Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade

Abstract

The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

What we claim is:  
     
         1 . A compound having the Formula (I):  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of hydrido, halo, hydroxy, hydroxyalkyl, amino, aminoalkyl, cyano, alkyl, alkenyl, haloalkyl, haloalkenyl, carboxy, carboxyalkyl, carboalkoxy, amidocarbonyl, acyl, phosphono, sulfo, O—R 6 , NH—R 6 , S—R 6 , S(O)—R 6 , and S(O) 2 —R 6 , wherein R 6  is selected from the group consisting of alkyl, alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, haloalkenyl, acyl, aroyl, and heteroaroyl;  
 B is formula (V):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N with the proviso that R 32 , R 33 , R 34 , R 35 , and R 36  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected to be Q b ;  
 R 9 , R 10, R   11 , R 12 , R 13 , R 16 , R 17 , R 18 , R 19 , R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, trialkylphosphonium, dialkylsulfoniumalkyl, carboxy, heteroaralkylthio, heteroaralkoxy, cycloalkylamino, acylalkyl, acylalkoxy, aryloylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, perhaloaralkyl, aralkylsulfonyl, aralkylsulfonylalkyl, aralkylsulfinyl, aralkylsulfinylalkyl, halocycloalkyl, halocycloalkenyl, cycloalkylsulfinyl, cycloalkylsulfinylalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl, heteroarylamino, N-heteroarylamino-N-alkylamino, heteroarylaminoalkyl, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, haloalkoxylalkyl, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, cycloalkoxyalkyl, cycloalkylalkoxy, cycloalkenyloxyalkyl, cycloalkylenedioxy, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxy, halocycloalkenyloxyalkyl, hydroxy, amino, alkoxyamino, thio, nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio, arylthioalkyl, heteroaralkoxyalkyl, alkylsulfinyl, alkylsulfinylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, heteroarylsulfinylalkyl, heteroarylsulfonylalkyl, alkylsulfonyl, alkylsulfonylalkyl, haloalkylsulfinylalkyl, haloalkylsulfonylalkyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl, heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkenyloxyalky, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkylalkanoyl, cycloalkenyl, lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl, aminoalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, atyloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboxyalkyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, arylamidocarbonylamido, carboalkoxyalkyl, carboalkoxyalkenyl, carboaralkoxy, carboxamido, carboxamidoalkyl, cyano, carbohaloalkoxy, phosphono, phosphonoalkyl, diaralkoxyphosphono, and diaralkoxyphosphonoalkyl;  
 R 32  and R 33 , R 33  and R 34 , R 34  and R 35 , and R 35  and R 36  substituent pairs are independently selected to form a spacer pair wherein a spacer pair is taken together to form a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having 5 through 8 contiguous members, a partially saturated heterocyclyl ring having 5 through 8 contiguous members, a heteroaryl ring having 5 through 6 contiguous members, and an aryl with the proviso that no more than one of the group consisting of spacer pairs R 32  and R 33 , R 33  and R 34 , R 34  and R 35 , and R 35  and R 36  are used at the same time;  
 R 9  and R 10 , R 10  and R 11 , R 11  and R 12 , and R 12  and R 13  spacer pairs are independently selected to form a spacer pair wherein a spacer pair is taken together to form a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having 5 through 8 contiguous members, a partially saturated heterocyclyl ring having 5 through 8 contiguous members, a heteroaryl ring having 5 through 6 contiguous members, and an aryl with the proviso that no more than one of the group consisting of spacer pairs R 9  and R 10 , R 10  and R 11 , R 11  and R 12 , and R 12  and R 13  is used at the same time;  
 B is formula (VI):  
                     
  wherein D 3 , D 4 , J 3 , and J 4  are independently selected from the group consisting of C, N, O, and S, no more than one of D 3 , D 4 , J 3 , and J 4  is O, no more than one of D 3 , D 4 , J 3 , and J 4  is S, and no more than three of D 1 , D 2 , J 1 , and J 2  are N with the proviso that R 32 , R 33 , R 34 , and R 35  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 B is selected from the group consisting of C3-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, C3-C8 haloalkyl, and C3-C8 haloalkenyl wherein each member of group B may be optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C4-C9 saturated heterocyclyl, and C4-C9 partially saturated heterocyclyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 10  position may be substituted with R 11 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 12  position may be substituted with R 33 , and a ring carbon or nitrogen atom four atoms from the point of attachment and adjacent to the R 11  and R 33  positions may be substituted with R 34 ;  
 A is selected from the group consisting of single covalent bond, (W 7 ) rr —(CH(R 15 )) pa  and (CH(R 15 )) pa —(W 7 ) rr  wherein rr is an integer selected from 0 through 1, pa is an integer selected from 0 through 6, and W 7  is selected from the group consisting of O, S, C(O), C(S), C(O)S, C(S)O, C(O)N(R 7 ), C(S)N(R 7 ), (R 7 )NC(O), (R 7 )NC(S), S(O), S(O) 2 , S(O) 2 N(R 7 ), (R 7 )NS(O) 2 , Se(O), Se(O) 2 , Se(O) 2 N(R 7 ), (R 7 )NSe(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), C(NR 7 )N(R 7 ), (R 7 )NC(NR 7 ), and N(R 7 ) with the proviso that no more than one of the group consisting of rr and pa are 0 at the same time;  
 R 7  and R 8  are independently selected from the group consisting of hydrido, hydroxy, alkyl, alkenyl, aryl, aralkyl, aryloxy, alkoxy, alkenyloxy, alkylthio, alkylamino, arylthio, arylamino, acyl, aroyl, heteroaroyl, aralkoxyalkyl, heteroaralkoxyalkyl, aryloxyalkyl, alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, heteroaryl, heteroaryloxy, heteroarylamino, heteroaralkyl, heteroaralkyloxy, heteroaralkylamino, and heteroaryloxyalkyl;  
 R 14 , R 15 , R 37 , R 38 , R 39 , R 40 , R 41  and R 42  are independently selected from the group consisting of hydrido, hydroxy, halo, cyano, aryloxy, amino, alkylamino, dialkylamino, hydroxyalkyl, aminoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy, trialkylsilyl, dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl, and diaralkoxyphosphonoalkyl with the proviso that R 37  and R 38  are independently selected from an acyl other than formyl;  
 R 14  and R 14 , when bonded to different carbons, are taken together to form a group selected from the group consisting of covalent bond, alkylene, haloalkylene, and a linear moiety spacer selected to form a ring selected from the group consisting of cycloalkyl ring having from 5 through 8 contiguous members, cycloalkenyl ring having from 5 through 8 contiguous members, and a heterocyclyl having from 5 through 8 contiguous members;  
 R 14  and R 15 , when bonded to different carbons, are taken together to form a group selected from the group consisting of covalent bond, alkylene, haloalkylene, and a linear moiety spacer selected to form a ring selected from the group consisting of a cycloalkyl ring having from 5 through 8 contiguous members, a cycloalkenyl ring having from 5 through 8 contiguous members, and a heterocyclyl having from 5 through 8 contiguous members;  
 R 15  and R 15 , when bonded to different carbons, are taken together to form a group selected from the group consisting of covalent bond, alkylene, haloalkylene, and a linear moiety spacer selected to form a ring selected from the group consisting of cycloalkyl ring having from 5 through 8 contiguous members, cycloalkenyl ring having from 5 through 8 contiguous members, and a heterocyclyl having from 5 through 8 contiguous members;  
 Ψ is selected from the group consisting of NR 5 , O, C(O), C(S), S, S(O), S(O) 2 , ON(R 5 ), P(O)(R 8 ), and CR 39 R 40  with the provisos that Ψ is selected from other than NR 5 , O, S, S(O), and S(O) 2  unless any two of X 0 , R 2 , R 1 , and J are other than hydrido, or that Ψ is selected from other than O, unless A is selected from other than methylene when B is phenyl, that Ψ is selected from other than C(O), unless A is selected from other than methyleneoxy when B is phenyl, or that Ψ is selected from other than NH unless A is selected from other than a single covalent bond when B is acyl, or that Ψ is selected from other than NH unless A is selected from other than S(O) or S(O) 2  when B is phenyl;  
 R 5  is selected from the group consisting of hydrido, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxy, alkoxy, alkenyloxy, alkylthio, arylthio, aralkoxyalkyl, heteroaralkoxyalkyl, aryloxyalkyl, alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, heteroaryl, heteroarylalkyl, monocarboalkoxyalkyl, monocarboalkoxy, dicarboalkoxyalkyl, monocarboxamido, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, and dialkoxyphosphonoalkyl;  
 R 39  and R 40 , when bonded to the same carbon, are taken together to form a group selected from a group consisting of oxo, thiono, R 5 —N, alkylene, haloalkylene, and a linear moiety spacer having from 2 through 7 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl ring having from 3 through 8 contiguous members, a cycloalkenyl ring having from 3 through 8 contiguous members, and a heterocyclyl ring having from 3 through 8 contiguous members;  
 X 0 , R 2  and R 1  are independently selected from the group consisting of Z 0 -Q, hydrido, alkyl, alkenyl, and halo;  
 X 0 , R 2  and R 1  are independently selected from the group consisting of amidino, guanidino, dialkylsulfonium, trialkylphosphonium, dialkylsulfoniumalkyl, heteroarylamino, amino, nitro, alkylamino, arylamino, aralkylamino, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, hydroxyhaloalkyl, cyano, and phosphono;  
 X 0  and R 1  are taken together to form a spacer pair wherein the spacer pair forms a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members and a partially saturated heterocyclyl ring having from 5 through 8 contiguous members with the proviso that no more than one of the group consisting of spacer pair X 0  and R 1  and spacer pair R 2  and R 1  is used at the same time;  
 X 0  and R 5  are taken together to form a spacer pair wherein the spacer pair forms a linear spacer moiety having from 2 through 5 contiguous atoms connecting the points of bonding of said spacer pair members to form a heterocyclyl ring having from 5 through 8 contiguous members;  
 X 0  and R 39  are taken together to form a spacer pair wherein the spacer pair forms a linear spacer moiety having from 2 through 5 contiguous atoms connecting the points of bonding of said spacer pair members to form a heterocyclyl ring having from 5 through 8 contiguous members;  
 X 0  and R 40  are taken together to form a spacer pair wherein the spacer pair forms a linear spacer moiety having from 2 through 5 contiguous atoms connecting the points of bonding of said spacer pair members to form a heterocyclyl ring having from 5 through 8 contiguous members;  
 X 0  is selected to form a linear moiety having from 2 through 5 contiguous atoms linked to the points of bonding of both R 39  and R 40  to form a heterocyclyl ring having from 5 through 8 contiguous members;  
 R 2  and R 1  are taken together to form a spacer pair wherein the spacer pair forms a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members and a partially saturated heterocyclyl ring having from 5 through 8 contiguous members with the proviso that no more than one of the group consisting of spacer pair X 0  and R 1  and spacer pair R 2  and R 1  is used at the same time;  
 X 0  and R 1  and R 2  and R 1  spacer pairs are selected independently to be —W═X—Y═Z— forming a ring selected from the group consisting of a heteroaryl ring having from 5 through 6 contiguous members and an aryl with the proviso that no more than one of the group consisting of spacer pair X 0  and R 1  and spacer pair R 2  and R 1  is used at the same time;  
 W, X, Y, and Z are independently selected from the group consisting of C(R 9 ), N, N(R 10 ), O, S and a covalent bond with the provisos that W, X, Y, and Z are independently selected to be a covalent bond when one of W, X, Y, and Z is selected from the group consisting of O and S, no more than one of W, X, Y, and Z is selected from the group consisting of O and S, no more than three of W, X, Y, and Z are selected from the group consisting of N and N(R 10 ), and C(R 9 ), N, N(R 10 ), O, and S are independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, the divalent nature of oxygen, and the aromaticity of the ring;  
 R 2  and R 4a , R 2  and R 4b , R 2  and R 14 , and R 2  and R 15  spacer pairs are independently selected to form spacer pairs wherein a spacer pair is taken together to form a linear moiety having from 2 through 5 contiguous atoms connecting the points of bonding of said spacer pair members to form a heterocyclyl ring having from 5 through 8 contiguous members with the proviso that no more than one of the group of spacer pairs consisting of R 2  and R 4a , R 2  and R 4b , R 2  and R 14 , and R 2  and R 15  is used at the same time;  
 R 2  is independently selected to form a linear moiety having from 2 through 5 contiguous atoms linked to the points of bonding of both R 4a  and R 4b  to form a heterocyclyl ring having from 5 through 8 contiguous members;  
 Z 0  is selected from the group consisting of covalent single bond, (CR 41 R 42 ) q  wherein q is an integer selected from 1 through 6, (CH(R 41 )) g —W 0 —(CH(R 42 )) p  wherein g and p are integers independently selected from 0 through 3 and W 0  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 41 ), (R 41 )NC(O), C(S)N(R 41 ), (R 41 )NC(S), OC(O)N(R 41 ), (R 41 )NC(O)O, SC(S)N(R 41 ), (R 41 )NC(S)S, SC(O)N(R 41 ), (R 41 )NC(O)S, OC(S)N(R 41 ), (R 41 )NC(S)O, N(R 42 )C(O)N(R 41 ), (R 41 )NC(O)N(R 42 ), N(R 42 )C(S)N(R 41 ), (R 41 )NC(S)N(R 41 ), S(O), S(O) 2 , S(O) 2 N(R 41 ), N(R 41 )S(O) 2 , Se, Se(O), Se(O) 2 , Se(O) 2 N(R 41 ), N(R 41 )Se(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 )N(R 41 ), ON(R 41 ), and SiR 28 R 29 , and (CH(R 41 )) e —W 2 —(CH(R 42 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 41 ═CR 42 , CR 41 R 42 ═C; vinylidene), and ethynylidene (C≡C; 1,2-ethynyl), with the provisos that R 41  and R 42  are selected from other than halo and cyano when directly bonded to N and Z 0  is directly bonded to the benzene ring, that W 0  is selected, wherein g is 0, from other than NHS(O) 2 CH 2 aryl or N(R 41 ) unless R 41  is selected from other than hydrido, alkyl, or aralkylsulfonyl, and Z 0  is selected from other than OC(O), C(O)N(H), and (H)NC(O), unless Q is selected from other than phenyl, 2-furyl, 2-thienyl, 4-thiazolyl, 2-pyridyl, 2-naphthyl, 1,2-dihydrobenzofuran-5-yl, 1,2-dihydrobenzofuran-6-yl, or 1,2-benzisoxazol-6-yl , or X 0  is selected from other than hydrido, halo, or methyl, or R 1  is selected from other than hydrido, fluoro, hydroxy, acetoxy, propanoyloxy, 2-carboxyacetoxy, 2,3 or 4-carboxypropanoyloxy, benzoyloxy, methyl, or methoxy;  
 R 28  and R 29  are independently selected from the group consisting of hydrido, hydroxyalkyl, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, acyl, aroyl, aralkanoyl, heteroaroyl, aralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, cyanoalkyl, dicyanoalkyl, carboxamidoalkyl, dicarboxamidoalkyl, cyanocarboalkoxyalkyl, carboalkoxyalkyl, dicarboalkoxyalkyl, cyanocycloalkyl, dicyanocycloalkyl, carboxamidocycloalkyl, dicarboxamidocycloalkyl, carboalkoxycyanocycloalkyl, carboalkoxycycloalkyl, dicarboalkoxycycloalkyl, formylalkyl, acylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, aralkylsulfinyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxy, dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl and diaralkoxyphosphonoalkyl;  
 R 28  and R 29  are taken together to form a linear moiety spacer having from 2 through 7 contiguous atoms and forming a ring selected from the group consisting of a cycloalkyl ring having from 3 through 8 contiguous members, a cycloalkenyl ring having from 3 through 8 contiguous members, and a heterocyclyl ring having from 3 through 8 contiguous members;  
 Q is formula (II):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N, with the proviso that R 9  R 10 , R 11 , R 12 , and R 13  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 Q is formula (III):  
                     
