alkyl with a straight or branched chain;  
         R 6  is R—NH wherein R is aryl;  
         R 9  is saturated or unsaturated alkyl with a straight or branched chain;  
         each optionally substituted by one or more hydroxy, halogen, amino or alkyl groups;  
         with the proviso that when R 2  is hydroxyethylamino, R 6  is not benzylamino or 3-hydroxybenzylamino.  
       
     
     
         2 - 28 . (Cancelled)