Marker for inflammatory conditions

Abstract

Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.

1 - 12 . (canceled)  
     
     
         13 . An article of manufacture for diagnosing an inflammatory condition in a non-pregnant patient, said article of manufacture comprising an anti-PAPP-A antibody and packaging material, wherein said anti-PAPP-A antibody can be used for measuring PAPP-A levels in a biological sample from said patient, and wherein said packaging material comprises a label or package insert indicating that said anti-PAPP-A antibody can be used for diagnosing said inflammatory condition.  
     
     
         14 . The article of manufacture of  claim 13 , wherein said biological sample is selected from the group consisting of whole blood, plasma, and serum.  
     
     
         15 . An article of manufacture for diagnosing an inflammatory condition in a non-pregnant patient, said article of manufacture comprising reagents for measuring levels of a plurality of polypeptides in a biological sample from said patient, wherein said plurality of polypeptides comprises PAPP-A and one or more of the polypeptides selected from the group consisting of high sensitivity C-reactive protein, creatine kinase MB, troponin I, troponin T, creatine kinase, creatinine, fibrinogen, interleukin-1, and interleukin-6.  
     
     
         16 . The article of manufacture of  claim 15 , wherein said biological sample is selected from the group consisting of whole blood, plasma, and serum.  
     
     
         17 - 22 . (canceled)