Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade

Abstract

The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

What we claim is:  
     
         1 . A compound of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a nitrogen with a removable hydrogen or a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , a nitrogen with a removable hydrogen or a carbon at the other position adjacent to the point of attachment is optionally substituted by R 36 , a nitrogen with a removable hydrogen or a carbon adjacent to R 32  and two atoms from the point of attachment is optionally substituted by R 33 , a nitrogen with a removable hydrogen or a carbon adjacent to R 36  and two atoms from the point of attachment is optionally substituted by R 35 , and a nitrogen with a removable hydrogen or a carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 9 , R 10 , R 11 , R 12 , R 13 , R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkylenedioxy, haloalkylthio, alkanoyloxy, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, alkoxyalkyl, haloalkoxylalkyl, hydroxy, amino, alkoxyamino, nitro, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylthioalkyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, alkylsulfonylalkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkylsulfonamido, amidosulfonyl, alkanoyl, haloalkanoyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aminoalkyl, haloalkoxyalkyl, carboxyalkyl, carboalkoxy, carboxy, carboxamido, carboxamidoalkyl, and cyano;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently optionally Q b ;  
 B is optionally selected from the group consisting of hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B may be optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is optionally a C3-C12 cycloalkyl or a C4-C9 heterocyclyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and nitrogens adjacent to the carbon at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 , a ring carbon three atoms from the point of attachment and adjacent to the R 10  position may be substituted with R 11 , a ring carbon three atoms from the point of attachment and adjacent to the R 12  position may be substituted with R 33 , and a ring carbon four atoms from the point of attachment and adjacent to the R 11  and R 33  positions may be substituted with R 34 ;  
 A is selected from the group consisting of a bond, (W 7 ) rr —(CH(R 15 )) pa , and (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 6, and W 7  is selected from the group consisting of O, S, C(O), (R 7 )NC(O), (R 7 )NC(S), and N(R 7 ), with the proviso that no more than one of the group consisting of rr and pa is 0 at the same time;  
 R 7  is selected from the group consisting of hydrido, hydroxy, and alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 Ψ is NH or NOH;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, alkyl, alkenyl, cyano, halo, haloalkyl, haloalkoxy, haloalkylthio, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, W 0 —(CH(R 42 )) p  wherein p is an integer selected from 0 through 3 and W 0  is selected from the group consisting of O, S, C(O), S(O), N(R 41 ), and ON(R 41 ), (CH(R 41 )) g —O wherein g is an integer selected from 1 through 3, and (CH(R 41 )) g —S wherein g is an integer selected from 1 through 3, with the proviso that Z 0  is directly bonded to the pyrimidinone ring;  
 Z 0  is optionally W 22 —(CH(R 42 )) h  wherein h is 0 or 1 and W 22  is selected from the group consisting of CR 41 ═CR 42 , 1,2-cyclopropyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 2,3-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl 2,6-piperidinyl, 3,4-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, and 3,4-tetrahydrofuranyl, wherein Z 0  is directly bonded to the pyrimidinone ring and W 22  is optionally substituted with one or more substituents selected from the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ;  
 R 41  and R 42  are independently selected from the group consisting of amidino, hydroxyamino, hydrido, hydroxy, amino, and alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a nitrogen with a removable hydrogen or a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , a nitrogen with a removable hydrogen or a carbon at the other position adjacent to the point of attachment is optionally substituted by R 13 , a nitrogen with a removable hydrogen or a carbon adjacent to R 9  and two atoms from the point of attachment is optionally substituted by R 10 , a nitrogen with a removable hydrogen or a carbon adjacent to R 13  and two atoms from the point of attachment is optionally substituted by R 12 , and a nitrogen with a removable hydrogen or a carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than phenyl when Z 0  is a bond;  
 Q is optionally hydrido with the proviso that Z 0  is other than a bond;  
 K is (CR 4a R 4b ) n  wherein n is 1 or 2;  
 R 4a  and R 4b  are independently selected from the group consisting of halo, hydrido, hydroxyalkyl, alkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;  
 E 0  is E 1 , when K is (CR 4a R 4b ) n , wherein E 1  is selected from the group consisting of a bond, C(O), C(S), C(O)N(R 7 ), (R 7 )NC(O), S(O) 2 , (R 7 )NS(O) 2 , and S(O) 2 N(R 7 );  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, nitro, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, alkenyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, haloalkoxyalkyl, carboalkoxy, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , aminoalkyl, hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time and with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, aminoalkyl, amino, dialkylamino, alkylamino, and hydroxyalkyl;  
 Q s  is selected from the group consisting of a bond, (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 4, and (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 3 and W 1  is selected from the group consisting of C(O)N(R 14 ), (R 14 )NC(O), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , and N(R 14 ), with the provisos that R 14  is selected from other than halo when directly bonded to N and that (CR 37 R 38 ) b , and (CH(R 14 )) c  are bonded to E 0 ;  
 R 14  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 37  and R 38  are independently selected from the group consisting of hydrido, alkyl, and haloalkyl;  
 R 38  is optionally aroyl or heteroaroyl, wherein R 38  is optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19 ;  
 Y 0  is optionally Y AT  wherein Y AT  is Q b -Q s ;  
 Y 0  is optionally Q b -Q ss  wherein Q ss  is (CH(R 14 )) e —W 2 —(CH(R 15 )) h , wherein e and h are independently 1 or 2 and W 2  is CR 4a ═CR 4b  with the proviso that (CH(R 14 )) e  is bonded to E 0 ;  
 Y 0  is optionally Q b -Q ssss  or Q b -Q ssssr  wherein Q ssss  is (CH(R 38 )) r —W 5  Q ssssr  is (CH(R 38 )) r —W 6 , r is an integer selected from 1 through 2, W 5  and W 6  are independently selected from the group consisting of 1,4-indenyl, 1,5-indenyl, 1,6-indenyl, 1,7-indenyl, 2,7-indenyl, 2,6-indenyl, 2,5-indenyl, 2,4-indenyl, 3,4-indenyl, 3,5-indenyl, 3,6-indenyl, 3,7-indenyl, 2,4-benzofuranyl, 2,5-benzofuranyl, 2,6-benzofuranyl, 2,7-benzofuranyl, 3,4-benzofuranyl, 3,5-benzofuranyl, 3,6-benzofuranyl, 3,7-benzofuranyl, 2,4-benzothiophenyl, 2,5-benzothiophenyl, 2,6-benzothiophenyl, 2,7-benzothiophenyl, 3,4-benzothiophenyl, 3,5-benzothiophenyl, 3,6-benzothiophenyl, 3,7-benzothiophenyl, 2,7-imidazo(1,2-a)pyridinyl, 3,4-imidazo(1,2-a)pyridinyl, 3,5-imidazo(1,2-a)pyridinyl, 3,6-imidazo(1,2-a)pyridinyl, 3,7-imidazo(1,2-a)pyridinyl, 2,4-indolyl, 2,5-indolyl, 2,6-indolyl, 2,7-indolyl, 3,4-indolyl, 3,5-indolyl, 3,6-indolyl, 3,7-indolyl, 1,4-isoindolyl, 1,5-isoindolyl, 1,6-isoindolyl, 2,4-isoindolyl, 2,5-isoindolyl, 2,6-isoindolyl, 2,7-isoindolyl, 1,3-isoindolyl, 3,4-indazolyl, 3,5-indazolyl, 3,6-indazolyl, 3,7-indazolyl, 2,4-benzoxazolyl, 2,5-benzoxazolyl, 2,6-benzoxazolyl, 2,7-benzoxazolyl, 3,4-benzisoxazolyl, 3,5-benzisoxazolyl, 3,6-benzisoxazolyl, 3,7-benzisoxazolyl, 1,4-naphthyl, 1,5-naphthyl, 1,6-naphthyl, 1,7-naphthyl, 1,8-naphthyl, 2,4-naphthyl, 2,5-naphthyl, 2,6-naphthyl, 2,7-naphthyl, 2,8-naphthyl, 2,4-quinolinyl, 2,5-quinolinyl, 2,6-quinolinyl, 2,7-quinolinyl, 2,8-quinolinyl, 3,4-quinolinyl, 3,5-quinolinyl, 3,6-quinolinyl, 3,7-quinolinyl, 3,8-quinolinyl, 4,5-quinolinyl, 4,6-quinolinyl, 4,7-quinolinyl, 4,8-quinolinyl, 1,4-isoquinolinyl, 1,5-isoquinolinyl, 1,6-isoquinolinyl, 1,7-isoquinolinyl, 1,8-isoquinolinyl, 3,4-isoquinolinyl, 3,5-isoquinolinyl, 3,6-isoquinolinyl, 3,7-isoquinolinyl, 3,8-isoquinolinyl, 4,5-isoquinolinyl, 4,6-isoquinolinyl, 4,7-isoquinolinyl, 4,8-isoquinolinyl, 3,4-cinnolinyl, 3,5-cinnolinyl, 3,6-cinnolinyl, 3,7-cinnolinyl, 3,8-cinnolinyl, 4,5-cinnolinyl, 4,6-cinnolinyl, 4,7-cinnolinyl, and 4,8-cinnolinyl, and each carbon and hydrido containing nitrogen member of the ring of the W 5  and of the ring of the W 6 ,other than the points of attachment of W 5  and W 6 , is optionally substituted with one or more of the group consisting of R 9 , R 10 , R 11 , and R 12 , with the proviso that Q b  is bonded to lowest number substituent position of each W 5 , with further proviso that Q b  is bonded to highest number substituent position of each W 6 , and with the additional proviso that (CH(R 38 )) r  is bonded to E 0 .  
 