  wherein D 3 , D 4 , J 3 , and J 4  are independently selected from the group consisting of C, N, O, and S, no more than one of D 3 , D 4 , J 3 , and J 4  is O, no more than one of D 3 , D 4 , J 3 , and J 4  is S, and no more than three of D 1 , D 2 , J 1 , and J 2  are N with the proviso that R 9 , R 10 , R 11 , and R 12  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 Q is selected from the group consisting of alkyl, alkoxy, alkylamino, alkylthio, haloalkylthio, alkenyl, alkynyl, saturated heterocyclyl, partially saturated heterocyclyl, acyl, aroyl, heteroaroyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, cycloalkylalkenyl, haloalkyl, haloalkoxy, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxyalkyl, and halocycloalkenyloxyalkyl with the proviso that Q is selected from other than than alkyl or alkenyl unless any one of X 0 , R 1 , and J are other than hydrido;  
 K is (CR 4a R 4b ) n  wherein n is an integer selected from 1 through 4;  
 R 4a  and R 4b  are independently selected from the group consisting of halo, hydrido, hydroxy, cyano, hydroxyalkyl, alkyl, alkenyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, aralkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkenyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, cyanoalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, haloalkylsulfinyl, arylsulfinylalkyl, arylsulfonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, and aralkylsulfonylalkyl;  
 R 4a  and R 4b , when bonded to the same carbon, are taken together to form a group selected from the group consisting of oxo, thiono, and a linear spacer moiety having from 2 through 7 contiguous atoms connected to form a ring selected from the group consisting of a cycloalkyl ring having 3 through 8 contiguous members, a cycloalkenyl ring having 5 through 8 contiguous members, and a heterocyclyl ring having 5 through 8 contiguous members;  
 E 0  is E 1 , when K is (CR 4a R 4b ) n , wherein E 1  is selected from the group consisting of a covalent single bond, O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), OC(O)N(R 7 ), (R 7 )NC(O)O, SC(S)N(R 7 ), (R 7 )NC(S)S, SC(O)N(R 7 ), (R 7 )NC(O)S, OC(S)N(R 7 ), (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , S(O) 2 N(R 7 )C(O), C(O)N(R 7 )S(O) 2 , Se, Se(O), Se(O) 2 , Se(O) 2 N(R 7 ), N(R 7 )Se(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 8 ), N(R 7 ), ON(R 7 ), SiR 28 R 29 , CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b ;  
 K is (CH(R 14 )) j -T wherein j is selected from a integer from 0 through 3 and T is selected from the group consisting of single covalent bond, O, S, and N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 E 0  is E 2 , when K is (CH(R 14 )) j -T, wherein E 2  is selected from the group consisting of a covalent single bond, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), (R 7 )NC(O)O, (R 7 )NC(S)S, (R 7 )NC(O)S, (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , S(O) 2 N(H)C(O), C(O)N(H)S(O) 2 , Se(O), Se(O) 2 , Se(O) 2 N(R 7 ), N(R 7 )Se(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), and N(R 7 );  
 K is G-(CH(R 15 )) k  wherein k is selected from an integer from 1 through 3 and G is selected from the group consisting of O, S, and N(R 7 ) with the proviso that R 15  is other than hydroxy, cyano, halo, amino, alkylamino, dialkylamino, and sulfhydryl when k is 1;  
 E 0  is E 3  when K is G-(CH(R 15 )) k  wherein E 3  is selected from the group consisting of a covalent single bond, O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), OC(O)N(R 7 ), (R 7 )NC(O)O, SC(S)N(R 7 ), (R 7 )NC(S)S, SC(O)N(R 7 ), (R 7 )NC(O)S, OC(S)N(R 7 ), (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , Se, Se(O), Se(O) 2 , Se(O) 2 N(R 7 ), N(R 7 )Se(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 7 ), ON(R 7 ), SiR 28 R 29 , CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b ;  
 Y 0  is formula (IV):  
                     
  wherein D 5 , D 6 , J 5 , and J 6  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, K 2  is independently selected from the group consisting of C, and N + , no more than one of D 5 , D 6 , J 5 , and J 6  is O, no more than one of D 5 , D 6 , J 5 , and J 6  is S, one of D 5 , D 6 , J 5 , and J 6  must be a covalent bond when two of D 5 , D 6 , J 5 , and J 6  are O and S, no more than three of D 5 , D 6 , J 5 , and J 6  are N when K 2  is N + , and no more than four of D 5 , D 6 , J 5 , and J 6  are N when K 2  is carbon with the provisos that R 16 , R 17 , R 18 , and R 19  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 R 16  and R 17  are independently taken together to form a linear moiety. spacer having from 3 through 6 contiguous atoms connected to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members, a partially saturated heterocyclyl ring having from 5 through 8 contiguous members, a heteroaryl having from 5 through 6 contiguous members, and an aryl;  
 R 18  and R 19  are independently taken together to form a linear moiety spacer having from 3 through 6 contiguous atoms connected to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members, a partially saturated heterocyclyl ring having from 5 through 8 contiguous members, a heteroaryl having from 5 through 6 contiguous members, and an aryl;  
 Q b  is selected from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , oxy, alkyl, alkylaminoalkyl, aminoalkyl, dialkylsulfoniumalkyl, and acylamino wherein R 20 , R 21 , and R 22  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, alkoxy, alkylamino, amino, and dialkylamino and that R 20 , R 21 , and R 22  must be other than be hydroxy, alkoxy, alkylamino, amino, and dialkylamino when K 2  is N + ;  
 R 20  and R 21 , R 20  and R 22 , and R 21  and R 22  pairs are independently selected to form a spacer pair wherein a spacer pair is taken together to form a linear moiety having from 4-through 7 contiguous atoms connecting the points of bonding of said spacer pair members to form a heterocyclyl ring having 5 through 8 contiguous members with the proviso that no more than one of the group consisting of spacer pairs R 20  and R 21 , R 20  and R 22 , and R 21  and R 22  is used at the same time;  
 Q b  is selected from the group consisting of N(R 26 )SO 2 N(R 23 )(R 24 ), N(R 26 )C(O)OR 5 , N(R 26 )C(O)SR 5 , N(R 26 )C(S)OR 5  and N(R 26 )C(S)SR 5  with the proviso that no more than one of R 23 , R 24 , and R 26  are hydroxy, alkoxy, alkylamino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom;  
 Q b  is selected from the group consisting of dialkylsulfonium, trialkylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 R 23 )(R 24 ), N(R 26 )C(O)N(R 23 )(R 24 ), N(R 26 )C(S)N(R 23 )(R 24 )C(NR 25 )OR 5 , C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(S)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(NR 25 )SR 5 , C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkyl amino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl;  
 R 23  and R 24  are taken together to form a linear spacer moiety having from 4 through 7 contiguous atoms connecting the points of bonding to form a heterocyclyl ring having 5 through 8 contiguous members;  
 R 23  and R 25 , R 24  and R 25 , R 25  and R 26 , R 24  and R 26 , and R 23  and R 26  pairs are independently selected to form a spacer pair wherein a spacer pair is taken together from the points of bonding of selected spacer pair members to form the group L—U—V wherein L, U, and V are independently selected from the group consisting of O, S, C(O), C(S), C(J H ) 2  S(O), SO 2 , OP(OR 31 )R 30 , P(O)R 30 , P(S)R 30 , C(R 30 )R 31 , C═C(R 30 )R 31 , (O) 2 POP(O) 2 , R 30 (O)POP(O)R 30 , Si(R 29 )R 28 , Si(R 29 )R 28 Si(R 29 )R 28 , Si(R 29 )R 28 OSi(R 29 )R 28 , (R 28 )R 29 COC(R 28 )R 29 , (R 28 )R 29 CSC(R 28 )R 29 , C(O)C(R 30 )═C(R 31 ), C(S)C(R 30 )═C(R 31 ), S(O)C(R 30 )═C(R 31 ), SO 2 C(R 30 )═C(R 31 ), PR 30 C(R 30 )═C(R 31 ), P(O)R 30 C(R 30 )═C(R 31 ), P(S)R 30 C(R 30 )═C(R 31 ), DC(R 30 )(R 31 )D, OP(OR 31 )R 30 , P(O)R 30 , P(S)R 30 , Si(R 28 )R 29  and N(R 30 ), and a covalent bond with the proviso that no more than any two of L, U and V are simultaneously covalent bonds and the heterocyclyl comprised of by L, U, and V has from 5 through 10 contiguous member;  
 D is selected from the group consisting of oxygen, C═O, C═S, S(O) m  wherein m is an integer selected from 0 through 2;  
 J H  is independently selected from the group consisting of OR 27 , SR 27  and N(R 20 )R 21 ;  
 R 27  is selected from the group consisting of hydrido, alkyl, alkenyl, alkynyl, aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, arylsulfinylalkyl, arylsulfonylalkyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl and aralkylsulfonylalkyl;  
 R 30  and R 31  are independently selected from hydrido, hydroxy, thiol, aryloxy, amino, alkylamino, dialkylamino, hydroxyalkyl, heteroaryloxyalkyl, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, haloaralkylsulfinylalkyl, aralkylsulfonylalkyl, cyanoalkyl, dicyanoalkyl, carboxamidoalkyl, dicarboxamidoalkyl, cyanocarboalkoxyalkyl, carboalkoxyalkyl, dicarboalkoxyalkyl, cyanocycloalkyl, dicyanocycloalkyl, carboxamidocycloalkyl, dicarboxamidocycloalkyl, carboalkoxycyanocycloalkyl, carboalkoxycycloalkyl, dicarboalkoxycycloalkyl, formylalkyl, acylalkyl, dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl, phosphonoalkyl, dialkoxyphosphonoalkoxy, diaralkoxyphosphonoalkoxy, phosphonoalkoxy, dialkoxyphosphonoalkylamino, diaralkoxyphosphonoalkylamino, phosphonoalkylamino, dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl, sulfonylalkyl, alkoxysulfonylalkyl, aralkoxysulfonylalkyl, alkoxysulfonylalkoxy, aralkoxysulfonylalkoxy, sulfonylalkoxy, alkoxysulfonylalkylamino, aralkoxysulfonylalkylamino, and sulfonylalkylamino;  
 R 30  and R 31  are taken to form a linear moiety spacer group having from 2 through 7 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl ring having from 3 through 8 contiguous members, a cycloalkenyl ring having from 3 through 8 contiguous members, and a heterocyclyl ring having from 3 through 8 contiguous members;  
 R 23  and R 25 , R 24  and R 25 , R 25  and R 26 , R 24  and R 26 , and R 23  and R 26  pairs are independently selected to form a spacer pair wherein a spacer pair is taken together from the points of bonding of selected spacer pair members to form the group L—U—V wherein L, U, and V are independently selected from the group of 1,2-disubstituted radicals consisting of a cycloalkyl radical, a cycloalkenyl radical wherein cycloalkyl and cycloalkenyl radicals are substituted with one or more groups selected from R 30  and R 31 , an aryl radical, an heteroaryl radical, a saturated heterocyclic radical and a partially saturated heterocyclic radical wherein said 1,2-substitutents are independently selected from C═O, C═S, C(R 28 )R 32 , S(O), S(O) 2 , OP(OR 31 )R 30 , P(O)R 30 , P(S)R 30  and Si(R 28 )R 29 ;  
 R 23  and R 25 , R 24  and R 25 , R 25  and R 26 , R 24  and R 26 , and R 23  and R 26  pairs are independently selected to form a spacer pair wherein a spacer pair is taken together from the points of bonding of selected spacer pair members to form the group L-U-V wherein L, U, and V are independently selected from the group of radicals consisting of 1,2-disubstituted alkylene radicals and 1,2-disubstituted alkenylene radical wherein said 1,2-substitutents are independently selected from C═O, C═S, C(R 28 )R 29 , S(O), S(O) 2 , OP(OR 31 )R 30 , P(O)R 30 , P(S)R 30 , and Si(R 28 )R 29  and said alkylene and alkenylene radical are substituted with one or more R 30  or R 31  substituents;  
 Q s  is selected from the group consisting of a single covalent bond, (CR 37 R 38 ) b —(W 0 ) az  wherein az is an integer selected from 0 through 1, b is an integer selected from 1 through 4, and W 0  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), SC(S)N(R 14 ), SC(O)N(R 14 ), OC(S)N(R 14 ), N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ), N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , Se, Se(O), Se(O) 2 , Se(O) 2 N(R 17 ), N(R 14 )Se(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 14 ), ON(R 14 ), and SiR 28 R 29 , (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 4, and W 1  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), (R 14 )NC(O)O, SC(S)N(R 14 ), (R 14 )NC(S)S, SC(O)N(R 14 ), (R 14 )NC(O)S, OC(S)N(R 14 ), (R 14 )NC(S)O, N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ), N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , Se, Se(O), Se(O) 2 , Se(O) 2 N(R 14 ), N(R 14 )Se(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 14 ), ON(R 14 ) SiR 28 R 29 , and (CH(R 14 )) e —W 2 —(CH(R 15 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b  with the provisos that R 14  and R 15  are selected from other than halo and cyano when directly bonded to N and that (CR 37 R 38 ) b , (CH(R 14 )) c , (CH(R 14 )) e  and are bonded to E 0 ;  
 R 37  and R 37 , when bonded to different carbons, are taken together to form a linear moiety spacer having from 1 through 7 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl ring having from 3 through 8 contiguous members, a cycloalkenyl ring having from 3 through 8 contiguous members, and a heterocyclyl ring having from 3 through 8 contiguous members;  
 R 37  and R 38 , when bonded to different carbons, are taken together to form a linear moiety spacer having from 1 through 7 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl ring having from 3 through 8 contiguous members, a cycloalkenyl ring having from 3 through 8 contiguous members, and a heterocyclyl ring having from 3 through 8 contiguous members;  
 R 38  and R 38 , when bonded to different carbons, are taken together to form a linear moiety spacer having from 1 through 7 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl ring having from 3 through 8 contiguous members, a cycloalkenyl ring having from 3 through 8 contiguous members, and a heterocyclyl ring having from 3 through 8 contiguous members;  
 R 37  and R 38 , when bonded to the same carbon, are taken together to form a group selected from a group consisting of oxo, thiono, alkylene, haloalkylene, and a linear moiety spacer having from 2 through 7 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl ring having from 3 through 8 contiguous members, a cycloalkenyl ring having from 3 through 8 contiguous members, and a heterocyclyl ring having from 3 through 8 contiguous members;  
 Y 0  is Q b -Q ss  wherein Q ss  is selected from the group consisting of (CR 37 R 38 ) f  wherein f is an integer selected from 1 through 6, (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 4, and W 1  is selected from the group consisting of W 1  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), (R 14 )NC(O)O, SC(S)N(R 14 ), (R 14 )NC(S)S, SC(O)N(R 14 ), (R 14 )NC(O)S, OC(S)N(R 14 ), (R 14 )NC(S)O, N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ) N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , Se, Se(O), Se(O) 2 , Se(O) 2 N(R 14 ), N(R 14 )Se(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 14 ), ON(R 14 ), SiR 28 R 29 , and (CH(R 14 )) e —W 2 —(CH(R 15 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b  with the provisos that R 14  and R 15  are selected from other than halo and cyano when directly bonded to N and that (CR 37 R 38 ) f , (CH(R 15 )) c , and (CH(R 15 )) e  are bonded to E 0 ;  
 Y 0  is Q b -Q sss  wherein Q sss  is (CH(R 38 )) r —W 3 , r is an integer selected from 1 through 3, and W 3  is selected from the group consisting of 1,1-cyclopropyl, 1,2-cyclopropyl, 1,1-cyclobutyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,4-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,5-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 1,4-piperazinyl, 2,3-piperazinyl, 2,5-piperazinyl, 2,6-piperazinyl, 1,2-pipcidinyl, 1,3-piperidinyl, 1,4-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,5-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 3,5-piperidinyl, 3,6-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2H-2,3-pyranyl, 2H-2,4-pyranyl, 2H-2,5-pyranyl, 4H-2,3-pyranyl, 4H-2,4-pyranyl, 4H-2,5-pyranyl, 2H-pyran-2-one-3,4-yl, 2H-pyran-2-one-4,5-yl, 4H-pyran-4-one-2,3-yl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, 3,4-tetrahydrofuranyl, 2,3-tetrahydropyranyl, 2,4-tetrahydropyranyl, 2,5-tetrahydropyranyl, 2,6-tetrahydropyranyl, 3,4-tetrahydropyranyl, and 3,5-tetrahydropyranyl with the proviso that (CH(R 38 )) r  is bonded to E 0  and Q b  is bonded to lowest numbered substituent position of each W 3 ;  
 Y 0  is Q b -Q sssr  wherein Q sssr  is (CH(R 38 )) r —W 4 , r is an integer selected from 1 through 3, and W 4  is selected from the group consisting of 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,4-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,5-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 1,4-piperazinyl, 2,3-piperazinyl, 2,5-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 1,4-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,5-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 3,5-piperidinyl, 3,6-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2H-2,3-pyranyl, 2H-2,4-pyranyl, 2H-2,5-pyranyl, 4H-2,3-pyranyl, 4H-2,4-pyranyl, 4H-2,5-pyranyl, 2H-pyran-2-one-3,4-yl, 2H-pyran-2-one-4,5-yl, 4H-pyran-4-one-2,3-yl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, 3,4-tetrahydrofuranyl, 2,3-tetrahydropyranyl, 2,4-tetrahydropyranyl, 2,5-tetrahydropyranyl, 2,6-tetrahydropyranyl, 3,4-tetrahydropyranyl, and 3,5-tetrahydropyranyl with the provisos that (CH(R 38 )) r  is bonded to E 0  and Q b  is bonded to highest number substituent position of each W 4 ;  
 Y 0  is Q b -Q ssss  wherein Q ssss  is (CH(R 38 )) r —W 5 , r is an integer selected from 1 through 3, and W 5  is selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to lowest number substituent position of each W 5  and that (CH(R 38 )) r  is bonded to E 0 ;  
 Y 0  is Q b -Q ssssr  wherein Q ssssr  is (CH(R 38 )) r —W 6 , r is an integer selected from 1 through 3, and W 6  is selected from the group consisting of 1,4-indenyl, 1-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to highest number substituent position of each W 6  and that (CH(R 38 )) r  is bonded to E 0 .  
 
