US2004180870A1PendingUtilityA1

Aqueous solvent for corticosteroids

54
Priority: Jul 6, 1999Filed: Mar 25, 2004Published: Sep 16, 2004
Est. expiryJul 6, 2019(expired)· nominal 20-yr term from priority
Inventors:Calvin Hanna
A61K 47/44A61K 9/0014A61K 47/14A61K 31/56A61K 47/10
54
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Claims

Abstract

A solvent comprising a combination of water and organic solvent(s) capable of dissolving a therapeutically effective amount of medicament(s) not readily soluble in aqueous solvents, said organic solvents including alcohol and glycol, and said medicaments including hydrocortisone.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 ) A clear stable one phase solution that is non-irritating and resistant to freezing comprising: 
 a) between about 30% and about 50% water;    b) propylene glycol;    c) 2-propanol or ethanol; and    d) hydrocortisone in an amount of from about 0.5% to about 2.0% (w/v), wherein said hydrocortisone is solubilized in said water.    
     
     
         2 ) The solution of  claim 1  wherein said water is present in an amount sufficient to expand an ear wick a therapeutically effective amount when from 1 to 7 drops of the solution are administered to the ear canal.  
     
     
         3 ) The solution of  claim 1  further comprising chloroxylenol in an amount of between about 0.1% (w/v) and about 0.4% (w/v).  
     
     
         4 ) The solution of  claim 1  further comprising chloroxylenol in an amount of about 0.1% (w/v).  
     
     
         5 ) The solution of  claim 1  further comprising pramoxine in an amount of between about 0.5% (w/v) and about 2.0% (w/v).  
     
     
         6 ) The solution of  claim 1  further comprising pramoxine in an amount of about 1.0% (w/v).  
     
     
         7 ) The solution of  claim 1  further comprising chloroxylenol in an amount of between about 0.1% (w/v) and about 0.4% (w/v) and pramoxine in an amount of between about 0.5% (w/v) and about 2.0% (w/v).  
     
     
         8 ) The solution of  claim 1  wherein said propylene glycol is present in an amount of between about 35% (v/v) and about 65% (v/v).  
     
     
         9 ) The solution of  claim 1  wherein said ethanol or 2-propanol is present in an amount of between about 10% (v/v) and about 80% (v/v).  
     
     
         10 ) The solution of  claim 2  wherein: 
 a) said 2-propanol or ethanol is present in an amount of between about 10% (v/v) and about 80% (v/v),  
 b) said propylene glycol is present in an amount of between about 35% (v/v) and about 65% (v/v), and  
 c) said water is present in an amount of between about 30% (v/v) and about 50% (v/v).  
 
     
     
         11 ) The solution of  claim 1  further comprising propylene glycol diacetate in an amount of between about 0.01% (w/v) and about 0.5% (w/v).  
     
     
         12 ) The solution of  claim 1  further comprising propylene glycol diacetate in an amount of about 0.01% (w/v).  
     
     
         13 ) The solution of  claim 1  further comprising mineral oil.  
     
     
         14 ) A clear stable one phase solution that is non-irritating and resistant to freezing comprising: 
 a) greater than about 33% water;    b) propylene glycol;    c) 2-propanol or ethanol; and    d) hydrocortisone in an amount of from about 0.5% to about 2.0% (w/v), wherein said hydrocortisone is solubilized in said water.    
     
     
         15 ) The solution of  claim 14  further comprising chloroxylenol in an amount of between about 0.1% (w/v) and about 0.4% (w/v).  
     
     
         16 ) The solution of  claim 14  further comprising chloroxylenol in an amount of about 0.1% (w/v).  
     
     
         17 ) The solution of  claim 14  further comprising pramoxine in an amount of between about 0.5% (w/v) and about 2.0% (w/v).  
     
     
         18 ) The solution of  claim 14  further comprising pramoxine in an amount of about 1.0% (w/v).  
     
     
         19 ) The solution of  claim 14  further comprising chloroxylenol in an amount of between about 0.1% (w/v) and about 0.4% (w/v) and pramoxine in an amount of between about 0.5% (w/v) and about 2.0% (w/v).  
     
     
         20 ) The solution of  claim 14  wherein said propylene glycol is present in an amount of between about 35% (v/v) and about 65% (v/v).  
     
     
         21 ) The solution of  claim 14  wherein said ethanol or 2-propanol is present in an amount of between about 10% (v/v) and about 80% (v/v).  
     
     
         22 ) The solution of  claim 14  further comprising propylene glycol diacetate in an amount of between about 0.01% (w/v) and about 0.5% (w/v).  
     
     
         23 ) The solution of  claim 14  further comprising propylene glycol diacetate in an amount of about 0.01% (w/v).  
     
     
         24 ) The solution of  claim 14  further comprising mineral oil.

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