     
     
         2 . Compound of  claim 1  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkylenedioxy, haloalkylthio, alkanoyloxy, alkoxy, hydroxy, amino, alkoxyamino, haloalkanoyl, nitro, alkylamino, alkylthio, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkylsulfonamido, amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 B is optionally selected from the group consisting of hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is optionally a C3-C12 cycloalkyl or C4-C9 heterocyclyl, wherein each ring carbon may be optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A may be optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and nitrogens adjacent to the carbon at the point of attachment may be optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment may be substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment may be substituted with R 12 , a ring carbon three atoms from the point of attachment and adjacent to the R 10  position may be substituted with R 11 , a ring carbon three atoms from the point of attachment and adjacent to the R 12  position may be substituted with R 33 , and a ring carbon four atoms from the point of attachment and adjacent to the R 11  and R 33  positions may be substituted with R 34 ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, alkoxyamino, alkanoyl, haloalkanoyl, amidino, guanidino, alkylenedioxy, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfamido, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, amidosulfonyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, and cyano;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is selected from the group consisting of O, S, C(O), (R 7 )NC(O), (R 7 )NC(S), and N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, W 0 —(CH(R 42 )) p  wherein p is an integer selected from 0 through 3 and W 0  is selected from the group consisting of O, S, and N(R 41 ), and (CH(R 41 )) g —O wherein g is an integer selected from 1 through 3, with the proviso that Z 0  is directly bonded to the pyrimidinone ring;  
 Z 0  is optionally W 22 —(CH(R 42 )) h  wherein h is 0 or 1 and W 22  is selected from the group consisting of 1,2-cyclopropyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 2,3-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, and 3,4-tetrahydrofuranyl, wherein Z 0  is directly bonded to the pyrimidinone ring and W 22  is optionally substituted with one or more substituents selected from the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ;  
 R 41  is selected from the group consisting of hydrido, hydroxy, amino, and alkyl;  
 R 42  is selected from the group consisting of amidino, hydroxyamino, hydrido, hydroxy, amino, and alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 Q is optionally hydrido with the proviso that Z 0  is selected from other than a bond;  
 K is CHR 4a  wherein R 4a  is selected from the group consisting of hydrido, hydroxyalkyl, alkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;  
 E 0  is selected from the group consisting of a bond, C(O)N(H), (H)NC(O), (R 7 )NS(O) 2 , and S(O) 2 N(R 7 );  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21  hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time and with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, amino, alkylamino and dialkylamino;  
 Q s  is selected from the group consisting of a bond, (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 4, and (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are integers independently selected from 1 through 3 and W 1  is selected from the group consisting of C(O)N(R 14 ), (R 14 )NC(O), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , and N(R 14 ), with the proviso that R 14  is selected from other than halo when directly bonded to N and with the further proviso that (CR 37 R 38 ) b , and (CH(R 14 )) c  are bonded to E 0 ;  
 R 14  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 37  and R 38  are independently selected from the group consisting of hydrido, alkyl, and haloalkyl;  
 R 38  is optionally aroyl or heteroaroyl, wherein R 38  is optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19 ;  
 Y 0  is optionally Y AT  wherein Y AT  is Q b -Q s ;  
 Y 0  is optionally Q b -Q ss  wherein Q ss  is (CH(R 14 )) e—W   2 —(CH(R 15 )) h , wherein e and h are independently 1 or 2 and W 2  is CR 4a ═CH with the proviso that (CH(R 14 )) e  is bonded to E 0 .  
 
     
     
         3 . Compound of  claim 2  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is (CH(R 15 )) pa —W wherein pa is an integer selected from 0 through 3 and W 7  is selected from the group consisting of O, S, and N(R 7 ) wherein R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl with the proviso that R 15  is other than hydroxy and halo when R 15  is on the carbon bonded directly to W 7 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —(CH(R 42 )) p  wherein p is an integer selected from 0 through 3 and W 0  is selected from the group consisting of O, S, and N(R 41 ), with the proviso that Z 0  is directly bonded to the pyrimidinone ring:  
 R 41  is selected from the group consisting of hydrido, hydroxy, and alkyl;  
 R 42  is selected from the group consisting of amidino, hydrido, hydroxy, amino, and alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, alkoxyamino, alkanoyl, haloalkanoyl, amidino, guanidino, alkylenedioxy, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfamido, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, amidosulfonyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, and cyano;  
 K is CHR 4a  wherein R 4a  is selected from the group consisting of hydrido, hydroxyalkyl, alkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;  
 E 0  is selected from the group consisting of a bond, C(O)N(H), (H)NC(O), (R 7 )NS(O) 2 , and S(O) 2 N(R 7 );  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkyl amino, and dialkylamino at the same time and with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, amino, alkylamino and dialkylamino;  
 Q s  is selected from the group consisting of a bond, (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 3, and (CH(R 14 )) c —W 1 —(CH(R 15 )) d  wherein c and d are independently 1 or 2 and W 1  is selected from the group consisting of C(O)N(R 14 ), (R 14 )NC(O), S(O), S(O) 2 , S(O) 2 N(R 14 ), N(R 14 )S(O) 2 , and N(R 14 ), with the proviso that R 14  is selected from other than halo when directly bonded to N and with the further proviso that (CR 37 R 38 ) b , and (CH(R 14 )) c  are bonded to E 0 ; R 14  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 14  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 R 37  and R 38  are independently selected from the group consisting of hydrido, alkyl, and haloalkyl;  
 R 38  is optionally aroyl and heteroaroyl;  
 Y 0  is optionally Q b -Q ss  wherein Q ss  is (CH(R 14 )) e —W 2 —CH(R 15 )) h , wherein e and h are integers independently selected from 1 through 2 and W 2  is CR 4a ═CH with the proviso that (CH(R 14 )) e  is bonded to E 0 .  
 
     
     
         4 . Compound of  claim 3  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, trialkylsilyl, C2-C4 alkyl, C3-C5 alkylenyl, C3-C4 alkenyl, C3-C4 alkynyl, and C2-C4 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 3 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , and R 34 ;  
 R 32 , R 33 , and R 34  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, and cyano;  
 A is (CH(R 15 )) pa —N(R 7 ) wherein pa is an integer selected from 0 through 2 and R 7  is selected from the group consisting of hydrido and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —CH(R 42 ) wherein W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, and hydroxy;  
 Q 5  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         5 . Compound of  claim 4  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, —CH 2 CH 2 CH 2 —, —CH 2 CH 2 CH 2 CH 2 —, butyl, 2-butenyl, 3-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 2,2,2-trifluoroethyl, 3,3 3-trifluoropropyl, and 2,2-difluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 3 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , and R 34 ;  
 R 32 , R 33 , and R 34  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 A is selected from the group consisting of a bond, NH, and N(CH 3 );  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 2-Q b -5-Q s -3R 16 -6-R 18 pyrazine,  
 3-Q b -6-Q s -2-R 18 -5-R 18 -4-R 19 pyridazine  
 2-Q b -5-Q s -4-R 17 -6-R 18 pyrimidine, 5-Q b -2-Q s -4-R 16 -6-R 19 pyrimidine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -5-Q s -4-R 16 -2-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 19 furan,  
 3-Q b -5-Q s -4-R 16 -2-R 19 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 imidazole, 2-Q b -4-Q s -5-R 17 imidazole,  
 3-Q b -5-Q s -4-R 16 isoxazole, 5-Q b -3-Q s -4-R 16 isoxazole,  
 2-Q b -5-Q s -4-R 16 pyrazole, 4-Q b -2-Q s -5-R 19 thiazole, and  
 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20 , R 21 , R 23 , and R 24  can be hydroxy, when any two of the group consisting of R 20 , R 21 , R 23 , and R 24  are bonded to the same atom and with the further proviso that said Q b  group is bonded directly to a carbon atom;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, propyl, butyl, isopropyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
 
     
     
         6 . Compound of  claim 4  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 A is selected from the group consisting of CH 2 N(CH 3 ), CH 2 N(CH 2 CH 3 ), CH 2 CH 2 N(CH 3 ), and CH 2 CH 2 N(CH 2 CH 3 );  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4- isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 2-Q b -5-Q s -3-R 16 -6-R 18 pyrazine,  
 3-Q b -6-Q s -2-R 18 -5-R 18 -4-R 19 pyridazine,  
 2Q b -5-Q s -4-R 17 -6-R 18 pyrimidine , 5-Q b -2-Q s -4-R 16 -6-R 19 pyrimidine  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -5-Q s -4-R 16 -2-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 17 furan,  
 3-Q b -5-Q s -4-R 16 -2-R 19 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 imidazole, 2-Q b -4-Q s -5-R 17 imidazole,  
 3-Q b -5-Q s -4-R 16 isoxazole, 5-Q b -3-Q s -4-R 16 isoxazole,  
 2-Q b -5-Q s -4-R 16 pyrazole, 4-Q b -2-Q s -5-R 19 thiazole, and  
 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl,1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 Q b  is selected from the group consisting of NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20 , R 21 , R 23 , and R 24  can be hydroxy, when any two of the group consisting of R 20 , R 21 , R 23 , and R 24  are bonded to the same atom and with the further proviso that said Q b  group is bonded directly to a carbon atom;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, propyl, butyl, isopropyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
 