     
     
         2 . The compound as recited in  claim 1  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of hydrido, halo, hydroxy, hydroxyalkyl, amino, aminoalkyl, cyano, alkyl, haloalkyl, carboxy, carboxyalkyl, carboalkoxy, amidocarbonyl, acyl, phosphono, sulfo, O—R 6 , NH—R 6 , S—R 6 , S(O)—R 6 , and S(O) 2 —R 6 , wherein R 6  is selected from the group consisting of alkyl, and haloalkyl, haloalkenyl;  
 B is formula (V):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N with the proviso that R 32 , R 33 , R 34 , R 35 , and R 36  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected to be Q b ;  
 R 9 , R 10 , R 11 , R 12 , R 13 , R 16 , R 17 , R 18 , R 19 , R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, trialkylphosphonium, dialkylsulfoniumalkyl, carboxy, heteroaralkylthio, heteroaralkoxy, cycloalkylamino, acylalkyl, acylalkoxy, aryloylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, perhaloaralkyl, aralkylsulfonyl, aralkylsulfonylalkyl, aralkylsulfinyl, aralkylsulfinylalkyl, halocycloalkyl, halocycloalkenyl, cycloalkylsulfinyl, cycloalkylsulfinylalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl, heteroarylamino, N-heteroarylamino-N-alkylamino, heteroarylaminoalkyl, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, haloalkoxylalkyl, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, cycloalkoxyalkyl, cycloalkylalkoxy, cycloalkenyloxyalkyl, cycloalkylenedioxy, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxy, halocycloalkenyloxyalkyl, hydroxy, amino, alkoxyamino, thio, nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio, arylthioalkyl, heteroaralkoxyalkyl, alkylsulfinyl, alkylsulfinylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, heteroarylsulfinylalkyl, heteroarylsulfonylalkyl, alkylsulfonyl, alkylsulfonylalkyl, haloalkylsulfinylalkyl, haloalkylsulfonylalkyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl, heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkenyloxyalky, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkylalkanoyl, cycloalkenyl, lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl, aminoalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboxyalkyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, arylamidocarbonylamido, carboalkoxyalkyl, carboalkoxyalkenyl, carboaralkoxy, carboxamido, carboxamidoalkyl, cyano, carbohaloalkoxy, phosphono, phosphonoalkyl, diaralkoxyphosphono, and diaralkoxyphosphonoalkyl;  
 R 32  and R 33 , R 33  and R 34 , R 34  and R 35 , and R 35  and R 36  pairs are independently selected to form a spacer pair wherein a spacer pair is taken together to form a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having 5 through 8 contiguous members, a partially saturated heterocyclyl ring having 5 through 8 contiguous members, a heteroaryl ring having 5 through 6 contiguous members, and an aryl with the proviso that no more than one of the group consisting of spacer pairs R 32  and R 33 , R 33  and R 34 , R 34  and R 35 , and R 35  and R 36  is used at the same time;  
 R 9  and R 10 , R 10  and R 11 , R 11  and R 12 , and R 12  and R 13  pairs are independently selected to form a spacer pair wherein a spacer pair is taken together to form a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having 5 through 8 contiguous members, a partially saturated heterocyclyl ring having 5 through 8 contiguous members, a heteroaryl ring having 5 through 6 contiguous members, and an aryl with the proviso that no more than one of the group consisting of spacer pairs R 9  and R 10 , R 10  and R 11 , R 11  and R 12 , and R 12  and R 13  is used at the same time;  
 B is selected from the group consisting of C3-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, C3-C8 haloalkyl, and C3-C8 haloalkenyl wherein each member of group B may be optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C4-C9 saturated heterocyclyl, and C4-C9 partially saturated heterocyclyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 10  position may be substituted with R 11 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 12  position may be substituted with R 33 , and a ring carbon or nitrogen atom four atoms from the point of attachment and adjacent to the R 11  and R 33  positions may be substituted with R 34 ;  
 A is selected from the group consisting of single covalent bond, (W 7 ) rr —(CH(R 15 )) pa  and (CH(R 15 )) pa —(W 7 ) rr  wherein rr is an integer selected from 0 through 1, pa is an integer selected from 0 through 6, and W 7  is selected from the group consisting of O, S, C(O), C(S), C(O)S, C(S)O, C(O)N(R 7 ), C(S)N(R 7 ), (R 7 )NC(O), (R 7 )NC(S), S(O), S(O) 2 , S(O) 2 N(R 7 ), (R 7 )NS(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), C(NR 7 )N(R 7 ), (R 7 )NC(NR 7 ), and N(R 7 ) with the proviso that no more than one of the group consisting of rr and pa is 0 at the same time;  
 R 7  and R 8  are independently selected from the group consisting of hydrido, hydroxy, alkyl, acyl, aroyl, heteroaroyl, and alkoxyalkyl;  
 R 14 , R 15 , R 37 , and R 38  are independently selected from the group consisting of hydrido, hydroxy, halo, cyano, hydroxyalkyl, alkoxy, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide, and carboxamidoalkyl;  
 Ψ is selected from the group consisting of NR 5 , O, C(O), C(S), S, S(O), S(O) 2 , ON(R 5 ), P(O)(R 8 ), and CR 39 R 40  with the provisos that Ψ is selected from other than NR 5 , O, S, S(O), and S(O) 2  unless any two of X 0 , R 2 , R 1 , and J are other than hydrido, or that Ψ is selected from other than O, unless A is selected from other than methylene when B is phenyl, that Ψ is selected from other than C(O), unless A is selected from other than methyleneoxy when B is phenyl, or that Ψ is selected from other than NH unless A is selected from other than a single covalent bond when B is acyl, or that Ψ is selected from other than NH unless A is selected from other than S(O) or S(O) 2  when B is phenyl;  
 R 5  is selected from the group consisting of hydrido, alkyl, alkoxy, alkoxyalkyl, haloalkyl, acyl, aroyl, and heteroaroyl;  
 R 39  and R 40  are independently selected from the group consisting of hydrido, hydroxy, halo, cyano, hydroxyalkyl, acyl, aroyl, heteroaroyl, acylamido, alkoxy, alkyl, alkoxyalkyl, haloalkyl, haloalkoxy, haloalkoxyalkyl, alkylsulfonyl, haloalkylsulfonyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide, and carboxamidoalkyl;  
 X 0 , R 2  and R 1  are independently selected from the group consisting of Z 0 -Q, hydrido, alkyl, alkenyl, and halo;  
 X 0 , R 2  and R 1  are independently selected from the group consisting of amidino, guanidino, dialkylsulfonium, trialkylphosphonium, dialkylsulfoniumalkyl, heteroarylamino, amino, nitro, alkylamino, arylamino, aralkylamino, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, hydroxyhaloalkyl, cyano, and phosphono;  
 X 0  and R 1  are taken together to form a spacer pair wherein the spacer pair forms a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members and a partially saturated heterocyclyl ring having from 5 through 8 contiguous members with the proviso that no more than one of the group consisting of spacer pair X 0  and R 1  and spacer pair R 2  and R 1  is used at the same time;  
 R 2  and R 1  are taken together to form a spacer pair wherein the spacer pair forms a linear moiety having from 3 through 6 contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members and a partially saturated heterocyclyl ring having from 5 through 8 contiguous members with the proviso that no more than one of the group consisting of spacer pair X 0  and R 1  and spacer pair R 2  and R 1  is used at the same time;  
 X 0  and R 1  and R 2  and R 1  spacer pairs are selected independently to be —W═X—Y═Z— forming a ring selected from the group consisting of a heteroaryl ring having from 5 through 6 contiguous members and an aryl with the proviso that no more than one of the group consisting of spacer pair X 0  and R 1  and spacer pair R 2  and R 1  is used at the same time;  
 W, X, Y, and Z are independently selected from the group consisting of C(R 9 ), N, N(R 10 ), O, S and a covalent bond with the provisos that one of W, X, Y, and Z is independently selected to be a covalent bond when one of W, X, Y, and Z is selected from the group consisting of O and S, no more than one of W, X, Y, and Z is selected from the group consisting of O and S, no more than three of W, X, Y, and Z are selected from the group consisting of N and N(R 10 ), and C(R 9 ), N, N(R 10 ), O, and S are independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, the divalent nature of oxygen, and the aromaticity of the ring;  
 Z 0  is selected from the group consisting of covalent single bond, (CR 41 R 42 ) q  wherein q is an integer selected from 1 through 6, (CH(R 41 )) g —W 0 —(CH(R 42 )) p  wherein g and p are integers independently selected from O through 3 and W 0  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 41 ), (R 41 )NC(O), C(S)N(R 41 ), (R 41 )NC(S), OC(O)N(R 41 ), (R 41 )NC(O)O, SC(S)N(R 41 ), (R 41 )NC(S)S, SC(O)N(R 41 ), (R 41 )NC(O)S, OC(S)N(R 41 ), (R 41 )NC(S)O, N(R 42 )C(O)N(R 41 ), (R 41 )NC(O)N(R 42 ), N(R 42 )C(S)N(R 41 ), (R 41 )NC(S)N(R 42 ), S(O), S(O) 2 , S(O) 2 N(R 41 ), N(R 41 )S(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 41 ), ON(R 41 ), and (CH(R 41 )) e —W 2 —(CH(R 42 )) h  wherein e and h are integers independently selected from O through 2 and W 2  is selected from the group consisting of CR 41 ═CR 42 , CR 41 R 42 ═C; vinylidene), and ethynylidene (C≡C; 1,2-ethynyl), with the provisos that R 41  and R 42  are selected from other than halo and cyano when directly bonded to N and Z 0  is directly bonded to the benzene ring, that W 0  is selected, wherein g is 0, from other than NHS(O) 2 CH 2 aryl or N(R 41 ) unless R 41  is selected from other than hydrido, alkyl, or aralkylsulfonyl, and Z 0  is selected from other than OC(O), C(O)N(H), and (H)NC(O), unless Q is selected from other than phenyl, 2-furyl, 2-thienyl, 4-thiazolyl, 2-pyridyl, 2-naphthyl, 1,2-dihydrobenzofuran-5-yl, 1,2-dihydrobenzofuran-6-yl, or 1,2benzisoxazol-6-yl , or X 0  is selected from other than hydrido, halo, or methyl, or R 1  is selected from other than hydrido, fluoro, hydroxy, acetoxy, propanoyloxy, 2-carboxyacetoxy, 2,3 or 4-carboxypropanoyloxy, benzoyloxy, methyl, or methoxy;  
 R 41  and R 42  are independently selected from the group consisting of hydrido, hydroxy, halo, cyano, aryloxy, hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, alkoxy, alkyl, aryl, aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkoxyalkyl, heteroaryloxyalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl, heteroaryl, heteroaralkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, alkylsulfonyl, haloalkylsulfonyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfonyl, cycloalkylsulfonyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfonyl, and aralkylsulfonylalkyl;  
 Q is formula (II):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N, with the proviso that R 9 , R 10 , R 11 , R 12 , and R 13  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 Q is formula (III):  
                     
  wherein D 3 , D 4 , J 3 , and J 4  are independently selected from the group consisting of C, N, O, and S, no more than one of D 3 , D 4 , J 3 , and J 4  is O, no more than one of D 3 , D 4 , J 3 , and J 4  is S, and no more than three of D 1 , D 2 , J 1 , and J 2  are N with the proviso that R 9 , R 10 , R 11 , and R 12  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 Q is selected from the group consisting of alkyl, alkoxy, alkylamino, alkylthio, haloalkylthio, alkenyl, alkynyl, saturated heterocyclyl, partially saturated heterocyclyl, acyl, aroyl, heteroaroyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, cycloalkylalkenyl, haloalkyl, haloalkoxy, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxyalkyl, and halocycloalkenyloxyalkyl with the proviso that Q is selected from other than than alkyl or alkenyl unless any one of X 0 , R 1  and J is other than hydrido;  
 K is (CR 4a R 4b ) n  wherein n is an integer selected from 1 through 2;  
 R 4a  and R 4b  are independently selected from the group consisting of halo, hydrido, hydroxy, cyano, hydroxyalkyl, alkyl, alkenyl, alkoxyalkyl, haloalkyl, haloalkenyl, and cyanoalkyl;  
 R 4a  and R 4b , when bonded to the same carbon, are taken together to form a group selected from the group consisting of oxo, and a linear spacer moiety having from 2 through 7 contiguous atoms connected to form a ring selected from the group consisting of a cycloalkyl ring having 3 through 8 contiguous members, a cycloalkenyl ring having 5 through 8 contiguous members, and a heterocyclyl ring having 5 through 8 contiguous members;  
 E 0  is E 1 , when K is (CR 4a R 4b ) n , wherein E 1  is selected from the group consisting of a covalent single bond, O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), OC(O)N(R 7 ), (R 7 )NC(O)O, SC(S)N(R 7 ), (R 7 )NC(S)S, SC(O)N(R 7 ), (R 7 )NC(O)S, OC(S)N(R), (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , S(O) 2 N(R 7 )C(O), C(O)N(R 7 )S(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 7 ), ON(R 7 ), CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b ;  
 K is (CH(R 14 )) j -T wherein j is selected from a integer from 0 through 2 and T is selected from the group consisting of single covalent bond, O, S, and N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 E 0  is E 2 , when K is (CH(R 14 )) j -T, wherein E 2  is selected from the group consisting of a covalent single bond, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), (R 7 )NC(O)O, (R 7 )NC(S)S, (R 7 )NC(O)S, (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , S(O) 2 N(H)C(O), C(O)N(H)S(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), and N(R 7 );  
 K is G-(CH(R 15 )) k  wherein k is selected from an integer from 1 through 2 and G is selected from the group consisting of O, S, and N(R 7 ) with the proviso that R 15  is other than hydroxy, cyano, halo, amino, alkylamino, dialkylamino, and sulfhydryl when k is 1;  
 E 0  is E 3 , when K is G-(CH(R 15 )) k , wherein E 3  is selected from the group consisting of a covalent single bond, O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), OC(O)N(R 7 ), (R 7 )NC(O)O, SC(S)N(R 7 ), (R 7 )NC(S)S, SC(O)N(R 7 ), (R 7 )NC(O)S, OC(S)N(R 7 ), (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 7 ), ON(R 7 ), CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═C 4a R 4b ;  
 Y 0  is formula (IV):  
                     
