US2004210061A1PendingUtilityA1

Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol

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Assignee: AVENTIS PHARMA INCPriority: Mar 13, 1998Filed: May 4, 2004Published: Oct 21, 2004
Est. expiryMar 13, 2018(expired)· nominal 20-yr term from priority
Inventors:Thomas HilpertHans-Wolfram FlemmingSandra K. Stolz-DunnJonathan C. EvansIan A. Tomlinson
C07D 211/22C07D 211/32
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Claims

Abstract

The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A process for preparing 4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]pyridine comprising the step of reacting lithiated veratrole with 4-pyridinecarboxaldehyde in the presence of a suitable aprotic solvent.  
     
     
         2 . The process according to  claim 1  wherein the aprotic solvent is toluene.  
     
     
         3 . The process according to  claim 1  wherein the aprotic solvent is a mixture of toluene and tetrahydrofuran.  
     
     
         4 . The process according to  claim 1  wherein the aprotic solvent is a mixture of toluene and hexane.  
     
     
         5 . A compound which is 4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]pyridine.

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