US2004127560A1PendingUtilityA1
Glucagon antagonists/inverse agonists
Priority: Nov 17, 2000Filed: Nov 13, 2003Published: Jul 1, 2004
Est. expiryNov 17, 2020(expired)· nominal 20-yr term from priority
C07C 275/28C07C 275/42C07C 2601/16C07D 209/48C07C 275/26C07C 317/42C07C 2601/14C07C 275/34C07D 271/06G06Q 30/06C07D 257/04C07D 319/08C07C 275/36C07C 323/44C07D 277/48C07D 319/20C07D 263/57C07D 277/28C07C 311/47C07D 333/36C07D 513/04C07C 275/30
46
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Claims
Abstract
Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.
Claims
exact text as granted — not AI-modified1 . A method for treating disorders or diseases wherein a glucagon antagonistic action is beneficial, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureido-methyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexyphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl-benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
2 . The method according to claim 1 , wherein the effective amount of the compound is in the range of from about 0.05 mg to about 2000 mg per day.
3 . The method according to claim 1 , wherein the effective amount of the compound is in the range of from about 0.1 mg to about 1000 mg per day.
4 . The method according to claim 1 , wherein the effective amount of the compound is in the range of from about 0.5 mg to about 500 mg per day.
5 . A method for treating glucagon-mediated disorders and diseases, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl}benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexyphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
6 . A method for treating hyperglycemia, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexyphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
7 . A method for lowering blood glucose in a mammal, said method comprising administering to said mammal an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-(1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexyphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino]propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
8 . A method for treating impaired glucose tolerance, said method comprising administering to a subject in need thereof an effective amount of a A compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]-benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfony-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexyphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]-benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]-benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]-benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]-benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]-benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoyl-amino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid. 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]-benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
9 . A method for treating Type 2 diabetes, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluomethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsufonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazo-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
10 . A method for delaying the progression from impaired glucose tolerance to Type 2 diabetes, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsufonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazo-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
11 . A method for delaying the progression from non-insulin requiring Type 2 diabetes to insulin requiring Type 2 diabetes, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-}4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino)propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]amino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]amino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
12 . A method for treating Type 1 diabetes, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsufonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazo-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-y)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-( 5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
13 . A method for treating obesity, said method comprising administering to a subject in need thereof an effective amount of a compound which is selected from
3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-5-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex1-enylphenyl)-3-(3-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-tert-butylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-hydroxymethyl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-iodophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylsulfonyl-4-butoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-ylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohexylcyclohexyl)ureidomethylbenzoylamino}propionic acid 3-{4-[3-[1(S)-(4-chlorophenyl)ethyl]-1-(4-cyclohex-1-enylphenyl)ureidomethylbenzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methyl phenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-isopropyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenylsulfamoyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2-[2,2,2-trifluoroethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylcyclohexyl)-3-(5-methylsulfonylthiophen-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-biphenyl-2-ylmethyl-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-trifluoromethyl-4-chlorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2,2,4,4-tetrafluorobenzo[1,3]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzothiazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,3,4,4-tetrafluorobenzo[1,4]dioxin-6-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-fluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitrophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-nitro-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-phenoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylcyclohexyl)-3-(3,5-difluorophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoyl-amino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-7-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(7-trifluoromethoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(4-fluro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,6-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromo-7-fluorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5,7-bis(trifluoromethyl)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,6,8,8-tetrafluoro-6H-dioxino[5,4-f]benzothiazol-2-yl)-ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5,6-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-fluoro-6-trifluoromethylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-(tetrafluoroethylenedioxo)benzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(6,7-dichlorobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethylthiobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-methylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-7-cyanobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-trifluoromethyl-6-bromobenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-tert-butylbenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(5-trifluromethyl-7-methoxybenzothiazol-2-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-methylsulfonyl-4-methylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-ethylthiophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-acetylphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-cyanophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-chloro-4-bromophenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-benzooxazol-2-yl-4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohexylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3-(2-methyl-2H-tetrazol-5-yl)phenyl)ureidomethyl]benzoylamino}propionic acid 3-{4-[3-(3-cyano-5-trifluoromethylphenyl)-1-(4-cyclohex-1-enylphenyl)ureidomethyl]benzoylamino}propionic acid or any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
14 . The method according to claim 1 , said method further comprising administering to a subject in need thereof an antidiabetic agent.
15 . The method according to claim 1 , said method further comprising administering to a subject in need thereof an antiobesity agent.
16 . The method according to claim 1 , said method further comprising administering to a subject in need thereof an antihypertensive agent.Join the waitlist — get patent alerts
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