  wherein D 5 , D 6 , J 5 , and J 6  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, K 2  is independently selected from the group consisting of C, and N + , no more than one of D 5 , D 6 , J 5 , and J 6  is O, no more than one of D 5 , D 6 , J 5 , and J 6  is S, one of D 5 , D 6 , J 5 , and J 6  must be a covalent bond when two of D 5 , D 6 , J 5 , and J 6  are O and S, no more than three of D 5 , D 6 , J 5 , and J 6  are N when K 2  is N + , and no more than four of D 5 , D 6 , J 5 , and J 6  are N when K 2  is carbon with the provisos that R 16 , R 17 , R 18 , and R 19  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 R 16  and R 17  are taken together to form a linear moiety spacer having from 3 through 6 contiguous atoms connected to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members, a partially saturated heterocyclyl ring having from 5 through 8 contiguous members, a heteroaryl having from 5 through 6 contiguous members, and an aryl;  
 Q b  is selected from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , oxy, alkyl, alkylaminoalkyl, aminoalkyl, dialkylsulfoniumalkyl, and acylamino wherein R 20 , R 21 , and R 22  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, alkoxy, alkylamino, amino, and dialkylamino and that R 20 , R 21 , and R 22  must be other than be hydroxy, alkoxy, alkylamino, amino, and dialkylamino when K 2  is N + ;  
 R 20  and R 21 , R 20  and R 22 , and R 21  and R 22  pairs are independently selected to form a spacer pair wherein a spacer pair is taken together to form a linear moiety having from 4 through 7 contiguous atoms connecting the points of bonding of said spacer pair members to form a heterocyclyl ring having 5 through 8 contiguous members with the proviso that no more than one of the group consisting of spacer pairs R 20  and R 21 , R 20  and R 22 , and R 21  and R 22  is used at the same time;  
 Q b  is selected from the group consisting of N(R 26 )SO 2 N(R 23 )(R 24 ), N(R 26 )C(O)OR 5 , N(R 26 )C(O)SR 5 , N(R 26 )C(S)OR 5  and N(R 26 )C(S)SR 5  with the proviso that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom;  
 Q b  is selected from the group consisting of dialkylsulfonium, trialkylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )C(O)N(R 23 )(R 24 ), N(R 26 )C(S)N(R 23 )(R 24 ), C(NR 25 )OR 5 , C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(S)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(NR 25 )SR 5 , C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl;  
 R 23  and R 24  are taken together to form a linear spacer moiety having from 4 through 7 contiguous atoms connecting the points of bonding to form a heterocyclyl ring having 5 through 8 contiguous members;  
 Q s  is selected from the group consisting of a single covalent bond, (CR 37 R 38 ) b —(W 0 ) az  wherein az is an integer selected from 0 through 1, b is an integer selected from 1 through 4, and W 0  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), SC(S)N(R 14 ), SC(O)N(R 14 ) OC(S)N(R 14 ), N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ) N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 14 ), ON(R 14 ), (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 4, and W 1  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), (R 14 )NC(O)O, SC(S)N(R 14 ), (R 14 )NC(S)S, SC(O)N(R 14 ), (R 14 )NC(O)S, OC(S)N(R 14 ), (R 14 )NC(S)O, N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ), N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ) P(O)(R 8 )N(R 7 ), N(R 14 ), ON(R 14 ), and (CH(R 14 )) e —W 2 —(CH(R 15 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b  with the provisos that R 14  and R 15  are selected from other than halo and cyano when directly bonded to N and that (CR 37 R 38 ) b , (CH(R 14 )) c , (CH(R 14 )) e  and are bonded to E 0 ;  
 Y 0  is Q b -Q ss  wherein Q ss  is selected from the group consisting of (CR 37 R 38 ) f  wherein f is an integer selected from 1 through 6, (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 4, and W 1  is selected from the group consisting of W 1  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), (R 14 )NC(O)O, SC(S)N(R 14 ), (R 14 )NC(S)S, SC(O)N(R 14 ), (R 14 )NC(O)S, OC(S)N(R 14 ), (R 14 )NC(S)O, N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ), N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ) N(R 14 )S(O) 2 , P(O)(R 8 ), N(R 7 )P(O)(R 8 ), P(O)(R 8 )N(R 7 ), N(R 14 ), ON(R 14 ), and (CH(R 14 )) e —W 2 —(CH(R 15 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b  with the provisos that R 14  and R 15  are selected from other than halo and cyano when directly bonded to N and that (CR 37 R 38 ) f , (CH(R 15 )) c , and (CH(R 15 )) e  are bonded to E 0 ;  
 Y 0  is Q b -Q sss , wherein Q sss  is (CH(R 38 )) r —W 3 , r is an integer selected from 1 through 3, and W 3  is selected from the group consisting of 1,1-cyclopropyl, 1,2-cyclopropyl, 1,1-cyclobutyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,4-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,5-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 1,4-piperazinyl, 2,3-piperazinyl, 2,5-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 1,4-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,5-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 3,5-piperidinyl, 3,6-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2H-2,3-pyranyl, 2H-2,4-pyranyl, 2H-2,5-pyranyl, 4H-2,3-pyranyl, 4H-2,4-pyranyl, 4H-2,5-pyranyl, 2H-pyran-2-one-3,4-yl, 2H-pyran-2-one-4,5-yl, 4H-pyran-4-one-2,3-yl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, 3,4-tetrahydrofuranyl, 2,3-tetrahydropyranyl, 2,4-tetrahydropyranyl, 2,5-tetrahydropyranyl, 2,6-tetrahydropyranyl, 3,4-tetrahydropyranyl, and 3,5-tetrahydropyranyl with the proviso that (CH(R 38 )) r  is bonded to E 0  and Q b  is bonded to lowest numbered substituent position of each W 3 ;  
 Y 0  is Q b -Q sssr , wherein Q sssr  is (CH(R 38 )) r —W 4 , r is an integer selected from 1 through 3, and W 4  is selected from the group consisting of 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,4-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,5-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 1,4-piperazinyl, 2,3-piperazinyl, 2,5-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 1,4-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,5-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 3,5-piperidinyl, 3,6-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2H-2,3-pyranyl, 2H-2,4-pyranyl, 2H-2,5-pyranyl, 4H-2,3-pyranyl, 4H-2,4-pyranyl, 4H-2,5-pyranyl, 2H-pyran-2-one-3,4-yl, 2H-pyran-2-one-4,5-yl, 4H-pyran-4-one-2,3-yl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, 3,4-tetrahydrofuranyl, 2,3-tetrahydropyranyl, 2,4-tetrahydropyranyl, 2,5-tetrahydropyranyl, 2,6-tetrahydropyranyl, 3,4-tetrahydropyranyl, and 3,5-tetrahydropyranyl with the provisos that (CH(R 38 )) r  is bonded to E 0  and Q b  is bonded to highest number substituent position of each W 4 ;  
 Y 0  is Q b -Q ssss , wherein Q ssss  is (CH(R 38 )) r —W 5 , r is an integer selected from 1 through 3, and W 5  is selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to lowest number substituent position of each W 5  and that (CH(R 38 )) r  is bonded to E 0 ;  
 Y 0  is Q b -Q ssssr , wherein Q ssssr  is (CH(R 38 )) r —W 6  an integer selected from 1 through 3, and W 6  is selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to highest number substituent position of each W 6  and that (CH(R 38 )) r  is bonded to E 0 .  
 
     
     
         3 . The compound as recited in  claim 1  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of hydrido, halo, hydroxy, hydroxyalkyl, amino, aminoalkyl, cyano, haloalkyl, carboxy, carboxyalkyl, amidocarbonyl, acyl, O—R 6 , NH—R 6 , S—R 6 , wherein R 6  is selected from the group consisting of alkyl and haloalkyl;  
 B is formula (V):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected to be Q b ;  
 R 9 , R 10 , R 11 , R 12 , R 13 , R 16 , R 17 , R 18 , R 19 , R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, trialkylphosphonium, dialkylsulfoniumalkyl, carboxy, heteroaralkylthio, heteroaralkoxy, cycloalkylamino, acylalkyl, acylalkoxy, aryloylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, perhaloaralkyl, aralkylsulfonyl, aralkylsulfonylalkyl, aralkylsulfinyl, aralkylsulfinylalkyl, halocycloalkyl, halocycloalkenyl, cycloalkylsulfinyl, cycloalkylsulfinylalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl, heteroarylamino, N-heteroarylamino-N-alkylamino, heteroarylaminoalkyl, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, haloalkoxylalkyl, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, cycloalkoxyalkyl, cycloalkylalkoxy, cycloalkenyloxyalkyl, cycloalkylenedioxy, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxy, halocycloalkenyloxyalkyl, hydroxy, amino, alkoxyamino, thio, nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylamino, aralkylamino, arylthio, arylthioalkyl, heteroaralkoxyalkyl, alkylsulfinyl, alkylsulfinylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, heteroarylsulfinylalkyl, heteroarylsulfonylalkyl, alkylsulfonyl, alkylsulfonylalkyl, haloalkylsulfinylalkyl, haloalkylsulfonylalkyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl, heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkenyloxyalky, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkylalkanoyl, cycloalkenyl, lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl, aminoalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, aralkyl, aryloxy, aralkoxy, aryloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, carboxyalkyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, arylamidocarbonylamido, carboalkoxyalkyl, carboalkoxyalkenyl, carboaralkoxy, carboxamido, carboxamidoalkyl, cyano, carbohaloalkoxy, phosphono, phosphonoalkyl, diaralkoxyphosphono, and diaralkoxyphosphonoalkyl;  
 B is selected from the group consisting of C3-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, C3-C8 haloalkyl, and C3-C8 haloalkenyl wherein each member of group B may be optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C4-C9 saturated heterocyclyl, and C4-C9 partially saturated heterocyclyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 10  position may be substituted with R 11 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 12  position may be substituted with R 33 , and a ring carbon or nitrogen atom four atoms from the point of attachment and adjacent to the R 11  and R 33  positions may be substituted with R 34 ;  
 A is selected from the group consisting of single covalent bond, (W 7 ) rr —(CH(R 15 )) pa  and (CH(R 15 )) pa —(W 7 ) rr  wherein rr is an integer selected from 0 through 1, pa is an integer selected from 0 through 6, and W 7  is selected from the group consisting of O, S, C(O), C(S), C(O)S, C(S)O, C(O)N(R 7 ), C(S)N(R 7 ), (R 7 )NC(O), (R 7 )NC(S), S(O), S(O) 2 , S(O) 2 N(R 7 ), (R 7 )NS(O) 2 , C(NR 7 )N(R 7 ), (R 7 )NC(NR 7 ), and N(R 7 ) with the proviso that no more than one of the group consisting of rr and pa is 0 at the same time;  
 R 7  and R 8  are independently selected from the group consisting of hydrido, hydroxy, alkyl, and alkoxyalkyl;  
 R 14 , R 15 , R 37 , and R 38  are independently selected from the group consisting of hydrido, hydroxy, halo, alkyl, alkoxyalkyl, haloalkyl, haloalkoxy, and haloalkoxyalkyl;  
 Ψ is selected from the group consisting of NR 5 , O, C(O), C(S), S, S(O), S(O) 2 , and CR 39 R 40  with the provisos that Ψ is selected from other than NR 5 , O, S, S(O), and S(O) 2  unless any two of X 0 , R 2 , R 1 , and J are other than hydrido, or that Ψ is selected from other than O, unless A is selected from other than methylene when B is phenyl, that Ψ is selected from other than C(O), unless A is selected from other than methyleneoxy when B is phenyl, or that Ψ is selected from other than NH unless A is selected from other than a single covalent bond when B is acyl, or that Ψ is selected from other than NH unless A is selected from other than S(O) or S(O) 2  when B is phenyl;  
 R 5  is selected from the group consisting of hydrido, alkyl, and alkoxy;  
 R 39  and R 40  are independently selected from the group consisting of hydrido, hydroxy, halo, hydroxyalkyl, alkyl, alkoxyalkyl, haloalkyl, haloalkoxy, and haloalkoxyalkyl;  
 X 0 , R 2  and R 1  are independently selected from the group consisting of Z 0 -Q, hydrido, alkyl, alkenyl, and halo;  
 X 0 , R 2  and R 1  are independently selected from the group consisting of amidino, guanidino, dialkyisulfonium, trialkylphosphonium, dialkylsulfoniumalkyl, heteroarylamino, amino, nitro, alkylamino, arylamino, aralkylamino, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, hydroxyhaloalkyl, cyano, and phosphono;  
 Z 0  is selected from the group consisting of covalent single bond, (CR 41 R 42 ) q  wherein q is an integer selected from 1 through 2, (CH(R 41 )) g —W 0 —(CH(R 42 )) p  wherein g and p are integers independently selected from 0 through 2 and W 0  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 41 ), (R 41 )NC(O), C(S)N(R 41 ), (R 41 )NC(S), OC(O)N(R 41 ), (R 41 )NC(O)O, SC(S)N(R 41 ), (R 41 )NC(S)S, SC(O)N(R 41 ), (R 41 )NC(O)S, OC(S)N(R 41 ), (R 41 )NC(S)O, N(R 42 )C(O)N(R 41 ), (R 41 )NC(O)N(R 42 ), N(R 42 )C(S)N(R 41 ), (R 41 )NC(S)N(R 42 ), S(O), S(O) 2 , S(O) 2 N(R 41 ), N(R 41 )S(O) 2 , N(R 41 ), ON(R 41 ), and (CH(R 41 )) e —W 2 —(CH(R 42 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 41 ═CR 42 , CR 41 R 42 ═C; vinylidene), and ethynylidene (C≡C; 1,2-ethynyl), with the provisos that R 41  and R 42  are selected from other than halo and cyano when directly bonded to N and Z 0  is directly bonded to the benzene ring, that W 0  is selected, wherein g is 0, from other than NHS(O) 2 CH 2 aryl or N(R 41 ) unless R 41  is selected from other than hydrido, alkyl, or aralkylsulfonyl, and Z 0  is selected from other than OC(O), C(O)N(H), and (H)NC(O), unless Q is selected from other than phenyl, 2-furyl, 2-thienyl, 4-thiazolyl, 2-pyridyl, 2-naphthyl, 1,2-dihydrobenzofuran-5-yl, 1,2-dihydrobenzofuran-6-yl, or 1,2-benzisoxazol-6-yl , or X 0  is selected from other than hydrido, halo, or methyl, or R 1  is selected from other than hydrido, fluoro, hydroxy, acetoxy, propanoyloxy, 2-carboxyacetoxy, 2,3 or 4-carboxypropanoyloxy, benzoyloxy, methyl, or methoxy;  
 R 41  and R 42  are independently selected from the group consisting of hydrido, hydroxy, halo, cyano, aryloxy, hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, alkoxy, alkyl, aryl, aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkoxyalkyl, heteroaryloxyalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, saturated heterocyclyl, partially saturated heterocyclyl, heteroaryl, and heteroaralkyl;  
 Q is formula (II):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N, with the proviso that R 9 , R 10 , R 11 , R 12 , and R 13  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 Q is selected from the group consisting of alkyl, alkoxy, alkylamino, alkylthio, haloalkylthio, saturated heterocyclyl, alkyl, partially saturated heterocyclyl, acyl, aroyl, heteroaroyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, cycloalkylalkenyl, haloalkyl, haloalkoxy, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxyalkyl, and halocycloalkenyloxyalkyl;  
 K is (CR 4a R 4b ) n  wherein n is the integer 1;  
 R 4a  and R 4b  are independently selected from the group consisting of halo, hydrido, hydroxy, hydroxyalkyl, alkyl, alkoxyalkyl, and haloalkyl;  
 E 0  is E 1 , when K is (CR 4a R 4b ) n , wherein E 1  is selected from the group consisting of a covalent single bond, O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), OC(O)N(R 7 ), (R 7 )NC(O)O, SC(S)N(R 7 ), (R 7 )NC(S)S, SC(O)N(R 7 ), (R 7 )NC(O)S, OC(S)N(R 7 ), (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , S(O) 2 N(R 7 )C(O), C(O)N(R 7 )S(O) 2 , N(R 7 ), ON(R 7 ), CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b ;  
 K is (CH(R 14 )) j -T wherein j is selected from a integer from 0 through 1 and T is selected from the group consisting of single covalent bond, O, S, and N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 E 0  is E 2 , when K is (CH(R 14 )) j -T, wherein E 2  is selected from the group consisting of a covalent single bond, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), (R 7 )NC(O)O, (R 7 )NC(S)S, (R 7 )NC(O)S, (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , S(O) 2 N(H)C(O), C(O)N(H)S(O) 2 , and N(R 7 );  
 K is G-(CH(R 15 )) k  wherein k is the integer 1 and G is selected from the group consisting of O, S, and N(R 7 );  
 E 0  is E 3 , when K is G-(CH(R 15 )) k , wherein E 3  is selected from the group consisting of a covalent single bond, O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 7 ), (R 7 )NC(O), C(S)N(R 7 ), (R 7 )NC(S), OC(O)N(R 7 ), (R 7 )NC(O)O, SC(S)N(R 7 ), (R 7 )NC(S)S, SC(O)N(R 7 ), (R 7 )NC(O)S, OC(S)N(R 7 ), (R 7 )NC(S)O, N(R 8 )C(O)N(R 7 ), (R 7 )NC(O)N(R 8 ), N(R 8 )C(S)N(R 7 ), (R 7 )NC(S)N(R 8 ), S(O), S(O) 2 , S(O) 2 N(R 7 ), N(R 7 )S(O) 2 , N(R 7 ), ON(R 7 ), CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b ;  
 Y 0  is formula (IV):  
                     
