US2004197273A1PendingUtilityA1

Suspension aerosol formulations

60
Assignee: MINNESOTA MINING & MFGPriority: Dec 18, 1991Filed: Apr 9, 2004Published: Oct 7, 2004
Est. expiryDec 18, 2011(expired)· nominal 20-yr term from priority
Inventors:Robert K. SchultzDavid W. SchultzMartin J. OliverRobert A. MorisPhilip A. Jinks
A61K 31/137A61K 31/44A61K 9/008A61K 9/124A61P 11/00
60
PatentIndex Score
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Cited by
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Claims

Abstract

A pharmaceutical suspension aerosol formulation containing HFA-227 as a propellant.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A process for preparing a metered dose inhaler comprising a container closed with a metering valve, said metered dose inhaler containing a pharmaceutical composition suitable for inhalation by a patient, comprising the steps of: 
 preparing a pharmaceutical suspension formulation consisting essentially of a therapeutically effective amount of one or more particulate drugs sufficient to provide a plurality of therapeutically effective doses of the drug and a propellant selected from the group consisting of HFC 134a, HFC 227, and a mixture thereof; and    providing said particulate drug and said propellant in said metered dose inhaler.    
     
     
         2 . The process of  claim 1 , wherein said metering valve contains a surfactant as a lubricant for the metering valve.  
     
     
         3 . The process of  claim 2 , wherein said metering valve comprises a valve stem and said valve stem contains a surfactant as a lubricant for the valve stem.  
     
     
         4 . The process of  claim 2 , wherein a pharmaceutical suspension is first prepared in bulk outside of said metered dose inhaler and then transferred to said metered dose inhaler equipped with said metering valve using a valve to valve transfer method.  
     
     
         5 . The process of  claim 3 , wherein a pharmaceutical suspension is first prepared in bulk outside of said metered dose inhaler and then transferred to said metered dose inhaler equipped with said metering valve using a valve to valve transfer method.  
     
     
         6 . The process of  claim 2 , wherein said pharmaceutical suspension is provided in a first container and is then transferred into said metered dose inhaler through said metering valve.  
     
     
         7 . The process of  claim 1 , wherein said pharmaceutical suspension is prepared in said metered dose inhaler.  
     
     
         8 . The process of  claim 1 , wherein said pharmaceutical suspension formulation contains a single drug.  
     
     
         9 . The process of  claim 2 , wherein said pharmaceutical suspension formulation contains a single drug.  
     
     
         10 . The process of  claim 3 , wherein said pharmaceutical suspension formulation contains a single drug.  
     
     
         11 . A metered dose inhaler prepared by a process according to  claim 1 .  
     
     
         12 . A metered dose inhaler prepared by a process according to  claim 2 .  
     
     
         13 . A metered dose inhaler prepared by a process according to  claim 3 .  
     
     
         14 . A metered dose inhaler prepared by a process according to  claim 4 .  
     
     
         15 . A metered dose inhaler prepared by a process according to  claim 5 .  
     
     
         16 . A metered dose inhaler prepared by a process according to  claim 6 .  
     
     
         17 . A metered dose inhaler prepared by a process according to  claim 7 .  
     
     
         18 . A metered dose inhaler prepared by a process according to  claim 8 .  
     
     
         19 . A metered dose inhaler prepared by a process according to  claim 9 .  
     
     
         20 . A metered dose inhaler prepared by a process according to  claim 10.

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