Stable polymer aqueous/aqueous emulsion system and uses thereof

Abstract

This invention provides a stable aqueous/aqueous emulsion system which is prepared with a hydrophilic polymer. This invention also provides the method of preparing a stable aqueous/aqueous emulsion. Finally, this invention provides an encapsulation comprising the emulsion system which is prepared with a hydrophilic polymer.

What is claimed is:  
     
         1 . A stable aqueous/aqueous emulsion system which is prepared with a hydrophilic polymer.  
     
     
         2 . The method of preparing for preparing a stable aqueous/aqueous emulsion comprising steps of: 
 a) selecting appropriate polymeric materials for dispersed phase and continuous phase which are immiscible, biocompatible and have biased partition to the active ingredients to be encapsulated;    b) selecting appropriate surface modifiers which are charged, non-toxic, and possessing a moderate interfacial tension between the above two phases;    c) developing phase diagram for the above; and    d) dispersing the dispersed phase into the continuous phase under an appropriate shear stress.    
     
     
         3 . The aqueous/aqueous emulsion system of  claim 1  with polymeric surface modifier.  
     
     
         4 . A method for encapsulating protein or peptide comprising the emulsion system of  claim 1 .  
     
     
         5 . The method of  claim 4  wherein the encapsulated protein or peptide is used for sustained release formulations or dry powder formulations.  
     
     
         6 . An encapsulation comprising the emulsion system which is prepared with a hydrophilic polymer.  
     
     
         7 . The encapsulation of  claim 6  which encapsulates protein, peptide, virus, bacterium, or cell.  
     
     
         8 . A liposome-based drug formulation which comprises the emulsion system of  claim 1 .  
     
     
         9 . Viral, bacterial or cell microencapsulation comprising the emulsion system of  claim 1 .  
     
     
         10 . A nano-sized preparation comprising the emulsion system of  claim 1 .  
     
     
         11 . The nano-sized preparation of  claim 10 , wherein the preparation is nano-sized crystallization, nano-sized precipitation or other nano-sized assembly.  
     
     
         12 . A diagnosis kit comprising the emulsion system of  claim 1.