Composition for keeping away vermin

Abstract

The invention describes essentially a non-therapeutical process for deterring vermin, which is based on the usage of the largely known compounds of formula (I), as defined herein before. Furthermore, it describes the corresponding vermin-deterring compositions which contain these substances as the active ingredient, compounds of formula (I) for the preparation of vermin-deterring compositions, and the use of compounds of formula (I) in the defence against vermin. Thus, the invention describes how and in which form the compounds of formula (I) or their acid addition salts are used to deter vermin from materials, places or warm-blooded animals.

What is claimed is  
     
         1 . A non-therapeutical process for deterring vermin from warm-blooded animals, whereby a compound of formula (I)  
       
         
           
           
               
               
           
         
       
       or one of its acid addition salts, wherein 
 R is hydrogen, C 1 -C 20 -alkyl or —C(O)—R 8 ; whereby R 8  is C 1 -C 20 -alkyl, C 1 -C 20 -alkoxy, unsubstituted phenyl or phenyl which is substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -haloalkoxy, halogen, cyano, hydroxyl, alkoxy, amino or nitro;  
 R 1  is hydrogen, C 1 -C 20 -alkyl, —C(O)—R 3 , —C(S)—R 4 , C(O)—O—R 5 , —C(O)—NH—R 9  or —C(S)—NH—R 7 ; whereby R 3 , R 4 , R 5 , R 6  and R 7 , independently of one another, signify C 1 -C 10 -alkyl, acetoxy, C 1 -C 10 -haloalkyl, C 1 -C 10 -alkoxy or C 1 -C 10 -haloalkoxy, or independently of one another, denote unsubstituted phenyl or phenyl which is substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -haloalkoxy, halogen, cyano, hydroxyl, C 1 -C 3 -alkoxy, amino, CHO or nitro;  
 R 2  and R 3 , independently of one another, are hydrogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -haloalkoxy, halogen, cyano, hydroxyl, amino, aryl or nitro;  
 R a  denotes hydrogen, unsubstituted C 1 -C 20 -alkyl or C 1 -C 20 -alkyl which is substituted once or many times by halogen, cyano, hydroxyl, alkoxy, nitro, phenyl, biphenyl, benzyloxy or phenoxyphenyl, whereby each phenyl, biphenyl, benzyloxy or phenoxyphenyl in turn is unsubstituted or substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -haloalkoxy, C 1 -C 3 -alkoxy, halogen, cyano, hydroxyl, amino or nitro; or it denotes C 3 -C 8 -cycloalkyl, phenyl, biphenyl, phenoxyphenyl or heterocyclyl, whereby each of these cyclic radicals is unsubstituted or substituted once or many times by C 1 -C 3 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -haloalkoxy, C 1 -C 3 -alkoxy, halogen, cyano, hydroxyl, amino, (C 1 -C 3 -alkyl) 2 N, acetyl or nitro; or it denotes C 1 -C 6 -alkylene-aryl , whereby the aryl radical is unsubstituted or substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -haloalkoxy, halogen, cyano, hydroxyl or nitro; or it denotes C 1 -C 20 -alkyl which, depending on the number of carbon atoms, is interrupted by oxygen at one or several positions; and  
 R b  signifies hydrogen, C 1 -C 20 -alkyl, heterocyclyl or aryl, whereby each of the cyclic radicals is unsubstituted or substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -haloalkoxy, C 2 -C 6 -alkenyl, halogen, cyano, hydroxyl, C 1 -C 3 -alkoxy, amino,(C 1 -C 3 -alkyl) 2 N, or nitro; is applied topically, together with a spreading additive, to the skin, the pelt or the plumage of the warm-blooded animal.  
 
     
     
         2 . Process according to  claim 1 , whereby a compound of formula (I) or one of its acid addition salts is applied, wherein 
 R is hydrogen or C 1 -C 6 alkyl;    R 1  is hydrogen, C 1 -C 6 -alkyl, —C(O)—R 3  or —C(S)—R 4 ; whereby R 3  and R 4  independently of one another, are C 1 -C 3 -alkyl, acetoxy, C 1 -C 3 -haloalkyl, or independently of one another, are unsubstituted phenyl or phenyl which is substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl or halogen;    R 2  and R 3  independently of one another, are hydrogen or C 1 -C 3 -alkyl;    R a  is hydrogen, C 5 -C 20 -alkyl, C 3 -C 8 -cycloalkyl or phenyl, whereby each of the cyclic radicals is unsubstituted or is substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy, halogen, amino, (C 1 -C 3 -alkyl) 2 N, or acetyl; and    R b  is hydrogen, unsubstituted phenyl or phenyl which is substituted once or many times by C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy, halogen, amino or (C 1 -C 3 -alkyl) 2 N; including the acid addition salts thereof.    
     
     
         3 . Process according to one of claims  1  or  2 , whereby a compound of formula (I) or one of its acid addition salts is applied, wherein R is hydrogen and the remaining substituents are defined as under formula (I).  
     