  wherein D 5 , D 6 , J 5 , and J 6  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, K 2  is independently selected from the group consisting of C and N + , no more than one of D 5 , D 6 , J 5 , and J 6  is O, no more than one of D 5 , D 6 , J 5 , and J 6  is S, one of D 5 , D 6 , J 5 , and J 6  must be a covalent bond when two of D 5 , D 6 , J 5 , and J 6  are O and S, no more than three of D 5 , D 6 , J 5 , and J 6  are N when K 2  is N + , and no more than four of D 5 , D 6 , J 5 , and J 6  are N when K 2  is carbon with the provisos that R 16 , R 17 , R 18 , and R 19  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 Q b  is selected from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , oxy, alkyl, alkylaminoalkyl, aminoalkyl, dialkylsulfoniumalkyl, and acylamino wherein R 20 , R 21 , and R 22  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino and that R 20 , R 21 , and R 22  must be other than be hydroxy, alkoxy, alkylamino, amino, and dialkylamino when K 2  is N + ;  
 Q b  is selected from the group consisting of N(R 26 )SO 2 N(R 23 )(R 24 ), N(R 26 )C(O)OR 5 , N(R 26 )C(O)SR 5 , N(R 26 )C(S)OR 5  and N(R 26 )C(S)SR 5  with the proviso that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom;  
 Q b  is selected from the group consisting of dialkylsulfonium, trialkylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )C(O)N(R 23 )(R 24 ), N(R 26 )C(S)N(R 23 )(R 24 ), C(NR 25 )OR 5 , C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(S)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(NR 25 )SR 5 , C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl;  
 Q s  is selected from the group consisting of a single covalent bond, (CR 37 R 38 ) b —(W 0 ) az  wherein az is an integer selected from 0 through 1, b is an integer selected from 1 through 2, and W 0  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), SC(S)N(R 14 ), SC(O)N(R 14 ), OC(S)N(R 14 ), N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ), N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )(O) 2 , N(R 14 ), ON(R 14 ), (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 2, and W 1  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), (R 14 )NC(O)O, SC(S)N(R 14 ), (R 14 )NC(S)S, SC(O)N(R 14 ), (R 14 )NC(O)S, OC(S)N(R 14 ), (R 14 )NC(S)O, N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ), N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , N(R 14 ), ON(R 14 ), and (CH(R 14 )) e —W 2 —(CH(R 15 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b  with the provisos that R 14  and R 15  are selected from other than halo and cyano when directly bonded to N and that (CR 37 R 38 ) b , (CH(R 14 )) c , (CH(R 14 )) e  and are bonded to E 0 ;  
 Y 0  is Q b -Q ss  wherein Q ss  is selected from the group consisting of (CR 37 R 7 ) f  wherein f is an integer selected from 1 through 4, (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 2, and W 1  is selected from the group consisting of W 1  is selected from the group consisting of O, S, C(O), C(S), C(O)O, C(S)O, C(O)S, C(S)S, C(O)N(R 14 ), (R 14 )NC(O), C(S)N(R 14 ), (R 14 )NC(S), OC(O)N(R 14 ), (R 14 )NC(O)O, SC(S)N(R 14 ), (R 14 )NC(S)S, SC(O)N(R 14 ), (R 14 )NC(O)S, OC(S)N(R 14 ), (R 14 )NC(S)O, N(R 15 )C(O)N(R 14 ), (R 14 )NC(O)N(R 15 ), N(R 15 )C(S)N(R 14 ), (R 14 )NC(S)N(R 15 ), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , N(R 14 ), ON(R 14 ), and (CH(R 14 )) e —W 2 —(CH(R 15 )) h  wherein e and h are integers independently selected from 0 through 2 and W 2  is selected from the group consisting of CR 4a ═CR 4b , ethynylidene (C≡C; 1,2-ethynyl), and C═CR 4a R 4b  with the provisos that R 14  and R 15  are selected from other than halo when directly bonded to N and that (CR 37 R 38 ) f , (CH(R 15 )) c , and (CH(R 15 )) e  are bonded to E 0 ;  
 Y 0  is Q b -Q sss  wherein QQ sss  is (CH(R 38 )) r —W 3 , r is an integer selected from 1 through 2, and W 3  is selected from the group consisting of 1,1-cyclopropyl, 1,2-cyclopropyl, 1,1-cyclobutyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,4-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,5-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 1,4-piperazinyl, 2,3-piperazinyl, 2,5-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 1,4-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,5-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 3,5-piperidinyl, 3,6-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2H-2,3-pyranyl, 2H-2,4-pyranyl, 2H-2,5-pyranyl, 4H-2,3-pyranyl, 4H-2,4-pyranyl, 4H-2,5-pyranyl, 2H-pyran-2-one-3,4-yl, 2H-pyran-2-one-4,5-yl, 4H-pyran-4-one-2,3-yl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, 3,4-tetrahydrofuranyl, 2,3-tetrahydropyranyl, 2,4-tetrahydropyranyl, 2,5-tetrahydropyranyl, 2,6-tetrahydropyranyl, 3,4-tetrahydropyranyl, and 3,5-tetrahydropyranyl with the proviso that (CH(R 38 )) r  is bonded to E 0  and Q b  is bonded to lowest numbered substituent position of each W 3 ;  
 Y 0  is Q b -Q sssr  wherein Q sssr  is (CH(R 38 )) r —W 4 , r is an integer selected from 1 through 2, and W 4  is selected from the group consisting of 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,4-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,5-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 1,4-piperazinyl, 2,3-piperazinyl, 2,5-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 1,4-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,5-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 3,5-piperidinyl, 3,6-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2H-2,3-pyranyl, 2H-2,4-pyranyl, 2H-2,5-pyranyl, 4H-2,3-pyranyl, 4H-2,4-pyranyl, 4H-2,5-pyranyl, 2H-pyran-2-one-3,4-yl, 2H-pyran-2-one-4,5-yl, 4H-pyran-4-one-2,3-yl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, 3,4-tetrahydrofuranyl, 2,3-tetrahydropyranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydropyranyl, 2,6-tetrahydropyranyl, 3,4-tetrahydropyranyl, and 3,5-tetrahydropyranyl with the provisos that (CH(R 38 )) r  is bonded to E 0  and Q b  is bonded to highest number substituent position of each W 4 ;  
 Y 0  is Q b -Q ssss  wherein Q ssss  is (CH(R 38 )) r —W 5 , r is an integer selected from 1 through 2, and W 5  is selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to lowest number substituent position of each W 5  and that (CH(R 38 )) r  is bonded to E 0 ;  
 Y 0  is Q b -Q ssssr  wherein Q ssssr  is (CH(R 38 )) r —W 6 , r is an integer selected from 1 through 2, and W 6  is selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to highest number substituent position of each W 6  and that (CH(R 38 )) r  is bonded to E 0 .  
 
     
     
         4 . The compound as recited in  claim 3  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of hydrido, halo, hydroxy, hydroxyalkyl, amino, aminoalkyl, O—R 6 , NH—R 6 , and S—R 6 , wherein R 6  is selected from the group consisting of alkyl and haloalkkyl;  
 B is formula (V):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected to be Q b ;  
 R 9 , R 10 , R 11 , R 12 , R 13 , R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, carboxy, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, haloalkoxylalkyl, hydroxy, amino, alkoxyamino, thio, nitro, lower alkylamino, alkylthio, alkylthioalkyl, alkylsulfinyl, alkylsulfinylalkyl, alkylsulfonyl, alkylsulfonylalkyl, haloalkylsulfinylalkyl, haloalkylsulfonylalkyl, alkylsulfonamido, alkylaminosulfonyl, amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl, alkanoyl, alkenoyl, haloalkanoyl, alkyl, alkenyl, alkenyloxy, alkenyloxyalky, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aminoalkyl, haloalkoxyalkyl, carboxyalkyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, carboalkoxyalkyl, carboalkoxyalkenyl, carboxamido, carboxamidoalkyl, and cyano;  
 B is selected from the group consisting of C3-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, C3-C8 haloalkyl, and C3-C8 haloalkenyl wherein each member of group B may be optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C4-C9 saturated heterocyclyl, and C4-C9 partially saturated heterocyclyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 10  position may be substituted with R 11 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 12  position may be substituted with R 33 , and a ring carbon or nitrogen atom four atoms from the point of attachment and adjacent to the R 11  and R 33  positions may be substituted with R 34 ;  
 A is selected from the group consisting of single covalent bond, (W 7 ) rr —(CH(R 15 )) pa  and (CH(R 15 )) pa —(W 7 ) rr  wherein rr is an integer selected from 0 through 1, pa is an integer selected from 0 through 6, and W 7  is selected from the group consisting of O, S, C(O), C(S), C(O)S, C(S)O, C(O)N(R 7 ), C(S)N(R 7 ), (R 7 )NC(O), (R 7 )NC(S), S(O), S(O) 2 , S(O) 2 N(R 7 ), (R 7 )NS(O) 2 , C(NR 7 )N(R 7 ), (R 7 )NC(NR 7 ), and N(R 7 ) with the proviso that no more than one of the group consisting of rr and pa is 0 at the same time;  
 R 7  and R 8  are independently selected from the group consisting of hydrido, hydroxy, alkyl, and alkoxyalkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 Ψ is NH with the provisos that Ψ is selected from other than NH unless any two of X 0 , R 2 , R 1 , and J are other than hydrido or that Ψ is selected from other than NH unless A is selected from other than a single covalent bond when B is acyl, or that Ψ is selected from other than NH unless A is selected from other than S(O) or S(O) 2  when B is phenyl;  
 X 0  is hydrido;  
 R 1  is selected from the group consisting of hydrido, alkyl, alkoxy, alkylamino, alkylthio, haloalkylthio, haloalkyl, haloalkoxy, and halo;  
 R 2  is selected from the group consisting of Z 0 -Q, hydrido, alkyl, alkenyl, and halo;  
 Z 0  is a covalent single bond;  
 Q is formula (II):  
                     
  wherein D 1 , D 2 , J 1 , J 2  and K 1  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is O, no more than one of D 1 , D 2 , J 1 , J 2  and K 1  is S, one of D 1 , D 2 , J 1 , J 2  and K 1  must be a covalent bond when two of D 1 , D 2 , J 1 , J 2  and K 1  are O and S, and no more than four of D 1 , D 2 , J 1 , J 2  and K 1  are N, with the proviso that R 9 , R 10 , R 11 , R 12 , and R 13  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 K is CR 4a R 4b ;  
 R 4a  and R 4b  are independently selected from the group consisting of halo, hydrido, hydroxy, alkyl, and haloalkyl;  
 E 0  is E 1 , when K is CR 4a R 4b , wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), C(S)N(H), (H)NC(S), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 K is (CH(R 14 )) j -T wherein j is selected from an integer from 0 through 1 and T is selected from the group consisting of single covalent bond and N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 E 0  is E 2 , when K is (CH(R 14 )) j -T, wherein E 2  is selected from the group consisting of C(O)N(H), (H)NC(O), C(S)N(H), (H)NC(S), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 R 14  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 Y 0  is formula (IV):  
                     
  wherein D 5 , D 6 , J 5 , and J 6  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, K 2  is independently selected from the group consisting of C and N + , no more than one of D 5 , D 6 , J 5 , and J 6  is O, no more than one of D 5 , D 6 , J 5 , and J 6  is S, one of D 5 , D 6 , J 5 , and J 6  must be a covalent bond when two of D 5 , D 6 , J 5 , and J 6  are O and S, no more than three of D 5 , D 6 , J 5 , and J 6  are N when K 2  is N + , and no more than four of D 5 , D 6 , J 5 , and J 6  are N when K 2  is carbon with the provisos that R 16 , R 17 , R 18 , and R 19  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, carboxy, haloalkylthio, alkoxy, hydroxy, amino, thio, nitro, lower alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, alkenoyl, haloalkanoyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyalkyl, aminoalkyl, haloalkoxyalkyl, carboalkoxy, carboalkoxyalkyl, and cyano;  
 Q b  is selected from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , oxy, alkyl, alkylaminoalkyl, aminoalkyl, dialkylsulfoniumalkyl, and acylamino wherein R 20 , R 21 , and R 22  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino and that R 20 , R 21 , and R 22  must be other than be hydroxy, alkoxy, alkylamino, amino, or dialkylamino when K 2  is N + ;  
 Q b  is N(R 26 )SO 2 N(R 23 )(R 24 ) with the proviso that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkyl amino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom;  
 Q b  is selected from the group consisting of dialkylsulfonium, trialkylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )C(O)N(R 23 )(R 24 ), N(R 26 )C(S)N(R 23 )(R 24 ), C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(S)N(R 26 )C(NR 26 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl;  
 Q s  is selected from the group consisting of a single covalent bond and (CR 37 R 38 ) b —(W 0 ) az  wherein az is an integer selected from 0 through 1, b is an integer selected from 1 through 2, and W 0  is selected from the group consisting of O, S, C(O), S(O) 2 , N(R 14 ), and ON(R 14 ) with the proviso that R 14  is selected from other than halo when directly bonded to N and that (CR 37 R 38 ) b  is bonded to E 0 ;  
 R 37  and R 38  are independently selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 Y 0  is Q b -Q sss  wherein Q ssss  is (CH(R 38 )) r —W 5 , r is an integer selected from 1 through 2, and W 5  is selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to lowest number substituent position of each W 5  and that (CH(R 38 )) r  is bonded to E 0 ;  
 Y 0  is Q b -Q sssr  wherein Q ssssr  is (CR(R 38 )) r —W 6 , r is an integer selected from 1 through 2, and W 6  is selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3, benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl with the proviso that Q b  is bonded to highest number substituent position of each W 6  and that (CH(R 38 )) r  is bonded to E 0 .  
 
