US2004228905A1PendingUtilityA1
Anti-inflammatory and antimicrobial uses for bioactive glass compositions
Priority: Sep 19, 1996Filed: Jun 10, 2004Published: Nov 18, 2004
Est. expirySep 19, 2016(expired)· nominal 20-yr term from priority
C03C 4/0007A61K 8/25A61Q 5/00A61L 15/46A61Q 19/00A61K 45/06A61Q 17/005A61Q 1/02A61L 15/18Y10S424/13A61L 15/44
47
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Claims
Abstract
Compositions and methods for treating wounds to significantly reduce the healing time, reduce the incidence of scar formation, improve the success of skin grafts, reduce the inflammatory response and providing anti-bacterial treatments to a patient in need thereof, that include small non-interlinked particles of bioactive glass or highly porous bioactive glass, are disclosed. Anti-bacterial solutions derived from bioactive glass, and methods of preparation and use thereof, are also disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with anti-bacterial agents and/or anti-inflammatory agents. The compositions can include an appropriate carrier for topical administration. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating small bioactive glass particles or porous bioactive glass into or onto the implanted materials. Anti-bacterial properties can also be imparted to devices used for in vitro and ex vivo cell culture by incorporating non-interlinked particles of bioactive glass into the devices. Anti-bacterial compositions derived from aqueous extracts of bioactive glass are also disclosed. These compositions can be used, for example, in food preparation, solutions used for cell culture, and buffer solutions, such as i.v. solutions.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A composition for the accelerated healing of wounds and burns and/or for improving the appearance of scar tissue resulting from such wounds and burns comprising non-linked, small particles of bioactive glass in a carrier.
2 . The composition of claim 1 , further comprising one or more therapeutic agents.
3 . The composition of claim 2 , wherein therapeutic agent(s) are selected from the group consisting of healing promotion agents, growth factors, anti-inflammatory agents and topical anesthetics.
4 . The composition of claim 2 , wherein the therapeutic agent is a topical antibiotic.
5 . The composition of claim 4 , wherein the topical antibiotic is selected from the group consisting of chloramphenicol, chlortetracycline, clyndamycin, clioquinol, erythromycin, framycetin, gramicidin, fusidic acid, gentamicin, mafenide, mupiroicin, neomycin, polymyxin B, bacitracin, silver sulfadiazine, tetracycline, chlortetracycline and combinations thereof.
6 . The composition of claim 1 , wherein the pharmaceutically acceptable carrier is a cream base, high moisture gel, white petrolatum, light mineral oil, or mixture thereof.
7 . The composition of claim 1 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
40-86
CaO
10-46
Na 2 O
0-35
P 2 O 5
2-8
CaF 2
0-25
B 2 O 3
0-10
K 2 O
0-8
MgO
0-5
8 . The composition of claim 1 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
45
CaO
24.5
Na 2 O
24.5
P 2 O 5
6
9 . The composition of claim 1 , wherein the bioactive glass has a particle size range less than about 90 microns as measured by SEM or laser light scattering techniques.
10 . The composition of claim 1 , wherein the bioactive glass has a particle size range less than about 20 microns as measured by SEM or laser light scattering techniques.
11 . The composition of claim 1 , wherein the bioactive glass has a particle size range less than about 2 microns as measured by SEM or laser light scattering techniques.
12 . A method for treating wounds and burns comprising the contacting of a wound with an effective wound healing amount of bioactive glass.
13 . A method for grafting skin comprising applying bioactive particulate glass to a graft site, the donor tissue, or both.
14 . The method of claim 13 , further comprising the application of a topical antibiotic to the graft site, the donor tissue, or both.
15 . A wound or burn dressing comprising a bandage, a topical antibiotic and non-linked particles of bioactive glass.
16 . The wound or burn dressing of claim 15 wherein the bandage is cotton, gauze, fiberglass, or synthetic material.
17 . The dressing of claim 16 wherein the fiberglass is made from bioactive glass
18 . A wound or burn treatment applicator apparatus comprising a topical carrier in a first chamber, a non-linked particles of bioactive glass in a second chamber and a mixing means for mixing the topical antibiotic and the bioactive glass.
19 . The apparatus of claim 18 , wherein the wound or burn treatment apparatus is a multi chamber syringe.
20 . A method for accelerating the healing of wounds or burns comprising contacting a wound or burn with an effective wound or burn healing accelerating amount of a particulate bioactive glass.
