Highly absorbable solid preparation

Abstract

A solid preparation improved in oral absorption and reduced in fluctuations of oral absorption can be obtained by incorporating an organic acid, particularly tartaric acid, in a solid preparation having, as an active ingredient, a high content of a quinolone compound, particularly sitafloxacin, having poor water solubility at pH around neutrality.

1 . A solid preparation comprising at least one compound selected from quinolone compounds or salts thereof, or hydrates thereof and tartaric acid.  
     
     
         2 . A solid preparation according to  claim 1 , wherein the quinolone compound is slightly soluble in water at pH around neutrality.  
     
     
         3 . A solid preparation according to  claim 2 , which comprises at least one selected from sitafloxacin represented by the following formula:  
       
         
           
           
               
               
           
         
       
       or salts thereof, or hydrates thereof and tartaric acid.  
     
     
         4 . A solid preparation according to any one of  claims 1  to  3 , which is in the form of tablets or capsules.  
     
     
         5 . A solid preparation according to  claim 4 , which is in the form of capsules.