     
     
         5 . The compound as recited in  claim 4  having the Formula I-S:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, bromo, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, methoxy, ethoxy, trifluoromethoxy, N-methylamino, N-ethylamino, methythio, ethylthio, and trifluoromethylthio;  
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 1,2,4-triazol-3-yl, 1,2,4-triazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,3,4-oxadiazol-3-yl, 1,3,4-oxadiazol-5-yl, 3-isothiazolyl, 5-isothiazolyl, 2-oxazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pryimidinyl, 3-pyridazinyl, 4-pyridazinyl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2,4-triazin-6-yl, and 1,2,3-triazin-4-yl, wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment may be substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment may be substituted by R 35 , and any carbon adjacent to both R 33  and R 35  may be substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, dimethylsulfonium, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, thio, nitro, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-N-methylamino, dimethylamino, N-ethylamino, methyltilo, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, acetyl, propanoyl, trifluoroacetyl, pentafluoropropanoyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, 2,2,2-trifluoro-1-trifluoromethyl-1-hydroxyethyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 B is selected from the group consisting of 1-propenyl, propyl, isopropyl, butyl, 2-butenyl, 3-butenyl, 2-butynyl, sec-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 1-methyl-2-butynyl, 3-pentyl, 1-ethyl-2-propenyl, 2-methylbutyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 2-methyl-3-butynyl, 3-methylbutyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-propyl-2-propenyl, 1-ethyl-2-butynyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 6-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-5-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methyl-4-hexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-4-pentenyl, 1-butyl-2-propenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 1-octyl, 2-octenyl, 3-octenyl, 4-octenyl, 5-octenyl, 6-octenyl, 7-octenyl, 2-octynyl, 3-octynyl, 4-octynyl, 5-octynyl, 6-octynyl, 2-octyl, 1-methyl-2-heptenyl, 1-methyl-3-heptenyl, 1-methyl-4-heptenyl, 1-methyl-5-heptenyl, 1-methyl-6-heptenyl, 1-methyl-2-heptynyl, 1-methyl-3-heptynyl, 1-methyl-4-heptenyl, 1-methyl-5-heptenyl, 1-methyl-6-heptenyl, 1-methyl-2-heptenyl, 1-methyl-3-heptynyl, 1-methyl-4-heptynyl, 1-methyl-5-heptynyl, 3-octyl, 1-ethyl-2-hexenyl, 1-ethyl-3-hexenyl, 1-ethyl-4-hexenyl, 1-ethyl-2-hexynyl, 1-ethyl-3-hexynyl, 1-ethyl-4-hexynyl, 1-ethyl-5-hexenyl, 1-pentyl-2-propenyl, 4-octyl, 1-propyl-2-pentenyl, 1-propyl-3-pentenyl, 1-propyl-4-pentenyl, 1-butyl-2-butenyl, 1-propyl-2-pentynyl, 1-propyl-3-pentynyl, 1-butyl-2-butnyl, 1-butyl-3-butenyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluoroheyyl, and 3,3,3-trifluoropropyl, wherein each member of group B may be optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, oxetan-2-yl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, thiaetan-2-yl, thiaetan-3-yl, cyclopentyl, cyclopent-2-enyl, cyclopent-3-enyl, cyclohexyl, 4-methylcyclohexyl, 4-chloro-3-ethylphenoxycyclohexyl, 3-trifluoromethoxyphenoxycyclohexyl, 3-trifluoromethylcyclohexyl, 4-trifluoromethylcyclohexyl, 3,5-bis-trifluoromethylcyclohexyl, adamantyl, 3-trifluoromethyladamantyl, norbornyl, 3-trifluoromethylnorbornyl, norbornenyl, 7-oxabicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexanyl, cyclohex-2-enyl, cyclohex-3-enyl, cycloheptyl, cyclohept-2-enyl, cyclohept-3-enyl, cyclooctyl, cyclooct-2-enyl, cyclooct-3-enyl, cyclooct-4-enyl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 2H-2-pyranyl, 2H-3-pyranyl, 2H-4-pyranyl, 4H-2-pyranyl, 4H-3-pyranyl, 4H-4-pyranyl, 2H-pyran-2-one-3-yl, 2H-pyran-2-one-4-yl, 2H-pyran-2-one-5-yl, 4H-pyran-4-one-2-yl, 4H-pyran4-one-3-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , and a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of amidino, guanidino, dimethylsulfonium, methylethylsulfonium, carboxy, methoxy, ethoxy, isopropoxy, propoxy, butoxy, hydroxy, amino, methoxyamino, ethoxyamino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-N-dimethylamino, N-methylamino, N-ethylamino, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, acetyl, propanoyl, butanoyl, trifluoroacetyl, pentafluoropropanoyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, 2,2,2-trifluoro-1-trifluoromethyl-1-hydroxyethyl, carboxymethyl, 2-carboxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 A is selected from the group consisting of single covalent bond, O, C(O), CH 2 , CH 3 CH, CF 3 CH, CH 3 CC(O), CF 3 CC(O), C(O)CCH 3 , C(O)CCF 3 , CH 2 C(O), (O)CCH 2 , CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CCH 2 , CF 3 CCH 2 , CH 3 CC(O)CH 2 , CF 3 CC(O)CH 2 , CH 2 C(O)CCH 3 , CH 2 C(O)CCF 3 , CH 2 CH 2 C(O), and CH 2 (O)CCH 2 ;  
 R 1  is selected from the group consisting of hydrido, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, N-methyl amino, N,N-dimethylamino, N-ethyl amino, N,N-diethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, trifuoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 1,2,4-triazol-3-yl, 1,2,4-triazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,3,4-oxadiazol-3-yl, 1,3,4-oxadiazol-5-yl, 3-isothiazolyl, 5-isothiazolyl, 2-oxazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2,4-triazin-6-yl, and 1,2,3-triazin-4-yl, wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment may be substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment may be substituted by R 12 , and any carbon adjacent to both R 10  and R 12  may be substituted by R 11 ;  
 K is CR 4a R 4b  wherein R 4a  and R 4b  are independently selected from the group consisting of chloro, fluoro, and hydrido;  
 E 0  is E 1 , when K is CR 4a R 4b , wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 K is selected from the group consisting of N(H) and CH 2 N(H);  
 E 0  is E 2 , when K is N(H) and CH 2 N(H), wherein E 2  is selected from the group consisting of C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 Y 0  is selected from the group of formulas consisting of:  
                                       
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, dimethylsulfoniumn, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, thio, nitro, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methyl sulfinyl, ethyl sulfinyl, methyl sulfonyl, ethyl sulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, acetyl, propanoyl, trifluoroacetyl, pentafluoropropanoyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, 2,2,2-trifluoro-1-trifluoromethyl-1-hydroxyethyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 Q b  is selected, when bonded to a carbon, from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , dimethylsulfonium, methylethylsulfonium, diethylsulfonium, trimethylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, methoxy, ethoxy, N-methylamino, N,N-dimethylamino, N,N,N-trimethylamino, or amino and that no more than one of R 23 , R 24 , and R 26  is hydroxy, methoxy, ethoxy, N-methylamino, N,N-dimethylamino, N,N,N-trimethylamino, or amino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, propyl, butyl, isopropyl, hydroxy, methoxy, ethoxy, isopropoxy, propoxy, 2-aminoethyl, 2-(N-methylamino)ethyl, 2-(N,N-dimethylamino)ethyl, 2-(N,N,N-trimethylamino)ethyl, N-(2-hydroxyethyl)amino, N,N-bis-(2-hydroxyethyl)amino, N-(2-hydroxyethyl)-N-(2-aminoethyl)amino, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino, and N,N,N-trimethylamino;  
 Q b  is selected, when bonded to a nitrogen, from the group consisting of oxy, methyl, ethyl, 2-aminoethyl, 2-(N-methylamino)ethyl, 2-(N,N-dimethylamino)ethyl, 2-(N,N,N-trimethylamino)ethyl, N-(2-hydroxyethyl)amino, N,N-bis-(2-hydroxyethyl)amino, amino, hydroxylamino, N-methoxyamino, N-methylamino, N,N-dimethylamino, and N,N,N-trimethylamino;  
 Q s  is selected from the group consisting of a single covalent bond, CH 2 , CH 3 CH, CF 2 , CF 3 CH, CH 2 O, CH 3 C(H)O, CF 3 C(H)O, CH 2 S, CH 3 C(H)S, CF 3 C(H)S, CH 2 C(O), CH 3 C(H)C(O), CF 3 C(H)C(O), and CF 2 C(O) with the proviso that Q s  is bonded to E 0  through a carbon atom.  
 
     
     
         6 . The compound as recited in  claim 1  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, hydroxy, hydroxyalkyl, amino, aminoalkyl, O—R 6 , NH—R 6 , and S—R 6 , wherein R 6  is selected from the group consisting of alkyl and haloalkyl;  
 B is selected from the group consisting of aryl and heteroaryl wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment may be substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment may be substituted by R 35 , and any carbon adjacent to both R 33  and R 35  may be substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, thio, nitro, lower alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, carboalkoxy, carboxamido, cyano, and Q b ;  
 B is selected from the group consisting of C3-C8 alkyl, C3-C8 alkenyl, C3-C8 haloalkyl, and C3-C8 haloalkenyl wherein each member of group B may be optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C4-C9 saturated heterocyclyl, and C4-C9 partially saturated heterocyclyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 10  position may be substituted with R 11 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 12  position may be substituted with R 33 , and a ring carbon or nitrogen atom four atoms from the point of attachment and adjacent to the R 11  and R 33  positions may be substituted with R 34 ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, thio, nitro, lower alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, carboalkoxy, carboxamido, and cyano;  
 A is selected from the group consisting of single covalent bond, (W 7 ) rr —(CH(R 15 )) pa  and (CH(R 15 )) pa —(W 7 ) rr  wherein rr is an integer selected from 0 through 1, pa is an integer selected from 0 through 6, and W 7  is selected from the group consisting of O, S, and C(O) with the proviso that no more than one of the group consisting of rr and pa is the integer 0 at the same time;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 Ψ is NH;  
 X 0  is hydrido;  
 R 1  is selected from the group consisting of hydrido, alkyl, alkoxy, alkylamino, alkylthio, haloalkylthio, haloalkyl, haloalkoxy, and halo;  
 R 2  is Q, wherein Q is selected from the group consisting of aryl and heteroaryl wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment may be substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment may be substituted by R 12 , and any carbon adjacent to both R 10  and R 12  may be substituted by R 11 ;  
 K is CR 4a R 4b  wherein R 4a  and R 4b  are independently selected from the group consisting of halo and hydrido;  
 E 0  is E 1 , when K is CR 4a R 4b , wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 K is (CH(R 14 )) j -T wherein j is selected from an integer from 0 through 1 and T is selected from the group consisting of single covalent bond and N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 R 7  is selected from the group consisting of hydrido, hydroxy, alkyl, and alkoxyalkyl;  
 R 14  is selected from the group consisting of hydrido and halo;  
 E 0  is E 2 , when K is (CH(R 14 )) j -T, wherein E 2  is selected from the group consisting of C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 Y 0  is formula (IV):  
                     
  wherein D 5 , D 6 , J 5  and J 6  are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one is a covalent bond, K 2  is independently selected from the group consisting of C and N + , no more than one of D 5 , D 6 , J 5 , and J 6  is O, no more than one of D 5 , D 6 , J 5 , and J 6  is S, one of D 5 , D 6 , J 5 , and J 6  must be a covalent bond when two of D 5 , D 6 , J 5 , and J 6  are O and S, no more than three of D 5 , D 6 , J 5 , and J 6  are N when K 2  is N + , and no more than four of D 5 , D 6 , J 5 , and J 6  are N when K 2  is carbon with the provisos that R 16 , R 17 , R 18 , and R 19  are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, dialkylsulfonium, carboxy, haloalkylthio, alkoxy, hydroxy, amino, thio, nitro, lower alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, alkenoyl, haloalkanoyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyalkyl, aminoalkyl, haloalkoxyalkyl, carboalkoxy, carboalkoxyalkyl, and cyano;  
 Q b  is selected from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , oxy, alkyl, alkylaminoalkyl, aminoalkyl, dialkylsulfoniumalkyl, and acylamino wherein R 20 , R 21 , and R 22  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino and that R 20 , R 21 , and R 22  must be other than be hydroxy, alkoxy, alkylamino, amino, or dialkylamino when K 2  is N + ;  
 Q b  is selected from the group consisting of dialkylsulfonium, trialkylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 23 , R 24 , and R 26  is hydroxy, alkoxy, alkylamino, amino, or dialkylamino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, alkoxy, alkylamino, dialkylamino, aminoalkyl, and hydroxyalkyl;  
 Q s  is selected from the group consisting of a single covalent bond and (CR 37 R 38 ) b   13  (W 0 ) az  wherein az is an integer selected from 0 through 1, b is the integer 1, and W 0  is selected from the group consisting of O, S, and C(O) with the proviso that (CR 37 R 38 ) b  is bonded to E 0 ;  
 R 37  and R 38  are independently selected from the group consisting of hydrido, halo, alkyl, and haloalkyl.  
 
     
     
         7 . The compound as recited in  claim 6  having the Formula I-MPS:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, hydroxy, hydroxymethyl, amino, aminomethyl, methoxy, trifluoromethoxy, N-methylamino, methythio, and trifluoromethylthio;  
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment may be substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment may be substituted by R 35 , and any carbon adjacent to both R 33  and R 35  may be substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, dimethylsulfonium, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, thio, nitro, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, acetyl, propanoyl, trifluoroacetyl, pentafluoropropanoyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, 2,2,2-trifluoro-1-trifluoromethyl-1-hydroxyethyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 B is selected from the group consisting of 1-propenyl, propyl, isopropyl, butyl, 2-butenyl, 3-butenyl, sec-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 2-pentyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 3-pentyl, 1-ethyl-2-propenyl, 2-methylbutyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 3-methylbutyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 2,2-difluoropropyl, 2-trifluoromethyl-3,3,3-trifluoropropyl, 1,1,1,2,2,2-hexafluoropropyl, 3,3,3-trifluoroprop-1-yl, and 3,3,3-trifluoroprop-2-yl, wherein each member of group B may be optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, oxetan-2-yl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, thiaetan-2-yl, thiaetan-3-yl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , and a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of amidino, guanidino, dimethylsulfonium, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-N-methylamino, dimethylamino, N-ethylamino, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, acetyl, propanoyl, trifluoroacetyl, pentafluoropropanoyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, 2,2,2-trifluoro-1-trifluoromethyl-1-hydroxyethyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 A is selected from the group consisting of single covalent bond, O, C(O), CH 2 , CH 3 CH, CF 3 CH, CH 3 CC(O), CF 3 CC(O), CC(O)CCH 3 , C(O)CCF 3 , CH 2 C(O), and (O)CCH 2 ;  
 R 1  is selected from the group consisting of hydrido, methyl, ethyl, propyl, methoxy, ethoxy, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, trifluoromethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment may be substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment may be substituted by R 12 , and any carbon adjacent to both R 10  and R 12  may be substituted by R 11 ;  
 K is CR 4a R 4b  wherein R 4a  and R 4b  are independently selected from the group consisting of chloro, fluoro, and hydrido;  
 E 0  is E 1 , when K is CR 4a R 4b , wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 K is selected from the group consisting of N(H) and CH 2 N(H);  
 E 0  is E 2 , when K is selected from the group consisting of N(H) and CH 2 N(H), wherein E 2  is selected from the group consisting of C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 Y 0  is selected from the group of formulas consisting of:  
                                       
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, methoxy, ethoxy, isopropoxy, methylthio, ethylthio, trifluoromethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, acetyl, propanoyl, trifluoroacetyl, pentafluoropropanoyl, methoxycarbonyl, ethoxycarbonyl, and cyano;  
 Q b  is selected, when bonded to a carbon, from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , dimethylsulfonium, methylethylsulfonium, diethylsulfonium, trimethylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, methoxy, ethoxy, N-methylamino, N,N-dimethylamino, N,N,N-trimethylamino, or amino and that no more than one of R 23 , R 24 , and R 26  is hydroxy, methoxy, ethoxy, N-methylamino, N,N-dimethylamino, N,N,N-trimethylamino, or amino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, hydroxy, methoxy, ethoxy, 2-aminoethyl, 2-(N-methylamino)ethyl, 2-(N,N-dimethylamino)ethyl, 2-(N,N,N-trimethylamino)ethyl, N-(2-hydroxyethyl)amino, N,N-bis-(2-hydroxyethyl)amino, N-(2-hydroxyethyl)-N-(2-aminoethyl)amino, N-methylamino, N,N-dimethylamino, and N,N,N-trimethylamino;  
 Q b  is selected, when bonded to a nitrogen, from the group consisting of oxy, methyl, ethyl, 2-aminoethyl, 2-(N-methylamino)ethyl, 2-(N,N-dimethylamino)ethyl, 2-(N,N,N-trimethylamino)ethyl, N-(2-hydroxyethyl)amino, N,N-bis-(2-hydroxyethyl)amino, amino, hydroxylamino, N-methoxyamino, N-methylamino, N,N-dimethylamino, and N,N,N-trimethylamino;  
 Q s  is selected from the group consisting of a single covalent bond, CH 2 , CH 3 CH, CF 2 , CF 3 CH, CH 2 O, CH 3 C(H)O, CF 3 C(H)O, CH 2 S, CH 3 C(H)S, CF 3 C(H)S, CH 2 C(O), CH 3 C(H)C(O), CF 3 C(H)C(O), and CF 2 C(O) with the proviso that Q s  is bonded to E 0  through a carbon atom.  
 
