Method and preparation containing idebenone for protecting human skin

Abstract

Also within the scope of the present invention are processes for producing the cosmetic agents of the invention, which is characterised in that active ingredient combinations of the invention are incorporated into cosmetic and dermatological formulations in a manner known per se. A method for reducing a skin change includes applying an amount of idebenone (6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone) or derivative of idebenone effective for reducing the skin change.

1 - 15 . (canceled)  
     
     
         16 . A method for reducing a skin change, comprising applying a topical preparation to the skin, the preparation comprising an amount of an agent effective for reducing the skin change, the agent comprising idebenone or a derivative of idebenone.  
     
     
         17 . The method as recited in  claim 16  wherein the skin change includes an aging of the skin.  
     
     
         18 . The method as recited in  claim 16  wherein the skin change includes a wrinkling of the skin.  
     
     
         19 . The method as recited in  claim 16  wherein the skin change includes an oxidative process.  
     
     
         20 . The method as recited in  claim 16  wherein the skin change includes a degenerative process.  
     
     
         21 . The method as recited in  claim 16  wherein the idebenone or derivative of idebenone has a concentration of from about 0.0001 to about 30% by weight of the preparation.  
     
     
         22 . The method as recited in  claim 16  wherein the derivative of idebenone is an ester of idebenone.  
     
     
         23 . The method as recited in  claim 16  wherein the topical preparation further comprises at least one of a glycosaminoglycan, a salt of a glycosaminoglycan, and a hyaluronidase inhibitor.  
     
     
         24 . The method as recited in  claim 16  wherein the preparation further comprises at least one ultraviolet filter.  
     
     
         25 . The method as recited in  claim 16  wherein the topical preparation further comprises at least one antioxidant.  
     
     
         26 . The method as recited in  claim 16  wherein the preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, an ointment, a wax, a lipstick, a soap, and a shampoo.  
     
     
         27 . The method as recited in  claim 16  wherein the applying is included in at least one of a cosmetic, an over-the-counter, a dermatological and a pharmaceutical treatment of the skin.  
     
     
         28 . A method for protecting human skin against an oxidative process, comprising applying a topical preparation to the skin, the preparation comprising an amount of an agent effective for reducing an amount of oxidants or free-radicals in the skin, the agent comprising idebenone or a derivative of idebenone.  
     
     
         29 . The method as recited in  claim 28  wherein the oxidative process is a photochemical reaction.  
     
     
         30 . The method as recited in  claim 28  wherein the oxidative process is a photochemical reaction due to an exposure of the skin to ultraviolet radiation.  
     
     
         31 . The method as recited in  claim 28  wherein the free-radicals include hydroxy radicals.  
     
     
         32 . The topical skin preparation as recited in  claim 28  wherein the free-radicals include at least one of hydroperoxides and aldehydes.  
     
     
         33 . The method as recited in  claim 28  wherein the idebenone or derivative of idebenone has a concentration of from about 0.0001 to about 30% by weight of the preparation.  
     
     
         34 . The method as recited in  claim 28  wherein the topical preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, an ointment, a wax, a lipstick, a soap, and a shampoo.  
     
     
         35 . The method as recited in  claim 28  wherein the derivative of idebenone is an ester of idebenone.  
     
     
         36 . The method as recited in  claim 28  wherein the topical preparation further comprises at least one of a glycosaminoglycan, a slat of a glycosaminoglycan, and a hyaluronidase inhibitor.  
     
     
         37 . The method as recited in  claim 28  wherein the preparation further comprises at least one ultraviolet filter.  
     
     
         38 . The method as recited in  claim 28  wherein the topical preparation further comprises at least one antioxidant.  
     
     
         39 . The method as recited in  claim 28  wherein the applying is included in at least one of a cosmetic, an over-the-counter, a dermatological and a pharmaceutical treatment of the skin.  
     
     
         40 . A method for stabilizing a cosmetic or dermatological preparation, comprising providing in the preparation an amount of an agent effective for reducing an amount of oxidants or free-radicals in the preparation, the agent comprising idebenone or a derivative of idebenone.  
     
     
         41 . The method as recited in  claim 40  wherein oxidants or free-radicals are degradation products of a component of the preparation.  
     
     
         42 . The method as recited in  claim 40  wherein oxidants or free-radicals are degradation products of a component of the preparation, the component being selected from the group consisting of vitamin A, a derivative of vitamin A, vitamin B, a derivative of vitamin B, vitamin C, a derivative of vitamin C, vitamin E, a derivative of vitamin C, hyaluronic acid and a derivative of hyaluronic acid.  
     
     
         43 . The method as recited in  claim 40  wherein the idebenone or derivative of idebenone has a concentration of from about 0.0001 to about 30% by weight of the preparation.  
     
     
         44 . The method as recited in  claim 40  wherein the preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, an ointment, a wax, a lipstick, a soap, and a shampoo.  
     
     
         45 . The method as recited in  claim 40  wherein the derivative of idebenone is an ester of idebenone.  
     
     
         46 . A skin protection preparation comprising: 
 an ultraviolet filter substance; and    an amount of an agent effective for reducing a formation of oxidation products in human skin due to an oxidative process, the agent comprising idebenone or a derivative of idebenone.    
     
     
         47 . The preparation as recited in  claim 46  wherein the ultraviolet filter substance is selected from the group consisting of a 4-aminobenzoic acid derivative, an ester of cinnamic acid, an ester of salicylic acid, a derivative of benzophenone, an ester of benzylidenemalonic acid.  
     
     
         48 . The preparation as recited in  claim 46  wherein the ultraviolet radiation includes ultraviolet B radiation from sunlight.  
     
     
         49 . The preparation as recited in  claim 46  wherein the idebenone or derivative of idebenone has a concentration of from about 0.001% to about 30% by weight of the preparation.  
     
     
         50 . The preparation as recited in  claim 46  wherein the derivative of idebenone is an ester of idebenone.  
     
     
         51 . The preparation as recited in  claim 46  wherein the preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, an ointment, a wax, a lipstick, a soap, and a shampoo.  
     
     
         52 . A stabilized topical skin preparation comprising: 
 a first component selected from the group consisting of vitamin A, a derivative of vitamin A, vitamin B, a derivative of vitamin B, vitamin C, a derivative of vitamin C, vitamin E, a derivative of vitamin C, hyaluronic acid and a derivative of hyaluronic acid; and    an amount of an agent effective for reducing oxidants or free-radical degradation products of the first component, the agent comprising idebenone or a derivative of idebenone.    
     
     
         53 . The preparation as recited in  claim 52  wherein the idebenone or derivative of idebenone has a concentration of from about 0.001% to about 30% by weight of the preparation.  
     
     
         54 . The preparation as recited in  claim 52  wherein the derivative of idebenone is an ester of idebenone.  
     
     
         55 . The preparation as recited in  claim 52  wherein the preparation is in the form of at least one of a lotion, a cream, a gel, a solution, a spray, a cleanser, an ointment, a wax, a lipstick, a soap, and a shampoo.