     
     
         7 . Compound of  claim 6  or a pharmaceutically acceptable salt thereof, wherein; 
 A is selected from the group consisting of CH 2 N(CH 3 ), CH 2 N(CH 2 CH 3 ), CH 2 CH 2 N(CH 3 ), and CH 2 CH 2 N(CH 2 CH 3 );  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, and N(CH 3 );  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl,  
 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-benzylphenyl, 3-amino-(2-phenylethyl)phenyl,  
 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl,  
 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl )amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 -aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl,  
 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl,  
 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl,  
 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl,  
 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl,  
 phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of:  
 
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
 
     
     
         8 . Compound of  claim 7  or a pharmaceutically acceptable salt thereof, where said compound is selected from the group consisting of: 
 2-[3-[2-[3-aminophenoxy]-6-chloro-N-[[4-aminoiminomethylphenyl]methyl]-5-[N,N-dimethylhydrazino]-4-oxo-1(4H)-pyrimidinyl]]acetamide;  
 2-[3-[2-[3-aminophenoxy]-6-chloro-5-[N-ethyl-N-methylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-4-oxo-1(4H)-pyrimidinyl]]acetamide;  
 2-[3-[2-[3-aminophenoxy]-6-chloro-5-[N,N-diethylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-4-oxo-1(4H)-pyrimidinyl]]acetamide;  
 2-[4-[3-[3-aminophenoxy]-N-[[4-aminoiminomethylphenyl]methyl]-6-[N,N-dimethylhydrazino]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide;  
 2-[4-[3-[3-aminophenoxy]-6-[N-ethyl-N-methylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide;  
 2-[4-[3-[3-aminophenoxy]-6-[N,N-diethylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide;  
 2-[3-[2-[3-amino-5-carboxyphenoxy]-6-chloro-N-[[4-aminoiminomethylphenyl]methyl]5-[N,N-dimethylhydrazino]4-oxo-1(4H)-pyrimidinyl]]acetamide;  
 2-[3-[2-[3-amino-5-carboxyphenoxy]-6-chloro-5-[N-ethyl-N-methylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-4-oxo-1(4H)-pyrimidinyl]]acetamide;  
 2-[3-[2-[3-amino-5-carboxyphenoxy]-6-chloro-5-[N,N-diethylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]4-oxo-1(4H)-pyrimidinyl]]acetamide;  
 2-[4-[3-[3-amino-5-carboxyphenoxy]-N-[[4-aminoiminomethylphenyl]methyl]-6-[N,N-dimethylhydrazino]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide;  
 2-[4-[3-[3-amino-5-carboxyphenoxy]-6-[N-ethyl-N-methylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide;  
 2-[4-[3-[3-amino-5-carboxyphenoxy]-6-[N,N-diethylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide.  
 
     
     
         9 . Compound of  claim 2  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 M is Nor R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclyl amino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16 or R 19  is optionally NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, alkyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         10 . Compound of  claim 9  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 2-Q b -5-Q s -3-R 16 -6-R 18 pyrazine,  
 3-Q b -6-Q s -2-R 18 -5-R 18 -4-R 19 pyridazine,  
 2-Q b -5-Q s -4-R 17 -6-R 18 pyrimidine, 5-Q b -2-Q s -4-R 16 -6-R 19 pyrimidine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -5-Q s -4-R 16 -2-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 17 furan,  
 3-Q b -5-Q s -4-R 16 -2-R 19 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 imidazole, 2-Q b -4-Q s -5-R 17 imidazole,  
 3-Q b -5-Q s -4-R 16 -isoxazole, 5-Q b -3-Q s -4-R 16 -isoxazole,  
 2-Q b -5-Q s -4-R 16 pyrazole, 4-Q b -2-Q s -5-R 19 thiazole, and  
 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido, with the proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, ethyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2  and CH 2 CH 2 .  
 
 
     
     
         11 . Compound of  claim 10  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;  
 A is selected from the group consisting of CH 2 , CH 3 CH, CF 3 CH, NHC(O), CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl,  
 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl,  
 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl,  
 3-amino-5(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl )phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl )phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl,  
 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl,  
 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl,  
 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl,  
 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl,  
 phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of:  
 
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 26 , R 29 , and Q b  are not simultaneously hydrido;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
 
     
     
         12 . Compound of  claim 9  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —(CH 2 ) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(H);  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently hydrido or alkyl;  
 Q s  is CH 2 .  
 
     
     
         13 . Compound of  claim 12  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, and 5-isoxazolyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro; R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, OCH 2 , SCH 2 , and N(H)CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene  
 3-Q b -5-Q s -4-R 16 -2-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 17 furan  
 3-Q b -5-Q s -4-R 16 -2-R 19 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 thiazole, and 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is NR 20 R 21  or C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, and ethyl;  
 Q s  is CH 2 .  
 
 
     
     
         14 . Compound of  claim 13  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;  
 A is selected from the group consisting of CH 2  and CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, and OCH 2 ;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl,  
 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl,  
 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl,  
 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl,  
 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl,  
 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl,  
 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl,  
 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of:  
 
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
 
     
     
         15 . Compound of  claim 14  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 4-methylphenyl, phenyl, 2-imidazoyl, 3-pyridyl, 4-pyridyl, and 3-trifluoromethyl-2-pyridyl;  
 A is selected from the group consisting of CH 2  and CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is Z 0 -Q;  
 Z is selected from the group consisting of a bond, O, S, and NH;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethyl benzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl,  
 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl,  
 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl,  
 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amidinobenzyl.  
 
 
     
     
         16 . Compound of  claim 9  where said compound is selected from the group of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-4-carboxy-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,4-diamino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenoxy, B is 3-aminophenyl, A is C(O)NH, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenoxy, B is 3-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-(N-methylamino)-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-methylsulfonamido-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenylthio, B is 4-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-methylaminophenoxy, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenylamino, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-2-thienyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-2-thienyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenylamino, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylamino, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-4-carboxy-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,4-diamino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenoxy, B is 3-aminophenyl, A is C(O)NH, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenoxy, B is 3-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-(N-methylamino)-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-methylsulfonamido-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenylthio, B is 4-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-methylaminophenoxy, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenylamino, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is3-amino-2-thienyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-2-thienyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl,  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenylamino, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxyphenylamino, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-4-carboxy-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,4-diamino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenoxy, B is 3-aminophenyl, A is C(O)NH, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenoxy, B is 3-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-(N-methylamino)-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-methylsulfonamido-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenylthio, B is 4-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-methylaminophenoxy, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenylamino, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-2-thienyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-2-thienyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R is 3,5-diaminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenylamino, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxyphenylamino, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N.  
 
     
     
         17 . Compound of  claim 2  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, C2-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         18 . Compound of  claim 17  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propynyl, 2-propenyl, propyl, isopropyl, butyl, 2-butenyl, 3-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 1-methyl-2-butynyl, 3-pentyl, 1-ethyl-2-propenyl, 2-methylbutyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 2-methyl-3-butynyl, 3-methylbutyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-propyl-2-propenyl, 1-ethyl-2-butynyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 6-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-5-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methyl-4-hexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-4-pentenyl, 1-butyl-2-propenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O , S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, 3,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 2-Q b -5-Q s -3-R 16 -6-R 18 pyrazine,  
 3-Q b -6-Q s -2-R 18 -5-R 18 -4-R 19 pyridazine,  
 2-Q b -5-Q s -4-R 17 -6-R 18 pyrimidine, 5-Q b -2-Q s -4-R 16 -6-R 19 pyrimidine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -5-Q s -4-R 16 -2-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 17 furan,  
 3-Q b -5-Q s -4-R 16 -2-R 19 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 imidazole, 2-Q b -4-Q s -5-R 17 imidazole,  
 3-Q b -5-Q s -4-R 16 isoxazole, 5-Q b -3-Q s -4-R 16 isoxazole,  
 2-Q b -5-Q s -4-R 16 pyrazole, 4-Q b -2-Q s -5-R 19 thiazole, and  
 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 R 16  or R 17  is optionally selected from the group consisting of NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 ), with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, ethyl, propyl, butyl, isopropyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
 
     
     
         19 . Compound of  claim 18  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 A is selected from the group consisting of a bond, CH 2 , NHC(O), CH 2 CH 2 , CH 2 CH 2 CH 2 , and CH 3 CHCH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl,  
 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl,  
 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl,  
 3-amino-5-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl,  
 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl,  
 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl,  
 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl,  
 phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of:  
 
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is hydrido or C(NR 25 )NR 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
 
     
     
         20 . Compound of  claim 17  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, C2-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino. cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —(CH 2 ) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(H);  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido and alkyl;  
 Q s  is CH 2 .  
 