     
     
         8 . The compound as recited in  claim 7  having the Formula I-EMPS:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, hydroxy, hydroxymethyl, amino, aminomethyl, methoxy, trifluoromethoxy, and N-methylamino;  
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, and 4-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment may be substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment may be substituted by R 35 , and any carbon adjacent to both R 33  and R 35  may be substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methoxy, ethoxy, hydroxy, amino, methoxyamino, ethoxyamino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-N-methylamino, dimethylamino, N-ethylamino, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, 2,2,2-trifluoro-1-trifluoromethyl-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, cyano, and Q b ;  
 B is selected from the group consisting of propyl, isopropyl, butyl, sec-butyl, isobutyl, 1-pentyl, 2-pentyl, 3-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-difluoropropyl, 2-trifluoromethyl-3,3,3-trifluoropropyl, 1,1,1,2,2,2-hexafluoropropyl, 3,3,3-trifluoroprop-1-yl, and 3,3,3-trifluoroprop-2-yl, wherein each member of group B may be optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, oxetan-2-yl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, thiaetan-2-yl, thiaetan-3-yl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon and nitrogen atoms adjacent to the carbon atom at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , and a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of amidino, guanidino, carboxy, methoxy, ethoxy, hydroxy, amino, methoxyamino, ethoxyamino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-N-methylamino, dimethylamino, N-ethylamino, acetyl, propanoyl, trifluoroacetyl, pentafluoropropanoyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 A is selected from the group consisting of single covalent bond, O, C(O), CH 2 , CH 2 C(O), and (O)CCH 2 ;  
 R 1  is selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, N-methylamino, dimethylamino, N-ethylamino, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, and bromo;  
 R 2  is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment may be substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment may be substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment may be substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment may be substituted by R 12 , and any carbon adjacent to both R 10  and R 12  may be substituted by R 11 ;  
 K is CR 4a R 4b  wherein R 4a  and R 4b  are independently selected from the group consisting of chloro, fluoro, and hydrido;  
 E 0  is E 1 , when K is CR 4a R 4b , wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 K is selected from the group consisting of N(H) and CH 2 N(H);  
 E 0  is E 2 , when K is selected from the group consisting of N(H) and CH 2 N(H), wherein E Z  is selected from the group consisting of C(O)N(H), (H)NC(O), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 Y 0  is selected from the group of formulas consisting of:  
                                       
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methoxy, ethoxy, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, bromo, acetyl, trifluoroacetyl, methoxycarbonyl, ethoxycarbonyl, and cyano;  
 Q b  is selected from the group consisting of NR 20 R 21 ,  + NR 20 R 21 R 22 , dimethylsulfonium, methylethylsulfonium, diethylsulfonium, trimethylphosphonium, C(NR 25 )NR 23 R 24 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), C(O)N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )C(NR 25 )N(R 23 )(R 24 ), N(R 26 )N(R 26 )SO 2 N(R 23 )(R 24 ), C(O)NR 23 R 24 , and C(O)NR 23 R 24  with the provisos that no more than one of R 20 , R 21 , and R 22  is hydroxy, methoxy, ethoxy, N-methylamino, N,N-dimethylamino, and N,N,N-trimethylamino, or amino and that no more than one of R 23 , R 24 , and R 26  is hydroxy, methoxy, ethoxy, N-methylamino, N,N-dimethylamino, N,N,N-trimethylamino, or amino when two of the group consisting of R 23 , R 24 , and R 26  are bonded to the same atom and that said Q b  group is bonded directly to a carbon atom;  
 R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, hydroxy, methoxy, ethoxy, 2-aminoethyl, 2-(N-methylamino)ethyl, 2-(N,N-dimethylamino)ethyl, 2-(N,N,N-trimethylamino)ethyl, N-(2-hydroxyethyl)amino, N,N-bis-(2-hydroxyethyl)amino, N-(2-hydroxyethyl)-N-(2-aminoethyl)amino, N-methylamino, N,N-dimethylamino, and N,N,N-trimethylamino;  
 Q s  is selected from the group consisting of a single covalent bond, CH 2 , CH 3 CH, CF 2 , CF 3 CH, CH 2 O, CH 3 C(H)O, CF 3 C(H)O, CH 2 C(O), CH 3 C(H)C(O), CF 3 C(H)C(O), and CF 2 C(O) with the proviso that Q s  is bonded to E 0  through a carbon atom.  
 
     
     
         9 . A composition for inhibiting thrombotic conditions in blood comprising a compound of any one of claims  1  through  8  and a pharmaceutically acceptable carrier.  
     
     
         10 . A method for inhibiting thrombotic conditions in blood comprising adding to blood a therapeutically effective amount of a composition of  claim 9 .  
     
     
         11 . A method for inhibiting formation of blood platelet aggregates in blood comprising adding to blood a therapeutically effective amount of a composition of  claim 9 .  
     
     
         12 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of a composition of  claim 9 .  
     
     
         13 . A method for treating or preventing venuous thromboembolism and pulmonary embolism in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of  claim 9 .  
     
     
         14 . A method for treating or preventing deep vein thrombosis in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of  claim 9 .  
     
     
         15 . A method for treating or preventing cardiogenic thromboembolism in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of  claim 9 .  
     
     
         16 . A method for treating or preventing thromboembolic stroke in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of  claim 9 .  
     
     
         17 . A method for treating or preventing thrombosis associated with cancer and cancer chemotherapy in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of  claim 9 .  
     
     
         18 . A method for treating or preventing unstable angina in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of  claim 9 .  
     
     
         19 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of a compound of any one of claims  1  through  8  with a therapeutically effective amount of fibrinogen receptor antagonist.  
     
     
         20 . The use of a compound of any one of claims  1  through  8 , or a pharmaceutically acceptable salt thereof, in the manufacture of medicament for inhibiting thrombus formation, treating thrombus formation, or preventing thrombus formation in a mammal.  
     
     
         21 . A compound of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, aminoalkyl, amidino, carboxy, carboxamido, alkylsulfinyl, acyl, cyano, O—R 6 , NH—R 6 , and S—R 6 , wherein R 6  is alkyl or haloalkyl;  
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a nitrogen with a removable hydrogen or a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , a nitrogen with a removable hydrogen or a carbon at the other position adjacent to the point of attachment is optionally substituted by R 36 , a nitrogen with a removable hydrogen or a carbon adjacent to R 32  and two atoms from the point of attachment is optionally substituted by R 33 , a nitrogen with a removable hydrogen or a carbon adjacent to R 36  and two atoms from the point of attachment is optionally substituted by R 35 , and a nitrogen with a removable hydrogen or a carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 9 , R 10 , R 11 , R 12 , R 13 , R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkylenedioxy, haloalkylthio, alkanoyloxy, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, alkoxyalkyl, haloalkoxylalkyl, hydroxy, amino, alkoxyamino, nitro, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylthioalkyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, alkylsulfonylalkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkylsulfonamido, amidosulfonyl, alkanoyl, haloalkanoyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aminoalkyl, haloalkoxyalkyl, carboxyalkyl, carboalkoxy, carboxy, carboxamido, carboxamidoalkyl, and cyano;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently optionally Q b ;  
 B is optionally selected from the group consisting of hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is optionally a C3-C12 cycloalkyl or C4-C9 saturated heterocyclyl, wherein each ring carbon is optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 10  position is optionally substituted with R 11 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 12  position is optionally substituted with R 33 , and a ring carbon or nitrogen four atoms from the point of attachment and adjacent to the R 11  and R 33  positions is optionally substituted with R 34 ;  
 A is selected from the group consisting of a bond, (W 7 ) rr —(CH(R 15 )) pa , and (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 6, and W 7  is selected from the group consisting of O, S, C(O), (R 7 )NC(O), (R 7 )NC(S), and N(R 7 ) with the proviso that no more than one of the group consisting of rr and pa is 0 at the same time and with the further proviso that W 7  is selected from other than C(O) when W 7  is bonded to Ψ;  
 R 7  is selected from the group consisting of hydrido, hydroxy, and alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 Ψ is NH or NOH;  
 X 0  and R 1  are independently selected from the group consisting of hydrido, alkyl, alkenyl, cyano, halo, haloalkyl, haloalkoxy, haloalkylthio, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, (CR 41 R 42 ) q  wherein q is an integer selected from 1 through 3, and (CH(R 41 )) g —W 0 —(CH(R 42 )) p  wherein g and p are integers independently selected from 0 through 3 and W 0  is selected from the group consisting of O, S, C(O), S(O), N(R 41 ), and ON(R 41 );  
 Z 0  is optionally (CH(R 41 )) e —W 22 —(CH(R 42 )) h  wherein e and h are independently 0 or 1 and W 22  is selected from the group consisting of CR 41 ═CR 42 , 1,2-cyclopropyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 2,3-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, and 3,4-tetrahydrofuranyl, wherein Z 0  is directly bonded to the benzene ring and W 22  is optionally substituted with one or more substituents selected from the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ;  
 R 41  and R 42  are independently selected from the group consisting of amidino, hydroxyamino, hydrido, hydroxy, amino, and alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a nitrogen with a removable hydrogen or a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , a nitrogen with a removable hydrogen or a carbon at the other position adjacent to the point of attachment is optionally substituted by R 13 , a nitrogen with a removable hydrogen or a carbon adjacent to R 9  and two atoms from the point of attachment is optionally substituted by R 10 , a nitrogen with a removable hydrogen or a carbon adjacent to R 13  and two atoms from the point of attachment is optionally substituted by R 12 , and a nitrogen with a removable hydrogen or a carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 Q is optionally hydrido with the proviso that Z 0  is selected from other than a bond;  
 K is CR 4a R 4b ;  
 R 4a  and R 4b  are independently selected from the group consisting of halo, hydrido, hydroxy, alkyl, and haloalkyl;  
 with the proviso that K is CR 4a R 4b , is E 1  wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), C(S)N(H), (H)NC(S), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 K is optionally (CH(R 14 )) j -T wherein j is 0 or 1 and T is a bond or N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 R 14  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 E 0 , with the proviso that K is (CH(R 14 )) j -T, is E 2  wherein E 2  is selected from the group consisting of C(O)N(H), (H)NC(O), C(S)N(H), (H)NC(S), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to said phenyl or said heteroaryl to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  bis optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, nitro, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, alkenyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, haloalkoxyalkyl, carboalkoxy, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , aminoalkyl, hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time, with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, aminoalkyl, amino, dialkylamino, alkylamino, and hydroxyalkyl;  
 Q s  is selected from the group consisting of a bond, (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 4, and (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 3 and W 1  is selected from the group consisting of C(O)N(R 14 ), (R 14 )NC(O), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , and N(R 14 ), with the proviso that R 14  is selected from other than halo when directly bonded to N, and with the additional proviso that (CR 37 R 38 ) b  and (CH(R 14 )) c  are bonded to E 0 ;  
 R 37  and R 38  are independently selected from the group consisting of hydrido, alkyl, and haloalkyl;  
 R 38  is optionally aroyl or heteroaroyl, wherein R 38  is optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19 ;  
 Y 0  is optionally Y AT  wherein Y AT  is Q b -Q s ;  
 Y 0  is optionally Q b -Q ss  wherein Q ss  is (CH(R 14 )) e —W 2 —(CH(R 15 )) h , wherein e and h are independently 1 or 2 and W 2  is CR 4a ═CR 4b , with the proviso that (CH(R 14 )) e  is bonded to E 0 .  
 
     
     
         22 . Compound of  claim 21  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, aminoalkyl, amidino, carboxy, carboxamido, alkylsulfinyl, formyl, cyano, O—R 6 , NH—R 6 , and S—R 6 , wherein R 6  is alkyl or haloalkyl;  
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkylenedioxy, haloalkylthio, alkanoyloxy, alkoxy, hydroxy, amino, alkoxyamino, haloalkanoyl, nitro, alkylamino, alkylthio, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkylsulfonamido, amidosulfonyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 B is optionally selected from the group consisting of hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is optionally a C3-C12 cycloalkyl or a C4-C9 saturated heterocyclyl, wherein each ring carbon is optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen atom adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 10  position is optionally substituted with R 11 , a ring carbon or nitrogen atom three atoms from the point of attachment and adjacent to the R 12  position is optionally substituted with R 33 , and a ring carbon or nitrogen atom four atoms from the point of attachment and adjacent to the R 11  and R 33  positions is optionally substituted with R 34 ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, alkoxyamino, alkanoyl, haloalkanoyl, amidino, guanidino, alkylenedioxy, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfamido, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, amidosulfonyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, and cyano;  
 A is bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is selected from the group consisting of O, S, C(O), (R 7 )NC(O), (R 7 )NC(S), and N(R 7 ), with the further proviso that W 7  is selected from other than C(O) when W 7  is bonded to the N(H) on the benzene ring;  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 R 1  and X 0  are independently selected from the group consisting of hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, (CR 41 R 42 ) q  wherein q is 1 or 2, and (CH(R 41 )) g —W 0 —(CH(R 42 )) p  wherein g and p are integers independently selected from 0 through 3 and W 0  is selected from the group consisting of O, S, C(O), S(O), N(R 41 ), and ON(R 41 );  
 Z 0  is optionally (CH(R 41 )) e —W 22 —(CH(R 42 )) h  wherein e and h are independently 0 or 1 and W 22  is selected from the group consisting of CR 41 ═CR 42 , 1,2-cyclopropyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 2,3-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, and 3,4-tetrahydrofuranyl, wherein Z 0  is directly bonded to the benzene ring and W 22  is optionally substituted with one or more substituents selected from the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ;  
 R 41  and R 42  are independently selected from the group consisting of hydrido, alkyl, hydroxy, and amino;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 Q is optionally hydrido with the proviso that Z 0  is other than a bond;  
 K is CR 4a R 4b ;  
 R 4a  and R 4b  are independently selected from the group consisting of halo, hydrido, and hydroxy;  
 E 0 , with the proviso that K is CR 4a R 4b , is E 1  wherein E 1  is selected from the group consisting of a covalent single bond, C(O)N(H), (H)NC(O), S(O) 2 N(H), and N(H)S(O) 2 ;  
 K is optionally (CH(R 14 )) j -T wherein j is 0 or 1 and T is a bond or N(R 7 ) with the proviso that (CH(R 14 )) j  is bonded to the phenyl ring;  
 R 14  is hydrido or halo;  
 E 0 , with the proviso that K is (CH(R 14 )) j -T, is E 2  wherein E 2  is selected from the group consisting of C(O)N(H), (H)NC(O), C(S)N(H), (H)NC(S), S(O) 2 N(H), N(H)S(O) 2 , S(O) 2 N(H)C(O), and C(O)N(H)S(O) 2 ;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three atoms from the point of attachment of Q s  to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time, with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, amino, alkylamino and dialkylamino;  
 Q s  is selected from the group consisting of a bond, (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 4, and (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 3 and W 1  is selected from the group consisting of C(O)N(R 14 ), (R 14 )NC(O), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , and N(R 14 ), with the proviso that R 14  is selected from other than halo when directly bonded to N, and with the additional proviso that (CR 37 R 38 ) b  and (CR 37 R 38 ) b , and (CH(R 14 )) c  are bonded to E 0 ;  
 R 37  and R 38  are independently selected from the group consisting of hydrido, alkyl, and haloalkyl;  
 R 38  is optionally aroyl or heteroaroyl, wherein R 38  is optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19 ;  
 Y 0  is optionally Y AT  wherein Y AT  is Q b -Q s ;  
 Y 0  is optionally Q b -Q ss  wherein Q ss  is (CH(R 14 )) e —W 2 —(CH(R 15 )) h , wherein e and h are independently 1 or 2 and W 2  is CR 4a ═CR 4b  with the proviso that (CH(R 14 )) e  is bonded to E 0 .  
 
     
     
         23 . Compound of  claim 22  or a pharmaceutically acceptable salt thereof, wherein;  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, aminoalkyl, cyano, O—R 6 , NH—R 6 , and S—R 6 , wherein R 6  is alkyl or haloalkyl;  
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three atoms from the point of attachment of Q s  to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, alkyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         24 . Compound of  claim 23  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1,2-dihydroxyethyl, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, methoxy, trifluoromethoxy, N-methylamino, methythio, and trifluoromethylthio;  
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 2-Q b -5-Q s -3-R 16 -6-R 18  pyrazine, 3-Q b -6-Q s -2-R 18 -5-R 18 -4-R 19  pyidazine, 2-Q b -5-Q s -4-R 17 -6-R 18  pyrimidine, 5-Q b -2-Q s -4-R 16 -6-R 19  pyrimidine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene, 3-Q b -5-Q s -4-R 16 -2-R 19  furan, 2-Q b -5-Q s -3-R 16 -4-R 17  furan, 3-Q b -5-Q s -4-R 16 -2-R 19  pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17  pyrrole, 4-Q b -2-Q s -5-R 19  imidazole, 2-Q b -4-Q s -5-R 17  imidazole, 3-Q b -5-Q s -4-R 16  isoxazole, 5-Q b -3-Q s -4-R 16  isoxazole, 2-Q b -5-Q s -4-R 16  pyrazole, 4-Q b -2-Q s -5-R 19  thiazole, and 2-Q b -5-Q s -4-R 17  thiazole;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methyl thio, ethyl thio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido, with the proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, ethyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2  and CH 2 CH 2 .  
 