     
         4 . Process according to one of  claims 1  to  3 , whereby a compound of formula (I) or one of its acid addition salts is applied, wherein R 1  is —C(O)—R 3 , whereby R 3  represents unsubstituted phenyl or phenyl which is substituted once or many times by C 1 -C 3 -alkyl, especially methyl, ethyl or isopropyl, and the remaining substituents are defined as in formula (I).  
     
     
         5 . Process according to one of claims  1  to 4, whereby a compound of formula (I) or one of its acid addition salts is applied, wherein R 2  and R 3 , independently of each other, are hydrogen or methyl and the remaining substituents are defined as under formula (I).  
     
     
         6 . Process according to one of claims  1  to 5, whereby a compound of formula (I) or one of its acid addition salts is applied, wherein R a  is C 5 -C 20 -alkyl, benzoyloxymethyl, 2,3-dihydro-benzo(b)furryl-2, unsubstituted phenyl or phenyl which is substituted once or many times by C 1 -C 3 -alkyl, methoxy or chlorine.  
     
     
         7 . Process according to one of claims  1  to 6, whereby a compound of formula (I) or one of its acid addition salts is applied, wherein R a  is a straight-chained C 7 -C 20 -alkyl.  
     
     
         8 . Process according to  claim 1 , whereby the active ingredient employed is one of the following named substances or one of their acid addition salts. 2-[n-(1-hydroxyhexyl)]piperidine, 2-[n-(1-hydroxyheptyl)]piperidine, 2-[n-(1-hydroxyoctyl)]-piperidine, 2-[n-(1-hydroxynonyl)]piperidine, 2-[n-(1-hydroxydecyl)]piperidine, 2-[n-(1-hydroxyundecyl)]piperidine, 2-[n-(1-hydroxydodecyl)]piperidine, 2-[n-(1-hydroxytridecyl)]-piperidine, 2-[n-(1-hydroxytetradecyl)]piperidine, 2-[n-(1-hydroxypentadecyl)]piperidine, 2-[n-(1-hydroxyhexadecyl)]piperidine, 2-[n-(1-hydroxyheptadecyl)]piperidine, 2-[n-(1-hydroxy-octadecyl)]piperidine, 2-[n-(1-hydroxynonadecyl)]piperidine, 2-[n-(1-hydroxyeicosyl)]-piperidine, 2-[n-(1-hydroxyeneicosyl)]piperidine, 2-[(1-cyclopentyl)(1-hydroxy)methyl]-piperidine, 2-[(1-phenyl)(1-hydroxy)methyl]-4-tert.butyl-piperidine, 2-[(1-phenyl)(1-hydroxy)-methyl]piperidine, N-methyl-2-[(1-phenyl)(1-hydroxy)methyl]piperidine, 2-[(1-diphenyl)(1-hydroxy)methyl]piperidine, 2-[(1-phenyl)(1-[2,3-dihydrobenzo(b)furryl](1-hydroxy)-methyl]piperidine, N-methyl-2-[(1-[4-methylphenyl])(1-hydroxy)methyl]piperidine, 2-[(1-[4-methylphenyl])(1-hydroxy)methyl]piperidine, 2-[(1-[4-isopropylphenyl])(1-hydroxy)-methyl]piperidine, N-methyl-2-[(1-[4-isopropylphenyl])(1-hydroxy)methyl]piperidine, 2-[(1-[4-methoxyphenyl])(1-hydroxy)methyl]piperidine, 2-[(1-[benzyloxymethyl])(1-hydroxy)methyl]-piperidine, 2-[(1-thienyl)(1-hydroxy)methyl]piperidine, 6,6-dimethyl-2-[(1-[4-chlorphenyl])(1-hydroxy)methyl]piperidine, N-acetyl-2-[(1-hydroxy)(1-undecyl)]piperidine or N-ethoxy-carbonyl-2-[(1-hydroxy)(1-undecyl)]piperidine.  
     
     
         9 . Process according to one of claims  1  to 8, whereby the compound of formula (I) is applied in the form of a pour-on or spot-on formulation.  
     
     
         10 . Process for deterring vermin from places or materials where they are not wanted, whereby an effective amount of a compound of formula (I) according to one of claims  1  to 8 is applied to the place or to the material, at which one would like to deter the insect.  
     
     
         11 . Composition for deterring vermin, whereby it contains a compound of formula (I) according to one of  claims 1  to  8  and a spreading additive.  
     
     
         12 . Process for the preparation of a composition for deterring vermin, whereby a compound of formula (I) according to one of  claims 1  to  8  is mixed with a spreading additive.  
     
     
         13 . A compound of formula (I) selected from the group consisting of 2-[n-(1-hydroxyhexyl)]piperidine, 2-[n-(1-hydroxyheptyl)]piperidine, 2-[n-(1-hydroxyoctyl)]-piperidine, N-acetyl-2-[(1-hydroxy)(1-undecyl)]piperidine and N-ethoxycarbonyl-2-[(1-hydroxy)(1-undecyl)]piperidine.