     
     
         21 . Compound of  claim 20  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 3-pentyl, 2-methylbutyl, 2-methyl-2-butenyl, 3-methylbutyl, 3-methyl-2-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methyl-4-hexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 A is optionally selected from the group consisting of CH 2 N(CH 3 ), CH 2 N(CH 2 CH 3 ), CH 2 CH 2 N(CH 3 ), and CH 2 CH 2 N(CH 2 CH 3 ) with the proviso that B is hydrido;  
 M is selected from the group consisting of N and R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, OCH 2 , SCH 2 , and N(H)CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -4-R 19 pyridine, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene,  
 3-Q b -5-Q s -4-R 16 -2-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 17 furan,  
 3-Q b -5-Q s -4-R 16 -2-R 19 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 thiazole, and 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is selected from the group consisting of NR 20 R 21 , C(NR 25 )NR 23 R 24 , and N(R 26 )C(NR 25 )N(R 23 )(R 24 );  
 R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, and ethyl;  
 Q s  is CH 2 .  
 
 
     
     
         22 . Compound of  claim 21  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 3-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 M is selected from the group consisting of N and R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, and OCH 2 ;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl,  
 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl,  
 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl,  
 3-carboxymethyl-5-hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl,  
 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl,  
 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl,  
 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl,  
 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of:  
 
 1-Q b -4-Q s -2-R 16 -3-R 17 -5R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido and methyl;  
 Q s  is CH 2 .  
 
 
     
     
         23 . Compound of  claim 22  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 3 CH, and CH 2 CH 2 ;  
 M is selected from the group consisting of N and R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, and S, NH;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutyl amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl,  
 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl,  
 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl,  
 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoroamidinobenzyl, and 3-fluoroamidinobenzyl.  
 
 
     
     
         24 . Compound of  claim 17  where said compound is selected from the group of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 2  is 3-aminophenoxy, B is 2,2,2-trifluoroethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is (S)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 5-amino-2-fluorophenoxy, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2-methyl-3-aminophenoxy, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is ethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is ethyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-propenyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is isopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is (R)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-propynyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 3-pentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl and M is CH;  
 R 2  is 3-aminophenoxy, B is ethyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is propyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 6-amidocarbonylhexyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 3-hydroxypropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 1-methoxy-2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-methoxyethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-propyl, A is single bond, Y 0  is 5-amidino-2-thienylmethyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-carboxyphenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2,2,2-trifluoroethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is (S)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 5-aminofluoro-3-carboxy-2-thienyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 4-methyl-3-amino-5-carboxy-2-thienyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is ethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is ethyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propenyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is isopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is (R)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propynyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 3-pentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is ethyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is propyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 6-amidocarbonylhexyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 3-hydroxypropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 1-methoxy-2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-methoxyethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 5-amidino-2-thienylmethyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-carboxy-5-carboxy-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2,2,2-trifluoroethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is (S)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 5-amino-2-fluoro-5-carboxyphenylthio, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2-methyl-3-amino-5-carboxyphenylthio, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is ethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is ethyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propenyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is isopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is (R)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propynyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 3-pentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is ethyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is propyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 6-amidocarbonylhexyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 3-hydroxypropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 1-methoxy-2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-methoxyethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propyl, A is single bond, Y 0  is 5-amidino-2-thienylmethyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-carboxy-5-carboxyphenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propyl A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxyphenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-amino-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diamino-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-amino-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diamino-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propyl A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxyphenylthio, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-amino-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diamino-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxyphenoxy, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N.  
 
     
     
         25 . Compound of  claim 2  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of C3-C7 cycloalkyl and C4 saturated heterocyclyl, wherein each ring carbon is optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbon sand a nitrogen adjacent to the carbon atom at the point of attachment is optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 , a ring carbon three atoms from the point of attachment and adjacent to the R 10  position is optionally substituted with R 11 , a ring carbon three atoms from the point of attachment and adjacent to the R 12  position is optionally substituted with R 33 , and a ring carbon atoms from the point of attachment and adjacent to the R 11  and R 33  positions is optionally substituted with R 34 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;  
 R 33  and R 34  independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is (R 7 )NC(O) or N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —(CH(R 42 )) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(R 41 );  
 R 41  and R 42  are independently hydrido or alkyl;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 16 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is hydroxy at the same time and with the further proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, alkyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2 , and CH 2 CH 2 .  
 
     
     
         26 . Compound of  claim 25  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, thiaetan-3-yl, cyclopentyl, cyclohexyl, norbornyl, 7-oxabicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexan-6-yl, cycloheptyl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 4H-2-pyranyl, 4H-3-pyranyl, 4H-4-pyranyl, 4H-4-pyran-one-2-yl, 4H-pyran-4-one-3-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein each ring carbon is optionally substituted with R 33 , ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , and a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, carboxymethyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methanesulfonamido, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, fluoro, chloro, bromo, cyano, cyclobutoxy, cyclohexoxy, cyclohexylmethoxy, 4-trifluoromethycyclohexylmethoxy, cyclopentoxy, benzyl, benzyloxy, 4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy, 4-bromobenzylamino, 5-bromopyrid-2-ylmethylamino, 4-butoxyphenamino, 3-chlorobenzyl, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-ethylbenzylamino, 4-chloro-3-ethylphenylamino, 3-chlorobenzyloxy, 4-chlorobenzyloxy, 4-chlorobenzylsulfonyl, 4-chlorophenylamino, 4-chlorophenylsulfonyl, 5-chloropyrid-3-yloxy, 2-cyanopyrid-3-yloxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, ,5-difluorophenoxy, 3,5-difluorobenzyloxy, 4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluorobenzyloxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy, 4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluorotrifluoromethylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy, 4-isopropyl-3-methylphenoxy, phenylamino, 1-phenylethoxy, 2-phenylethoxy, 2-phenylethyl, 2-phenylethylamino, phenylsulfonyl, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, and 3-trifluoromethylthiophenoxy;  
 R 33  and R 34  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, methoxyamino, ethoxyamino, acetamido, trifluoroacetamido, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 2,2,2-trifluoro-1-hydroxyethyl, methoxycarbonyl, ethoxycarbonyl, amidocarbonyl, N-methylamidocarbonyl, N,N-dimethylamidocarbonyl, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), N(OH), CH 2 , CH 3 CH, CF 3 CH, NHC(O), N(CH 3 )C(O), C(O)NH, C(O)N(CH 3 ), CH 2 CH 2 , CH 2 CH 2 CH 2 , CH 3 CHCH 2 , and CF 3 CHCH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, 1-aminoethyl, methylamino, dimethylamino, cyano, methyl, ethyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, methoxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxyamino, methylthio, ethylthio, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, and bromo;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, N(CH 3 ), OCH 2 , SCH 2 , N(H)CH 2 , and N(CH 3 )CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, 5-isoxazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, and 1,3,5-triazin-2-yl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 2-Q b -5-Q s -3-R 16 -6-R 18 pyrazine,  
 3-Q b -6-Q s -2-R 18 -5-R 18 -4-R 19 pyridazine,  
 2-Q b -5-Q s -4-R 17 -6-R 18 pyrimidine, 5-Q b -2-Q s -4-R 16 -6-R 19 pyrimidine,  
 3-Q b -5-Q s -4-R 19 -2-R 19 thiophene, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -5-Q s -4-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 17 furan,  
 3-Q b -5-Q s -4-R 16 -2-R 10 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 imidazole, 2-Q b -4-Q s -5-R 17 imidazole,  
 3-Q b -5-Q s -4-R 16 isoxazole, 5-Q b -3-Q s -4-R 16 isoxazole,  
 2-Q b -5-Q s -4-R 16 pyrazole, 4-Q b -2-Q s -5-R 19 thiazole, and  
 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, isopropyl, propyl, carboxy, amidino, guanidino, methoxy, ethoxy, isopropoxy, propoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, N-ethylamino, methylthio, ethylthio, isopropylthio, trifluoromethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, fluoro, chloro, bromo, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido, with the proviso that no more than one of R 23  and R 24  is hydroxy at the same time;  
 R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, ethyl, and hydroxy;  
 Q s  is selected from the group consisting of a bond, CH 2  and CH 2 CH 2 .  
 