21 . A method for improving the appearance of the scar formed during the healing of wounds or burns comprising contacting a wound or burn with an effective scar appearance improving amount of a non-linked, particulate bioactive glass.
22 . The method of claim 21 wherein the bioactive glass is present in a composition comprising the bioactive glass in the form of non-linked, small particles of bioactive glass and a suitable carrier.
23 . The composition of claim 1 , wherein the bioactive glass particles have been combined with a biocompatible, biodegradable material to form a composite material.
24 . A method of reducing the level of inflammation in a wound by contacting the wound with an effective inflammation reducing amount of a bioactive glass.
25 . The method of claim 24 wherein the inflammation is chronic inflammation.
26 . A method of reducing the level of bacterial infection in a wound comprising contacting the wound with an effective antibacterial amount of a bioactive glass.
27 . The method of claim 26 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
40-86
CaO
10-46
Na 2 O
0-35
P 2 O 5
2-8
CaF 2
0-25
B 2 O 3
0-10
K 2 O
0-8
MgO
0-5
28 . The method of claim 26 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
45
CaO
24.5
Na 2 O
24.5
P 2 O 5
6
29 . The method of claim 26 , wherein the bioactive glass has a particle size range less than about 90 microns as measured by SEM or laser light scattering techniques.
30 . The method of claim 26 , wherein the bioactive glass has a particle size range less than about 20 microns as measured by SEM or laser light scattering techniques.
31 . The method of claim 26 , wherein the bioactive glass has a particle size range less than about 2 microns as measured by SEM or laser light scattering techniques.
32 . An antibacterial composition comprising non-linked, small particles of bioactive glass.
33 The composition of claim 32 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
40-86
CaO
10-46
Na 2 O
0-35
P 2 O 5
2-8
CaF 2
0-25
B 2 O 3
0-10
K 2 O
0-8
MgO
0-5
34 . The composition of claim 32 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
45
CaO
24.5
Na 2 O
24.5
P 2 O 5
6
35 . The composition of claim 32 , wherein the bioactive glass has a particle size range less than about 90 microns as measured by SEM or laser light scattering techniques.
36 . The composition of claim 32 , wherein the bioactive glass has a particle size range less than about 20 microns as measured by SEM or laser light scattering techniques.
37 . The composition of claim 32 , wherein the bioactive glass has a particle size range less than about 2 microns as measured by SEM or laser light scattering techniques.
38 . An antibacterial composition comprising an aqueous extract of small particles of bioactive glass.
39 . The composition of claim 38 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
40-86
CaO
10-46
Na 2 O
0-35
P 2 O 5
2-8
CaF 2
0-25
B 2 O 3
0-10
K 2 O
0-8
MgO
0-5
40 . The composition of claim 38 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
45
CaO
24.5
Na 2 O
24.5
P 2 O 5
6
41 . Cosmetic products comprising non-interlinked particles of bioactive glass and/or an aqueous extract thereof in combination with a liquid cosmetic base containing water.
42 . The cosmetic products of claim 41 , wherein the cosmetic base comprises a liquid material selected from the group consisting of liquid foundation, skin lotion, milky lotion, shampoo, hair rinse and cream.
43 The cosmetic products of claim 41 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
40-86
CaO
10-46
Na 2 O
0-35
P 2 O 5
2-8
CaF 2
0-25
B 2 O 3
0-10
K 2 O
0-8
MgO
0-5
44 . The cosmetic products of claim 41 , wherein the bioactive glass has a composition by weight percentage:
Component
Percent
SiO 2
45
CaO
24.5
Na 2 O
24.5
P 2 O 5
6
45 . The cosmetic products of claim 41 , wherein the bioactive glass has a particle size range less than about 90 microns as measured by SEM or laser light scattering techniques.
46 . The cosmetic products of claim 41 , wherein the bioactive glass has a particle size range less than about 20 microns as measured by SEM or laser light scattering techniques.
47 . The cosmetic products of claim 41 , wherein the bioactive glass has a particle size range less than about 2 microns as measured by SEM or laser light scattering techniques.
48 . Prosthetic implants, sutures, stents, screws, plates and tubes comprising the composition of claim 1 .
49 . Devices used for in vitro cell culture comprising the composition of claim 1.Join the waitlist — get patent alerts
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