US2004131569A1PendingUtilityA1

Increasing skin cell renewal with water-soluble vitamin E

51
Priority: Dec 19, 2002Filed: Oct 10, 2003Published: Jul 8, 2004
Est. expiryDec 19, 2022(expired)· nominal 20-yr term from priority
Inventors:Louise M. SchneiderMelissa L. HundeyJohn V. Scimeca
A61K 2800/28A61K 8/678A61Q 19/00
51
PatentIndex Score
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Cited by
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References
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Claims

Abstract

The present invention relates to a method of enhancing the rate of skin exfoliation by incorporating a water-soluble Vitamin E derivative into a cosmetic composition that contains water and is suitable for application to mammalian skin. The composition has a pH from about 4.5 to 9 and can increase the rate of natural skin exfoliation by at least 10%.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A composition for enhancing the rate of mammalian skin exfoliation comprising from 0.05% to about 30% of a water-soluble Vitamin E derivative selected from the group consisting of Sodium Vitamin E Phosphate, Lauryl Imino Dipropionic Acid Tocopheryl Phosphate, Tocopheryl Glucoside, Tocopheryl Succinate, Tocophersolan (Tocopheryl Polyethylene Glycol 1000 Succinate), Vitamin E derivatives having beta-alanine functionality, Tocophereth-5,10,12,18, and 50, and mixtures thereof and a carrier comprising water, where the composition has a pH from about 4.5 to 9 and the water-soluble Vitamin E derivative is substantially in the water.  
     
     
         2 . The composition of  claim 1 , where the water-soluble Vitamin E derivative is selected from the group consisting of Sodium Vitamin E Phosphate, Lauryl Imino Dipropionic Acid Tocopheryl Phosphate, Vitamin E derivatives having beta-alanine functionality, and mixtures thereof.  
     
     
         3 . The composition of  claim 1 , where the composition does not comprise squalene or squalane.  
     
     
         4 . The composition of  claim 1 , where the water-soluble Vitamin E derivative includes a Sodium Vitamin E Phosphate.  
     
     
         5 . The composition of  claim 1 , where the water-soluble Vitamin E derivative includes a Disodium Lauriminodipropionate Tocopheryl Phosphate.  
     
     
         6 . The composition of  claim 1 , where the composition comprises from 0.1% to about 20% of the water-soluble Vitamin E derivative.  
     
     
         7 . The composition of  claim 1 , where the composition comprises from 0.1% to about 10% of the water-soluble Vitamin E derivative.  
     
     
         8 . The composition of  claim 1 , where the carrier further comprises a cosmetic ingredient.  
     
     
         9 . The composition of  claim 1 , where the composition has a pH from 4.8 to 8.2.  
     
     
         10 . The composition of  claim 1 , where the composition has a pH from 5.6 to 7.9.  
     
     
         11 . A method of enhancing the natural rate of mammalian skin exfoliation comprising topically applying to the skin a composition comprising from 0.05% to about 30% of a Vitamin E derivative having beta-alanine functionality and a carrier comprising water, where the composition has a pH from about 4.5 to 9.  
     
     
         12 . The method of  claim 11 , where the composition comprises from 0.1% to about 10% of the Vitamin E derivative having beta-alanine functionality.  
     
     
         13 . The method of  claim 11 , where the Vitamin E derivative having beta-alanine functionality includes a Disodium Lauriminodipropionate Tocopheryl Phosphate.  
     
     
         14 . The method of  claim 11 , where the composition further comprises a cosmetic ingredient.  
     
     
         15 . The method of  claim 11 , where the composition has a pH from 4.8 to 8.2.  
     
     
         16 . The method of  claim 11 , where the composition has a pH from 5.6 to 7.9.  
     
     
         17 . The method of  claim 11 , where the natural rate of skin exfoliation is accelerated by at least 10%.  
     
     
         18 . The method of  claim 11 , where the natural rate of skin exfoliation is accelerated by at least 15%.  
     
     
         19 . The method of  claim 11 , where sting % is reduced by at least 25% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.  
     
     
         20 . The method of  claim 11 , where sting % is reduced by at least 50% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.  
     
     
         21 . The method of  claim 11 , where the natural rate of skin exfoliation is accelerated by at least 10% and sting % is reduced by at least 25% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.  
     
     
         22 . The method of  claim 11 , where the natural rate of skin exfoliation is accelerated by at least 20% and sting % is reduced by at least 50% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.  
     
     
         23 . The method of  claim 11  where the composition is formulated as a solution, gel, lotion, cream, or ointment.  
     
     
         24 . The method of  claim 11  where the topical application is on at least a daily basis.  
     
     
         25 . A method of improving the texture of mammalian skin comprising topically applying to the skin a composition comprising from 0.05% to about 30% of a water-soluble Vitamin E derivative selected from the group consisting of Sodium Vitamin E Phosphate, Lauryl Imino Dipropionic Acid Tocopheryl Phosphate, Tocopheryl Glucoside, Tocopheryl Succinate, Tocophersolan (Tocopheryl Polyethylene Glycol 1000 Succinate), Vitamin E derivatives having beta-alanine functionality, Tocophereth-5,10,12,18, and 50, and mixtures thereof and a carrier comprising water, where the composition has a pH from about 4.5 to 9.  
     
     
         26 . The method of  claim 25 , where the Vitamin E derivative having beta-alanine functionality includes a Disodium Lauriminodipropionate Tocopheryl Phosphate.  
     
     
         27 . The method of  claim 25 , where the composition has a pH from 5.6 to 7.9.  
     
     
         28 . The method of  claim 25 , where the natural rate of skin exfoliation is accelerated by at least 15%.  
     
     
         29 . The method of  claim 25 , where sting % is reduced by at least 25% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.  
     
     
         30 . The method of  claim 25  where the composition is formulated as a solution, gel, lotion, cream, or ointment.  
     
     
         31 . A method of refinishing mammalian skin comprising topically applying to the skin a composition comprising from 0.05% to about 30% of a water-soluble Vitamin E derivative selected from the group consisting of Sodium Vitamin E Phosphate, Lauryl Imino Dipropionic Acid Tocopheryl Phosphate, Tocopheryl Glucoside, Tocopheryl Succinate, Tocophersolan (Tocopheryl Polyethylene Glycol 1000 Succinate), Vitamin E derivatives having beta-alanine functionality, Tocophereth-5,10,12,18, and 50, and mixtures thereof and a carrier comprising water, where the composition has a pH from about 4.5 to 9.  
     
     
         32 . The method of  claim 31 , where the Vitamin E derivative having beta-alanine functionality includes a Disodium Lauriminodipropionate Tocopheryl Phosphate.  
     
     
         33 . The method of  claim 31 , where the composition has a pH from 5.6 to 7.9.  
     
     
         34 . The method of  claim 31 , where the natural rate of skin exfoliation is accelerated by at least 15%.  
     
     
         35 . The method of  claim 31 , where sting % is reduced by at least 25% in relation to that achieved with an exfoliating acid having a pKa of 4.0 and below.  
     
     
         36 . The method of  claim 31  where the composition is formulated as a solution, gel, lotion, cream, or ointment.

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