     
     
         25 . Compound of  claim 24  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, amino, aminomethyl, methoxy, trifluoromethoxy, and N-methylamino;  
 B is selected from the group consisting of 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;  
 A is selected from the group consisting of CH 2 , CH 3 CH, CF 3 CH, NHC(O), CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;  
 Q is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl, 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl, 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl, 3-amino-5-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene;  
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
     
     
         26 . Compound of  claim 23  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, and aminoalkyl;  
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three atoms from the point of attachment of Q s  to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently hydrido or alkyl;  
 Q s  is CH 2 .  
 
     
     
         27 . Compound of  claim 26  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, amino, and aminomethyl;  
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, and 5-isoxazolyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, chloro, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is selected from the group consisting of phenyl, 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to the benzene ring is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, 3-Q b -5-Q s -4-R 16 -2-R 19  furan, 2-Q b -5-Q s -3-R 16 -4-R 17  furan, 3-Q b -5-Q s -4-R 16 -2-R 19  pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17  pyrrole, 4-Q b -2-Q s -5-R 19  thiazole, and 2-Q b -5-Q s -4-R 17  thiazole;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is NR 20 R 21  or C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, and ethyl;  
 Q s  is CH 2 .  
 
     
     
         28 . Compound of  claim 27  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, trifluoromethyl, hydroxy, hydroxymethyl, amino, and aminomethyl;  
 B is selected from the group consisting of 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;  
 A is CH 2  or CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl, 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl, 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene;  
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
     
     
         29 . Compound of  claim 28  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, hydroxy, hydroxymethyl, and amino;  
 B is selected from the group consisting of 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 4-methylphenyl, phenyl, 2-imidazoyl, 3-pyridyl, 4-pyridyl, and 3-trifluoromethyl-2-pyridyl;  
 A is CH 2  or CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl, 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amdinobenzyl.  
 
     
     
         30 . Compound of  claim 23  where said compound is selected from the group of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is 2-imidazoyl, A is CH 2 CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-carboxyphenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-imidazoyl, A is CH 2 CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-carboxyphenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido.  
 
     
     
         31 . Compound of  claim 22  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, aminoalkyl, cyano, O—R 6 , NH—R 6 , and S—R 6 , wherein R 6  is alkyl or haloalkyl;  
 B is selected from the group consisting of hydrido, C2-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three atoms from the point of attachment of Q s  to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         32 . Compound of  claim 31  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1,2-dihydroxyethyl, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, methoxy, trifluoromethoxy, N-methylamino, methythio, and trifluoromethylthio;  
 B is selected from the group consisting of hydrido, ethyl, 2-propynyl, 2-propenyl, propyl, isopropyl, butyl, 2-butenyl, 3-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 1-methyl-2-butynyl, 3-pentyl, 1-ethyl-2-propenyl, 2-methylbutyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 2-methyl-3-butynyl, 3-methylbutyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-propyl-2-propenyl, 1-ethyl-2-butynyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 6-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-5-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methylhexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-4-pentenyl, 1-butyl-2-propenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 A is selected from the group consisting of bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 Y 0  is selected from the group consisting of: 3-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 2-Q b -5-Q s -3-R 16 -6-R 18  pyrazine, 3-Q b -5-Q s -2-R 18 -5-R 18 -4-R 19  pyridazine, 2-Q b -5-Q s -4-R 17 -6-R 18  pyrimidine, 5-Q b -2-Q s -4-R 16 -6-R 19  pyrimidine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene, 3-Q b -5-Q s -4-R 16 -2-R 19  furan, 2-Q b -5-Q s -3-R 16 -4-R 17  furan, 3-Q b -5-Q s -4-R 16 -2-R 19  pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17  pyrrole, 4-Q b -2-Q s -5-R 19  imidazole, 2-Q b -4-Q s -5-R 17  imidazole, 3-Q b -5-Q s -4-R 16  isoxazole, 5-Q b -3-Q s -4-R 16  isoxazole, 2-Q b -5-Q s -4-R 16  pyrazole, 4-Q b -2-Q s -5-R 19  thiazole, and 2-Q b -5-Q s -4-R 17  thiazole;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, propyl, butyl, isopropyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         33 . Compound of  claim 32  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, amino, aminomethyl, methoxy, trifluoromethoxy, and N-methylamino;  
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 A is selected from the group consisting of a bond, CH 2 , NHC(O), CH 2 CH 2 , CH 2 CH 2 CH 2 , and CH 3 CHCH 2 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;  
 Q is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl, 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl, 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl, 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene;  
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
     
     
         34 . Compound of  claim 31  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, and aminoalkyl;  
 B is selected from the group consisting of hydrido, C2-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three atoms from the point of attachment of Q s  to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently hydrido or alkyl;  
 Q s  is CH 2 .  
 
     
     
         35 . Compound of  claim 34  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, amino, and aminomethyl;  
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 3-pentyl, 2-methylbutyl, 2-methyl-2-butenyl, 3-methylbutyl, 3-methyl-2-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methylhexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 A is optionally selected from the group consisting of CH 2 N(CH 3 ), CH 2 N(CH 2 CH 3 ), CH 2 CH 2 N(CH 3 ), and CH 2 CH 2 N(CH 2 CH 3 ) with the proviso that B is hydrido;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, chloro, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is selected from the group consisting of phenyl, 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to the benzene ring is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, 3-Q b -5-Q s -4-R 16 -2-R 19  furan, 2-Q b -5-Q s -3-R 16 -4-R 17  furan, 3-Q b -5-Q s -4-R 16 -2-R 19  pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17  pyrrole, 4-Q b -2-Q s -5-R 19  thiazole, and 2-Q b -5-Q s -4-R 17  thiazole;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is selected from the group consisting of NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 );  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, and ethyl;  
 Q s  is CH 2 .  
 
     
     
         36 . Compound of  claim 35  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, trifluoromethyl, hydroxy, hydroxymethyl, amino, and aminomethyl;  
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-(N-propylamidocarbonyl)phenyl, 3-amino-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl, 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl, 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene;  
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
     
     
         37 . Compound of  claim 36  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, hydroxy, hydroxymethyl, and amino;  
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl, 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amidinobenzyl.  
 
     
     
         38 . Compound of  claim 31  where said compound is selected from the group of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 R 2  is 3-aminophenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 5-amino-2-fluorophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 2-methyl-3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propenyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is (R)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propynyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-pentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methypropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is propyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 6-amidocarbonylhexyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-hydroxypropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methylpropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-methoxy-2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methoxyethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 5-amidino-2-thienylmethyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 5-amino-2-methylthiophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is bromo;  
 R 2  is 3-amino-5-carboxamidophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzyl-N-methylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-phenyl-2-propyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2,4-dichlorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(4-bromobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-isobutylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cycloheptylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-pyridylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-pyridylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-(4-methoxyphenyl)ethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-phenylpropyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2,2-diphenylethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-naphthylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(1,2,3,4-tetrahydronaphth-2-ylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-carboxyphenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzylbenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 5-amino-2-fluorophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 2-methyl-3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propenyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is (R)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propynyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-pentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is ethyl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methypropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is propyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 6-amidocarbonylhexyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 3-hydroxypropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methylpropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-methoxy-2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-methoxyethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 5-amidino-2-thienylmethyl, J is fluoro, and R 1  is chloro;  
 R 2  is 5-amino-2-methylthiophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is bromo;  
 R 2  is 3-amino-5-carboxamidophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzyl-N-methylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-phenyl-2-propyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2,4-dichlorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(4-bromobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-isobutylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-cycloheptylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-pyridylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-pyridylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-(4-methoxyphenyl)ethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(3-phenylpropyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2,2-diphenylethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-naphthylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(1,2,3,4-tetrahydronaphth-2-ylmethyl)amidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-carboxyphenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-carboxyphenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 2,2,2-trifluoroethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is (S)-2-butyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is isopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzylbenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is ethyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is ethyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is isopropyl, A is a bond, Y 0  is 4-amidinobenzylbenzyl, J is fluoro, and R 1  is hydrido.  
 
     
     
         39 . Compound of  claim 22  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, aminoalkyl, cyano, O—R 6 , NH—R 6 , and S—R 6 , wherein R 6  is alkyl or haloalkyl;  
 B is a C3-C7 cycloalkyl or a C4-C6 saturated heterocyclyl, wherein each ring carbon is optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 10  position is optionally substituted with R 11 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 12  position is optionally substituted with R 33 , and a ring carbon or nitrogen four atoms from the point of attachment and adjacent to the R 11  and R 33  positions is optionally substituted with R 34 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 R 33  and R 34  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, and cyano;  
 R 33  is optionally Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three atoms from the point of attachment of Q s  to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally NR 20 R 21  or and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, alkyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         40 . Compound of  claim 39  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1,2-dihydroxyethyl, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, methoxy, trifluoromethoxy, N-methylamino, methythio, and trifluoromethylthio;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, thiaetan-3-yl, cyclopentyl, cyclohexyl, norbornyl, 7-oxabicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexan-6-yl, cycloheptyl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 4H-2-pyranyl, 4H-3-pyranyl, 4H-4-pyranyl, 4H-pyran-4-one-2-yl, 4H-pyran-4-one-3-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein each ring carbon is optionally substituted with R 33 , ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , and a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethyl amino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluorotrifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 R 33  is selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , CH 2 CH 2 , O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 2-Q b -5-Q s -3-R 16 -6-R 18  pyrazine, 3-Q b -6-Q s -2-R 18 -5-R 18 -4-R 19  pyridazine, 2-Q b -5-Q s -4-R 17 -6-R 18  pyrimidine, 5-Q b -2-Q s -4-R 16 -6-R 19  pyrimidine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene, 3-Q b -5-Q s -4-R 16 -2-R 19  furan, 2-Q b -5-Q s -3-R 16 -4-R 17  furan, 3-Q b -5-Q s -4-R 16 -2-R 19  pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17  pyrrole, 4-Q b -2-Q s -5-R 19  imidazole, 2-Q b -4-Q s -5-R 17  imidazole, 3-Q b -5-Q s -4-R 16  isoxazole, 5-Q b -3-Q s -4-R 16  isoxazole, 2-Q b -5-Q s -4-R 16  pyrazole, 4-Q b -2-Q s -5-R 10  thiazole, and 2-Q b -5-Q s -4-R 17  thiazole;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido, with the proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, ethyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2  and CH 2 CH 2 .  
 
     
     
         41 . Compound of  claim 40  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, amino, aminomethyl, methoxy, trifluoromethoxy, and N-methylamino;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, 1-pyrrolidinyl, 1-piperidinyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 7-oxabicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexanyl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 4H-2-pyranyl, 4H-3-pyranyl, 4H-4-pyranyl, 4H-pyran-4-one-2-yl, 4H-pyran-4-one-3-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl;  
 A is selected from the group consisting of a bond, CH 2 , NHC(O), CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, CH 2 , O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;  
 Q is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl, 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl, 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl, 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylapinophenyl, 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene;  
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
     
     
         42 . Compound of  claim 39  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, and aminoalkyl;  
 B is a C3-C7 cycloalkyl or a C4-C6 saturated heterocyclyl, wherein each ring carbon is optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 10  position is optionally substituted with R 11 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 12  position is optionally substituted with R 33 , and a ring carbon or nitrogen four atoms from the point of attachment and adjacent to the R 11  and R 33  positions is optionally substituted with R 34 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 R 33  and R 34  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, and cyano;  
 R 33  is optionally Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 1  and X o  are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three atoms from the point of attachment of Q s  to said phenyl or said heteroaryl is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently hydrido or alkyl;  
 Q s  is CH 2 .  
 
     
     
         43 . Compound of  claim 42  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, chloro, trifluoromethyl, hydroxy, hydroxymethyl, amino, and aminomethyl;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, bicyclo[3.1.0]hexan-6-yl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein each ring carbon is optionally substituted with R 33 , ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment are optionally substituted with R 10 , and a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 R 33  is selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, carboxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, chloro, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is selected from the group consisting of phenyl, 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to the benzene ring is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 ;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, 3-Q b -5-Q s -4-R 16 -2-R 19  furan, 2-Q b -5-Q s -3-R 16 -4-R 17  furan, 3-Q b -5-Q s -4-R 16 -2-R 19  pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17  pyrrole, 4-Q b -2-Q s -5-R 19  thiazole, and 2-Q b -5-Q s -4-R 17  thiazole;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is NR 20 R 21  or C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, and ethyl;  
 Q s  is CH 2 .  
 
     
     
         44 . Compound of  claim 43  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, trifluoromethyl, hydroxy, hydroxymethyl, amino, and aminomethyl;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 1-pyrrolidinyl and 1-piperidinyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl, 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl, 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl, 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl, 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl, 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl, 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl, 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl, 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of: 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19  benzene, 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19  pyridine, 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19  pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19  thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17  thiophene;  
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
     
     
         45 . Compound of  claim 44  or a pharmaceutically acceptable salt thereof, wherein; 
 J is selected from the group consisting of fluoro, hydroxy, hydroxymethyl, and amino;  
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, and 1-piperidinyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;  
 X o  is selected from the group consisting of hydrido, hydroxy, amino, amidino, aminomethyl, cyano, methyl, trifluoromethyl, hydroxymethyl, and fluoro;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is selected from the group consisting of 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl, 3-amino-5-(N-benzylamidosulfonyl)phenyl, 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, 3-amino-5-(N-ethylamidocarbonyl)phenyl, 3-amino-5-(N-isopropylamidocarbonyl)phenyl, 3-amino-5-(N-propylamidocarbonyl)phenyl, 3-amino-5-(N-isobutylamidocarbonyl)phenyl, 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl, 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl, 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl, 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl, 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl;  
 Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amdinobenzyl.  
 
     
     
         46 . Compound of  claim 39  where said compound is selected from the group of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 R 2  is 3-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 5-amino-2-thienyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is oxalan-2-yl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-piperidinyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-pyrrolidinyl, A is CH 2 CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 2-aminocarboxypyridyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is hydroxy, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 5-amino-2-thienyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-aminophenyl, B is oxalan-2-yl, A is CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-piperidinyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-aminophenyl, B is 1-pyrrolidinyl, A is CH 2 CH 2 CH 2 , Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 2-amino-6-carboxypyridyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3,5-diaminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-carboxy-5-aminophenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopropyl, A is a bond, Y 0  is 4-amidino-2-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is hydrido;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclobutyl, A is a bond, Y 0  is 4-amidino-3-fluorobenzyl, J is fluoro, and R 1  is chloro;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenyl, B is cyclopentyl, A is a bond, Y 0  is 4-amidinobenzyl, J is fluoro, and R 1  is chloro.  
 
     
     
         47 . A composition for inhibiting thrombotic conditions in blood comprising a compound of  claim 21  and a pharmaceutically acceptable carrier.  
     
     
         48 . A composition for inhibiting thrombotic conditions in blood comprising a compound of  claim 21  and a pharmaceutically acceptable carrier.  
     
     
         49 . A method for inhibiting thrombotic conditions in blood comprising adding to blood a therapeutically effective amount of a composition of  claim 21 .  
     
     
         50 . A method for inhibiting formation of blood platelet aggregates in blood comprising adding to blood a therapeutically effective amount of a composition of  claim 21 .  
     
     
         51 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of a composition of  claim 21 .  
     
     
         52 . A method for treating or preventing venuous thromboembolism and pulmonary embolism in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of  claim 21 .  
     
     
         53 . A method for treating or preventing deep vein thrombosis in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of  claim 21 .  
     
     
         54 . A method for treating or preventing cardiogenic thromboembolism in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of  claim 21 .  
     
     
         55 . A method for treating or preventing thromboembolic stroke in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of  claim 21 .  
     
     
         56 . A method for treating or preventing thrombosis associated with cancer and cancer chemotherapy in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of  claim 21 .  
     
     
         57 . A method for treating or preventing unstable angina in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of  claim 21 .  
     
     
         58 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of a compound of  claim 21  with a therapeutically effective amount of fibrinogen receptor antagonist.  
     
     
         59 . The use of a compound of  claim 21 , or a pharmaceutically acceptable salt thereof, in the manufacture of medicament for inhibiting thrombus formation, treating thrombus formation, or preventing thrombus formation in a mammal.