 
     
     
         27 . Compound of  claim 26  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, 1-pyrrolidinyl, 1-piperidinyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 7-oxabicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexan-6-yl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 4H-2-pyranyl, 4H-3-pyranyl, 4H-pyranyl, 4H-pyran-4-one-2-yl, 4H-pyran-4-one-3-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl;  
 A is selected from the group consisting of a bond, CH 2 , NHC(O), CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 M is selected from the group consisting of N and R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, amino, amidino, hydroxyamino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, hydroxymethyl, methoxyamino, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, N(CH 3 ), OCH 2 , and SCH 2 ;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-benzylphenyl, 3-amino-5-(2-phenylethyl)phenyl,  
 3-amino-5-benzylaminophenyl, 3-amino-5-(2-phenylethylamino)phenyl,  
 3-amino-5-benzyloxyphenyl, 3-amino-5-(2-phenylethoxy)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 3-aminophenyl, 3-amino-5-(4-trifluoromethylbenzylamino)phenyl,  
 3-amino-(4-trifluoromethylbenzyloxy)phenyl, 3-carboxyphenyl,  
 3-carboxy-5-hydroxyphenyl, 3-amino-5-carboxyphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl,  
 3-methanesulfonylaminophenyl, 2-methoxyphenyl, 3-methoxyphenyl,  
 3-methoxyaminophenyl, 3-methoxycarbonylphenyl, 2-methylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl,  
 phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of:  
 
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 16  or R 19  is optionally C(NR 25 )NR 23 R 24  with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24  or hydrido;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
 
     
     
         28 . Compound of  claim 25  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is a C3-C7 cycloalkyl or a C4-C6 saturated heterocyclyl, wherein each ring carbon is optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 10  position is optionally substituted with R 11 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 12  position is optionally substituted with R 33 , and a ring carbon or nitrogen four atoms from the point of attachment and adjacent to the R 11  and R 33  positions is optionally substituted with R 34 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkoxy, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboxy, carboxamido, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, alkoxy, alkoxyamino, hydroxy, amino, alkylamino, alkylsulfonamido, amidosulfonyl, hydroxyalkyl, aminoalkyl, halo, haloalkyl, carboalkoxy, carboxy, carboxamido, carboxyalkyl, and cyano;  
 R 33  and R 34  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, carboalkoxy, carboxy, carboxamido, and cyano;  
 R 33  is optionally Q b ;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is N(R 7 );  
 R 7  is hydrido or alkyl;  
 R 15  is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;  
 R 2  is Z 0 -Q;  
 Z 0  is a bond or W 0 —(CH 2 ) p  wherein p is 0 or 1 and W 0  is selected from the group consisting of O, S, and N(H);  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 Y 0  is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Q s , a carbon two or three contiguous atoms from the point of attachment of Q s  to the phenyl or heteroaryl ring is substituted by Q b , a carbon adjacent to the point of attachment of Q s  is optionally substituted by R 17 , another carbon adjacent to the point of attachment of Q s  is optionally substituted by R 18 , a carbon adjacent to Q b  is optionally substituted by R 17 , and another carbon adjacent to Q b  is optionally substituted by R 19 ;  
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally NR 20 R 21  or C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, and C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently hydrido or alkyl;  
 Q s  is CH 2 .  
 
     
     
         29 . Compound of  claim 28  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, bicyclo[3.1.0]hexan-6-yl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein each ring carbon is optionally substituted with R 33 , ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment are optionally substituted with R 10 , and a ring carbon or nitrogen atom adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 13 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 R 33  is selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 M is selected from the group consisting of N and R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, OCH 2 , SCH 2 , and N(H)CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 Y 0  is selected from the group consisting of:  
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine, 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine, 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene,  
 3-Q b -5-Q s -4-R 16 -2-R 19 furan, 2-Q b -5-Q s -3-R 16 -4-R 17 furan,  
 3-Q b -5-Q s -4-R 16 -2-R 19 pyrrole, 2-Q b -5-Q s -3-R 16 -4-R 17 pyrrole,  
 4-Q b -2-Q s -5-R 19 thiazole, and 2-Q b -5-Q s -4-R 17 thiazole; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is NR 20 R 21  or C(NR 25 )NR 23 R 24 ;  
 R 20 , R 21 , R 23 , R 24 , and R 25  are independently selected from the group consisting of hydrido, methyl, and ethyl;  
 Q s  is CH 2 .  
 
 
     
     
         30 . Compound of  claim 29  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 1-pyrrolidinyl and 1-piperidinyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, and OCH 2 ;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl,  
 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl,  
 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl,  
 3-carboxymethyl-5hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl,  
 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl,  
 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl,  
 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl  
 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when R 0  is a bond; 
 Y 0  is selected from the group consisting of:  
 
 1-Q b -4-Q s -2-R 16 -3-R 17 -5-R 18 -6-R 19 benzene,  
 2-Q b -5-Q s -6-R 17 -4-R 18 -3-R 19 pyridine,  
 3-Q b -6-Q s -2-R 16 -5-R 18 -4-R 19 pyridine,  
 3-Q b -5-Q s -4-R 16 -2-R 19 thiophene, and 2-Q b -5-Q s -3-R 16 -4-R 17 thiophene; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is C(R 25 )R 23 R 24 ;  
 R 23 , R 24 , and R 25  are independently hydrido or methyl;  
 Q s  is CH 2 .  
 
 
     
     
         31 . Compound of  claim 30  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, and 1-piperidinyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, and S, NH;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl,  
 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl,  
 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl,  
 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y 0  is selected from the group consisting of 5-amidino-2-thienylmethyl, 4-amidinobenzyl, 2-fluoro-4-amidinobenzyl, and 3-fluoro-4-amidinobenzyl.  
 
 
     
     
         32 . Compound of  claim 25  where said compound is selected from the group of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 2  is 3-aminophenoxy, B is cyclopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclopentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclopropyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclopentyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2-hydroxyphenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2,6-dichlorophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is cyclopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclopentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclopropyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclopentyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CCl;  
 R 2  is 3-aminophenoxy, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 2-hydroxyphenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 2,6-dichlorophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxyphenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxyphenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl )amidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-amino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diamino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amidocarbonyl-5-amino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diamino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-amino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diamino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxyphenylthio, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxyphenoxy, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N.  
 
     
     
         33 . Compound of  claim 2  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkylenedioxy, haloalkylthio, alkanoyloxy, alkoxy, hydroxy, amino, alkoxyamino, haloalkanoyl, nitro, alkylamino, alkylthio, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkylsulfonamido, amidosulfonyl, alkyl, alkenyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyalkyl, alkylamino, carboalkoxy, carboxy, carboxamido, cyano, and Q b ;  
 B is optionally selected from the group consisting of hydrido, trialkylsilyl, C2-C8 alkyl, C3-C8 alkylenyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is optionally a C3-C12 cycloalkyl or a C4-C9 saturated heterocyclyl, wherein each ring carbon is optionally substituted with R 33 , a ring carbon other than the ring carbon at the point of attachment of B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 10  position is optionally substituted with R 11 , a ring carbon or nitrogen three atoms from the point of attachment and adjacent to the R 12  position is optionally substituted with R 33 , and a ring carbon or nitrogen four atoms from the point of attachment and adjacent to the R 11  and R 33  positions is optionally substituted with R 34 ;  
 R 9 , R 10 , R 11 , R 12 , and R 13  are independently selected from the group consisting of hydrido, acetamido, haloacetamido, alkoxyamino, alkanoyl, haloalkanoyl, amidino, guanidino, alkylenedioxy, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkylamino, N-alkyl-N-arylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylthio, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, alkylsulfamido, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, amidosulfonyl, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, and cyano;  
 A is a bond or (CH(R 15 )) pa —(W 7 ) rr  wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W 7  is selected from the group consisting of O, S, C(O), (R 7 )NC(O), (R 7 )NC(S), and N(R 7 );  
 R 7  is selected from the group consisting of hydrido, hydroxy and alkyl;  
 R 15  is selected from the group consisting of hydrido, hydroxy, halo, alkyl, and haloalkyl;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, alkyl, cyano, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, alkylamino, amidino, hydroxy, hydroxyamino, alkoxy, hydroxyalkyl, alkoxyamino, thiol, and alkylthio;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, W 0 —(CH(R 42 )) p  wherein p is an integer selected from 0 through 3 and W 0  is selected from the group consisting of O, S, and N(R 41 ), and (CH(R 41 )) g —O wherein g is an integer selected from 1 through 3, with the proviso that Z 0  is directly bonded to the pyrimidinone ring;  
 Z 0  is optionally W 22 —(CH(R 42 )) h  wherein h is 0 or 1 and W 22  is selected from the group consisting of 1,2-cyclopropyl, 1,2-cyclobutyl, 1,2-cyclohexyl, 1,3-cyclohexyl, 1,2-cyclopentyl, 1,3-cyclopentyl, 2,3-morpholinyl, 2,4-morpholinyl, 2,6-morpholinyl, 3,4-morpholinyl, 3,5-morpholinyl, 1,2-piperazinyl, 1,3-piperazinyl, 2,3-piperazinyl, 2,6-piperazinyl, 1,2-piperidinyl, 1,3-piperidinyl, 2,3-piperidinyl, 2,4-piperidinyl, 2,6-piperidinyl, 3,4-piperidinyl, 1,2-pyrrolidinyl, 1,3-pyrrolidinyl, 2,3-pyrrolidinyl, 2,4-pyrrolidinyl, 2,5-pyrrolidinyl, 3,4-pyrrolidinyl, 2,3-tetrahydrofuranyl, 2,4-tetrahydrofuranyl, 2,5-tetrahydrofuranyl, and 3,4-tetrahydrofuranyl, wherein Z 0  is directly bonded to the pyrimidinone ring and W 22  is optionally substituted with one or more substituents selected from the group consisting of R 9 , R 10 , R 11 , R 12 , and R 13 ;  
 R 41  and R 42  are independently selected from the group consisting of hydrido, hydroxy, and amino;  
 Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 Q is optionally hydrido with the proviso that Z 0  is selected from other than a bond;  
 K is CHR 4a  wherein R 4a  is selected from the group consisting of hydrido, hydroxyalkyl, alkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;  
 E 0  is selected from the group consisting of a bond, C(O)N(H), (H)NC(O), (R 7 )NS(O) 2 , and S(O) 2 N(R 7 );  
 Y AT  is Q b -Q s ;  
 Q s is (CR 37 R 38 ) b  wherein b is an integer selected from 1 through 4, R 37  is selected from the group consisting of hydrido, alkyl, and haloalkyl, and R 38  is selected from the group consisting of hydrido, alkyl, haloalkyl, aroyl, and heteroaroyl with the proviso that there is at least one aroyl or heteroaroyl substituent, with the further proviso that no more than one aroyl or heteroaroyl is bonded to (CR 37 R 38 ) b  at the same time, with the still further proviso that said aroyl and said heteroaroyl are optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19 , with another further proviso that said aroyl and said heteroaroyl are bonded to the CR 37 R 38  that is directly bonded to E 0 , with still another further proviso that no more than one alkyl or one haloalkyl is bonded to a CR 37 R 38  at the same time, and with the additional proviso that said alkyl and haloalkyl are bonded to a carbon other than the one bonding said aroyl or said heteroaroyl; R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;  
 R 16  or R 19  is optionally selected from the group consisting of NR 20 R 21 , N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that R 16 , R 19 , and Q b  are not simultaneously hydrido;  
 Q b  is selected from the group consisting of NR 20 R 21 , hydrido, N(R 26 )C(NR 25 )N(R 23 )(R 24 ), and C(NR 25 )NR 23 R 24 , with the proviso that no more than one of R 20  and R 21  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time and with the further proviso that no more than one of R 23  and R 24  is selected from the group consisting of hydroxy, amino, alkylamino, and dialkylamino at the same time; R 20 , R 21 , R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, alkyl, hydroxy, amino, alkylamino and dialkylamino.  
 
