Method of plasma polymerisation of substituted benzenes, polymeric material obtainable by the method, and use thereof

Abstract

A method of plasma polymerisation of monomers for providing a cross-linked polymeric material, the method comprising: treating a monomer gas in a plasma, said monomer gas comprising one or more monomers selected from substituted benzenes, wherein said plasma is generated by a multiple phase AC supply or a DC supply at a plasma power density allowing a substantial portion of substituent groups of said substituted benzenes to be preserved.

1 . A method of plasma polymerisation of monomers for providing a cross-linked polymeric material, the method comprising: treating a monomer gas in a plasma, said monomer gas comprising one or more monomers selected from substituted benzenes, wherein said plasma is generated by a multiple phase AC supply or a DC supply at a plasma power density allowing a substantial portion of substituent groups of said substituted benzenes to be preserved.  
     
     
         2 . The method according to  claim 1  wherein said substituted benzenes have the general formula:  
       Ar(R n ) n    
       wherein Ar is a benzene ring, n is 1-6 and R n  is n substituents (R 1 , R 2 , R 3 , R 4 , R 5 , R 6 ) covalently bound to the benzene ring, the substituents (R 1 , R 2 , R 3 , R 4 , R 5 , R 6 ) being independently selected from C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -alkylcarbonyl, C 1-6 -alkylcarbonyl, C 1-6 -alkoxycarbonyl, carbamoyl, mono- and di(C 1-6 -alkyl)aminocarbonyl, formyl, hydroxy, carboxy, carbamido, thiolo, nitro, cyano, nitro, amino, mono- and di(C 1-6 -alkyl)amino, and halogen (fluoro, chloro, iodo, bromo), wherein the C 1-6 -alkyl and C 1-6 -alkoxy groups in the above may be substituted with substituents, preferably 1-3 substituents, selected from hydroxy, C 1-6 -alkoxy, carboxy, amino, mono- and di(C 1-6 -alkyl)amino and halogen.  
     
     
         2 . The method according to  claim 1  wherein said substituted benzenes are selected from the group consisting of: benzoylchloride, benzoylbromide, 2,3-epoxypropyl-benzene, benzaldehyde, thiophenol, phenol, aniline, and methyl-substituted compounds thereof.  
     
     
         3 . A method according to any one of  claim 1  or  2  wherein less than 40%, preferably less than 30%, in particular less than 10% of the double bonds originating from said substituted benzenes are left in the material.  
     
     
         4 . A method according to any one of claims  1 - 3  wherein more than 1%, preferably more than 10%, in particular more than 20% of said substituent groups are preserved.  
     
     
         5 . A method according to any one of claims  1 - 4  wherein the monomer or monomers of the general formula constitutes at least 5% of the monomer gas.  
     
     
         6 . A method according to any one of claims  1 - 5  wherein a said multiple phase AC supply is a two phase AC, or a three phase AC supply.  
     
     
         7 . A method according to any one of claims  1 - 4  wherein said plasma power density of the plasma is at the most 15 W/l, preferably at the most 10 W/l.  
     
     
         8 . A method according to any one of claims  1 - 4  wherein said plasma power density of the plasma is in the range of 10 mW/l to 15 W/l, preferably 10 mW/l to 10 W/l, in particular 10 mW/l to 5 W/l.  
     
     
         9 . A polymeric material obtainable by the plasma polymerisation method defined in any one of claims  1 - 8 .  
     
     
         10 . A coated substrate, the substrate being coated with a layer of a polymeric material as defined in any one of the claims  1 - 9 .  
     
     
         11 . A coated substrate according to  claim 10  wherein said layer of said polymeric material is coated in said treatment in said plasma.  
     
     
         12 . Use of a polymeric material as defined in  claim 9  or  10  as a diffusion barrier, said polymeric material having less than 30% of the double bonds originating from said substituted benzenes are left in the material.  
     
     
         13 . Use of a polymeric material or a coated substrate as defined in any one of claims  9 - 12  as a substrate for immobilizing chemical substances.  
     
     
         14 . Use of a polymeric material or a coated substrate according to  claim 13  wherein said polymeric material has more than 1% of substituent groups preserved.  
     
     
         15 . Use of a polymeric material or a coated substrate according to  claim 13  or  14  wherein said substance is selected from the group consisting of oligo RNA, oligo DNA, oligo PNA, proteins, peptides, hormones, blood components, antigens and antibodies.