Porphyrin compound, albumin inclusion compound thereof and artificial oxygen carrier

Abstract

A porphyrin compound represented by general formula (A): Also disclosed are a porphyrin metal complex-albumin inclusion compound having a porphyrin compound, in which M denotes Fe or Co, included in albumin, and an artificial oxygen carrier containing the porphyrin metal complex-albumin inclusion compound as an active component.

What is claimed is:  
     
         1 . A porphyrin compound represented by general formula (A):  
       
         
           
           
               
               
           
         
       
       where R 1  denotes a C 1 -C 18  alkyloxy group, a C 1 -C 18  alkylamino group, or a peptide having 1-6 α-amino acids and having a hydroxyl group, a benzyl oxy group or a methoxy group at the C-terminal; R 2  denotes a residual group after removal of an amino group and a carboxyl group from an α-amino acid; R 3  denotes a C 1 -C 18  alkyloxy group, a C 1 -C 18  alkylamino group, or a peptide having 1-6 α-amino acids and having a hydroxyl group, a benzyloxy group or a methoxy group at the C-terminal; each R 4  and each R 5  denote either a methyl group, or a hydrogen atom, a vinyl group, an ethyl group, a 1-methoxyethyl group, a 1-bromoethyl group or a formyl group, wherein, where each R 4  denotes a methyl group, each R 5  denotes a hydrogen atom, a vinyl group, an ethyl group, a 1-methoxyethyl group, 1-bromoethyl group or a formyl group, and where each R 4  denotes a hydrogen atom, a vinyl group, an ethyl group, a 1-methoxyethyl group, a 1-bromoethyl group or a formyl group, each R 5  denotes a methyl group; M denotes two hydrogen atoms bonded to the two pyrrole nitrogen atoms or an ion of a transition metal belonging to the fourth to fifth periods in the Periodic Table; X − denotes a halogen ion that is present where M denotes the transition metal ion; and n which denotes the number of X is the number obtained by subtracting 2 from the valency of the transition metal ion.  
     
     
         2 . The porphyrin compound according to  claim 1 , wherein each R 4  denotes a hydrogen atom, a vinyl group, an ethyl group, a 1-methoxy ethyl group, a 1-bromo ethyl group or a formyl group, and each R 5  denotes a methyl group.  
     
     
         3 . The porphyrin compound according to  claim 1 , wherein each R 4  denotes a methyl group, and each R 5  denotes a vinyl group, an ethyl group, a 1-methoxy ethyl group, a 1-bromo ethyl group or a formyl group.  
     
     
         4 . The porphyrin compound according to  claim 1 , wherein M denotes Fe or Co.  
     
     
         5 . The porphyrin compound according to  claim 4 , wherein Fe is divalent or trivalent.  
     
     
         6 . The porphyrin compound according to  claim 4 , wherein Co is divalent.  
     
     
         7 . A porphyrin metal complex-albumin inclusion compound having the porphyrin compound defined in  claim 4  included in albumin.  
     
     
         8 . An artificial oxygen carrier comprising the porphyrin metal complex-albumin inclusion compound defined in  claim 7  as an active component.