     
     
         34 . Compound of  claim 33  of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyrrolyl, 3-pyrrolyl, 2-imidazolyl, 4-imidazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-thiazolyl, 3-isoxazolyl, and 5-isoxazolyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to A is optionally substituted by R 32 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 36 , a carbon adjacent to R 32  and two atoms from the carbon at the point of attachment is optionally substituted by R 33 , a carbon adjacent to R 36  and two atoms from the carbon at the point of attachment is optionally substituted by R 35 , and any carbon adjacent to both R 33  and R 35  is optionally substituted by R 34 ;  
 R 32 , R 33 , R 34 , R 35 , and R 36  are independently selected from the group consisting of hydrido, amidino, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, dimethylamino, methoxyamino, methylthio, ethylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, hydroxymethyl, amidocarbonyl, carboxy, cyano, and Q b ;  
 B is optionally selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butenyl, 2-butynyl, sec-butyl, tert-butyl, isobutyl, 2-methylpropenyl, 1-pentyl, 2-pentenyl, 3-pentenyl, 2-pentynyl, 3-pentynyl, 2-pentyl, 3-pentyl, 2-methylbutyl, 2-methyl-2-butenyl, 3-methylbutyl, 3-methyl-2-butenyl, 1-hexyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 2-hexyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 3-hexyl, 1-ethyl-2-butenyl, 1-heptyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 2-heptynyl, 3-heptynyl, 4-heptynyl, 5-heptynyl, 2-heptyl, 1-methyl-2-hexenyl, 1-methyl-3-hexenyl, 1-methyl-4-hexenyl, 1-methyl-2-hexynyl, 1-methyl-3-hexynyl, 1-methyl-4-hexynyl, 3-heptyl, 1-ethyl-2-pentenyl, 1-ethyl-3-pentenyl, 1-ethyl-2-pentynyl, 1-ethyl-3-pentynyl, 2,2,2-trifluoroethyl, 2,2-difluoropropyl, 4-trifluoromethyl-5,5,5-trifluoropentyl, 4-trifluoromethylpentyl, 5,5,6,6,6-pentafluorohexyl, and 3,3,3-trifluoropropyl, wherein each member of group B is optionally substituted at any carbon up to and including 5 atoms from the point of attachment of B to A with one or more of the group consisting of R 32 , R 33 , R 34 , R 35 , and R 36 ;  
 B is optionally selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, bicyclo[3.1.0]hexan-6-yl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-dioxanyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, and 3-tetrahydrothienyl, wherein each ring carbon is optionally substituted with R 33 , ring carbons and a nitrogen adjacent to the carbon atom at the point of attachment are optionally substituted with R 9  or R 13 , a ring carbon or nitrogen adjacent to the R 9  position and two atoms from the point of attachment is optionally substituted with R 10 , and a ring carbon or nitrogen adjacent to the R 13  position and two atoms from the point of attachment is optionally substituted with R 12 ;  
 R 9 , R 11 , and R 13  are independently selected from the group consisting of hydrido, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, N-methylamino, N,N-dimethylamino, methylthio, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, fluoro, chloro, bromo, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, hydroxymethyl, 1-hydroxyethyl, amidocarbonyl, N-methylamidocarbonyl, carboxy, and cyano;  
 R 10  and R 12  are independently selected from the group consisting of hydrido, amidino, amidocarbonyl, N-methylamidocarbonyl, N-benzylamidocarbonyl, N-(2-chlorobenzyl)amidocarbonyl, N-(3-fluorobenzyl)amidocarbonyl, N-(2-trifluoromethylbenzyl)amidocarbonyl, N-(1-phenylethyl)amidocarbonyl, N-(1-methyl-1-phenylethyl)amidocarbonyl, N-benzylamidosulfonyl, N-(2-chlorobenzyl)amidosulfonyl, N-ethylamidocarbonyl, N-isopropylamidocarbonyl, N-propylamidocarbonyl, N-isobutylamidocarbonyl, N-(2-butyl)amidocarbonyl, N-cyclobutylamidocarbonyl, N-cyclopentylamidocarbonyl, N-cyclohexylamidocarbonyl, guanidino, methyl, ethyl, methoxy, ethoxy, hydroxy, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, carboxy, carboxymethyl, amino, acetamido, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoroacetamido, aminomethyl, N-methylamino, dimethylamino, methoxyamino, amidosulfonyl, N-methylamidosulfonyl, N,N-dimethylamidosulfonyl, methanesulfonamido, methoxycarbonyl, fluoro, chloro, bromo, and cyano;  
 A is selected from the group consisting of a bond, NH, N(CH 3 ), CH 2 , CH 3 CH, CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, methylamino, cyano, methyl, trifluoromethyl, methoxy, methylthio, trifluoromethoxy, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, OCH 2 , SCH 2 , and N(H)CH 2 ;  
 Q is selected from the group consisting of phenyl, 2-thienyl, 2-furyl, 2-pyrrolyl, 2-imidazolyl, 2-thiazolyl, 3-isoxazolyl, 2-pyridyl, and 3-pyridyl, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z 0  is optionally substituted by R 9 , the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R 13 , a carbon adjacent to R 9  and two atoms from the carbon at the point of attachment is optionally substituted by R 10 , a carbon adjacent to R 13  and two atoms from the carbon at the point of attachment is optionally substituted by R 12 , and any carbon adjacent to both R 10  and R 12  is optionally substituted by R 11 , with the proviso that Q is other than a phenyl when Z 0  is a bond;  
 Y AT  is Q b -Q s ;  
 Q s  is selected from the group consisting of:  
 C[R 37 (benzoyl)(CR 37 R 38 ) b ],  
 C[R 37 (2-pyridylcarbonyl)(CR 37 R 38 ) b ],  
 C[R 37 (3-pyridylcarbonyl)(CR 37 R 38 ) b ],  
 C[R 37 (4-pyridylcarbonyl)(CR 37 R 38 ) b ],  
 C[R 37 (2-thienylcarbonyl)(CR 37 R 38 ) b ],  
 C[R 37 (3-thienylcarbonyl)(CR 37 R 38 ) b ],  
 C[R 37 (2-thiazolylcarbonyl)(CR 37 R 38 ) b ],  
 C[R 37 (4-thiazolylcarbonyl)(CR 37 R 38 ) b ], and  
 C[R 37 (5-thiazolylcarbonyl)((CR 37 R 38 ) b ],  
 wherein b is an integer selected from 1 through 3, R 37  and R 38  are independently selected from the group consisting of hydrido, alkyl, and haloalkyl, with the proviso that said benzoyl and the heteroaroyls are optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19  with the proviso that R 17  and R 18  are optionally substituted at a carbon selected from other than the meta and para carbons relative to the carbonyl of the benzoyl or heteroaroyl, with the further proviso that said benzoyl or said heteroaroyl are bonded to the carbon directly bonded to amide nitrogen of the 1-(amidocarbonymethylene) group, and with the still further proviso that is no more than one alkyl or one haloalkyl is bonded to a CR 37 R 38  at the same time; 
 R 16 , R 17 , R 18 , and R 19  are independently selected from the group consisting of hydrido, methyl, ethyl, amidino, guanidino, methoxy, hydroxy, amino, aminomethyl, 1-aminoethyl, 2-aminoethyl, N-methylamino, dimethylamino, methylthio, ethylthio, trifluoromethylthio, methylsulfinyl, methylsulfonyl, trifluoromethyl, pentafluoroethyl, 2,2,2-trifluoroethyl, trifluoromethoxy, fluoro, chloro, hydroxymethyl, carboxy, and cyano;  
 Q b  is C(NR 25 )NR 23 R 24  or N(R 26 )C(NR 25 )N(R 23 )(R 24 );  
 R 23 , R 24 , R 25 , and R 26  are independently selected from the group consisting of hydrido, methyl, and ethyl.  
 
 
     
     
         35 . Compound of  claim 34  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of 2-aminophenyl, 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-carboxyphenyl, 3-carboxy-5-hydroxyphenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 3,4-difluorophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-methoxyaminophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, phenyl, 3-trifluoromethylphenyl, 2-imidazoyl, 2-pyridyl, 3-pyridyl, 5-chloro-3-trifluoromethyl-2-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, and 3-trifluoromethyl-2-pyridyl;  
 B is optionally selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 B is optionally selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, 1-pyrrolidinyl and 1-piperidinyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 3 CH, CH 2 CH 2 , and CH 2 CH 2 CH 2 ;  
 M is N or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, fluoro, and chloro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, NH, and OCH 2 ;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amidocarbonyl-5-aminophenyl,  
 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl )amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 5-amino-2-fluorophenyl,  
 3-amino-5-hydroxymethylphenyl, 5-amino-3-methoxycarbonylphenyl,  
 3-amidinophenyl, 3-amino-2-methylphenyl, 5-amino-2-methylthiophenyl,  
 3-aminophenyl, 3-carboxyphenyl, 3-carboxy-5-aminophenyl,  
 3-carboxy-5-hydroxyphenyl, 3-carboxymethyl-5-aminophenyl,  
 3-carboxymethyl-5hydroxyphenyl, 3-carboxymethylphenyl, 3-chlorophenyl,  
 2-chlorophenyl, 3-cyanophenyl, 3,5-diaminophenyl, 3-dimethylaminophenyl,  
 2-fluorophenyl, 3-fluorophenyl, 2,5-difluorophenyl, 2-hydroxyphenyl,  
 3-hydroxyphenyl, 3-methanesulfonylaminophenyl, 2-methoxyphenyl,  
 3-methoxyphenyl, 3-methoxyaminophenyl, 3-methoxycarbonylphenyl,  
 2-methylaminophenyl, 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl,  
 4-methylphenyl, phenyl, 3-trifluoroacetamidophenyl, 3-trifluoromethylphenyl,  
 2-trifluoromethylphenyl, 5-amino-2-thienyl, 5-amino-3-thienyl,  
 3-bromo-2-thienyl, 3-pyridyl, 4-pyridyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y AT  is Q b -Q s ;  
 Q s  is selected from the group consisting of:  
 
 [CH(benzoyl)](CH 2 ) b , [CH(2-pyridylcarbonyl)](CH 2 ) b ,  
 [CH(3-pyridylcarbonyl)](CH 2 ) b , [CH(4-pyridylcarbonyl)](CH 2 ) b ,  
 [(CH(2-thienylcarbonyl)](CH 2 ) b , [(CH(3-thienylcarbonyl)](CH 2 ) b ,  
 [CH(2-thiazolylcarbonyl)](CH 2 ) b , [CH(4-thiazolylcarbonyl)](CH 2 ) b , and [CH(5-thiazolylcarbonyl)](CH 2 ) b ,  
 wherein b is an integer selected from 1 through 3, with the proviso that said benzoyl and said heteroaroyls are optionally substituted with one or more substituents selected from the group consisting of R 16 , R 17 , R 18 , and R 19  with the proviso that R 17  and R 18  are optionally substituted at a carbon selected from other than the meta and para carbons relative to the carbonyl of the benzoyl or the heteroaroyl, and that said benzoyl or said heteroaroyl are bonded to the carbon directly bonded to amide nitrogen of the 1-(amidocarbonymethylene) group; 
 R 16  and R 19  are independently selected from the group consisting of hydrido, amidino, amino, aminomethyl, methoxy, methylamino, hydroxy, hydroxymethyl, fluoro, chloro, and cyano;  
 R 17  and R 18  are independently selected from the group consisting of hydrido, fluoro, chloro, hydroxy, hydroxymethyl, amino, carboxy, and cyano;  
 Q b  is N(R 26 )C(NR 25 )N(R 23 )(R 24 );  
 R 23 , R 24 , R 25 , and R 26  are independently hydrido or methyl.  
 
 
     
     
         36 . Compound of  claim 35  or a pharmaceutically acceptable salt thereof, wherein; 
 B is selected from the group consisting of 3-aminophenyl, 3-amidinophenyl, 4-amidinophenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2-fluorophenyl, 4-methylphenyl, phenyl, 2-imidazoyl, 3-pyridyl, 4-pyridyl, and 3-trifluoromethyl-2-pyridyl;  
 B is optionally selected from the group consisting of hydrido, ethyl, 2-propenyl, 2-propynyl, propyl, isopropyl, butyl, 2-butyl, (R)-2-butyl, (S)-2-butyl, tert-butyl, isobutyl, 1-pentyl, 3-pentyl, 2-methylbutyl, 2,2,2-trifluoroethyl, 6-amidocarbonylhexyl, 4-methyl-2-pentyl, 3-hydroxypropyl, 1-methoxy-2-propyl, 2-methoxyethyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2-dimethylaminopropyl, 2-cyanoethyl, 6-hydroxyhexyl, 2-hydroxyethyl, 2-amidinoethyl, 2-guanidinoethyl, 3-guanidinopropyl, 4-guanidinobutyl, 3-hydroxypropyl, 4-hydroxybutyl, 6-cyanohexyl, 2-dimethylaminoethyl, 3-methylbutyl, 2-methylbutyl, (S)-2-methylbutyl, 3-aminopropyl, 2-hexyl, and 4-aminobutyl;  
 B is optionally selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxalan-2-yl, 2-(2R)-bicyclo[2.2.1]-heptyl, oxetan-3-yl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, and 1-piperidinyl;  
 A is selected from the group consisting of a bond, CH 2 , CH 2 CH 2  and CH 2 CH 2 CH 2 ;  
 M is or R 1 —C;  
 R 1  is selected from the group consisting of hydrido, hydroxy, hydroxymethyl, amino, aminomethyl, cyano, methyl, trifluoromethyl, and fluoro;  
 R 2  is Z 0 -Q;  
 Z 0  is selected from the group consisting of a bond, O, S, and NH;  
 Q is selected from the group consisting of  
 3-amidocarbonyl-5-aminophenyl, 3-amino-5-(N-benzylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(3-fluorobenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-(1-methyl-1-phenylethyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-benzylamidosulfonyl)phenyl,  
 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl,  
 3-amino-5-(N-ethylamidocarbonyl)phenyl,  
 3-amino-5-(N-isopropylamidocarbonyl)phenyl,  
 3-amino-5-(N-propylamidocarbonyl)phenyl,  
 3-amino-5-(N-isobutylamidocarbonyl)phenyl,  
 3-amino-5-(N-(2-butyl)amidocarbonyl)phenyl,  
 3-amino-5-(N-cyclobutylamidocarbonyl )phenyl,  
 3-amino-5-(N-cyclopentylamidocarbonyl)phenyl,  
 3-amino-5-(N-cyclohexylamidocarbonyl)phenyl, 3-aminophenyl,  
 3-carboxy-5-aminophenyl, 3-chlorophenyl, 3,5-diaminophenyl,  
 3-dimethylaminophenyl, 3-hydroxyphenyl, 3-methanesulfonylaminophenyl,  
 3-methylaminophenyl, 2-methylphenyl, 3-methylphenyl, phenyl,  
 3-trifluoroacetamidophenyl, 3-bromo-2-thienyl, 2-thienyl, and 3-thienyl, with the proviso that Q is other than a phenyl or a substituted phenyl when Z 0  is a bond; 
 Y AT  is selected from the group consisting of 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, 5-guanidino-1-oxo-1-(4-thiazolyl)-2-pentyl, 5-guanidino-1-oxo-1-(5thiazolyl)-2-pentyl, 5-guanidino-1-oxo-1-(4-amino-2-thiazolyl)-2-pentyl, and 5-guanidino-1-oxo-1-phenyl-2-pentyl.  
 
 
     
     
         37 . Compound of  claim 33  where said compound is selected from the group of the Formula:  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein: 
 R 2  is 3-aminophenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diaminophenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-aminophenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diaminophenoxy, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-aminophenoxy, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diaminophenoxy, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-aminophenoxy, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-aminophenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diaminophenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-aminophenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diaminophenylthio, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-aminophenylthio, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diaminophenylthio, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-aminophenylthio, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-2-thienyl B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diamino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-amino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diamino-2-thienyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-amino-2-thienyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3,5-diamino-2-thienyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-carboxy-5-amino-2-thienyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-aminophenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diaminophenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-5-aminophenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diaminophenoxy, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-5-aminophenoxy, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diaminophenoxy, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-5-aminophenoxy, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenoxy, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-aminophenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diaminophenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-5-aminophenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diaminophenylthio, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-5-aminophenylthio, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diaminophenylthio, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-5-aminophenylthio, B is cyclobutyl A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenylthio, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diamino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-5-amino-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is phenyl, A is CH 2 CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diamino-2-thienyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl and M is N;  
 R 2  is 3-carboxy-5-amino-2-thienyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is isopropyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3,5-diamino-2-thienyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-carboxy-amino-2-thienyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)-2-thienyl, B is cyclobutyl, A is single bond, Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N.  
 
     
     
         38 . A composition for inhibiting thrombotic conditions in blood comprising a compound of any one of claims  8 ,  16 ,  24 ,  32 , and  37  and a pharmaceutically acceptable carrier.  
     
     
         39 . A composition for inhibiting thrombotic conditions in blood comprising a compound of any one of claims  1  through  7 , claims  9  through  15 , claims  17  through  23 , claims  25  through  31 , and claims  33  through  36  and a pharmaceutically acceptable carrier.  
     
     
         40 . A method for inhibiting thrombotic conditions in blood comprising adding to blood a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         41 . A method for inhibiting formation of blood platelet aggregates in blood comprising adding to blood a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         42 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         43 . A method for treating or preventing venuous thromboembolism and pulmonary embolism in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         44 . A method for treating or preventing deep vein thrombosis in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of of any one of claims  38  and  39 .  
     
     
         45 . A method for treating or preventing cardiogenic thromboembolism in a mammal comprising administering to the mammal a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         46 . A method for treating or preventing thromboembolic stroke in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         47 . A method for treating or preventing thrombosis associated with cancer and cancer chemotherapy in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         48 . A method for treating or preventing unstable angina in humans and other mammals comprising administering to the mammal a therapeutically effective amount of a composition of any one of claims  38  and  39 .  
     
     
         49 . A method for inhibiting thrombus formation in blood comprising adding to blood a therapeutically effective amount of a compound of any one of claims  1  through  37  with a therapeutically effective amount of fibrinogen receptor antagonist.  
     
     
         50 . The use of a compound of any one of claims  1  through  37 , or a pharmaceutically acceptable salt thereof, in the manufacture of medicament for inhibiting thrombus formation, treating thrombus formation, or preventing thrombus formation in a mammal.  
     
     
         51 . A method of treating or preventing a TF VIIA-mediated disorder in a subject by administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, said compound selected from the group consisting of: 
 2-[3-[2-[3-aminophenyl]-6-chloro-N-[[4-aminoiminomethylphenyl]methyl]-5-[N,N-dimethylhydrazino]-4-oxo-1(4H)-pyrimidinyl]]acetamide;    2-[3-[2-[3-aminophenyl]-6-chloro-5[N-ethyl-N-methylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-4-oxo-1(4H)-pyrimidinyl]]acetamide;    2-[3-[2-[3-aminophenyl]-6-chloro-5-[N,N-diethylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-4-oxo-1(4H)-pyrimidinyl]]acetamide;    2-[3-[2-[3-aminophenyl]-5-[N-(azetidin-1-yl)amino]-6-chloro-N-[[4-aminoiminomethylphenyl]methyl]-4-oxo-1(4H)-pyrimidinyl]]acetamide;    2-[4-[3-[3-aminophenyl]-N-[[4-aminoiminomethylphenyl]methyl ]-6-[N,N-dimethylhydrazino]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide;    2-[4-[3-[3-aminophenyl]-6-[N-ethyl-N-methylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-5-oxo-1(5H)-1,2,4triazinyl]]acetamide;    2-[4-[3-[3-aminophenyl ]-6-[N,N-diethylhydrazino]-N-[[4-aminoiminomethylphenyl]methyl]-5-oxo-1(5H)-1,2,4triazinyl]]acetamide;    2-[4-[3-[3-aminophenyl]-6-[N-(azetidin-1-yl)amino]-N-[[4-aminoiminomethylphenyl]methyl]-5-oxo-1(5H)-1,2,4-triazinyl]]acetamide.    
     
     
         52 . A method of treating or preventing a TF VIIA-mediated disorder in a subject by administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, said compound of the formula:  
       
         
           
           
               
               
           
         
       
       wherein: 
 R 2  is 3-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-dimethylaminophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2-methylphenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenyl, B is 3-aminophenyl, A is C(O)NH, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenyl, B is 3-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-(N-methylamino)phenyl, B is phenyl A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-methylsulfonamidophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenyl, B is 4-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-methylaminophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-methylphenyl, B is 4-phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-dimethylaminophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 2-methylphenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenyl, B is 3-aminophenyl, A is C(O)NH, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenyl, B is 3-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-(N-methylamino)phenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-methylsulfonamidophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2 is phenyl, B is 4-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-methylaminophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is phenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-methylphenyl, B is 4-phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-dimethylaminophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 2-methylphenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is phenyl, B is 3-aminophenyl, A is C(O)NH, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is phenyl, B is 3-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-(N-methylamino)phenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-methylsulfonamidophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is phenyl, B is 4-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-methylaminophenyl, B is phenyl A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is phenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-methylphenyl, B is 4-phenyl, A is CH 2 CH 2  , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-dimethylaminophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 2-methylphenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenyl, B is 3-aminophenyl, A is C(O)NH, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenyl, B is 3-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-(N-methylamino)phenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-methylsulfonamidophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenyl, B is 4-amidinophenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N; R 2  is 3-methylaminophenyl, B is phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenyl, B is phenyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-methylphenyl, B is 4-phenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenoxy, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxy-2-thienyl, B is 3-chlorophenyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2,2,2-trifluoroethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is (S)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 5-amino-2-fluorophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2-methyl-3-aminophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is ethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is ethyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-propenyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is (R)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-propynyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 3-pentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is ethyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is propyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 6-amidocarbonylhexyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 3-hydroxypropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 3-methoxy-2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 3-methoxy-2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-methoxy-2-ethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 5-amidino-2-thienylmethyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 4amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-carboxyphenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 4amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2,2,2-trifluoroethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is (S)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 5-amino-2-fluorophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 2-methyl-3-aminophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is ethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is ethyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-propenyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is isopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is (R)-2-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-propynyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 3-pentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is hydrido, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is ethyl, A is CH , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is CH 3 CH, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is propyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 6-amidocarbonylhexyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is tert-butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 3-hydroxypropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-methylpropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is butyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 3-methoxy-2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 3-methoxy-2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-methoxy-2-ethyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 5-amidino-2-thienylmethyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 4amidino-3-fluorobenzyl, and M is N;  
 R 2  is 3-carboxyphenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxyphenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carbomethoxyphenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxyphenyl, B is 2-propyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-aminophenyl, B is cycylopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 5-amino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2-hydroxyphenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 2,6-dichlorophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-aminophenyl, B is cycylopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 5-amino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is CH 2 , Y 0  is 4- amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 2-hydroxyphenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 2,6-dichlorophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-aminophenyl, B is cycylopropyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidino-3-fluorobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 5-amino-2-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclopropyl, A is CH 2 , Y 0  is 4-amidinobenzyl and M is CF;  
 R 2  is 3-aminophenyl, B is 2-(2R)-bicyclo[2.2.1]-heptyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclopentyl, A is single bond, Y 0  is 4-amidino-2-fluorobenzyl, and M is CF;  
 R 2  is 3-aminophenyl, B is cyclohexyl, A is CH 2 CH 2 , Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 2-hydroxyphenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-thienyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 2,6-dichlorophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CF;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is N;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CH;  
 R 2  is 3-amidocarbonyl-5-aminophenyl, B is cyclobutyl, A is single bond, is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-benzylamidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-chlorobenzyl)amidosulfonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-(N-(2-trifluoromethylbenzyl)amidocarbonyl)phenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3,5-diaminophenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl;  
 R 2  is 3-amino-5-carboxyphenyl, B is cyclobutyl, A is single bond, Y 0  is 4-amidinobenzyl, and M is CCl.  
 
     
     
         53 . A method of treating or preventing a TF VIIA-mediated disorder in a subject by administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, said compound of the formula:  
       
         
           
           
               
               
           
         
       
       wherein; 
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 ,Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CH;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CF;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is CCl;  
 R 2  is 3-aminophenyl, B is phenyl, A is CH 2 , Y AT  is 5-guanidino-1-oxo-1-(2-thiazolyl)-2-pentyl, and M is N.